{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:19:53Z","timestamp":1770452393036,"version":"3.49.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2019,3,11]]},"DOI":"10.1007\/s12098-018-2794-x","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T02:50:14Z","timestamp":1543891814000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dengue and Chikungunya Infections in Children"],"prefix":"10.1007","volume":"86","author":[{"given":"Nitin","family":"Dhochak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil K.","family":"Kabra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Lodha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"2794_CR1","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S1473-3099(16)00026-8","volume":"16","author":"JD Stanaway","year":"2016","unstructured":"Stanaway JD, Shepard DS, Undurraga EA, et al. The global burden of dengue: an analysis from the global burden of disease study 2013. Lancet Infect Dis. 2016;16:712\u201323.","journal-title":"Lancet Infect Dis"},{"key":"2794_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mjafi.2014.09.011","volume":"71","author":"MS Mustafa","year":"2015","unstructured":"Mustafa MS, Rasotgi V, Jain S, Gupta V. Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control. Med J Armed Forces India. 2015;71:67\u201370.","journal-title":"Med J Armed Forces India"},{"key":"2794_CR3","doi-asserted-by":"publisher","first-page":"e50972","DOI":"10.1371\/journal.pone.0050972","volume":"7","author":"M Chan","year":"2012","unstructured":"Chan M, Johansson MA. The incubation periods of dengue viruses. PLoS One. 2012;7:e50972.","journal-title":"PLoS One"},{"key":"2794_CR4","doi-asserted-by":"publisher","unstructured":"Sellahewa KH. Pathogenesis of dengue haemorrhagic fever and its impact on case management. ISRN Infect Dis. 2013; Article ID: 571646, 6 pages. https:\/\/doi.org\/10.5402\/2013\/571646.","DOI":"10.5402\/2013\/571646"},{"key":"2794_CR5","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.jinf.2014.07.020","volume":"69","author":"LM Verhagen","year":"2014","unstructured":"Verhagen LM, de Groot R. Dengue in children. J Infect. 2014;69:S77\u201386.","journal-title":"J Infect"},{"key":"2794_CR6","first-page":"59","volume":"11","author":"SK Kabra","year":"1998","unstructured":"Kabra SK, Juneja R, Madhulika, et al. Myocardial dysfunction in children with dengue haemorrhagic fever. Natl Med J India. 1998;11:59\u201361.","journal-title":"Natl Med J India"},{"key":"2794_CR7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0972-9062.172809","volume":"52","author":"S Pothapregada","year":"2015","unstructured":"Pothapregada S, Kamalakannan B, Thulasingam M. Role of platelet transfusion in children with bleeding in dengue fever. J Vector Borne Dis. 2015;52:304\u20138.","journal-title":"J Vector Borne Dis"},{"key":"2794_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4103\/0974-777X.188596","volume":"8","author":"S Pothapregada","year":"2016","unstructured":"Pothapregada S, Kamalakannan B, Thulasingham M, Sampath S. Clinically profiling pediatric patients with dengue. J Global Infect Dis. 2016;8:115\u201320.","journal-title":"J Global Infect Dis"},{"key":"2794_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s12098-015-1942-9","volume":"83","author":"S Pothapregada","year":"2016","unstructured":"Pothapregada S, Kamalakannan B, Thulasingam M. Clinical profile of atypical manifestations of dengue fever. Indian J Pediatr. 2016;83:493\u20139.","journal-title":"Indian J Pediatr"},{"key":"2794_CR10","unstructured":"Dengue: Guidelines for diagnosis, treatment, prevention and control: new edition. Geneva: World Health Organization; 2009. Available at: http:\/\/www.who.int\/iris\/handle\/10665\/44188. Accessed 13 May 2018."