{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:55:50Z","timestamp":1777632950629,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s12098-019-03032-0","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T07:03:36Z","timestamp":1564383816000},"page":"1089-1093","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Utility of CSF Xpert MTB\/RIF in Diagnosis of Tubercular Meningitis in Children"],"prefix":"10.1007","volume":"86","author":[{"given":"Jyothy","family":"A.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7772-2413","authenticated-orcid":false,"given":"Vinod H.","family":"Ratageri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivanand","family":"Illalu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Fattepur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Wari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"3032_CR1","unstructured":"WHO. WHO Global tuberculosis report 2016 [Internet]. 2016. Available at: \nhttp:\/\/www.who.int\/tb\/publications\/global_report\/en\/\n\n. Accessed 14 Jan 2018."},{"key":"3032_CR2","unstructured":"RNTCP (DGHS), TB India 2016 by RNTCP Annual Report. Available at: \nhttps:\/\/www.tbcindia.gov.in\/showfile.php?lid=3180\n\n. Accessed 10 Dec 2018."},{"key":"3032_CR3","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.2217\/fmb.12.86","volume":"7","author":"F Brancusi","year":"2012","unstructured":"Brancusi F, Farrar J, Heemskerk D. Tuberculous meningitis in adults: a review of a decade of developments focusing on prognostic factors for outcome. Future Microbiol. 2012;7:1101\u201316.","journal-title":"Future Microbiol"},{"key":"3032_CR4","unstructured":"Sarah JG, Martin AE. Tuberculosis and fungal and parasitic infections of cental nervous system. In: Albright AL, Pollack IF, Adelson PD, editors. Principles and Practice of Pediatric Neurosurgery, 2nd ed. New York: Thieme Medical Publishers; 2013. p. 1182\u201396."},{"key":"3032_CR5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.5588\/ijtld.14.0394","volume":"19","author":"RS Solomons","year":"2015","unstructured":"Solomons RS, Visser DH, Friedrich SO, et al. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int J Tuberc Lung Dis. 2015;19:74\u201380.","journal-title":"Int J Tuberc Lung Dis"},{"key":"3032_CR6","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/S0140-6736(11)60438-8","volume":"377","author":"CC Boehme","year":"2011","unstructured":"Boehme CC, Nicol MP, Nabeta P, et al. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB\/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet. 2011;377:1495\u2013505.","journal-title":"Lancet."},{"key":"3032_CR7","unstructured":"World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB\/RIF assay for the diagnosis of pulmonary and extrapulmonary TB in adults and children: policy update. World Health Organization (2013). Available at: \nhttp:\/\/www.who.int\/iris\/handle\/10665\/112472\n\n. Accessed 14 Jan 2019."},{"key":"3032_CR8","doi-asserted-by":"publisher","first-page":"716","DOI":"10.4103\/0028-3886.72178","volume":"58","author":"JMK Murthy","year":"2010","unstructured":"Murthy JMK. Tuberculous meningitis: the challenges. Neurol India. 2010;58:716\u201322.","journal-title":"Neurol India"},{"key":"3032_CR9","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S1473-3099(10)70138-9","volume":"10","author":"S Marais","year":"2010","unstructured":"Marais S, Thwaites G, Schoeman JF, et al. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect Dis. 2010;10:803\u201312.","journal-title":"Lancet Infect Dis"},{"key":"3032_CR10","doi-asserted-by":"crossref","unstructured":"Alvarez-Uria G, Azcona JM, Midde M, Naik PK, Reddy S, Reddy R. Rapid diagnosis of pulmonary and extrapulmonary tuberculosis in HIV-infected patients. Comparison of LED fluorescent microscopy and the GeneXpert MTB\/RIF assay in a district hospital in India. Tuberc Res Treat. 2012;1\u20134.Article ID: 932862.","DOI":"10.1155\/2012\/932862"},{"key":"3032_CR11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1128\/JCM.01834-13","volume":"52","author":"NTQ Nhu","year":"2014","unstructured":"Nhu NTQ, Heemskerk D, Thu DDA, et al. Evaluation of GeneXpert MTB\/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol. 2014;52:226\u201333.","journal-title":"J Clin Microbiol"},{"key":"3032_CR12","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s12098-016-2096-0","volume":"83","author":"R Bhatia","year":"2016","unstructured":"Bhatia R, Dayal R, Jindal S, Agarwal D, Goyal A. GeneXpert for diagnosis of tubercular meningitis. Indian J Pediatr. 