{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:16:34Z","timestamp":1780917394123,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Department of Biotechnology, Government of India","award":["DBT\/BT\/20550\/PFN\/20\/1293\/2017"],"award-info":[{"award-number":["DBT\/BT\/20550\/PFN\/20\/1293\/2017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12098-025-05445-6","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:05:31Z","timestamp":1740013531000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates"],"prefix":"10.1007","volume":"93","author":[{"given":"Krishna Rao","family":"Gurugubelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-7348","authenticated-orcid":false,"given":"Vishnu Bhat","family":"Ballambattu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"5445_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4137\/CMPed.S40070","volume":"10","author":"D Sharma","year":"2016","unstructured":"Sharma D, Shastri S, Sharma P. Intrauterine growth restriction: antenatal and postnatal aspects. Clin Med Insights Pediatr. 2016;10:67\u201383.","journal-title":"Clin Med Insights Pediatr"},{"key":"5445_CR2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1369\/0022155418772574","volume":"66","author":"SS Singal","year":"2018","unstructured":"Singal SS, Nygard K, Gratton R, et al. Increased insulin-like growth factor binding protein-1 phosphorylation in decidualized stromal mesenchymal cells in human intrauterine growth restriction placentas. J Histochem Cytochem. 2018;66:617\u201330.","journal-title":"J Histochem Cytochem"},{"key":"5445_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13148-016-0238-x","volume":"8","author":"M Roifman","year":"2016","unstructured":"Roifman M, Choufani S, Turinsky AL, et al. Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction. Clin Epigenet. 2016;8:70.","journal-title":"Clin Epigenet"},{"key":"5445_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000502739","volume":"92","author":"JS Renes","year":"2019","unstructured":"Renes JS, Van Doorn J, Hokken-Koelega AC. Current insights into the role of the growth hormone-insulin-like growth factor system in short children born small for gestational age. Horm Res Paediatr. 2019;92:15\u201327.","journal-title":"Horm Res Paediatr"},{"key":"5445_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13148-016-0178-5","volume":"8","author":"AR Nawathe","year":"2016","unstructured":"Nawathe AR, Christian M, Kim SH, Johnson M, Savvidou MD, Terzidou V. Insulin-like growth factor axis in pregnancies affected by fetal growth disorders. Clin Epigenet. 2016;8:11.","journal-title":"Clin Epigenet"},{"key":"5445_CR6","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/pr.2015.40","volume":"77","author":"D Madeleneau","year":"2015","unstructured":"Madeleneau D, Buffat C, Mondon F, et al. Transcriptomic analysis of human placenta in intrauterine growth restriction. Pediatr Res. 2015;77:799\u2013807.","journal-title":"Pediatr Res"},{"key":"5445_CR7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/humupd\/6.5.495","volume":"6","author":"DJ Fowler","year":"2000","unstructured":"Fowler DJ, Nicolaides KH, Miell JP. Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract. Hum Reprod Update. 2000;6:495\u2013504.","journal-title":"Hum Reprod Update"},{"key":"5445_CR8","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1210\/jc.2018-00820","volume":"104","author":"MB Gupta","year":"2019","unstructured":"Gupta MB, Abu Shehab M, Nygard K, et al. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab. 2019;104:408\u201322.","journal-title":"J Clin Endocrinol Metab"},{"key":"5445_CR9","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.4172\/2167-0897.1000135","volume":"3","author":"S Murki","year":"2014","unstructured":"Murki S, Sharma DK. Intrauterine growth retardation\u2013A review article. J Neonatal Biol. 2014;3:2167\u20130897.","journal-title":"J Neonatal Biol"},{"key":"5445_CR10","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1080\/14767058.2017.1347922","volume":"31","author":"R Gurugubelli Krishna","year":"2018","unstructured":"Gurugubelli Krishna R, Vishnu Bhat B. Molecular mechanisms of intrauterine growth restriction. J Matern Fetal Neonatal Med. 2018;31:2634\u201340.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"5445_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/14767058.2019.1615875","volume":"34","author":"R Gurugubelli Krishna","year":"2021","unstructured":"Gurugubelli Krishna R, Bhat BV, Bobby Z, et al. Are global DNA methylation and telomere length useful biomarkers for identifying intrauterine growth restricted neonates? J Matern Fetal Neonatal Med. 2021;34:761\u20134.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"5445_CR12","doi-asserted-by":"publisher","first-page":"101153","DOI":"10.1016\/j.genrep.2021.101153","volume":"23","author":"MK Sibin","year":"2021","unstructured":"Sibin MK, Hothi O, Misra P, et al. DNA methylation status of P2 promoter of IGF2 gene in growth restricted neonates. Gene Rep. 2021;23:101153.","journal-title":"Gene Rep"},{"key":"5445_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/(SICI)1098-2795(199803)49:3<229::AID-MRD2>3.0.CO;2-Q","volume":"49","author":"SN Abu-Amero","year":"1998","unstructured":"Abu-Amero SN, Ali Z, Bennett P, Vaughan JI, Moore GE. Expression of the insulin\u2010like growth factors and their receptors in term placentas: a comparison between normal and IUGR births. Mol Reprod Dev. 1998;49:229\u201335.","journal-title":"Mol Reprod Dev"},{"key":"5445_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ghir.2010.12.002","volume":"21","author":"M Koutsaki","year":"2011","unstructured":"Koutsaki M, Sifakis S, Zaravinos A, Koutroulakis D, Koukoura O, Spandidos DA. Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction. Growth Horm IGF Res. 2011;21:31\u20136.","journal-title":"Growth Horm IGF Res"},{"key":"5445_CR15","first-page":"1548","volume":"80","author":"LC Giudice","year":"1995","unstructured":"Giudice LC, de Zegher F, Gargosky SE, et al. