{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:08:21Z","timestamp":1790197701706,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s12098-023-04527-7","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T03:01:49Z","timestamp":1685070109000},"page":"969-973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Modified Atkins Diet vs. Ketogenic Diet in the Management of Children with Epileptic Spasms Refractory to First Line Treatment: An Open Labelled, Randomized Controlled Trial"],"prefix":"10.1007","volume":"90","author":[{"given":"Shobhna","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surekha","family":"Dabla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-1830","authenticated-orcid":false,"given":"Jaya Shankar","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"4527_CR1","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1111\/j.0013-9580.2004.02404.x","volume":"45","author":"AL Lux","year":"2004","unstructured":"Lux AL, Osborne JP. A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the west delphi group. Epilepsia. 2004;45:1416\u201328.","journal-title":"Epilepsia"},{"key":"4527_CR2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jpeds.2005.11.041","volume":"148","author":"S Hamano","year":"2006","unstructured":"Hamano S, Yamashita S, Tanaka M, Yoshinari S, Minamitani M, Eto Y. Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause. J Pediatr. 2006;148:485\u20138.","journal-title":"J Pediatr"},{"key":"4527_CR3","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.yebeh.2009.01.023","volume":"14","author":"EH Kossoff","year":"2009","unstructured":"Kossoff EH, Hartman AL, Rubenstein JE, Vining EPG. High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. Epilepsy Behav. 2009;14:674\u20136.","journal-title":"Epilepsy Behav"},{"key":"4527_CR4","first-page":"186","volume":"20","author":"N Noureen","year":"2010","unstructured":"Noureen N, Rana MT. Clinical profile and response to oral prednisolone in infantile spasm. J Coll Physicians Surg Pak. 2010;20:186\u20139.","journal-title":"J Coll Physicians Surg Pak"},{"key":"4527_CR5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1684\/epd.2007.0144","volume":"9","author":"JW Wheless","year":"2007","unstructured":"Wheless JW, Clarke DF, Arzimanoglou A, Carpenter D. Treatment of pediatric epilepsy: european expert opinion. Eplileptic Disord. 2007;9:353\u2013412.","journal-title":"Eplileptic Disord"},{"key":"4527_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s11940-007-0012-7","volume":"9","author":"AD Malphrus","year":"2007","unstructured":"Malphrus AD, Wilfong AA. Use of the newer antiepileptic drugs in pediatric epilepsies. Curr Treat Options Neurol. 2007;9:256\u201367.","journal-title":"Curr Treat Options Neurol"},{"key":"4527_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.seizure.2011.08.009","volume":"21","author":"S Sharma","year":"2012","unstructured":"Sharma S, Sankhyan N, Gulati S, Agarwala A. Use of the modified Atkins diet in infantile spasms refractory to first-line treatment. Seizure. 2012;21:45\u20138.","journal-title":"Seizure"},{"key":"4527_CR8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1542\/peds.108.1.129","volume":"108","author":"DR Nordli Jr","year":"2001","unstructured":"Nordli DR Jr, Kuroda MM, Carroll J, et al. Experience with the ketogenic diet in infants. Pediatrics. 2001;108:129\u201333.","journal-title":"Pediatrics"},{"key":"4527_CR9","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.braindev.2006.03.011","volume":"28","author":"SH Eun","year":"2006","unstructured":"Eun SH, Kang HC, Kim DW, Kim HD. Ketogenic diet for treatment of infantile spasms. Brain and Dev. 2006;28:566\u201371.","journal-title":"Brain and Dev"},{"key":"4527_CR10","first-page":"CD001903","volume":"6","author":"KJ Martin-McGill","year":"2020","unstructured":"Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN. Ketogenic diets for drug-resistant epilepsy. Cochrane Database Syst Rev. 2020;6:CD001903.","journal-title":"Cochrane Database Syst Rev"},{"key":"4527_CR11","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/epi.16543","volume":"61","author":"L Lyons","year":"2020","unstructured":"Lyons L, Schoeler NE, Langan D, Cross JH. Use of ketogenic diet therapy in infants with epilepsy: a systematic review and meta-analysis. Epilepsia. 2020;61:1261\u201381.","journal-title":"Epilepsia"},{"key":"4527_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1528-1167.2008.01831.x","volume":"49","author":"EH Kossoff","year":"2008","unstructured":"Kossoff EH, Dorward JL. The modified atkins diet. Epilepsia. 2008;49:37\u201341.","journal-title":"Epilepsia"},{"key":"4527_CR13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1528-1167.2006.00438.x","volume":"47","author":"EH Kossoff","year":"2006","unstructured":"Kossoff EH, McGrogan JR, Bluml RM, Pillas DJ, Rubenstein JE, Vining EP. A modified atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia. 2006;47:421\u20134.","journal-title":"Epilepsia"},{"key":"4527_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1177\/08830738211004747","volume":"36","author":"S Sharma","year":"2021","unstructured":"Sharma S, Goel S, Kapoor D, et al. Evaluation of the modified atkins diet for the treatment of epileptic spasms refractory to hormonal therapy: a randomized controlled trial. J Child Neurol. 