{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:47:25Z","timestamp":1774532845741,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s12098-020-03637-w","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T04:15:42Z","timestamp":1611720942000},"page":"1086-1091","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and Efficacy of Primary Hypofractionated Gamma Knife Radiosurgery for Giant Hypothalamic Hamartoma"],"prefix":"10.1007","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5679-3439","authenticated-orcid":false,"given":"Manjul","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasant","family":"Maskara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Sankhyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra Kumar","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag K.","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parwinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupinder","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman","family":"Batish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Mohindra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"3637_CR1","first-page":"177","volume":"120","author":"JE Paillas","year":"1969","unstructured":"Paillas JE, Roger J, Toga M, et al. Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision. Rev Neurol (Paris). 1969;120:177\u201394.","journal-title":"Rev Neurol (Paris)"},{"key":"3637_CR2","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/00004583-200106000-00015","volume":"40","author":"A Weissenberger","year":"2001","unstructured":"Weissenberger A, Dell M, Liow K, et al. Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2001;40:696\u2013703.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3637_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/S1525-5050(03)00086-6","volume":"4","author":"D Nguyen","year":"2003","unstructured":"Nguyen D, Singh S, Zaatreh M, et al. Hypothalamic hamartomas: seven cases and review of the literature. Epilepsy Behav. 2003;4:246\u201358.","journal-title":"Epilepsy Behav"},{"key":"3637_CR4","unstructured":"Tassinari CA, Riguzzi P, Rizzi R, et al. Gelastic seizures. In: Tuxhorn I, Holthausen H, editors. Paediatric Epilepsy Syndromes and their Surgical Management. London: John Libbey. 1997;429\u201346."},{"key":"3637_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/0013-4694(95)00063-5","volume":"95","author":"C Munari","year":"1995","unstructured":"Munari C, Kahane P, Francione S, et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol. 1995;95:154\u201360.","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"Suppl 3","key":"3637_CR6","first-page":"s266","volume":"36","author":"R Kuzniecky","year":"1995","unstructured":"Kuzniecky R, Guthrie B, Mountz J, et al. Hypothalamic hamartomas and gelastc seizures: evidence for subcortical seizure generation by ictal SPECT and cerebral stimulation. Epilepsia. 1995;36(Suppl 3):s266.","journal-title":"Epilepsia."},{"key":"3637_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.spen.2005.04.002","volume":"12","author":"JF Kerrigan","year":"2005","unstructured":"Kerrigan JF, Ng YT, Chung S, Rekate HL. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol. 2005;12:119\u201331.","journal-title":"Semin Pediatr Neurol"},{"key":"3637_CR8","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1111\/j.1528-1167.2010.02739.x","volume":"51","author":"S Kameyama","year":"2010","unstructured":"Kameyama S, Masuda H, Murakami H. Ictogenesis and symptomatogenesis of gelastic seizures in hypothalamic hamartoma: an ictal SPECT study. Epilepsia. 2010;51:2270\u20139.","journal-title":"Epilepsia."},{"issue":"Suppl. 2","key":"3637_CR9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/epi.13755","volume":"58","author":"J Scholly","year":"2017","unstructured":"Scholly J, Staack AM, Kahane P, et al. Hypothalamic hamartoma: epileptogenesis beyond the lesion? Epilepsia. 2017;58(Suppl. 2):32\u201340.","journal-title":"Epilepsia."