{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:27:22Z","timestamp":1783700842937,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T00:00:00Z","timestamp":1510358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"None"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s12098-017-2487-x","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T20:16:18Z","timestamp":1510344978000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Fungal and Parasitic CNS Infections"],"prefix":"10.1007","volume":"86","author":[{"given":"Pratibha","family":"Singhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arushi Gahlot","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,11]]},"reference":[{"key":"2487_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4103\/0028-3886.35686","volume":"55","author":"A Redmond","year":"2007","unstructured":"Redmond A, Dancer C, Woods ML. Fungal infections of the central nervous system: a review of fungal pathogens and treatment. Neurol India. 2007;55:251\u20139.","journal-title":"Neurol India"},{"key":"2487_CR2","volume-title":"Fungal infections of the central nervous system","author":"P Singhi","year":"2016","unstructured":"Singhi P, Nallaswamy K, Singhi S. Fungal infections of the central nervous system. 2nd ed. New York: Oxford University Press; 2016.","edition":"2"},{"key":"2487_CR3","volume-title":"Fungal infections","author":"S Singhi","year":"2014","unstructured":"Singhi S. Fungal infections. 1st ed. London: Mac Keith Press; 2014.","edition":"1"},{"key":"2487_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.4103\/0022-3859.41802","volume":"54","author":"H Teive","year":"2008","unstructured":"Teive H, Carsten AL, Iwamoto FM, et al. Fungal encephalitis following bone marrow transplantation: clinical findings and prognosis. J Postgrad Med. 2008;54:203\u20135.","journal-title":"J Postgrad Med"},{"key":"2487_CR5","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/INF.0b013e318062115c","volume":"26","author":"TE Zaoutis","year":"2007","unstructured":"Zaoutis TE, Roilides E, Chiou CC, et al. Zygomycosis in children: a systematic review and analysis of reported cases. Pediatr Infect Dis J. 2007;26:723\u20137.","journal-title":"Pediatr Infect Dis J"},{"key":"2487_CR6","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1080\/0036554021000026936","volume":"34","author":"T Gumbo","year":"2002","unstructured":"Gumbo T, Chemaly RF, Isada CM, Hall GS, Gordon SM. Late complications of Candida (Torulopsis) glabrata fungemia: description of a phenomenon. Scand J Infect Dis. 2002;34:817\u20138.","journal-title":"Scand J Infect Dis"},{"key":"2487_CR7","first-page":"935","volume":"35","author":"S Likasitwattanakul","year":"2004","unstructured":"Likasitwattanakul S, Poneprasert B, Sirisanthana V. Cryptococcosis in HIV-infected children. Southeast Asian J Trop Med Public Health. 2004;35:935\u20139.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2487_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/cid\/cir379","volume":"53","author":"MD Lindsley","year":"2011","unstructured":"Lindsley MD, Mekha N, Baggett HC, et al. Evaluation of a newly developed lateral flow immunoassay for the diagnosis of cryptococcosis. Clin Infect Dis. 2011;53:321\u20135.","journal-title":"Clin Infect Dis"},{"key":"2487_CR9","volume-title":"Fungal meningitis","author":"JL Horan","year":"2014","unstructured":"Horan JL, Perfect JR. Fungal meningitis. 4th ed. Wolters Kluwer Health: Philadelphia; 2014.","edition":"4"},{"key":"2487_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4103\/0028-3886.35685","volume":"55","author":"KK Jain","year":"2007","unstructured":"Jain KK, Mittal SK, Kumar S, Gupta RK. Imaging features of central nervous system fungal infections. Neurol India. 2007;55:241\u201350.","journal-title":"Neurol India"},{"key":"2487_CR11","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1086\/596757","volume":"48","author":"PG Pappas","year":"2009","unstructured":"Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503\u201335.","journal-title":"Clin Infect Dis"},{"key":"2487_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1086\/649858","volume":"50","author":"JR Perfect","year":"2010","unstructured":"Perfect JR, Dismukes WE, Dromer F, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:291\u2013322.","journal-title":"Clin Infect Dis"},{"key":"2487_CR13","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1086\/599105","volume":"48","author":"B Spellberg","year":"2009","unstructured":"Spellberg B, Walsh TJ, Kontoyiannis DP, Edwards J Jr, Ibrahim AS. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis. 2009;48:1743\u201351.","journal-title":"Clin Infect Dis"},{"key":"2487_CR14","volume-title":"Cerebral malaria","author":"DG Postels","year":"2014","unstructured":"Postels DG, Taylor TE. Cerebral malaria. 4th ed. Philadelphia: Wolters Kluwer Health; 2014.","edition":"4"},{"key":"2487_CR15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/jnnp.69.4.433","volume":"69","author":"CR Newton","year":"2000","unstructured":"Newton CR, Hien TT, White N. Cerebral malaria. J Neurol Neurosurg Psychiatry. 2000;69:433\u201341.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2487_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0020-7519(94)90022-1","volume":"24","author":"IA Clark","year":"1994","unstructured":"Clark IA, Rockett KA. Sequestration, cytokines, and malaria pathology. Int J Parasitol. 1994;24:165\u20136.","journal-title":"Int J Parasitol"},{"key":"2487_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molbiopara.2009.03.006","volume":"166","author":"CA Moxon","year":"2009","unstructured":"Moxon CA, Heyderman RS, Wassmer SC. Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol. 2009;166:99\u2013108.","journal-title":"Mol Biochem Parasitol"},{"key":"2487_CR18","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1016\/j.ajpath.2011.01.016","volume":"178","author":"K Dorovini-Zis","year":"2011","unstructured":"Dorovini-Zis K, Schmidt K, Huynh H, et al. The neuropathology of fatal cerebral malaria in Malawian children. Am J Pathol. 