{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:41:53Z","timestamp":1776973313150,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s12098-022-04087-2","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T05:07:56Z","timestamp":1646629676000},"page":"665-672","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic Disorders among Children Presenting with Acute Encephalopathy"],"prefix":"10.1007","volume":"89","author":[{"given":"Kirti","family":"Singhal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-5577","authenticated-orcid":false,"given":"Meenakshi","family":"Bothra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urmila","family":"Jhamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"4087_CR1","unstructured":"National Institute of Neurological Disorders and Stroke. Encephalopathy Information Page. Available at: https:\/\/www.ninds.nih.gov\/Disorders\/All-Disorders\/Encephalopathy-Information-Page. Accessed on 1 May 2021."},{"key":"4087_CR2","doi-asserted-by":"publisher","first-page":"E69","DOI":"10.1542\/peds.102.6.e69","volume":"102","author":"BK Burton","year":"1998","unstructured":"Burton BK. Inborn errors of metabolism in infancy: a guide to diagnosis. Pediatrics. 1998;102:E69.","journal-title":"Pediatrics"},{"key":"4087_CR3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1136\/adc.2011.300998","volume":"97","author":"E Davies","year":"2011","unstructured":"Davies E, Connolly D, Mordekar S. Encephalopathy in children: an approach to assessment and management. Arch Dis Child. 2011;97:452\u20138.","journal-title":"Arch Dis Child"},{"key":"4087_CR4","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s13312-012-0216-0","volume":"49","author":"S Sharma","year":"2012","unstructured":"Sharma S, Mishra D, Aneja S, Kumar R, Jain A, Vashishtha V. Consensus guidelines on evaluation and management of suspected acute viral encephalitis in children in India. Indian Pediatr. 2012;49:897\u2013910.","journal-title":"Indian Pediatr"},{"key":"4087_CR5","doi-asserted-by":"crossref","unstructured":"Modi M, Goyal MK, Jain A, et al. Tuberculous meningitis: challenges in diagnosis and management: Lessons learnt from Prof. Dastur's article published in 1970. Neurol India. 2018;66:1550\u20137.","DOI":"10.4103\/0028-3886.246224"},{"key":"4087_CR6","first-page":"2936","volume-title":"Nelson Textbook of Pediatrics","author":"CG Prober","year":"2016","unstructured":"Prober CG, Srinivas NS, Mathew R. Central nervous system infections. In: Kleigman RM, Stanton BF, Schor NF, St Geme JW, Behrman RE, editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier; 2016. p.2936\u201348.","edition":"20"},{"key":"4087_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2147\/PHMT.S79058","volume":"7","author":"P Singhi","year":"2016","unstructured":"Singhi P, Gahlot AG. Pediatric neurocysticercosis: current challenges and future prospects. Pediatric Health, Med Ther. 2016;7:5\u201318.","journal-title":"Pediatric Health, Med Ther"},{"key":"4087_CR8","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.4103\/0976-3147.116472","volume":"4","author":"H Alvis Miranda","year":"2013","unstructured":"Alvis Miranda H, Castellar-Leones SM, Elzain MA, Moscote-Salazar LR. Brain abscess: Current management. J Neurosci Rural Pract. 2013;4:S67-81.","journal-title":"J Neurosci Rural Pract"},{"key":"4087_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15720-2","volume-title":"Inborn Metabolic Diseases: Diagnosis and Treatment","author":"JM Saudubray","year":"2012","unstructured":"Saudubray JM, Berghe G, Walter JH. Inborn Metabolic Diseases: Diagnosis and Treatment. 5th ed. New York: Springer-Verlag, Berlin Heidelberg; 2012. p.28\u201330.","edition":"5"},{"key":"4087_CR10","unstructured":"Comstock JP, Garber AJ. Ketonuria. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths. 1990. p.658\u201360."