2016;83:1353\u20135.","journal-title":"Indian J Pediatr"},{"key":"3032_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001536","volume":"10","author":"VB Patel","year":"2013","unstructured":"Patel VB, Theron G, Lenders L, et al. Diagnostic accuracy of quantitative PCR (Xpert MTB\/RIF) for tuberculous meningitis in a high burden setting: a prospective study. PLoS Med. 2013;10:e1001536.","journal-title":"PLoS Med"},{"key":"3032_CR14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S1474-4422(05)70019-3","volume":"4","author":"GE Thwaites","year":"2005","unstructured":"Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol. 2005;4:160\u201370.","journal-title":"Lancet Neurol"},{"key":"3032_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1164\/rccm.200912-1931OC","volume":"182","author":"VB Patel","year":"2010","unstructured":"Patel VB, Singh R, Connolly C, et al. Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population. Am J Respir Crit Care Med. 2010;182:569\u201377.","journal-title":"Am J Respir Crit Care Med"},{"key":"3032_CR16","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1542\/peds.2008-1353","volume":"123","author":"GTJ Van Well","year":"2009","unstructured":"Van Well GTJ, Paes BF, Terwee CB, et al. Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa. Pediatrics. 2009;123:e1\u20138.","journal-title":"Pediatrics."},{"key":"3032_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1258\/rsmacta.41.1.13","volume":"41","author":"M Ozate\u015f","year":"2000","unstructured":"Ozate\u015f M, Kemaloglu S, G\u00fcrkan F, Ozkan U, Ho\u015foglu S, Sim\u015fek MM. CT of the brain in tuberculous meningitis. A review of 289 patients. Acta Radiol. 2000;41:13\u20137.","journal-title":"Acta Radiol"},{"key":"3032_CR18","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1128\/CMR.00042-07","volume":"21","author":"RB Rock","year":"2008","unstructured":"Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev. 2008;21:243\u201361.","journal-title":"Clin Microbiol Rev"},{"key":"3032_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133477","volume":"10","author":"EG Miftode","year":"2015","unstructured":"Miftode EG, Dorneanu OS, Leca DA, et al. Tuberculous meningitis in children and adults: a 10-year retrospective comparative analysis. PLoS One. 2015;10:e0133477.","journal-title":"PLoS One"},{"key":"3032_CR20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.5.e49","volume":"102","author":"A Yarami\u015f","year":"1998","unstructured":"Yarami\u015f A, Gurkan F, Elevli M, et al. Central nervous system tuberculosis in children: a review of 214 cases. Pediatrics. 1998;102:E49.","journal-title":"Pediatrics."},{"key":"3032_CR21","doi-asserted-by":"publisher","first-page":"400","DOI":"10.4103\/0976-3147.181475","volume":"7","author":"A Israni","year":"2016","unstructured":"Israni A, Dave D, Mandal A, et al. Tubercular meningitis in children: clinical, pathological, and radiological profile and factors associated with mortality. J Neurosci Rural Pract. 2016;7:400\u20134.","journal-title":"J Neurosci Rural Pract"},{"key":"3032_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1186\/s12879-016-1923-2","volume":"16","author":"ND Bang","year":"2016","unstructured":"Bang ND, Caws M, Truc TT, et al. Clinical presentations, diagnosis, mortality and prognostic markers of tuberculous meningitis in Vietnamese children: a prospective descriptive study. BMC Infect Dis. 2016;16:573.","journal-title":"BMC Infect Dis"},{"key":"3032_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/WCO.0b013e3283602814","volume":"26","author":"GE Thwaites","year":"2013","unstructured":"Thwaites GE. Advances in the diagnosis and treatment of tuberculous meningitis. Curr Opin Neurol. 2013;26:295\u2013300.","journal-title":"Curr Opin Neurol"}],"container-title":["The Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-019-03032-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12098-019-03032-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-019-03032-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T23:27:17Z","timestamp":1595028437000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12098-019-03032-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3032"],"URL":"https:\/\/doi.org\/10.1007\/s12098-019-03032-0","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]},"assertion":[{"value":"17 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}