{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:21:19Z","timestamp":1782494479646,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12098-025-05469-y","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T18:37:49Z","timestamp":1743359869000},"page":"526-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recurrent Abdominal Pain in a Child - Evaluation and Management"],"prefix":"10.1007","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-6975","authenticated-orcid":false,"given":"Jayendra","family":"Seetharaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"5469_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/adc.33.168.165","volume":"33","author":"J Apley","year":"1958","unstructured":"Apley J, Naish N. Recurrent abdominal pains: A field survey of 1,000 school children. Arch Dis Child. 1958;33:165\u201370.","journal-title":"Arch Dis Child"},{"key":"5469_CR2","first-page":"4","volume":"55","author":"AB Benninga","year":"2017","unstructured":"Benninga AB, Nurko N, Faure F. [Rome IV diagnostic criteria of childhood functional Gastrointestinal disorders]. Zhonghua Er Ke Za Zhi. 2017;55:4\u201314.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"5469_CR3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/MPG.0b013e3181de0639","volume":"51","author":"G Dhroove","year":"2010","unstructured":"Dhroove G, Chogle A, Saps M. A million-dollar work-up for abdominal pain: is it worth it? J Pediatr Gastroenterol Nutr. 2010;51:579\u201383.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5469_CR4","doi-asserted-by":"crossref","unstructured":"Di Lorenzo C, Colletti RB, Lehmann HP, et al. Chronic abdominal pain in children: A technical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:249\u201361.","DOI":"10.1097\/01.MPG.0000154661.39488.AC"},{"key":"5469_CR5","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","volume":"130","author":"A Rasquin","year":"2006","unstructured":"Rasquin A, Di Lorenzo C, Forbes D, et al. Childhood functional Gastrointestinal disorders: child\/adolescent. Gastroenterology. 2006;130:1527\u201337.","journal-title":"Gastroenterology"},{"key":"5469_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/archdischild-2012-302273","volume":"98","author":"NJ Wright","year":"2013","unstructured":"Wright NJ, Hammond PJ, Curry JI. Chronic abdominal pain in children: help in spotting the organic diagnosis. Arch Dis Child Educ Pract Ed. 2013;98:32\u20139.","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"5469_CR7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2174\/1574887109666140423124521","volume":"9","author":"C Romano","year":"2014","unstructured":"Romano C, Porcaro F. Current issues in the management of pediatric functional abdominal pain. Rev Recent Clin Trials. 2014;9:13\u201320.","journal-title":"Rev Recent Clin Trials"},{"key":"5469_CR8","doi-asserted-by":"publisher","first-page":"e0126982","DOI":"10.1371\/journal.pone.0126982","volume":"10","author":"JJ Korterink","year":"2015","unstructured":"Korterink JJ, Diederen K, Benninga MA, Tabbers MM. Epidemiology of pediatric functional abdominal pain disorders: A meta-analysis. PLoS ONE. 2015;10:e0126982.","journal-title":"PLoS ONE"},{"key":"5469_CR9","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s12664-016-0680-x","volume":"35","author":"V Bhatia","year":"2016","unstructured":"Bhatia V, Deswal S, Seth S, Kapoor A, Sibal A, Gopalan S. Prevalence of functional Gastrointestinal disorders among adolescents in Delhi based on Rome III criteria: A school-based survey. Indian J Gastroenterol. 2016;35:294\u20138.","journal-title":"Indian J Gastroenterol"},{"key":"5469_CR10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.5152\/tjg.2021.20679","volume":"32","author":"S Saini","year":"2021","unstructured":"Saini S, Narang M, Srivastava S, Shah D. Behavioral intervention in children with functional abdominal pain disorders: A promising option. Turk J Gastroenterol. 2021;32:443\u201350.","journal-title":"Turk J Gastroenterol"},{"key":"5469_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2174\/1872213X13666181228154940","volume":"13","author":"AKC Leung","year":"2019","unstructured":"Leung AKC, Wong AHC, Leung AAM, Hon KL. Urinary tract infection in children. Recent Pat Inflamm Allergy Drug Discov. 2019;13:2\u201318.","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"5469_CR12","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.lpm.2011.09.018","volume":"41","author":"D Debray","year":"2012","unstructured":"Debray D, Franchi-Abella S, Irtan S, Girard M. [Cholelithiasis in infants, children and adolescents]. Presse Med. 2012;41:466\u201373.","journal-title":"Presse Med"},{"key":"5469_CR13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/tropej\/50.6.328","volume":"50","author":"MI El Mouzan","year":"2004","unstructured":"El Mouzan MI, Abdullah AM. Peptic ulcer disease in children and adolescents. J Trop Pediatr. 2004;50:328\u201330.","journal-title":"J Trop Pediatr"},{"key":"5469_CR14","doi-asserted-by":"publisher","first-page":"6667","DOI":"10.3748\/wjg.v11.i42.6667","volume":"11","author":"J Yakoob","year":"2005","unstructured":"Yakoob J, Jafri W, Abid S, et al. Giardiasis in patients with dyspeptic symptoms. World J Gastroenterol. 2005;11:6667\u201370.","journal-title":"World J Gastroenterol"},{"key":"5469_CR15","first-page":"830","volume":"39","author":"NA Buch","year":"2002","unstructured":"Buch NA, Ahmad SM, Ahmed SZ, Ali SW, Charoo BA, Hassan MU. Recurrent abdominal pain in children. Indian Pediatr. 