},{"key":"3637_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.yebeh.2008.02.016","volume":"13","author":"GP Prigatano","year":"2008","unstructured":"Prigatano GP, Wethe JV, Gray JA, et al. Intellectual functioning in presurgical patients with hypothalamic hamartoma and refractory epilepsy. Epilepsy Behav. 2008;13:149\u201355.","journal-title":"Epilepsy Behav"},{"key":"3637_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1212\/WNL.57.1.43","volume":"57","author":"CM Frattali","year":"2001","unstructured":"Frattali CM, Liow K, Craig GH, et al. Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology. 2001;57:43\u20136.","journal-title":"Neurology."},{"issue":"Suppl. 2","key":"3637_CR12","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/epi.13759","volume":"58","author":"K Wagner","year":"2017","unstructured":"Wagner K, Jennifer W, Schulze-Bonhage A, et al. Cognition in epilepsy patients with hypothalamic hamartomas. Epilepsia. 2017;58(Suppl. 2):85\u201393.","journal-title":"Epilepsia."},{"key":"3637_CR13","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1111\/j.1528-1167.2006.00516.x","volume":"47","author":"YT Ng","year":"2006","unstructured":"Ng YT, Rekate HL, Prenger EC, et al. Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia. 2006;47:1192\u2013202.","journal-title":"Epilepsia."},{"key":"3637_CR14","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1212\/01.wnl.0000310644.40767.aa","volume":"70","author":"YT Ng","year":"2008","unstructured":"Ng YT, Rekate HL, Prenger EC, et al. Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy. Neurology. 2008;70:1543\u20138.","journal-title":"Neurology."},{"issue":"2","key":"3637_CR15","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2010.11.FOCUS10250","volume":"30","author":"S Wait","year":"2011","unstructured":"Wait S, Abla AA, Killory BD, et al. Surgical approaches to hypothalamic hamartomas. Neurosurg Focus. 2011;30(2):E2.","journal-title":"Neurosurg Focus"},{"issue":"2","key":"3637_CR16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3171\/2012.5.JNS112256","volume":"117","author":"C Drees","year":"2012","unstructured":"Drees C, Chapman K, Prenger E, et al. Seizure outcome and complications following hypothalamic hamartoma treatment in adults: endoscopic, open, and gamma knife procedures. J Neurosurg. 2012;117(2):255\u201361.","journal-title":"J Neurosurg"},{"issue":"Suppl. 2","key":"3637_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/epi.13773","volume":"58","author":"J Regis","year":"2017","unstructured":"Regis J, Cross JH, Kerrigan JF. Achieving a cure for hypothalamic hamartomas: a Sisyphean quest? Epilepsia. 2017;58(Suppl. 2):7\u201311.","journal-title":"Epilepsia."},{"issue":"1","key":"3637_CR18","first-page":"1005","volume":"1","author":"JA D\u00edaz-Mart\u00ednez","year":"2017","unstructured":"D\u00edaz-Mart\u00ednez JA, Arenas-Ruiz JA, Quezada-Bautista AA, et al. Hypothalamic hamartomas: a review. JSM Pediatr Neurol. 2017;1(1):1005.","journal-title":"JSM Pediatr Neurol"},{"issue":"Suppl","key":"3637_CR19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3171\/2010.8.GKS101027","volume":"113","author":"AA Abla","year":"2010","unstructured":"Abla AA, Shetter AG, Chang SW, et al. Gamma knife surgery for hypothalamic hamartomas and epilepsy: patient selection and outcomes. J Neurosurg. 2010;113(Suppl):207\u201314.","journal-title":"J Neurosurg"},{"key":"3637_CR20","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00381-006-0139-y","volume":"22","author":"J Regis","year":"2006","unstructured":"Regis J, Scavarda D, Tamura M, et al. Epilepsy related to hypothalamic hamartomas: surgical management with special reference to gamma knife surgery. Childs Nerv Syst. 2006;22:881\u201395.","journal-title":"Childs Nerv Syst"},{"key":"3637_CR21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.spen.2007.03.005","volume":"14","author":"J Regis","year":"2007","unstructured":"Regis J, Scavarda D, Tamura M, et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Semin Pediatr Neurol. 