{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T19:06:16Z","timestamp":1788721576988,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s12098-022-04166-4","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T06:02:22Z","timestamp":1654063342000},"page":"1086-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Natural Versus Synthetic Surfactant Therapy in Respiratory Distress Syndrome of Prematurity"],"prefix":"10.1007","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-8462","authenticated-orcid":false,"given":"Dipen V.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvik C.","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mili","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan L.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karamchand","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somashekhar M.","family":"Nimbalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"4166_CR1","doi-asserted-by":"crossref","unstructured":"Soll RF. Synthetic surfactant for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2000;1998:CD001149.","DOI":"10.1002\/14651858.CD001149"},{"key":"4166_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007836","author":"N Seger","year":"2009","unstructured":"Seger N, Soll R. Animal derived surfactant extract for treatment of respiratory distress syndrome. Cochrane Database Syst Rev. 2009. https:\/\/doi.org\/10.1002\/14651858.CD007836.","journal-title":"Cochrane Database Syst Rev"},{"key":"4166_CR3","doi-asserted-by":"crossref","unstructured":"Bahadue FL, Soll R. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2012;11:CD001456.","DOI":"10.1002\/14651858.CD001456.pub2"},{"key":"4166_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000141","author":"R Soll","year":"2009","unstructured":"Soll R, Ozek E. Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2009. https:\/\/doi.org\/10.1002\/14651858.CD000141.","journal-title":"Cochrane Database Syst Rev"},{"key":"4166_CR5","first-page":"1684","volume":"126","author":"RM Hubbard","year":"2018","unstructured":"Hubbard RM, Choudhury KM, Lim G. Treatment patterns and clinical outcomes in neonates diagnosed with respiratory distress syndrome in a low-income country: a report from Bangladesh. Anesth Analg. 2018;126:1684\u20136.","journal-title":"AnesthAnalg"},{"key":"4166_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1159\/000326628","volume":"99","author":"D Vidyasagar","year":"2011","unstructured":"Vidyasagar D, Velaphi S, Bhat VB. Surfactant replacement therapy in developing countries. Neonatology. 2011;99:355\u201366.","journal-title":"Neonatology"},{"key":"4166_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jinteco.2006.09.008","volume":"72","author":"C Papageorgiou","year":"2007","unstructured":"Papageorgiou C, Savvides A, Zachariadis M. International medical technology diffusion. J Int Econ. 2007;72:409\u201327.","journal-title":"J Int Econ"},{"key":"4166_CR8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/pr.2016.203","volume":"81","author":"S Sardesai","year":"2017","unstructured":"Sardesai S, Biniwale M, Wertheimer F, Garingo A, Ramanathan R. Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future. Pediatr Res. 2017;81:240\u20138.","journal-title":"Pediatr Res"},{"key":"4166_CR9","doi-asserted-by":"publisher","unstructured":"Soll RF, Blanco F. Natural surfactant extract versus synthetic surfactant for neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2001. https:\/\/doi.org\/10.1002\/14651858.CD000144. Update. In: Cochrane Database Syst Rev. 2015;5:CD000144.","DOI":"10.1002\/14651858.CD000144"},{"key":"4166_CR10","doi-asserted-by":"publisher","unstructured":"Ardell S, Pfister RH, Soll R. Animal derived surfactant extract versus protein free synthetic surfactant for the prevention and treatment of respiratory distress syndrome. Cochrane Database Syst Rev. 2015. https:\/\/doi.org\/10.1002\/14651858.CD000144. Update. In: Cochrane Database Syst Rev. 2015;8:CD000144","DOI":"10.1002\/14651858.CD000144"},{"key":"4166_CR11","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1542\/peds.2005-0202","volume":"115","author":"J Kattwinkel","year":"2005","unstructured":"Kattwinkel J. Synthetic surfactants: the search goes on. Pediatrics. 2005;115:1075\u20136.","journal-title":"Pediatrics"},{"key":"4166_CR12","doi-asserted-by":"crossref","unstructured":"Sankar MJ, Gupta N, Jain K, Agarwal R, Paul VK. Efficacy and safety of surfactant replacement therapy for preterm neonates with respiratory distress syndrome in low-and middle-income countries: a systematic review. J Perinatol. 2016;36 Suppl1:S36\u201348.","DOI":"10.1038\/jp.2016.31"},{"key":"4166_CR13","doi-asserted-by":"crossref","unstructured":"Dechant KL, Faulds D. Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome. Drugs. 1991;42:877\u201394.","DOI":"10.2165\/00003495-199142050-00009"},{"key":"4166_CR14","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S0022-3476(05)80143-X","volume":"117","author":"C Bose","year":"1990","unstructured":"Bose C, Corbet A, Bose G, et al. Improved outcome at 28 days of age for very low birth weight infants treated with a single dose of a synthetic surfactant. J Pediatr. 1990;117:947\u201353.","journal-title":"J Pediatr"},{"key":"4166_CR15","doi-asserted-by":"crossref","unstructured":"Corbet A, Bucciarelli R, Goldman S, Mammel M, Wold D, Long W. Decreased mortality rate among small premature infants treated at birth with a single dose of synthetic surfactant: a multicenter controlled trial. American Exosurf Pediatric Study Group 1. J Pediatr. 1991;118:277\u201384.","DOI":"10.1016\/S0022-3476(05)80502-5"},{"key":"4166_CR16","unstructured":"World Health Organization. WHO model list of essential medicines, 20th list. March 2017, amended August 2017. Available at:\u00a0https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/273826\/EML-20-eng.pdf. Accessed on 18 Mar\u00a02022."