{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:35:22Z","timestamp":1771486522215,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/n\/a","name":"PGIMER","doi-asserted-by":"publisher","award":["THESIS GRANT"],"award-info":[{"award-number":["THESIS GRANT"]}],"id":[{"id":"10.13039\/n\/a","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s12098-022-04084-5","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T22:15:28Z","timestamp":1645222528000},"page":"989-995","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circulating Histones and Severity of Illness in Children with Sepsis: A Prospective Observational Study"],"prefix":"10.1007","volume":"89","author":[{"given":"Vishal","family":"Sidana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javed","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-9846","authenticated-orcid":false,"given":"Karthi","family":"Nallasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prateek","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muralidharan","family":"Jayashree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"4084_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","volume":"6","author":"C Fleischmann-Struzek","year":"2018","unstructured":"Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis:a systematic review. Lancet Respir Med. 2018;6:223\u201330.","journal-title":"Lancet Respir Med"},{"key":"4084_CR2","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/TA.0b013e318270d595","volume":"73","author":"ME Kutcher","year":"2012","unstructured":"Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ. Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C. J Trauma Acute Care Surg. 2012;73:1389\u201394.","journal-title":"J Trauma Acute Care Surg"},{"key":"4084_CR3","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1038\/cdd.2013.69","volume":"20","author":"GR Wickman","year":"2013","unstructured":"Wickman GR, Julian L, Mardilovich K, et al. Blebs produced by actin\u2013myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs. Cell Death Differ. 2013;20:1293\u2013305.","journal-title":"Cell Death Differ"},{"key":"4084_CR4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","volume":"13","author":"SR Clark","year":"2007","unstructured":"Clark SR, Ma AC, Tavener SA, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med. 2007;13:463\u20139.","journal-title":"Nat Med"},{"key":"4084_CR5","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.2847","volume":"18","author":"BG Yipp","year":"2012","unstructured":"Yipp BG, Petri B, Salina D, et al. Dynamic NETosis is carried out by live neutrophils in human and mouse bacterial abscesses and during severe gram-positive infection. Nat Med. 2012;18:1386\u201393.","journal-title":"Nat Med"},{"key":"4084_CR6","doi-asserted-by":"crossref","unstructured":"Chen R, Kang R, Fan XG, Tang D. Release and activity of histone in diseases. Cell Death Dis. 2014;5:e1370.","DOI":"10.1038\/cddis.2014.337"},{"key":"4084_CR7","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1002\/hep.24501","volume":"54","author":"H Huang","year":"2011","unstructured":"Huang H, Evankovich J, Yan W, et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology. 2011;54:999\u20131008.","journal-title":"Hepatology"},{"key":"4084_CR8","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","volume":"15","author":"J Xu","year":"2009","unstructured":"Xu J, Zhang X, Pelayo R, et al. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009;15:1318\u201321.","journal-title":"Nat Med"},{"key":"4084_CR9","doi-asserted-by":"crossref","unstructured":"Matics TJ, Sanchez-Pinto LN. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically ill children. JAMA Pediatr. 2017;171:e172352.","DOI":"10.1001\/jamapediatrics.2017.2352"},{"key":"4084_CR10","doi-asserted-by":"publisher","first-page":"e558","DOI":"10.1016\/j.ijid.2012.03.007","volume":"16","author":"Q Chen","year":"2012","unstructured":"Chen Q, Ye L, Jin Y, et al. Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients. Int J Infect Dis. 2012;16:e558\u201364.","journal-title":"Int J Infect Dis"},{"key":"4084_CR11","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1097\/01.CCM.0000074719.40109.95","volume":"31","author":"S Zeerleder","year":"2003","unstructured":"Zeerleder S, Zwart B, Wuillemin WA, et al. Elevated nucleosome levels in systemic inflammation and sepsis. Crit Care Med. 2003;31:1947\u201351.","journal-title":"Crit Care Med"},{"key":"4084_CR12","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.thromres.2015.06.035","volume":"136","author":"KCAA Wildhagen","year":"2015","unstructured":"Wildhagen KCAA, Wiewel MA, Schultz MJ, et al. Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients. Thromb Res. 2015;136:542\u20137.","journal-title":"Thromb Res"},{"key":"4084_CR13","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1097\/CCM.0000000000001162","volume":"43","author":"Y Alhamdi","year":"2015","unstructured":"Alhamdi Y, Abrams ST, Cheng Z, et al. Circulating histones are major mediators of cardiac injury in patients with sepsis. Crit Care Med. 2015;43:2094\u2013103.","journal-title":"Crit Care Med"},{"key":"4084_CR14","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1097\/01.ccm.0000729768.72574.9e","volume":"49","author":"N Yehya","year":"2021","unstructured":"Yehya N, Fazelinia H, Lawrence GG, et al. Plasma nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome. Crit Care Med. 2021;49:1149\u201358.","journal-title":"Crit Care Med"},{"key":"4084_CR15","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s12185-019-02798-5","volume":"111","author":"K Harada-Shirado","year":"2020","unstructured":"Harada-Shirado K, Wang X, Mori H, et al. Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia. Int J Hematol. 2020;111:378\u201387.","journal-title":"Int J Hematol"},{"key":"4084_CR16","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1001\/jama.2016.0136","volume":"315","author":"Y Alhamdi","year":"2016","unstructured":"Alhamdi Y, Abrams ST, Lane S, Wang G, Toh CH. Histone-associated thrombocytopenia in patients who are critically ill. JAMA. 2016;315:817\u20139.","journal-title":"JAMA"},{"key":"4084_CR17","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1182\/blood-2011-01-332676","volume":"118","author":"TA Fuchs","year":"2011","unstructured":"Fuchs TA, Bhandari AA, Wagner DD. Histones induce rapid and profound thrombocytopenia in mice. Blood. 2011;118:3708\u201314.","journal-title":"Blood"},{"key":"4084_CR18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1164\/rccm.201206-1037OC","volume":"187","author":"ST Abrams","year":"2013","unstructured":"Abrams ST, Zhang N, Manson J, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med. 2013;187:160\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"4084_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12959-018-0190-4","volume":"17","author":"Y Yokoyama","year":"2019","unstructured":"Yokoyama Y, Ito T, Yasuda T, et al. Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study. Thromb J. 2019;17:1.","journal-title":"Thromb J"},{"key":"4084_CR20","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1186\/s13054-014-0543-8","volume":"18","author":"ML Ekaney","year":"2014","unstructured":"Ekaney ML, Otto GP, Sossdorf M, et al. Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care. 2014;18:543.","journal-title":"Crit Care"},{"key":"4084_CR21","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1097\/CCM.0b013e318265695f","volume":"40","author":"S Zeerleder","year":"2012","unstructured":"Zeerleder S, Stephan F, Emonts M, et al. Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C. Crit Care Med. 2012;40:3224\u20139.","journal-title":"Crit Care Med"},{"key":"4084_CR22","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.4049\/jimmunol.1203181","volume":"191","author":"ST Abrams","year":"2013","unstructured":"Abrams ST, Zhang N, Dart C, et al. Human CRP defends against the toxicity of circulating histones. J Immunol. 2013;191:2495\u2013502.","journal-title":"J Immunol"},{"key":"4084_CR23","doi-asserted-by":"crossref","unstructured":"Wildhagen KCAA, Garc\u00eda de Frutos P, Reutelingsperger CP, et al. Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood. 2014;123:1098\u2013101.","DOI":"10.1182\/blood-2013-07-514984"},{"key":"4084_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jim.2009.06.003","volume":"347","author":"AN Hoofnagle","year":"2009","unstructured":"Hoofnagle AN, Wener MH. The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. J Immunol Methods. 2009;347:3\u201311.","journal-title":"J Immunol Methods"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04084-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-022-04084-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04084-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T03:32:47Z","timestamp":1663385567000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-022-04084-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["4084"],"URL":"https:\/\/doi.org\/10.1007\/s12098-022-04084-5","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]},"assertion":[{"value":"6 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PGIMER Institute ethics committee approved this study (IEC\/2018\/00351, dated 26\/03\/2018). Informed consent was taken from parents\/legal guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}