2007;14:73\u20139.","journal-title":"Semin Pediatr Neurol"},{"key":"3637_CR22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1159\/000094036","volume":"84","author":"D Mathieu","year":"2006","unstructured":"Mathieu D, Kondziolka D, Niranjan A, Flickinger J, Lunsford LD. Gamma knife radiosurgery for refractory epilepsy caused by hypothalamic hamartomas. Stereotact Funct Neurosurg. 2006;84:82\u20137.","journal-title":"Stereotact Funct Neurosurg"},{"issue":"Suppl","key":"3637_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3171\/2010.8.GKS101059","volume":"113","author":"D Mathieu","year":"2010","unstructured":"Mathieu D, Deacon C, Pinard CA, Kenny B, Duval J. Gamma knife surgery for hypothalamic hamartomas causing refractory epilepsy: preliminary results from a prospective observational study. J Neurosurg. 2010;113(Suppl):215\u201321.","journal-title":"J Neurosurg"},{"issue":"Suppl. 2","key":"3637_CR24","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/epi.13754","volume":"58","author":"J Regis","year":"2017","unstructured":"Regis J, Lagmari M, Carron R, et al. Safety and efficacy of gamma knife radiosurgery in hypothalamic hamartomas with severe epilepsies: a prospective trial in 48 patients and review of the literature. Epilepsia. 2017;58(Suppl. 2):60\u201371.","journal-title":"Epilepsia."},{"key":"3637_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2176\/nmc.43.61","volume":"43","author":"O Delalande","year":"2003","unstructured":"Delalande O, Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo). 2003;43:61\u20138.","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"4","key":"3637_CR26","doi-asserted-by":"publisher","first-page":"826","DOI":"10.4103\/neuroindia.NI_220_17","volume":"65","author":"KK Mukherjee","year":"2017","unstructured":"Mukherjee KK, Kumar N, Tripathi M, et al. Dose fractionated gamma knife radiosurgery for large arteriovenous malformations on daily or alternate day schedule outside the linear quadratic model: proof of concept and early results. A substitute to volume fractionation. Neurol India. 2017;65(4):826\u201335.","journal-title":"Neurol India"},{"key":"3637_CR27","doi-asserted-by":"crossref","unstructured":"Tripathi M, Rekhapalli R, Batish A, et al. Safety and efficacy of primary multisession dose fractionated gamma knife radiosurgery for jugular paragangliomas. World Neurosurg. 2019 Jul 16.","DOI":"10.1016\/j.wneu.2019.07.090"},{"key":"3637_CR28","unstructured":"Engel J Jr, Van Neaa PC, Rasmussen TB, Oejmann LM: Outcome with respect to epileptic seizures. In: Engel J Jr, editor. Surgical Treatment of the Epilepsies, 2 ed. 1993. p. 609\u201321."},{"key":"3637_CR29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.6065\/apem.2019.24.1.55","volume":"24","author":"R Kumar","year":"2019","unstructured":"Kumar R, Yadav J, Sahu JK, Tripathi M, Ahuja C, Dayal D. Episodes of prolonged \u201ctrance-like state\u201d in an infant with hypothalamic hamartoma. Ann Pediatr Endocrinol Metab. 2019;24:55\u20139.","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"6","key":"3637_CR30","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2013.3.FOCUS1356","volume":"34","author":"S Mittal","year":"2013","unstructured":"Mittal S, Mittal M, Montes JL, et al. Hypothalamic hamartomas. Part 2. Surgical considerations and outcome. Neurosurg Focus. 2013;34(6):E7.","journal-title":"Neurosurg Focus"},{"key":"3637_CR31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1684\/j.1950-6945.2003.tb00021.x","volume":"5","author":"M Fohlen","year":"2003","unstructured":"Fohlen M, Lellouch A, Delalande O. Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients. Epileptic Disord. 2003;5:267\u201373.","journal-title":"Epileptic Disord"},{"key":"3637_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1684\/j.1950-6945.2003.tb00019.x","volume":"5","author":"A Palmini","year":"2003","unstructured":"Palmini A, Paglioli-Neto E, Montes J, Farmer JP. The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses. Epileptic Disord. 