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We aimed to describe long-term mortality trends for these malignancies in Spain over a 26\u00a0year period, focusing on differences between early-onset (&lt;\u200950\u00a0years) and late-onset (\u2265\u200950\u00a0years) disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mortality data (1999\u20132024) were obtained from the Spanish National Institute of Statistics. Age-standardised mortality rates (ASMRs) were calculated per 100,000 women using the 2013 European Standard Population. Joinpoint regression estimated annual percentage changes (APC) and average annual percentage changes (AAPC) with 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total annual deaths rose from 9531 to 11,641, despite declining ASMRs for most sites. Breast cancer mortality decreased consistently (AAPC\u2009\u2212\u20091.4%; 95% CI\u2009\u2212\u20091.5,\u2009\u2212\u20091.3), with a more pronounced reduction in the\u2009&lt;\u200950\u00a0group (AAPC\u2009\u2212\u20092.5%). Significant ASMR declines were observed for uterus NOS (\u2212\u20092.3%), ovary (\u2212\u20090.7%), and cervix uteri (\u2212\u20090.6%). In the\u2009&lt;\u200950 cohort, ovarian cancer mortality fell sharply (AAPC\u2009\u2212\u20092.1%). Conversely, corpus uteri cancer was the only site showing an increasing trend (AAPC\u2009+\u20090.4%; 95% CI 0.1, 0.8), with a steeper increase observed among women\u2009\u2265\u200950\u00a0years. Non-monotonic trends were identified for less common gynaecological cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mortality rates for breast and most gynaecological cancers in Spain have declined, although absolute deaths have increased. These trends are potentially consistent with advances in prevention and care alongside population ageing. The rise in corpus uteri cancer represents an emerging public health concern potentially associated with increasing metabolic risk factors, highlighting the need for targeted prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12094-026-04412-7","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:39:11Z","timestamp":1780486751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early- versus late-onset mortality trends in breast and female genital cancers in Spain, 1999\u20132024"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-0501","authenticated-orcid":false,"given":"Luc\u00eda","family":"Cayuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-8795","authenticated-orcid":false,"given":"Antoni","family":"Llueca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-9054","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Librero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-766X","authenticated-orcid":false,"given":"Victoria","family":"Achaval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-5972","authenticated-orcid":false,"given":"Francisco Herrero","family":"Machancoses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-9402","authenticated-orcid":false,"given":"Aurelio","family":"Cayuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"4412_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jncc.2025.02.002","volume":"5","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Ji Y, Liu S, Li J, Wu J, Jin Q, et al. 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