{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:48:57Z","timestamp":1793753337637,"version":"4.6.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s12098-022-04394-8","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T05:04:55Z","timestamp":1672117495000},"page":"168-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":144,"title":["Management of Dengue: An Updated Review"],"prefix":"10.1007","volume":"90","author":[{"given":"Anshula","family":"Tayal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil Kumar","family":"Kabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Lodha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"4394_CR1","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature. 2013;496:504\u20137.","journal-title":"Nature"},{"key":"4394_CR2","volume-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization","year":"2009","unstructured":"World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. New Ed. Geneva: World Health Organization; 2009. PMID: 23762963.","edition":"New"},{"key":"4394_CR3","volume-title":"Dengue haemorrhagic fever: diagnosis, treatment, prevention, and control","author":"World Health Organization","year":"1997","unstructured":"World Health Organization. Dengue haemorrhagic fever: diagnosis, treatment, prevention, and control. 2nd ed. Geneva: World Health Organization; 1997. Available at:\u00a0 https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/41988\/9241545003_eng.pdf?sequence=1&isAllowed=y. Accessed on 12 Nov 2022.","edition":"2"},{"key":"4394_CR4","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1111\/j.1365-3156.2006.01678.x","volume":"11","author":"S Bandyopadhyay","year":"2006","unstructured":"Bandyopadhyay S, Lum LCS, Kroeger A. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health. 2006;11:1238\u201355.","journal-title":"Trop Med Int Health"},{"key":"4394_CR5","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1086\/520435","volume":"29","author":"NM Dung","year":"1999","unstructured":"Dung NM, Day NP, Tam DT, et al. Fluid replacement in dengue shock syndrome: a randomized, double-blind comparison of four intravenous-fluid regimens. Clin Infect Dis. 1999;29:787\u201394.","journal-title":"Clin Infect Dis"},{"key":"4394_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1086\/318479","volume":"32","author":"NT Ngo","year":"2001","unstructured":"Ngo NT, Cao XT, Kneen R, et al. Acute Management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour. Clin Infect Dis. 2001;32:204\u201313.","journal-title":"Clin Infect Dis"},{"key":"4394_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJMoa044057","volume":"353","author":"BA Wills","year":"2005","unstructured":"Wills BA, Nguyen MD, Ha TL, et al. Comparison of three fluid solutions for resuscitation in dengue shock syndrome. N Engl J Med. 2005;353:877\u201389.","journal-title":"N Engl J Med"},{"key":"4394_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000371500","volume":"42","author":"R Chaurasia","year":"2015","unstructured":"Chaurasia R, Zaman S, Chatterjee K, Das B. Retrospective review of platelet transfusion practices during 2013 dengue epidemic of Delhi. India Transfus Med Hemother. 2015;42:227\u201331.","journal-title":"India Transfus Med Hemother"},{"key":"4394_CR9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0972-9062.172809","volume":"52","author":"S Pothapregada","year":"2015","unstructured":"Pothapregada S, Kamalakannan B, Thulasingam M. Role of platelet transfusion in children with bleeding in dengue fever. J Vector Borne Dis. 2015;52:304\u20138.","journal-title":"J Vector Borne Dis"},{"key":"4394_CR10","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1016\/S0140-6736(17)30269-6","volume":"389","author":"DC Lye","year":"2017","unstructured":"Lye DC, Archuleta S, Syed-Omar SF, et al. Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial. Lancet. 