2021;36:686\u201391.","journal-title":"J Child Neurol"},{"key":"4527_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/ane.12830","volume":"137","author":"G Prezioso","year":"2018","unstructured":"Prezioso G, Carlone G, Zaccara G, Verrotti A. Efficacy of ketogenic diet for infantile spasms: a systematic review. Acta Neurol Scand. 2018;137:4\u201311.","journal-title":"Acta Neurol Scand"},{"key":"4527_CR16","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.seizure.2008.10.004","volume":"18","author":"S Weber","year":"2009","unstructured":"Weber S, M\u00f8lgaard C, Uldall P. Modified atkins diet to children and adolescents with medical intractable epilepsy. Seizure. 2009;18:237\u201340.","journal-title":"Seizure"},{"key":"4527_CR17","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S1474-4422(08)70092-9","volume":"7","author":"EG Neal","year":"2008","unstructured":"Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7:500\u20136.","journal-title":"Lancet Neurol"},{"key":"4527_CR18","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s13760-019-01225-0","volume":"121","author":"B Poorshiri","year":"2021","unstructured":"Poorshiri B, Barzegar M, Tahmasebi S, Shiva S, Raeisi S, Ebadi Z. The efficacy comparison of classic ketogenic diet and modified Atkins diet in children with refractory epilepsy: a clinical trial. Acta Neurol Belg. 2021;121:483\u20137.","journal-title":"Acta Neurol Belg"},{"key":"4527_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/epi.13256","volume":"57","author":"JA Kim","year":"2016","unstructured":"Kim JA, Yoon JR, Lee EJ, et al. Efficacy of the classic ketogenic and the modified atkins diets in refractory childhood epilepsy. Epilepsia. 2016;57:51\u20138.","journal-title":"Epilepsia"},{"key":"4527_CR20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1528-1167.2006.00910.x","volume":"48","author":"H-C Kang","year":"2007","unstructured":"Kang H-C, Lee HS, You SJ, Kang DC, Ko TS, Kim HD. Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia. 2007;48:182\u20136.","journal-title":"Epilepsia"},{"key":"4527_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.4103\/0972-2327.194463","volume":"19","author":"R Mehta","year":"2016","unstructured":"Mehta R, Goel S, Sharma S, Jain P, Mukherjee SB, Aneja S. Efficacy and tolerability of the modified Atkins diet in young children with refractory epilepsy: Indian experience. Ann Indian Acad Neurol. 2016;19:523\u20137.","journal-title":"Ann Indian Acad Neurol"},{"key":"4527_CR22","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/epi.12069","volume":"54","author":"S Sharma","year":"2013","unstructured":"Sharma S, Sankhyan N, Gulati S, Agarwala A. Use of the modified atkins diet for treatment of refractory childhood epilepsy: a randomized controlled trial. Epilepsia. 2013;54:481\u20136.","journal-title":"Epilepsia"},{"key":"4527_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.seizure.2010.11.010","volume":"20","author":"MJ Miranda","year":"2011","unstructured":"Miranda MJ, Mortensen M, Povlsen JH, Nielsen H, Beniczky S. Danish study of a modified atkins diet for medically intractable epilepsy in children: can we achieve the same results as with the classical ketogenic diet? Seizure. 2011;20:151\u20135.","journal-title":"Seizure"},{"key":"4527_CR24","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1177\/0884533608326138","volume":"23","author":"BA Zupec-Kania","year":"2008","unstructured":"Zupec-Kania BA, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract. 2008;23:589\u201396.","journal-title":"Nutr Clin Pract"},{"key":"4527_CR25","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/j.1528-1167.2010.02586.x","volume":"51","author":"AM Hong","year":"2010","unstructured":"Hong AM, Turner Z, Hamdy RF, Kossoff EH. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia. 2010;51:1403\u20137.","journal-title":"Epilepsia"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-023-04527-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-023-04527-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-023-04527-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:24:30Z","timestamp":1729470270000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-023-04527-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,26]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["4527"],"URL":"https:\/\/doi.org\/10.1007\/s12098-023-04527-7","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,26]]},"assertion":[{"value":"12 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Awarded the first prize in MD poster competition in Dr. K. C. Chaudhuri Trust and Indian Journal of Pediatrics function held on 9th October 2022 at AIIMS, Delhi.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Presentation at a Meeting"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}