},{"key":"4087_CR11","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1093\/cid\/cix229","volume":"64","author":"C Britto","year":"2017","unstructured":"Britto C, Pollard AJ, Voysey M, Blohmke CJ. An appraisal of the clinical features of pediatric enteric fever: systematic review and meta-analysis of the age-stratified disease occurrence. Clin Infect Dis. 2017;64:1604\u201311.","journal-title":"Clin Infect Dis"},{"key":"4087_CR12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1177\/088307380201700511","volume":"17","author":"NS Shah","year":"2002","unstructured":"Shah NS, Mitchell WG, Boles RG. Mitochondrial disorders: a potentially under-recognized etiology of infantile spasms. J Child Neurol. 2002;17:369\u201372.","journal-title":"J Child Neurol"},{"key":"4087_CR13","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1542\/peds.2004-0718","volume":"114","author":"F Scaglia","year":"2004","unstructured":"Scaglia F, Towbin JA, Craigen WJ, et al. Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease. Pediatrics. 2004;114:925\u201331.","journal-title":"Pediatrics"},{"key":"4087_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1023\/B:BOLI.0000045771.66300.2a","volume":"27","author":"E Neumaier-Probst","year":"2004","unstructured":"Neumaier-Probst E, Harting I, Seitz A, Ding C, K\u00f6lker S. Neuroradiological findings in glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency). J Inherit Metab Dis. 2004;27:869\u201376.","journal-title":"J Inherit Metab Dis"},{"key":"4087_CR15","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.jocn.2013.10.030","volume":"21","author":"R Konanki","year":"2014","unstructured":"Konanki R, Gulati S, Saxena R, et al. Profile of prothrombotic factors in Indian children with ischemic stroke. J Clin Neurosci. 2014;21:1315\u20138.","journal-title":"J Clin Neurosci"},{"key":"4087_CR16","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/fcp.12145","volume":"29","author":"P Bhatia","year":"2015","unstructured":"Bhatia P, Singh N. Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol. 2015;29:522\u20138.","journal-title":"Fundam Clin Pharmacol"},{"key":"4087_CR17","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1212\/01.wnl.0000244435.27645.54","volume":"67","author":"E Morava","year":"2006","unstructured":"Morava E, Heuvel LVD, Hol F, et al. Mitochondrial disease criteria: diagnostic applications in children. Neurology. 2006;67:1823\u20136.","journal-title":"Neurology"},{"key":"4087_CR18","doi-asserted-by":"crossref","unstructured":"Maksoud MA, ELsayed SM, Shatla RH, et al. Frequency of inborn errors of metabolism screening for children with unexplained acute encephalopathy at an emergency department. Neuropsychiatr Dis Treat. 2018;14:1715\u201320.","DOI":"10.2147\/NDT.S165833"},{"key":"4087_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12098-010-0008-2","volume":"77","author":"M Kamate","year":"2010","unstructured":"Kamate M, Chetal V, Kulgod V, Patil V, Christopher R. Profile of inborn errors of metabolism in a tertiary care centre PICU. Indian J Pediatr. 2010;77:57\u201360.","journal-title":"Indian J Pediatr"},{"key":"4087_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00431-006-0265-2","volume":"166","author":"P Jouvet","year":"2007","unstructured":"Jouvet P, Touati G, Lesage F, et al. Impact of inborn errors of metabolism on admission and mortality in a pediatric intensive care unit. Eur J Pediatr. 2007;166:461\u20135.","journal-title":"Eur J Pediatr"},{"key":"4087_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13023-016-0510-3","volume":"11","author":"M Alfadhel","year":"2016","unstructured":"Alfadhel M, Benmeakel M, Hossain MA, et al. Thirteen year retrospective review of the spectrum of inborn errors of metabolism presenting in a tertiary center in Saudi Arabia. Orphanet J Rare Dis. 2016;11:126.","journal-title":"Orphanet J Rare Dis"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-022-04087-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04087-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:16:51Z","timestamp":1655443011000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-022-04087-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["4087"],"URL":"https:\/\/doi.org\/10.1007\/s12098-022-04087-2","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"assertion":[{"value":"10 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}