2017;389:1611\u20138.","journal-title":"Lancet"},{"key":"4394_CR11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s12288-013-0242-7","volume":"30","author":"B Prashantha","year":"2014","unstructured":"Prashantha B, Varun S, Sharat D, et al. Prophyactic platelet transfusion in stable dengue fever patients: is it really necessary? Indian J Hematol Blood Transfus. 2014;30:126\u20139.","journal-title":"Indian J Hematol Blood Transfus"},{"key":"4394_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1159\/000495118","volume":"46","author":"V Sundar","year":"2019","unstructured":"Sundar V, Bhaskar E. Effect of platelet transfusion on clot strength in dengue fever with thrombocytopenia related bleeding: a thromboelastography-based study. Transfus Med Hemother. 2019;46:457\u201360.","journal-title":"Transfus Med Hemother"},{"key":"4394_CR13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1159\/000354837","volume":"40","author":"MZ Khan Assir","year":"2013","unstructured":"Khan Assir MZ, Kamran U, Ahmad HI, et al. Effectiveness of platelet transfusion in dengue fever: a randomized controlled trial. Transfus Med Hemother. 2013;40:362\u20138.","journal-title":"Transfus Med Hemother"},{"key":"4394_CR14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/trstmh\/trx079","volume":"111","author":"S Rajapakse","year":"2017","unstructured":"Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Fernando SD. Prophylactic and therapeutic interventions for bleeding in dengue: a systematic review. Trans R Soc Trop Med Hyg. 2017;111:433\u20139.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"4394_CR15","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1080\/20469047.2019.1697574","volume":"40","author":"A Chuansumrit","year":"2020","unstructured":"Chuansumrit A, Apiwattanakul N, Sirachainan N, et al. The use of immature platelet fraction to predict time to platelet recovery in patients with dengue infection. Paediatr Int Child Health. 2020;40:124\u20138.","journal-title":"Paediatr Int Child Health"},{"key":"4394_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.actatropica.2018.01.017","volume":"181","author":"R Patil","year":"2018","unstructured":"Patil R, Bajpai S, Ghosh K, Shetty S. Microparticles as prognostic biomarkers in dengue virus infection. Acta Trop. 2018;181:21\u20134.","journal-title":"Acta Trop"},{"key":"4394_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1097\/01.mbc.0000186837.78432.2f","volume":"16","author":"A Chuansumrit","year":"2005","unstructured":"Chuansumrit A, Wangruangsatid S, Lektrakul Y, et al. Control of bleeding in children with dengue hemorrhagic fever using recombinant activated factor VII: a randomized, double-blind, placebo-controlled study. Blood Coagul Fibrinolysis. 2005;16:549\u201355.","journal-title":"Blood Coagul Fibrinolysis"},{"key":"4394_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002592","volume":"7","author":"TH Nguyen","year":"2013","unstructured":"Nguyen TH, Nguyen TH, Vu TT, et al. Corticosteroids for dengue - why don\u2019t they work? PLoS Negl Trop Dis. 2013;7:e2592.","journal-title":"PLoS Negl Trop Dis"},{"key":"4394_CR19","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1093\/cid\/cis655","volume":"55","author":"DT Tam","year":"2012","unstructured":"Tam DT, Ngoc TV, Tien NT, et al. Effects of short-course oral corticosteroid therapy in early dengue infection in Vietnamese patients: a randomized, placebo- controlled trial. Clin Infect Dis. 2012;55:1216\u201324.","journal-title":"Clin Infect Dis"},{"key":"4394_CR20","doi-asserted-by":"crossref","unstructured":"Zhang F, Kramer CV. Corticosteroids for dengue infection. Cochrane Database Syst Rev. 2014;2014:CD003488.","DOI":"10.1002\/14651858.CD003488.pub3"},{"key":"4394_CR21","unstructured":"World Health Organization- Regional Office for South-East Asia. Comprehensive Guidelines for Prevention and Treatment of Dengue and Dengue Hemorrhagic Fever. Revised and expanded edition. WHO, SEARO. 2011. Available at:\u00a0https:\/\/apps.who.int\/iris\/rest\/bitstreams\/909932\/retrieve. Accessed on 20 Sept 2022."},{"key":"4394_CR22","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S1474-4422(13)70150-9","volume":"12","author":"FJ Carod-Artal","year":"2013","unstructured":"Leowattana W, Leowattana T. Dengue hemorrhagic fever and the liver. World J Hepatol. 