2003;5:249\u201355.","journal-title":"Epileptic Disord"},{"key":"3637_CR33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.spen.2007.03.007","volume":"14","author":"JV Rosenfeld","year":"2007","unstructured":"Rosenfeld JV, Feiz-Erfan I. Hypothalamic hamartoma treatment: surgical resection with the transcallosal approach. Semin Pediatr Neurol. 2007;14:88\u201398.","journal-title":"Semin Pediatr Neurol"},{"key":"3637_CR34","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.yebeh.2012.03.024","volume":"24","author":"KE Stabell","year":"2012","unstructured":"Stabell KE, Bakke SJ, Egge A. Cognitive and neurological sequelae after stereoendoscopic disconnection of a hypothalamic hamartoma. A case study. Epilepsy Behav. 2012;24:274\u20138.","journal-title":"Epilepsy Behav"},{"issue":"Suppl. 2","key":"3637_CR35","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/epi.13760","volume":"58","author":"F Castinetti","year":"2017","unstructured":"Castinetti F, Brue T, Morange I, Carron R, R\u00e9gis J. Gamma knife radiosurgery for hypothalamic hamartoma preserves endocrine functions. Epilepsia. 2017;58(Suppl. 2):72\u20136.","journal-title":"Epilepsia."},{"key":"3637_CR36","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1210\/jc.2002-022018","volume":"88","author":"H Jung","year":"2003","unstructured":"Jung H, Neumaier Probst E, Hauffa BP, et al. Association of morphological characteristics with precocious puberty and\/or gelastic seizures in hypothalamic hamartoma. J Clin Endocrinol Metab. 2003;88:4590\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"3637_CR37","doi-asserted-by":"crossref","unstructured":"Kameyama S, Shirozu H, Masuda H, et al. MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas. J Neurosurg. 2015;124(5):1503\u201312.","DOI":"10.3171\/2015.4.JNS1582"},{"key":"3637_CR38","doi-asserted-by":"crossref","unstructured":"Tandon V, Sarat Chandra P, Doddamani RS, et al. Stereotactic radiofrequency thermocoagulation of hypothalamic hamartoma using robotic guidance (ROSA) coregistered with O-arm guidance preliminary technical note. World Neurosurg. 2018;112:267\u201374.","DOI":"10.1016\/j.wneu.2018.01.193"},{"key":"3637_CR39","doi-asserted-by":"crossref","unstructured":"Du VX, Gandhi SV, Rekate HL, Mehta AD. Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma? Epilepsia. 2017;58(Suppl 2):77\u201384.","DOI":"10.1111\/epi.13751"},{"key":"3637_CR40","doi-asserted-by":"crossref","unstructured":"Wilfong A, Curry DJ. Hypothalamic hamartomas: optimal approach to clinical evaluation and diagnosis. Epilepsia. 2013;54:5.","DOI":"10.1111\/epi.12454"},{"key":"3637_CR41","doi-asserted-by":"crossref","unstructured":"Schulze-Bonhage A, Homberg V, Trippel M, et al. Interstitial radiosurgery in the treatment of gelastic epilepsy. Neurology. 2008;71:277\u201382.","DOI":"10.1212\/01.wnl.0000318279.92233.82"},{"issue":"1","key":"3637_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S1470-2045(18)30659-4","volume":"2","author":"A Wolf","year":"2019","unstructured":"Wolf A, Naylor K, Tam M, et al. Risk of radiation-associated intracranial malignancy after stereotactic radiosurgery: a retrospective, multicentre, cohort study. Lancet Oncol. 2019;2(1):159\u201364.","journal-title":"Lancet Oncol"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-020-03637-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-020-03637-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-020-03637-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T01:24:43Z","timestamp":1724376283000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-020-03637-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["3637"],"URL":"https:\/\/doi.org\/10.1007\/s12098-020-03637-w","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]},"assertion":[{"value":"21 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}