{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:43Z","timestamp":1792783423776,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["No. 252300421368"],"award-info":[{"award-number":["No. 252300421368"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Top Talents Funding of the Second Affiliated Hospital of Zhengzhou University","award":["No. 2020BJRCB04"],"award-info":[{"award-number":["No. 2020BJRCB04"]}],"id":[{"id":"https:\/\/ror.org\/026bqfq17","id-type":"ROR","asserted-by":"crossref"}]},{"name":"BEIJING SCIENCE AND TECHNOLOGY INNOVATION MEDICAL DEVELOPMENT FOUNDATION","award":["No. KC2023-JX-0186-FM054"],"award-info":[{"award-number":["No. KC2023-JX-0186-FM054"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-026-04361-1","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:21:05Z","timestamp":1779099665000},"page":"4806-4818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FXN predicts poor prognosis in colon adenocarcinoma and correlates with immune cell infiltration"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5991-1295","authenticated-orcid":false,"given":"Mengya","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-5235","authenticated-orcid":false,"given":"Na","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"issue":"1","key":"4361_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2236364","volume":"15","author":"Z Wang","year":"2023","unstructured":"Wang Z, Dan W, Zhang N, et al. Colorectal cancer and gut microbiota studies in China. Gut Microbes. 2023;15(1):2236364.","journal-title":"Gut Microbes"},{"key":"4361_CR2","unstructured":"Ferlay J, Ervik M, Lam F, et al. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer. 2020, Available from: https:\/\/gco.iarc.fr\/today, accessed date: 28 Aug 2022"},{"issue":"28","key":"4361_CR3","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.3748\/wjg.v23.i28.5041","volume":"23","author":"FG Campos","year":"2017","unstructured":"Campos FG. Colorectal cancer in young adults: a difficult challenge. World J Gastroenterol. 2017;23(28):5041\u20134.","journal-title":"World J Gastroenterol"},{"issue":"3","key":"4361_CR4","first-page":"105","volume":"7","author":"AR Marley","year":"2016","unstructured":"Marley AR, Nan H. Epidemiology of colorectal cancer. Int J Mol Epidemiol Genet. 2016;7(3):105\u201314.","journal-title":"Int J Mol Epidemiol Genet"},{"issue":"10","key":"4361_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174","volume":"14","author":"Y Xi","year":"2021","unstructured":"Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol. 2021;14(10):101174.","journal-title":"Transl Oncol"},{"key":"4361_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102676","volume":"123","author":"A Audisio","year":"2024","unstructured":"Audisio A, Fazio R, Dapr\u00e0 V, et al. Neoadjuvant chemotherapy for early-stage colon cancer. Cancer Treat Rev. 2024;123:102676.","journal-title":"Cancer Treat Rev"},{"issue":"10","key":"4361_CR7","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.3748\/wjg.v29.i10.1569","volume":"29","author":"W Leowattana","year":"2023","unstructured":"Leowattana W, Leowattana P, Leowattana T. Systemic treatment for metastatic colorectal cancer. World J Gastroenterol. 2023;29(10):1569\u201388.","journal-title":"World J Gastroenterol"},{"issue":"10","key":"4361_CR8","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1136\/gutjnl-2014-309086","volume":"64","author":"EH Schreuders","year":"2015","unstructured":"Schreuders EH, Ruco A, Rabeneck L, et al. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64(10):1637\u201349.","journal-title":"Gut"},{"issue":"9-10","key":"4361_CR9","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1089\/acm.2018.0125","volume":"24","author":"KI Block","year":"2018","unstructured":"Block KI, Block PB, Gyllenhaal C. Integrative treatment for colorectal cancer: a comprehensive approach. J Altern Complement Med. 2018;24(9\u201310):890\u2013901.","journal-title":"J Altern Complement Med"},{"key":"4361_CR10","doi-asserted-by":"publisher","first-page":"1105180","DOI":"10.3389\/fimmu.2023.1105180","volume":"14","author":"J Shi","year":"2023","unstructured":"Shi J, Sun Z, Gao Z, et al. Radioimmunotherapy in colorectal cancer treatment: present and future. Front Immunol. 2023;14:1105180.","journal-title":"Front Immunol"},{"key":"4361_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2023.107181","volume":"151","author":"MK Culley","year":"2023","unstructured":"Culley MK, Rao RJ, Mehta M, et al. Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function. Vascul Pharmacol. 2023;151:107181. https:\/\/doi.org\/10.1016\/j.vph.2023.107181.","journal-title":"Vascul Pharmacol"},{"issue":"4","key":"4361_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ng0897-345","volume":"16","author":"H Koutnikova","year":"1997","unstructured":"Koutnikova H, Campuzano V, Foury F, et al. Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin. Nat Genet. 