},{"key":"2794_CR11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/1471-2334-10-142","volume":"10","author":"V Tricou","year":"2010","unstructured":"Tricou V, Vu HTT, Quynh NVN, et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis. 2010;10:142.","journal-title":"BMC Infect Dis"},{"key":"2794_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/srep27663","volume":"6","author":"B-T Teoh","year":"2016","unstructured":"Teoh B-T, Sam S-S, Tan K-K, et al. The use of NS1 rapid diagnostic test and qRT-PCR to complement IgM ELISA for improved dengue diagnosis from single specimen. Sci Rep. 2016;6:27663.","journal-title":"Sci Rep"},{"key":"2794_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003171","volume":"8","author":"EA Hunsperger","year":"2014","unstructured":"Hunsperger EA, Yoksan S, Buchy P, et al. Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody. PLoS Negl Trop Dis. 2014;8:e3171.","journal-title":"PLoS Negl Trop Dis"},{"key":"2794_CR14","unstructured":"Handbook for Clinical Management of Dengue. World Health Organization & UNICEF\/UNDP\/World Bank\/WHO Special Programme for Research and Training in Tropical Diseases; 2012. Available at: http:\/\/www.who.int\/iris\/handle\/10665\/76887. Accessed 13 May 2018."},{"key":"2794_CR15","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJMoa044057","volume":"353","author":"BA Wills","year":"2005","unstructured":"Wills BA, Nguyen MD, Ha TL, et al. Comparison of three fluid solutions for resuscitation in dengue shock syndrome. N Engl J Med. 2005;353:877\u201389.","journal-title":"N Engl J Med"},{"key":"2794_CR16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1086\/318479","volume":"32","author":"NT Ngo","year":"2001","unstructured":"Ngo NT, Cao XT, Kneen R, et al. Acute management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour. Clin Infect Dis. 2001;32:204\u201313.","journal-title":"Clin Infect Dis"},{"key":"2794_CR17","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1086\/520435","volume":"29","author":"NM Dung","year":"1999","unstructured":"Dung NM, Day NP, Tam DT, et al. Fluid replacement in dengue shock syndrome: a randomized, double-blind comparison of four intravenous-fluid regimens. Clin Infect Dis. 1999;29:787\u201394.","journal-title":"Clin Infect Dis"},{"key":"2794_CR18","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1016\/S0140-6736(17)30269-6","volume":"389","author":"DC Lye","year":"2017","unstructured":"Lye DC, Archuleta S, Syed-Omar SF, et al. Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial. Lancet. 2017;389:1611\u20138.","journal-title":"Lancet"},{"key":"2794_CR19","first-page":"452","volume":"35","author":"SK Kabra","year":"1998","unstructured":"Kabra SK, Jain Y, Kabra M, et al. Role of platelet transfusion in dengue hemorrhagic fever. Indian Pediatr. 1998;35:452\u20135.","journal-title":"Indian Pediatr"},{"key":"2794_CR20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/00003246-198602000-00015","volume":"14","author":"P Ewalenko","year":"1986","unstructured":"Ewalenko P, Deloof T, Peeters J. Composition of fresh frozen plasma. Crit Care Med. 1986;14:145\u20136.","journal-title":"Crit Care Med"},{"key":"2794_CR21","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/S0140-6736(00)02036-5","volume":"355","author":"T Solomon","year":"2000","unstructured":"Solomon T, Dung NM, Vaughn DW, et al. Neurological manifestations of dengue infection. Lancet. 2000;355:1053\u20139.","journal-title":"Lancet"},{"key":"2794_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s12098-011-0551-5","volume":"79","author":"HC Gala","year":"2012","unstructured":"Gala HC, Avasthi BS, Lokeshwar MR. Dengue shock syndrome with two atypical complications. Indian J Pediatr. 2012;79:386\u20138.","journal-title":"Indian J Pediatr"},{"key":"2794_CR23","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"J-I Henter","year":"2007","unstructured":"Henter J-I, Horne A, Aric\u00f3 M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124\u201331.","journal-title":"Pediatr Blood Cancer"},{"key":"2794_CR24","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jcv.2012.06.005","volume":"55","author":"LH Tan","year":"2012","unstructured":"Tan LH, Lum LCS, Omar SFS, Kan FK. Hemophagocytosis in dengue: comprehensive report of six cases. J Clin Virol. 