2021;13:1968\u201376.","journal-title":"Lancet Neurol"},{"key":"4394_CR23","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.4254\/wjh.v13.i12.1968","volume":"13","author":"W Leowattana","year":"2021","unstructured":"Carod-Artal FJ, Wichmann O, Farrar J, Gasc\u00f3n J. Neurological complications of dengue virus infection. Lancet Neurol. 2013;12:906\u201319.","journal-title":"World J Hepatol"},{"key":"4394_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2005","volume":"28","author":"HTN Giang","year":"2018","unstructured":"Giang HTN, Banno K, Minh LHN, et al. Dengue hemophagocytic syndrome: a systematic review and meta-analysis on epidemiology, clinical signs, outcomes, and risk factors. Rev Med Virol. 2018;28:e2005.","journal-title":"Rev Med Virol"},{"key":"4394_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jcv.2015.06.004","volume":"69","author":"WF Wan Jamaludin","year":"2015","unstructured":"Wan Jamaludin WF, Periyasamy P, Wan Mat WR, Abdul Wahid SF. Dengue infection associated hemophagocytic syndrome: therapeutic interventions and outcome. J Clin Virol. 2015;69:91\u20135.","journal-title":"J Clin Virol"},{"key":"4394_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.721857","volume":"9","author":"D Singh","year":"2021","unstructured":"Singh D, Raghunathan V, Dhaliwal M, Rastogi N, Chadha R, Yadav SP. Soluble interleukin-2 receptor level as a marker of hemophagocytic lymphohistiocytosis in children with severe dengue. Front Pediatr. 2021;9:721857.","journal-title":"Front Pediatr"},{"key":"4394_CR27","doi-asserted-by":"publisher","first-page":"11856","DOI":"10.1038\/s41598-020-68844-z","volume":"10","author":"APS Rathore","year":"2020","unstructured":"Rathore APS, Senanayake M, Athapathu AS, et al. Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients. Sci Rep. 2020;10:11856.","journal-title":"Sci Rep"},{"key":"4394_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2022.104821","volume":"128","author":"S Sivasubramanian","year":"2022","unstructured":"Sivasubramanian S, Mohandas S, Gopalan V, et al. Serum levels of matrix metalloproteinases as prognostic markers for severe dengue with plasma leakage. Exp Mol Pathol. 2022;128:104821.","journal-title":"Exp Mol Pathol"},{"key":"4394_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267186","volume":"17","author":"K Yuan","year":"2022","unstructured":"Yuan K, Chen Y, Zhong M, Lin Y, Liu L. Risk and predictive factors for severe dengue infection: a systematic review and meta-analysis. PLoS ONE. 2022;17:e0267186.","journal-title":"PLoS ONE"},{"key":"4394_CR30","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1186\/s12879-021-06409-9","volume":"21","author":"T Tsheten","year":"2021","unstructured":"Tsheten T, Clements ACA, Gray DJ, Adhikary RK, Wangdi K. Clinical features and outcomes of COVID-19 and dengue co-infection: a systematic review. BMC Infect Dis. 2021;21:729.","journal-title":"BMC Infect Dis"},{"key":"4394_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2339","volume":"32","author":"AE El-Qushayri","year":"2022","unstructured":"El-Qushayri AE, Kamel AMA, Reda A, Ghozy S. Does dengue and COVID-19 co-infection have worse outcomes? A systematic review of current evidence. Rev Med Virol. 2022;32:e2339.","journal-title":"Rev Med Virol"},{"key":"4394_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2340","author":"CNBS Prapty","year":"2022","unstructured":"Prapty CNBS, Rahmat R, Araf Y, et al. SARS-CoV-2 and dengue virus co-infection: epidemiology, pathogenesis, diagnosis, treatment, and management. Rev Med Virol. 2022. https:\/\/doi.org\/10.1002\/rmv.2340.","journal-title":"Rev Med Virol"},{"key":"4394_CR33","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ejmech.2019.05.010","volume":"176","author":"SN Dighe","year":"2019","unstructured":"Dighe SN, Ekwudu O, Dua K, Chellappan DK, Katavic PL, Collet TA. Recent update on anti-dengue drug discovery. Eur J Med Chem. 2019;176:431\u201355.","journal-title":"Eur J Med Chem"},{"key":"4394_CR34","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1007\/s43450-022-00258-6","volume":"32","author":"K Kalaimathi","year":"2022","unstructured":"Kalaimathi K, Rani JMJ, Vijayakumar S, et al. Anti-dengue potential of mangiferin: intricate network of dengue to human genes. Rev Bras Farmacogn. 