2011;178:2146\u201358.","journal-title":"Am J Pathol"},{"key":"2487_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1462-5822.2010.01528.x","volume":"13","author":"SC Wassmer","year":"2011","unstructured":"Wassmer SC, Moxon CA, Taylor T, Grau GE, Molyneux ME, Craig AG. Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cell Microbiol. 2011;13:198\u2013209.","journal-title":"Cell Microbiol"},{"key":"2487_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0065-308X(08)60021-4","volume":"31","author":"NJ White","year":"1992","unstructured":"White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol. 1992;31:83\u2013173.","journal-title":"Adv Parasitol"},{"key":"2487_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu144","volume":"137","author":"SM Kariuki","year":"2014","unstructured":"Kariuki SM, Newton CR. Retinopathy, histidine-rich protein-2 and perfusion pressure in cerebral malaria. Brain. 2014;137:e298.","journal-title":"Brain"},{"key":"2487_CR22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nm986","volume":"10","author":"TE Taylor","year":"2004","unstructured":"Taylor TE, Fu WJ, Carr RA, et al. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med. 2004;10:143\u20135.","journal-title":"Nat Med"},{"key":"2487_CR23","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/infdis\/jit500","volume":"209","author":"SM Kariuki","year":"2014","unstructured":"Kariuki SM, Gitau E, Gwer S, et al. Value of plasmodium falciparum histidine-rich protein 2 level and malaria retinopathy in distinguishing cerebral malaria from other acute encephalopathies in Kenyan children. J Infect Dis. 2014;209:600\u20139.","journal-title":"J Infect Dis"},{"key":"2487_CR24","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","volume":"383","author":"NJ White","year":"2014","unstructured":"White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM. Malaria. Lancet. 2014;383:723\u201335.","journal-title":"Lancet"},{"key":"2487_CR25","doi-asserted-by":"crossref","unstructured":"Jones KL, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev. 2007:CD005967.","DOI":"10.1002\/14651858.CD005967.pub2"},{"key":"2487_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2166\/wh.2007.014","volume":"6","author":"ME Shoff","year":"2008","unstructured":"Shoff ME, Rogerson A, Kessler K, Schatz S, Seal DV. Prevalence of Acanthamoeba and other naked amoebae in South Florida domestic water. J Water Health. 2008;6:99\u2013104.","journal-title":"J Water Health"},{"key":"2487_CR27","first-page":"1114","volume-title":"Pathogenic and opportunistic free-living amebas. Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea","author":"G Visvesvara","year":"2006","unstructured":"Visvesvara G, Maguire J. Pathogenic and opportunistic free-living amebas. Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. Philadelphia: Churchill Livingstone; 2006. p. 1114\u201325."},{"key":"2487_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.vetpar.2006.08.010","volume":"143","author":"GS Visvesvara","year":"2007","unstructured":"Visvesvara GS, Booton GC, Kelley DJ, et al. In vitro culture, serologic and molecular analysis of Acanthamoeba isolated from the liver of a keel-billed toucan (Ramphastos sulfuratus). Vet Parasitol. 2007;143:74\u20138.","journal-title":"Vet Parasitol"},{"key":"2487_CR29","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1001\/jama.285.19.2450","volume":"285","author":"BB Gelman","year":"2001","unstructured":"Gelman BB, Rauf SJ, Nader R, et al. Amoebic encephalitis due to Sappinia diploidea. JAMA. 2001;285:2450\u20131.","journal-title":"JAMA"},{"key":"2487_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-695X.2007.00232.x","volume":"50","author":"GS Visvesvara","year":"2007","unstructured":"Visvesvara GS, Moura H, Schuster FL. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunol Med Microbiol. 2007;50:1\u201326.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2487_CR31","first-page":"1217","volume":"27","author":"P Singh","year":"2006","unstructured":"Singh P, Kochhar R, Vashishta RK, et al. Amebic meningoencephalitis: spectrum of imaging findings. Am J Neuroradiol. 2006;27:1217\u201321.","journal-title":"Am J Neuroradiol"},{"key":"2487_CR32","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1128\/JCM.00875-06","volume":"44","author":"Y Qvarnstrom","year":"2006","unstructured":"Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol. 2006;44:3589\u201395.","journal-title":"J Clin Microbiol"},{"key":"2487_CR33","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/j.1750-3639.1997.tb01076.x","volume":"7","author":"AJ Martinez","year":"1997","unstructured":"Martinez AJ, Visvesvara GS. Free-living, amphizoic and opportunistic amebas. Brain Pathol. 1997;7:583\u201398.","journal-title":"Brain Pathol"},{"key":"2487_CR34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1086\/589747","volume":"47","author":"AR Tunkel","year":"2008","unstructured":"Tunkel AR, Glaser CA, Bloch KC, et al. The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2008;47:303\u201327.","journal-title":"Clin Infect Dis"},{"key":"2487_CR35","first-page":"112","volume":"74","author":"N Poungvarin","year":"1991","unstructured":"Poungvarin N, Jariya P. The fifth nonlethal case of primary amoebic meningoencephalitis. J Med Assoc Thailand. 1991;74:112\u20135.","journal-title":"J Med Assoc Thailand"}],"container-title":["The Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12098-017-2487-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-017-2487-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-017-2487-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T10:26:25Z","timestamp":1567765585000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12098-017-2487-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["2487"],"URL":"https:\/\/doi.org\/10.1007\/s12098-017-2487-x","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,11]]},"assertion":[{"value":"22 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Source of\u00a0Funding"}}]}}