2012;55:79\u201382.","journal-title":"J Clin Virol"},{"key":"2794_CR25","unstructured":"WHO. Revised SAGE recommendation on use of dengue vaccine. Available at: http:\/\/www.who.int\/immunization\/diseases\/dengue\/revised_SAGE_recommendations_dengue_vaccines_apr2018\/en\/. Accessed 23 May 2018."},{"key":"2794_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41182-016-0004-y","volume":"44","author":"ML Moi","year":"2016","unstructured":"Moi ML, Takasaki T, Kurane I. Human antibody response to dengue virus: implications for dengue vaccine design. Trop Med Health. 2016;44:1.","journal-title":"Trop Med Health"},{"key":"2794_CR27","doi-asserted-by":"crossref","unstructured":"Petersen LR, Powers AM. Chikungunya: epidemiology. F1000Res. 2016;5:84.","DOI":"10.12688\/f1000research.7171.1"},{"key":"2794_CR28","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1086\/605496","volume":"49","author":"JE Staples","year":"2009","unstructured":"Staples JE, Breiman RF, Powers AM. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis. 2009;49:942\u20138.","journal-title":"Clin Infect Dis"},{"key":"2794_CR29","unstructured":"NVBDCP. National Vector Borne Disease Control Programme. Available at: http:\/\/www.nvbdcp.gov.in\/chik-cd.html. Accessed 30 May 2018."},{"key":"2794_CR30","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jtbi.2014.04.033","volume":"356","author":"CA Manore","year":"2014","unstructured":"Manore CA, Hickmann KS, Xu S, Wearing HJ, Hyman JM. Comparing dengue and chikungunya emergence and endemic transmission in A. aegypti and A. albopictus. J Theor Biol. 2014;356:174\u201391.","journal-title":"J Theor Biol"},{"key":"2794_CR31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrmicro2368","volume":"8","author":"O Schwartz","year":"2010","unstructured":"Schwartz O, Albert ML. Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol. 2010;8:491\u2013500.","journal-title":"Nat Rev Microbiol"},{"key":"2794_CR32","unstructured":"Guidelines on Clinical Management of Chikungunya Fever. Available at: http:\/\/www.wpro.who.int\/mvp\/topics\/ntd\/Clinical_Mgnt_Chikungunya_WHO_SEARO.pdf. Accessed 30 May 2018."},{"key":"2794_CR33","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.medmal.2015.05.007","volume":"45","author":"F Simon","year":"2015","unstructured":"Simon F, Javelle E, Cabie A, et al. French guidelines for the management of chikungunya (acute and persistent presentations). November 2014. M\u00e9d Mal Infect. 2015;45:243\u201363.","journal-title":"M\u00e9d Mal Infect"},{"key":"2794_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2174\/1874312901610010129","volume":"10","author":"BA Goupil","year":"2016","unstructured":"Goupil BA, Mores CN. A review of chikungunya virus-induced arthralgia: clinical manifestations, therapeutics, and pathogenesis. Open Rheumatol J. 2016;10:129\u201340.","journal-title":"Open Rheumatol J"},{"key":"2794_CR35","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ijid.2016.09.009","volume":"51","author":"JR Torres","year":"2016","unstructured":"Torres JR, Falleiros-Arlant LH, Due\u00f1as L, Pleitez-Navarrete J, Salgado DM, Castillo JB-D. Congenital and perinatal complications of chikungunya fever: a Latin American experience. Int J Infect Dis. 2016;51:85\u20138.","journal-title":"Int J Infect Dis"},{"key":"2794_CR36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1590\/0037-8682-0375-2016","volume":"50","author":"O S\u00e1 PK de","year":"2017","unstructured":"S\u00e1 PK de O, Nunes de MM, Leite IR, et al. Chikungunya virus infection with severe neurologic manifestations: report of four fatal cases. Rev Soc Bras Med Trop. 2017;50:265\u20138.","journal-title":"Rev Soc Bras Med Trop"},{"key":"2794_CR37","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s13312-017-1040-3","volume":"54","author":"A Singh","year":"2017","unstructured":"Singh A, Jain R. Neurological manifestations of chikungunya in children. Indian Pediatr. 