2022;32:410\u201320.","journal-title":"Rev Bras Farmacogn"},{"key":"4394_CR35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13104-022-06040-0","volume":"15","author":"T Ratanakomol","year":"2022","unstructured":"Ratanakomol T, Roytrakul S, Wikan N, Smith DR. Oroxylin A shows limited antiviral activity towards dengue virus. BMC Res Notes. 2022;15:154.","journal-title":"BMC Res Notes"},{"key":"4394_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.746110","volume":"12","author":"R Shukla","year":"2021","unstructured":"Shukla R, Rajpoot RK, Poddar A, et al. Cocculus hirsutus- Derived Phytopharmaceutical drug has potent anti-dengue activity. Front Microbiol. 2021;12:746110.","journal-title":"Front Microbiol"},{"key":"4394_CR37","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1080\/13543784.2016.1201063","volume":"25","author":"H Beesetti","year":"2016","unstructured":"Beesetti H, Khanna N, Swaminathan S. Investigational drugs in early development for treating dengue infection. Expert Opin Investig Drugs. 2016;25:1059\u201369.","journal-title":"Expert Opin Investig Drugs"},{"key":"4394_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112304","volume":"144","author":"WH Wang","year":"2021","unstructured":"Wang WH, Urbina AN, Lin CY, et al. Targets and strategies for vaccine development against dengue viruses. Biomed Pharmacother. 2021;144:112304.","journal-title":"Biomed Pharmacother"},{"key":"4394_CR39","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1016\/j.vaccine.2017.09.089","volume":"35","author":"SB Halstead","year":"2017","unstructured":"Halstead SB. Dengvaxia sensitizes seronegatives to vaccine enhanced disease regardless of age. Vaccine. 2017;35:6355\u20138.","journal-title":"Vaccine"},{"key":"4394_CR40","doi-asserted-by":"crossref","unstructured":"Dengue vaccine. WHO position paper, September 2018 - recommendations. Vaccine. 2019;37:4848\u20139.","DOI":"10.1016\/j.vaccine.2018.09.063"},{"key":"4394_CR41","doi-asserted-by":"crossref","unstructured":"Biswal S, Reynales H, Saez-Llorens X, et al. TIDES Study Group. Efficacy of a tetravalent dengue vaccine in healthy children and adolescents. N Engl J Med. 2019;381:2009\u201319.","DOI":"10.1056\/NEJMoa1903869"},{"key":"4394_CR42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/cid\/ciab864","volume":"75","author":"L Rivera","year":"2022","unstructured":"Rivera L, Biswal S, S\u00e1ez-Llorens X, et al. Three-year efficacy and safety of Takeda\u2019s dengue vaccine candidate (TAK-003). Clin Infect Dis. 2022;75:107\u201317.","journal-title":"Clin Infect Dis"},{"key":"4394_CR43","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/infdis\/jiv082","volume":"212","author":"BD Kirkpatrick","year":"2015","unstructured":"Kirkpatrick BD, Durbin AP, Pierce KK, et al. Robust and balanced immune responses to all 4 dengue virus serotypes following administration of a single dose of a live attenuated tetravalent dengue vaccine to healthy, flavivirus-naive adults. J Infect Dis. 2015;212:702\u201310.","journal-title":"J Infect Dis"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04394-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-022-04394-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-022-04394-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T11:01:57Z","timestamp":1744196517000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-022-04394-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,27]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["4394"],"URL":"https:\/\/doi.org\/10.1007\/s12098-022-04394-8","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,27]]},"assertion":[{"value":"23 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}