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This study assessed survival outcomes and treatment-related toxicity in patients who underwent TBI-based myeloablative conditioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective single-center study of patients who underwent allo-HSCT after TBI-based conditioning at a reference TBI-unit serving transplant across the Community of Madrid. Between 2011 and 2020, most patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952) received 10\u00a0Gy in 2\u00a0Gy fractions twice daily. Primary endpoints were overall survival (OS), disease-free survival (DFS), and relapse; secondary endpoints included non-relapse mortality (NRM), disease-related mortality (DRM), and toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      58 patients underwent TBI-based conditioning using peripheral blood stem cells (PBSC;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937), umbilical cord blood (UCB;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919), or bone marrow (BM;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091); one patient died before graft infusion. Diagnoses were B-ALL (79.3%), followed by T-ALL (15.5%), non-Hodgkin lymphoma (3.4%), and acute myeloid leukemia (1.7%). Median follow-up was 28\u00a0months. At 12\u00a0months, OS, DFS, and relapse were 64%, 48%, and 29%, respectively. PBSC transplantation had significantly higher 12-month OS than UCB (78% vs. 37%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Six-month NRM was 5% and 8% in PBSC recipients vs. 43% and 54% in UCB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Graft-versus-host disease occurred in 51.7%, pulmonary complications in 32.8%, and neurological toxicity in 25.9%. Secondary malignancies were reported in four patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TBI-based conditioning achieved acceptable outcomes in PBSC recipients but was associated with markedly higher NRM in UCB recipients. These findings highlight graft source as a critical determinant of survival and support individualized strategies in allo-HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12094-026-04523-1","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:41:09Z","timestamp":1786466469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total body irradiation-based conditioning in allogeneic transplantation in patients with hematological malignancies: impact in outcomes by stem-cell source"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-0540","authenticated-orcid":false,"given":"Uriel Alexander","family":"Corro Verde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Romero Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gil Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez Valc\u00e1rcel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sarri\u00f3n Rubio De la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"De la Fuente Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"4523_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1200\/JCO.20","volume":"39","author":"C Peters","year":"2020","unstructured":"Peters C, Dalle J-H, Locatelli F, Poetschger U, Sedlacek P, Buechner J, et al. 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No additional intervention, sample or procedure was performed for research purposes.\nGiven the extended study period (2011\u20132020) and the clinical profi le of the cohort (patients undergoing allogeneicHSCT with TBI-based conditioning), a substantial proportion of patients had died or were no longer in active follow-upat the time of analysis, making individual re-contact and re-consent unfeasible.\nAll data were pseudonymised\/anonymised prior to analysis, and results are reported exclusively in aggregate, withno possibility of identifying individual patients.\nThe study was reviewed and approved by our institutional Research Ethics Committee which granted a waiver of therequirement for individual informed consent for this retrospective analysis, in accordance with applicable Spanishand European legislation ([Ley 14\/2007, de 3 de julio, de Investigaci\u00f3n Biom\u00e9dica]; [Regulation (EU) 2016\/679,GDPR]; and its Spanish transposition, [LOPDGDD 3\/2018]).\nThe study was conducted in accordance with the principles of the Declaration of Helsinki.\nWe enclose the approval letter issued by our institutional Research Ethics Committee (CEIm), which documents boththe approval of the study and the waiver of the individual informed consent requirement, for the Editorial Offi ce'srecords.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}