2017;54:249.","journal-title":"Indian Pediatr"},{"key":"2794_CR38","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3201\/eid1502.080902","volume":"15","author":"P Lewthwaite","year":"2009","unstructured":"Lewthwaite P, Vasanthapuram R, Osborne JC, et al. Chikungunya virus and central nervous system infections in children, India. Emerg Infect Dis. 2009;15:329\u201331.","journal-title":"Emerg Infect Dis"},{"key":"2794_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ijid.2016.05.010","volume":"48","author":"L Crosby","year":"2016","unstructured":"Crosby L, Perreau C, Madeux B, et al. Severe manifestations of chikungunya virus in critically ill patients during the 2013\u20132014 Caribbean outbreak. Int J Infect Dis. 2016;48:78\u201380.","journal-title":"Int J Infect Dis"},{"key":"2794_CR40","doi-asserted-by":"publisher","first-page":"S471","DOI":"10.1093\/infdis\/jiw274","volume":"214","author":"BW Johnson","year":"2016","unstructured":"Johnson BW, Russell BJ, Goodman CH. Laboratory diagnosis of chikungunya virus infections and commercial sources for diagnostic assays. J Infect Dis. 2016;214:S471\u20134.","journal-title":"J Infect Dis"},{"key":"2794_CR41","doi-asserted-by":"publisher","first-page":"e0004953","DOI":"10.1371\/journal.pntd.0004953","volume":"10","author":"P Patel","year":"2016","unstructured":"Patel P, Abd El Wahed A, Faye O, et al. A field-deployable reverse transcription recombinase polymerase amplification assay for rapid detection of the chikungunya virus. PLoS Negl Trop Dis. 2016;10:e0004953.","journal-title":"PLoS Negl Trop Dis"},{"key":"2794_CR42","doi-asserted-by":"publisher","first-page":"e0033","DOI":"10.5041\/RMMJ.10260","volume":"7","author":"M Krutikov","year":"2016","unstructured":"Krutikov M, Manson J. Chikungunya virus infection: an update on joint manifestations and management. Rambam Maimonides Med J. 2016;7:e0033. https:\/\/doi.org\/10.5041\/RMMJ.10260.","journal-title":"Rambam Maimonides Med J"},{"key":"2794_CR43","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.12688\/f1000research.12461.1","volume":"6","author":"K Tharmarajah","year":"2017","unstructured":"Tharmarajah K, Mahalingam S, Zaid A. Chikungunya: vaccines and therapeutics. F1000Res. 2017;6:2114.","journal-title":"F1000Res"},{"key":"2794_CR44","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1186\/s13071-018-2942-1","volume":"11","author":"MB Zaidi","year":"2018","unstructured":"Zaidi MB, Garcia-Cordero J, Rivero-Gomez R, et al. Competitive suppression of dengue virus replication occurs in chikungunya and dengue co-infected Mexican infants. Parasit Vectors. 2018;11:378.","journal-title":"Parasit Vectors"},{"key":"2794_CR45","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1007\/s10096-017-3061-1","volume":"36","author":"S Mukherjee","year":"2017","unstructured":"Mukherjee S, Dutta SK, Sengupta S, Tripathi A. Evidence of dengue and chikungunya virus co-infection and circulation of multiple dengue serotypes in a recent Indian outbreak. Eur J Clin Microbiol Infect Dis. 2017;36:2273\u20139.","journal-title":"Eur J Clin Microbiol Infect Dis"}],"container-title":["The Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-018-2794-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-018-2794-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-018-2794-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:14:28Z","timestamp":1744175668000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-018-2794-x"}},"subtitle":["Guest Editor: Bhim S. Pandhi"],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3,11]]}},"alternative-id":["2794"],"URL":"https:\/\/doi.org\/10.1007\/s12098-018-2794-x","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]},"assertion":[{"value":"6 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}