{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T13:03:34Z","timestamp":1794575014235,"version":"4.9.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to evaluate available volume status assessment tools in nephrotic syndrome (NS). Sixty children with INS were subdivided into hypovolemic and nonhypovolemic groups based on fractional excretion of sodium (FeNa%); all were studied for inferior vena cava collapsibility index (IVCCI), plasma atrial natriuretic peptide (ANP), and body composition monitor (BCM). Forty-four patients had nonhypovolemic and 16 had hypovolemic states. ANP did not differ between both groups. IVCCI was higher in hypovolemic group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with sensitivity 87.5% and specificity 81.8% for hypovolemia detection, while BCM overhydration (BCM-OH) values were higher in nonhypovolemic group (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) with sensitivity\u2009=\u200968.2% and specificity\u2009=\u200975% for detection of hypervolemia. FeNa% showed negative correlation with IVCCI (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u22120.578, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and positive correlation with BCM-OH (<jats:italic>r<\/jats:italic>\u2009=\u20090.33, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), while FeNa% showed nonsignificant correlation to ANP concentration. IVCCI is a reliable tool for evaluating volume status in NS and is superior to BCM.<\/jats:p>","DOI":"10.1007\/s12098-022-04177-1","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T07:23:36Z","timestamp":1655450616000},"page":"1113-1116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inferior Vena Cava Collapsibility Index: A Precise, Noninvasive Tool for Evaluation of Edema in Children with Nephrotic Syndrome"],"prefix":"10.1007","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-3607","authenticated-orcid":false,"given":"Hanan","family":"El-Halaby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-3820","authenticated-orcid":false,"given":"Ashraf","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5811","authenticated-orcid":false,"given":"Mohamed","family":"El-Assmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-2651","authenticated-orcid":false,"given":"Hussein Abdelaziz","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-9028","authenticated-orcid":false,"given":"Riham","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"4177_CR1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.2215\/CJN.04390808","volume":"4","author":"G Kapur","year":"2009","unstructured":"Kapur G, Valentini RP, Imam AA, Mattoo TK. Treatment of severe edema in children with nephrotic syndrome with diuretics alone\u2014a prospective study. Clin J Am Soc Nephrol. 2009;4:907\u201313.","journal-title":"Clin J Am Soc Nephrol"},{"key":"4177_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s004670000536","volume":"16","author":"O Donmez","year":"2001","unstructured":"Donmez O, Mir S, Ozyurek R, Cura A, Kabasakal C. Inferior vena cava indices determine volume load in minimal lesion nephrotic syndrome. Pediatr Nephrol. 2001;16:251\u20135.","journal-title":"Pediatr Nephrol"},{"key":"4177_CR3","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3906\/sag-1312-130","volume":"45","author":"MA Buyukavci","year":"2015","unstructured":"Buyukavci MA, Civilibal M, Elevli M, Selcuk Duru HN. Hypo- and hypervolemic edema in children with steroid sensitive nephrotic syndrome. Turk J Med Sci. 2015;45:178\u201383.","journal-title":"Turk J Med Sci"},{"key":"4177_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3906\/sag-1312-132","volume":"45","author":"K Ozdemir","year":"2015","unstructured":"Ozdemir K, Mir MS, Dincel N, et al. Bioimpedance for assessing volume status in children with nephrotic syndrome. Turk J Med Sci. 2015;45:339\u201344.","journal-title":"Turk J Med Sci"},{"key":"4177_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/ki.1988.256","volume":"34","author":"C Peterson","year":"1988","unstructured":"Peterson C, Madsen B, Perlman A, Chan AY, Myers BD. Atrial natriuretic peptide and the renal response to hypervolemia in nephrotic humans. Kidney Int. 1988;34:825\u201331.","journal-title":"Kidney Int"},{"key":"4177_CR6","first-page":"65","volume":"10","author":"EH Garin","year":"1990","unstructured":"Garin EH, Paul RV. Atrial natriuretic factor in idiopathic minimal-lesion nephrotic syndrome. Child Nephrol Urol. 1990;10:65\u20137.","journal-title":"Child Nephrol Urol"},{"key":"4177_CR7","doi-asserted-by":"publisher","first-page":"4274856","DOI":"10.1155\/2019\/4274856","volume":"2019","author":"S Brantlov","year":"2019","unstructured":"Brantlov S, J\u00f8dal L, Frydensbjerg Andersen R, Lange A, Rittig S, Ward LC. Bioimpedance resistance indices and cell membrane capacitance used to assess disease status and cell membrane integrity in children with nephrotic syndrome. Sci World J. 2019;2019:4274856.","journal-title":"Sci World J"},{"key":"4177_CR8","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s11255-008-9344-9","volume":"40","author":"Y Tabel","year":"2008","unstructured":"Tabel Y, Mungan I, Karakurt C, Kocak G, Gungor S. Is edema in minimal change disease of childhood really hypovolemic? Int Urol Nephrol. 2008;40:757\u201361.","journal-title":"Int Urol Nephrol"},{"key":"4177_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4196\/kjpp.2009.13.1.1","volume":"13","author":"EH Bae","year":"2009","unstructured":"Bae EH, Lee J, Ma SK, Kim SW. Changes of atrial natriuretic peptide system in rats with puromycin aminonucleoside-induced nephrotic syndrome. Korean J Physiol Pharmacol. 2009;13:1\u20137.","journal-title":"Korean J Physiol Pharmacol"},{"key":"4177_CR10","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1093\/oxfordjournals.ndt.a027452","volume":"11","author":"J Plum","year":"1996","unstructured":"Plum J, Mirzaian Y, Grabensee B. Atrial natriuretic peptide, sodium retention, and proteinuria in nephrotic syndrome. Nephrol Dial Transpl. 1996;11:1034\u201342.","journal-title":"Nephrol Dial Transpl"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04177-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-022-04177-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04177-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T04:12:44Z","timestamp":1665807164000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-022-04177-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["4177"],"URL":"https:\/\/doi.org\/10.1007\/s12098-022-04177-1","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]},"assertion":[{"value":"20 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by Mansoura Faculty of Medicine Institutional Research Board (R.21.02.1189).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}