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab. 1995;80:1548\u201355.","journal-title":"J Clin Endocrinol Metab"},{"key":"5445_CR16","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1203\/00006450-199607000-00018","volume":"40","author":"J Leger","year":"1996","unstructured":"Leger J, Noel M, Limal JM, Czernichow P. Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor (IGF) I, and IGF-binding protein 3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Study Group of IUGR. Pediatr Res. 1996;40:101\u20137.","journal-title":"Pediatr Res"},{"key":"5445_CR17","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ymgme.2005.07.028","volume":"86","author":"R Randhawa","year":"2005","unstructured":"Randhawa R, Cohen P. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab. 2005;86:84\u201390.","journal-title":"Mol Genet Metab"},{"key":"5445_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1868-7083-5-21","volume":"5","author":"T Gu","year":"2013","unstructured":"Gu T, Gu HF, Hilding A, et al. Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men. Clin Epigenetics. 2013;5:21.","journal-title":"Clin Epigenetics"},{"key":"5445_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s43042-021-00153-0","volume":"22","author":"SM Hafez","year":"2021","unstructured":"Hafez SM, Abou-youssef HES, Awad MAK, et al. Insulin-like growth factor binding protein 1 DNA methylation in type 2 diabetes. Egypt J Med Hum Genet. 2021;22:29.","journal-title":"Egypt J Med Hum Genet"},{"key":"5445_CR20","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1210\/endo.131.4.1382958","volume":"131","author":"KC McLellan","year":"1992","unstructured":"McLellan KC, Hooper SB, Bocking AD, et al. Prolonged hypoxia induced by the reduction of maternal uterine blood flow alters insulin-like growth factor-binding protein-1 (IGFBP-1) and IGFBP-2 gene expression in the ovine fetus. Endocrinology. 1992;131:1619\u201328.","journal-title":"Endocrinology"},{"key":"5445_CR21","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1203\/00006450-199408000-00004","volume":"36","author":"PJ Tapanainen","year":"1994","unstructured":"Tapanainen PJ, Bang P, Wilson K, Unterman TG, Vreman HJ, Rosenfeld RG. Maternal hypoxia as a model for intrauterine growth retardation: effects on insulin-like growth factors and their binding proteins. Pediatr Res. 1994;36:152\u20138.","journal-title":"Pediatr Res"},{"key":"5445_CR22","first-page":"2653","volume":"86","author":"RM Popovici","year":"2001","unstructured":"Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC. Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab. 2001;86:2653\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"5445_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0002-9378(93)90137-8","volume":"169","author":"J Verhaeghe","year":"1993","unstructured":"Verhaeghe J, Van Bree R, Van Herc V, Laureys J, Bouillon R, Van Assche FA. C-peptide, insulin-like growth factors1 and3 and insulin-like growth factor binding protein-1 in umbilical cord serum: correlations with birth weight. Am J Obstet Gynecol. 1993;169:89\u201397.","journal-title":"Am J Obstet Gynecol"},{"key":"5445_CR24","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1073\/pnas.0407443102","volume":"102","author":"S Kajimura","year":"2005","unstructured":"Kajimura S, Aida K, Duan C. Insulin-like growth factor binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci USA. 2005;102:1240\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5445_CR25","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1172\/JCI0210077","volume":"110","author":"PA Crossey","year":"2002","unstructured":"Crossey PA, Pillai CC, Miell JP. Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice. J Clin Invest. 2002;110:411\u20138.","journal-title":"J Clin Invest"},{"key":"5445_CR26","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1210\/endo.136.9.7544274","volume":"136","author":"K Rajkumar","year":"1995","unstructured":"Rajkumar K, Barron D, Lewitt MS, Murphy LJ. Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice. Endocrinology. 1995;136:4029\u201334.","journal-title":"Endocrinology"},{"key":"5445_CR27","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1203\/00006450-200104000-00008","volume":"49","author":"E Kajantie","year":"2001","unstructured":"Kajantie E, Hytinantti T, Koistinen R, et al. Markers of type I and type III collagen turnover, insulin-like growth factors, and their binding proteins in cord plasma of small premature infants: relationships with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment. Pediatr Res. 2001;49:481\u20139.","journal-title":"Pediatr Res"},{"key":"5445_CR28","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4236\/health.2020.123022","volume":"12","author":"X Li","year":"2020","unstructured":"Li X, Yu B, Wu X, et al. Associations between placental insulin-like growth factor-1 gene expression, DNA methylation and intrauterine growth restriction. Health. 2020;12:270\u201380.","journal-title":"Health"},{"key":"5445_CR29","first-page":"4266","volume":"85","author":"K Ong","year":"2000","unstructured":"Ong K, Kratzsch J, Kiess W, Costello M, Scott C, Dunger D. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II\/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and childhood. J Clin Endocrinol Metab. 2000;85:4266\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"5445_CR30","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1111\/j.1651-2227.2011.02336.x","volume":"100","author":"SK Akram","year":"2011","unstructured":"Akram SK, Carlsson-Skwirut C, Bhutta ZA, S\u00f6der O. Placental IGF\u2010I, IGFBP\u20101, zinc, and iron, and maternal and infant anthropometry at birth. Acta Paediatr. 2011;100:1504\u20139.","journal-title":"Acta Paediatr"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-025-05445-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-025-05445-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-025-05445-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T18:02:44Z","timestamp":1767463364000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-025-05445-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5445"],"URL":"https:\/\/doi.org\/10.1007\/s12098-025-05445-6","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"1 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}