},{"key":"4166_CR17","doi-asserted-by":"crossref","unstructured":"Jobe AH, Ikegami M. Biology of surfactant. Clin Perinatol. 2001;28:655\u2013 69.","DOI":"10.1016\/S0095-5108(05)70111-1"},{"key":"4166_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0009-3084(00)00228-0","volume":"110","author":"EJ Veldhuizen","year":"2001","unstructured":"Veldhuizen EJ, Diemel RV, Putz G, van Golde LM, Batenburg JJ, Haagsman HP. Effect of the hydrophobic surfactant proteins on the surface activity of spread films in the captive bubble surfactometer. Chem Phys Lipids. 2001;110:47\u201355.","journal-title":"ChemPhys Lipids"},{"key":"4166_CR19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1056\/NEJM199302113280606","volume":"328","author":"LM Nogee","year":"1993","unstructured":"Nogee LM, de Mello DE, Dehner LP, Colten HR. Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis. N Engl J Med. 1993;328:406\u201310.","journal-title":"N Engl J Med"},{"key":"4166_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1203\/00006450-200108000-00001","volume":"50","author":"FS Cole","year":"2001","unstructured":"Cole FS, Hamvas A, Nogee LM. Genetic disorders of neonatal respiratory function. Pediatr Res. 2001;50:157\u201362.","journal-title":"Pediatr Res"},{"key":"4166_CR21","doi-asserted-by":"publisher","first-page":"7794","DOI":"10.1073\/pnas.92.17.7794","volume":"92","author":"JC Clark","year":"1995","unstructured":"Clark JC, Wert SE, Bachurski CJ, et al. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA. 1995;92:7794\u20138.","journal-title":"Proc Natl AcadSci USA"},{"key":"4166_CR22","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1651-2227.2000.tb00328.x","volume":"89","author":"AK Kukkonen","year":"2000","unstructured":"Kukkonen AK, Virtanen M, J\u00e4rvenp\u00e4\u00e4 AL, Pokela ML, Ikonen S, Fellman V. Randomized trial comparing natural and synthetic surfactant: increased infection rate after natural surfactant? Acta Paediatr. 2000;89:556\u201361.","journal-title":"Acta Paediatr"},{"key":"4166_CR23","doi-asserted-by":"publisher","first-page":"F497","DOI":"10.1136\/archdischild-2017-312722","volume":"102","author":"DG Sweet","year":"2017","unstructured":"Sweet DG, Turner MA, Stra\u0148\u00e1k Z, et al. A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 2017;102:F497-503.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"4166_CR24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jpeds.2020.06.024","volume":"225","author":"R Ramanathan","year":"2020","unstructured":"Ramanathan R, Biniwale M, Sekar K, et al. Synthetic surfactant CHF5633 compared with poractantalfa in the treatment of neonatal respiratory distress syndrome: amulticenter, double-blind, randomized, controlled clinical trial. J Pediatr. 2020;225:90\u20136.","journal-title":"J Pediatr"},{"key":"4166_CR25","first-page":"149","volume":"9","author":"G Flores-Nava","year":"1995","unstructured":"Flores-Nava G, L\u00f3pez-Padilla M, Barrera-Mill\u00e1n E, Escobedo-Ch\u00e1vez E, Thompson-Chagoyan O, Humberto JR. Ensayocl\u00ednico con un surfactante artificial para el tratamiento del s\u00edndrome de dificultad respiratoria neonatal. Perinatol Reprod Hum. 1995;9:149\u201355.","journal-title":"PerinatolReprod Hum"},{"key":"4166_CR26","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3109\/14767058.2014.997203","volume":"29","author":"N Duman","year":"2016","unstructured":"Duman N, T\u00fcz\u00fcn F, Sever AH, et al. Nasal intermittent positive pressure ventilation with or without very early surfactant therapy for the primary treatment of respiratory distress syndrome. J Matern Fetal Neonatal Med. 2016;29:252\u20137.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"4166_CR27","doi-asserted-by":"crossref","unstructured":"Bryson HM, Whittington R. Colfosceril palmitate. A pharmacoeconomic evaluation of a synthetic surfactant preparation (Exosurf Neonatal) in infants with respiratory distress syndrome. Pharmacoeconomics. 1994;6:563\u201377.","DOI":"10.2165\/00019053-199406060-00009"},{"key":"4166_CR28","doi-asserted-by":"publisher","first-page":"358","DOI":"10.2165\/00019053-199406040-00003","volume":"6","author":"ME Backhouse","year":"1994","unstructured":"Backhouse ME, Mauskopf JA, Jones D, et al. Economic outcomes of colfosceril palmitate rescue therapy in infants weighing 1250g or more with respiratory distress syndrome: results from a randomised trial. Pharmacoeconomics. 1994;6:358\u201369.","journal-title":"Pharmacoeconomics"},{"key":"4166_CR29","doi-asserted-by":"publisher","first-page":"e1588","DOI":"10.1542\/peds.2011-1395","volume":"128","author":"N Singh","year":"2011","unstructured":"Singh N, Hawley KL, Viswanathan K. Efficacy of porcine versus bovine surfactants for preterm newborns with respiratory distress syndrome: systematic review and meta-analysis. Pediatrics. 2011;128:e1588\u201395.","journal-title":"Pediatrics"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04166-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-022-04166-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04166-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T04:12:57Z","timestamp":1665807177000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-022-04166-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["4166"],"URL":"https:\/\/doi.org\/10.1007\/s12098-022-04166-4","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"23 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Ethics Committee of H M Patel Center for Medical Care and Education, Karamsad, Gujarat.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}