{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:40:36Z","timestamp":1769150436513,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s12098-021-03972-6","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T02:02:21Z","timestamp":1636164141000},"page":"192-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cerebrospinal Fluid Leucine-Rich Alpha-2 Glycoprotein (LRG) Levels in Children with Acute Bacterial Meningitis"],"prefix":"10.1007","volume":"89","author":[{"given":"Kushal","family":"Talukder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajniti","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhisek","family":"Abhinay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragini","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Om P.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tej Bali","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"3972_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.4103\/0972-2327.120491","volume":"16","author":"SF Mohammadi","year":"2013","unstructured":"Mohammadi SF, Patil AB, Nadagir SD, Nandihal N, Lakshminarayana SA. A Diagnostic value of latex agglutination test in diagnosis of acute bacterial meningitis. Ann Indian Acad Neurol. 2013;16:645\u20139.","journal-title":"Ann Indian Acad Neurol"},{"key":"3972_CR2","doi-asserted-by":"crossref","unstructured":"Nigrovic LE, Kuppermann N, Malley R; Bacterial Meningitis Study Group of the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. Acad Emerg Med. 2008;15:522\u201328.","DOI":"10.1111\/j.1553-2712.2008.00117.x"},{"key":"3972_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s12098-015-1689-3","volume":"82","author":"S Aneja","year":"2015","unstructured":"Aneja S. Acute bacterial meningitis-early diagnosis and complications. Indian J Pediatr. 2015;82:303\u20135.","journal-title":"Indian J Pediatr"},{"key":"3972_CR4","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1016\/j.jpeds.2013.03.028","volume":"163","author":"SP Fitzwater","year":"2013","unstructured":"Fitzwater SP, Ramachandran P, Nedunchelian K, Kahn G, Santosham A, Chandran A. Bacterial meningitis in children <2 years of age in a tertiary care hospital in South India: an assessment of clinical and laboratory features. J Pediatr. 2013;163:S32\u20137.","journal-title":"J Pediatr"},{"key":"3972_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/S0959-440X(01)00266-4","volume":"11","author":"B Kobe","year":"2001","unstructured":"Kobe B, Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol. 2001;11:725\u201332.","journal-title":"Curr Opin Struct Biol"},{"key":"3972_CR6","doi-asserted-by":"crossref","unstructured":"Haupt H, Baudner S. Isolation and characterization of an unknown, leucine-rich 3.1-S-alpha2-glycoprotein from human serum. Hoppe Seylers Z Physiol Chem. 1977;358:639\u201346.","DOI":"10.1515\/bchm2.1977.358.1.639"},{"key":"3972_CR7","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.bbrc.2009.03.104","volume":"382","author":"R Shirai","year":"2009","unstructured":"Shirai R, Hirano F, Ohkura N, Ikeda K, Inoue S. Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response. Biochem Biophys Res Commun. 2009;382:776\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"3972_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jns.2018.07.006","volume":"392","author":"PF Chong","year":"2018","unstructured":"Chong PF, Sakai Y, Torisu H, et al. Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis. J Neurol Sci. 2018;392:51\u20135.","journal-title":"J Neurol Sci"},{"key":"3972_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-3-7091-0923-6_20","volume":"113","author":"M Nakajima","year":"2012","unstructured":"Nakajima M, Miyajima M, Ogino I, et al. Brain localization of leucine-rich \u03b12-glycoprotein and its role. Acta Neurochir Suppl. 2012;113:97\u2013101.","journal-title":"Acta Neurochir Suppl"},{"key":"3972_CR10","doi-asserted-by":"publisher","first-page":"3384","DOI":"10.1038\/s41598-020-60450-3","volume":"10","author":"M Fujimoto","year":"2020","unstructured":"Fujimoto M, Matsumoto T, Serada S, et al. Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis. Sci Rep. 2020;10:3384.","journal-title":"Sci Rep"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-021-03972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-021-03972-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-021-03972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T12:33:17Z","timestamp":1641558797000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-021-03972-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,6]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["3972"],"URL":"https:\/\/doi.org\/10.1007\/s12098-021-03972-6","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,6]]},"assertion":[{"value":"5 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}