1997;16(4):345\u201351.","journal-title":"Nat Genet"},{"key":"4361_CR13","doi-asserted-by":"publisher","first-page":"16381","DOI":"10.1073\/pnas.0906784106","volume":"106","author":"ML Huang","year":"2009","unstructured":"Huang ML, Becker EM, et al. Elucidation of the mechanism of mitochondrial iron loading in Friedreich\u2019s ataxia by analysis of a mouse mutant. Proc Natl Acad Sci USA. 2009;106:16381\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"4361_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.5","volume":"2","author":"I Guccini","year":"2011","unstructured":"Guccini I, Serio D, Cond\u00f2 I, et al. Frataxin participates to the hypoxia-induced response in tumors. Cell Death Dis. 2011;2(2):e123.","journal-title":"Cell Death Dis"},{"issue":"2","key":"4361_CR15","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1074\/jbc.M511064200","volume":"281","author":"TJ Schulz","year":"2006","unstructured":"Schulz TJ, Thierbach R, Voigt A, et al. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J Biol Chem. 2006;281(2):977\u201381.","journal-title":"J Biol Chem"},{"issue":"24","key":"4361_CR16","doi-asserted-by":"publisher","first-page":"16750","DOI":"10.1074\/jbc.M511960200","volume":"281","author":"I Cond\u00f2","year":"2006","unstructured":"Cond\u00f2 I, Ventura N, Malisan F, et al. A pool of extramitochondrial frataxin that promotes cell survival. J Biol Chem. 2006;281(24):16750\u20136.","journal-title":"J Biol Chem"},{"key":"4361_CR17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1158\/0008-5472.CAN-20-1488","volume":"81","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhao G, Condello S, et al. Frizzled-7 identifies platinum-tolerant ovarian cancer cells susceptible to ferroptosis. Cancer Res. 2021;81:384\u201399.","journal-title":"Cancer Res"},{"key":"4361_CR18","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1166\/jbn.2020.2991","volume":"16","author":"Y Huang","year":"2020","unstructured":"Huang Y, Lin J, Xiong Y, et al. Superparamagnetic iron oxide nanoparticles induce ferroptosis of human ovarian cancer stem cells by weakening cellular autophagy. J Biomed Nanotechnol. 2020;16:1612\u201322.","journal-title":"J Biomed Nanotechnol"},{"issue":"8","key":"4361_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110506","volume":"27","author":"S Xu","year":"2024","unstructured":"Xu S, Liu Y, Yang S, et al. FXN targeting induces cell death in ovarian cancer stem-like cells through PRDX3-mediated oxidative stress. iScience. 2024;27(8):110506.","journal-title":"iScience"},{"key":"4361_CR20","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nrc3153","volume":"11","author":"P Sharma","year":"2011","unstructured":"Sharma P, Wagner K, Wolchok JD, et al. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer. 2011;11:805\u201312.","journal-title":"Nat Rev Cancer"},{"key":"4361_CR21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejca.2018.12.019","volume":"1 09","author":"DP Modest","year":"2019","unstructured":"Modest DP, Pant S, Sartore-Bianchi A. Treatment sequencing in metastatic colorectal cancer. Eur J Cancer. 2019;1 09:70\u201383.","journal-title":"Eur J Cancer"},{"issue":"2","key":"4361_CR22","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s10555-023-10158-3","volume":"43","author":"R Abedizadeh","year":"2024","unstructured":"Abedizadeh R, Majidi F, Khorasani HR, et al. Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments. Cancer Metastasis Rev. 2024;43(2):729\u201353.","journal-title":"Cancer Metastasis Rev"},{"issue":"3","key":"4361_CR23","doi-asserted-by":"publisher","DOI":"10.1093\/bjsopen\/zrae038","volume":"8","author":"HG Smith","year":"2024","unstructured":"Smith HG, Nilsson PJ, Shogan BD, et al. Neoadjuvant treatment of colorectal cancer: comprehensive review. BJS Open. 2024;8(3):zrae038.","journal-title":"BJS Open."},{"issue":"16","key":"4361_CR24","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1200\/JCO.2014.59.7633","volume":"33","author":"MG Fakih","year":"2015","unstructured":"Fakih MG. Metastatic colorectal cancer: current state and future directions. J Clin Oncol. 2015;33(16):1809\u201324.","journal-title":"J Clin Oncol"},{"issue":"3","key":"4361_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","volume":"18","author":"RS Riley","year":"2019","unstructured":"Riley RS, June CH, Langer R, et al. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019;18(3):175\u201396.","journal-title":"Nat Rev Drug Discov"},{"issue":"13","key":"4361_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136967","volume":"25","author":"C Salva de Torres","year":"2024","unstructured":"Salva de Torres C, Baraibar I, Saoudi Gonz\u00e1lez N, et al. Current and emerging treatment paradigms in colorectal cancer: integrating hallmarks of cancer. Int J Mol Sci. 2024;25(13):6967.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"4361_CR27","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.2764","volume":"45","author":"JN Weinstein","year":"2013","unstructured":"Weinstein JN, Collisson EA, Mills GB, et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013;45(10):1113\u201320.","journal-title":"Nat Genet"},{"issue":"5","key":"4361_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001453","volume":"10","author":"L Marisa","year":"2013","unstructured":"Marisa L, de Reyni\u00e8s A, Duval A, et al. Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med. 2013;10(5):e1001453.","journal-title":"PLoS Med"},{"issue":"17","key":"4361_CR29","doi-asserted-by":"publisher","first-page":"7131","DOI":"10.1073\/pnas.0902232106","volume":"106","author":"M Sheffer","year":"2009","unstructured":"Sheffer M, Bacolod MD, Zuk O, et al. Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A. 2009;106(17):7131\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4361_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106143","volume":"9","author":"G Valcz","year":"2014","unstructured":"Valcz G, Patai AV, Kalm\u00e1r A, P\u00e9terfia B, et al. Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect. PLoS ONE. 2014;9(11):e106143.","journal-title":"PLoS ONE"},{"issue":"9","key":"4361_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106748","volume":"9","author":"X Sol\u00e9","year":"2014","unstructured":"Sol\u00e9 X, Crous-Bou M, Cordero D, et al. Discovery and validation of new potential biomarkers for early detection of colon cancer. PLoS ONE. 2014;9(9):e106748.","journal-title":"PLoS ONE"},{"issue":"3","key":"4361_CR32","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1053\/j.gastro.2009.11.005","volume":"138","author":"JJ Smith","year":"2010","unstructured":"Smith JJ, Deane NG, Wu F, et al. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology. 2010;138(3):958\u201368.","journal-title":"Gastroenterology"},{"issue":"1","key":"4361_CR33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong P, Finotello F, Angelova M, et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017;18(1):248\u201356.","journal-title":"Cell Rep"},{"issue":"12","key":"4361_CR34","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/cells13121040","volume":"13","author":"YN Dong","year":"2024","unstructured":"Dong YN, Mercado-Ay\u00f3n E, Coulman J, et al. The regulation of the disease-causing gene FXN. Cells. 2024;13(12):1040.","journal-title":"Cells"},{"key":"4361_CR35","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/978-3-030-28151-9_13","volume":"93","author":"IH Castro","year":"2019","unstructured":"Castro IH, Pignataro MF, Sewell KE, et al. Frataxin structure and function. Subcell Biochem. 2019;93:393\u2013438.","journal-title":"Subcell Biochem"},{"key":"4361_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.52601\/bpr.2021.200038","volume":"7","author":"W Zhang","year":"2021","unstructured":"Zhang W, Xu L, Zhao H, et al. Mammalian mitochondrial iron-sulfur cluster biogenesis and transfer and related human diseases. Biophys Rep. 2021;7:127\u201341.","journal-title":"Biophys Rep"},{"issue":"11","key":"4361_CR37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136459","volume":"131","author":"MK Culley","year":"2021","unstructured":"Culley MK, Zhao J, Tai YY, et al. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. J Clin Invest. 2021;131(11):e136459.","journal-title":"J Clin Invest"},{"issue":"7","key":"4361_CR38","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1161\/CIRCRESAHA.123.323160","volume":"133","author":"J Gao","year":"2023","unstructured":"Gao J, Huang C, Kong L, et al. SIRT3 regulates clearance of apoptotic cardiomyocytes by deacetylating frataxin. Circ Res. 2023;133(7):631\u201347.","journal-title":"Circ Res"},{"key":"4361_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103878","volume":"87","author":"X Shi","year":"2025","unstructured":"Shi X, Zhao Y, Gao HY, et al. NFS1, together with FXN, protects cells from ferroptosis and DNA damage in diffuse large B-cell lymphoma. Redox Biol. 2025;87:103878.","journal-title":"Redox Biol"},{"key":"4361_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1064432","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang L, Wang L, He P. Comprehensive analysis of immune-related gene signature based on ssGSEA algorithms in the prognosis and immune landscape of hepatocellular carcinoma. Front Genet. 2022;13:1064432.","journal-title":"Front Genet"},{"issue":"7269","key":"4361_CR41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08460","volume":"462","author":"DA Barbie","year":"2009","unstructured":"Barbie DA, Tamayo P, Boehm JS, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009;462(7269):108\u201312.","journal-title":"Nature"},{"key":"4361_CR42","first-page":"95","volume":"7","author":"D Kaushik","year":"2025","unstructured":"Kaushik D, Xu B, Kumar M. Biomarkers in immunology: their impact on immune function and response. Adv Biomark Sci Tech. 2025;7:95\u2013110.","journal-title":"Adv Biomark Sci Tech"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04361-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-026-04361-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04361-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:41:48Z","timestamp":1790160108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-026-04361-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["4361"],"URL":"https:\/\/doi.org\/10.1007\/s12094-026-04361-1","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"10 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study has been approved by the Institutional Research Ethics Committee of the Second Affiliated Hospital of Zhengzhou University. Ethics Approval Number: KY2025433.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was provided by every patient.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}