2002;39:830\u20134.","journal-title":"Indian Pediatr"},{"key":"5469_CR16","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.cgh.2007.09.012","volume":"5","author":"JR Bloomer","year":"2007","unstructured":"Bloomer JR, McGuire BM. Intermittent unexplained abdominal pain: is it porphyria? Clin Gastroenterol Hepatol. 2007;5:1255\u20138. quiz 44.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5469_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1542\/peds.64.1.43","volume":"64","author":"WM Liebman","year":"1979","unstructured":"Liebman WM. Recurrent abdominal pain in children: lactose and sucrose intolerance, a prospective study. Pediatrics. 1979;64:43\u20135.","journal-title":"Pediatrics"},{"key":"5469_CR18","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/s12887-023-04154-3","volume":"23","author":"X Bao","year":"2023","unstructured":"Bao X, Yu W, Chu Z, Gao J, Zhou M, Gu Y. Functional abdominal pain disorders in children in Southern Anhui Province, China are related to academic stress rather than academic performance. BMC Pediatr. 2023;23:333.","journal-title":"BMC Pediatr"},{"key":"5469_CR19","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1097\/MPG.0000000000000319","volume":"58","author":"CF Gijsbers","year":"2014","unstructured":"Gijsbers CF, Benninga MA, Schweizer JJ, Kneepkens CM, Vergouwe Y, Buller HA. Validation of the Rome III criteria and alarm symptoms for recurrent abdominal pain in children. J Pediatr Gastroenterol Nutr. 2014;58:779\u201385.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5469_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.23736\/S0026-4946.16.04247-X","volume":"69","author":"C Tolone","year":"2017","unstructured":"Tolone C, Pellino V, Piccirillo M, Letizia M, Belfiore I, Tolone S. Recurrent abdominal pain in children: underlying pathologies in the absence of alarm symptoms. Minerva Pediatr. 2017;69:239\u201344.","journal-title":"Minerva Pediatr"},{"key":"5469_CR21","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1136\/bmj.297.6652.837","volume":"297","author":"DW Gray","year":"1988","unstructured":"Gray DW, Dixon JM, Collin J. The closed eyes sign: an aid to diagnosing non-specific abdominal pain. BMJ. 1988;297:837.","journal-title":"BMJ"},{"key":"5469_CR22","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/ajg.2013.131","volume":"109","author":"P Henderson","year":"2014","unstructured":"Henderson P, Anderson NH, Wilson DC. The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease: A systematic review and meta-analysis. Am J Gastroenterol. 2014;109:637\u201345.","journal-title":"Am J Gastroenterol"},{"key":"5469_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1067\/mem.2000.105658","volume":"36","author":"SG Rothrock","year":"2000","unstructured":"Rothrock SG, Pagane J. Acute appendicitis in children: emergency department diagnosis and management. Ann Emerg Med. 2000;36:39\u201351.","journal-title":"Ann Emerg Med"},{"key":"5469_CR24","doi-asserted-by":"publisher","first-page":"310","DOI":"10.25122\/jml-2021-0067","volume":"14","author":"ND Stenczel","year":"2021","unstructured":"Stenczel ND, Purcarea MR, Tribus LC, Oniga GH. The role of the intestinal ultrasound in Crohn\u2019s disease diagnosis and monitoring. J Med Life. 2021;14:310\u20135.","journal-title":"J Med Life"},{"key":"5469_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1259\/bjr\/68274086","volume":"78","author":"V Rathaus","year":"2005","unstructured":"Rathaus V, Shapiro M, Grunebaum M, Zissin R. Enlarged mesenteric lymph nodes in asymptomatic children: the value of the finding in various imaging modalities. Br J Radiol. 2005;78:30\u20133.","journal-title":"Br J Radiol"},{"key":"5469_CR26","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2214\/AJR.10.5970","volume":"197","author":"MS Gee","year":"2011","unstructured":"Gee MS, Nimkin K, Hsu M, et al. Prospective evaluation of MR enterography as the primary imaging modality for pediatric Crohn disease assessment. Am J Roentgenol. 2011;197:224\u201331.","journal-title":"Am J Roentgenol"},{"key":"5469_CR27","doi-asserted-by":"publisher","first-page":"e0216394","DOI":"10.1371\/journal.pone.0216394","volume":"14","author":"OF Adeniyi","year":"2019","unstructured":"Adeniyi OF, Odeghe EA, Lawal MA, Olowu AO, Ademuyiwa A. Recurrent abdominal pain and upper Gastrointestinal endoscopy findings in children and adolescents presenting at the Lagos university teaching hospital. PLoS ONE. 2019;14:e0216394.","journal-title":"PLoS ONE"},{"key":"5469_CR28","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1155\/2012\/960104","volume":"17","author":"RL Levy","year":"2012","unstructured":"Levy RL, van Tilburg MA. Functional abdominal pain in childhood: background studies and recent research trends. Pain Res Manag. 2012;17:413\u20137.","journal-title":"Pain Res Manag"},{"key":"5469_CR29","doi-asserted-by":"crossref","unstructured":"Hyams JS, Di Lorenzo C, Saps M, Shulman RJ, Staiano A, van Tilburg M. Functional disorders: children and adolescents. Gastroenterology. 2016;150:1456-68.E2.","DOI":"10.1053\/j.gastro.2016.02.015"},{"key":"5469_CR30","first-page":"433","volume":"7","author":"G Dogan","year":"2020","unstructured":"Dogan G, Yavuz S, Aslantas H, Ozyurt BC, Kasirga E. Is low FODMAP diet effective in children with irritable bowel syndrome? North Clin Istanb. 2020;7:433\u20137.","journal-title":"North Clin Istanb"},{"key":"5469_CR31","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000510795","volume":"76","author":"KM Boradyn","year":"2020","unstructured":"Boradyn KM, Przybylowicz KE, Jarocka-Cyrta E. Low FODMAP diet is not effective in children with functional abdominal pain: A randomized controlled trial. Ann Nutr Metab. 2020;76:334\u201344.","journal-title":"Ann Nutr Metab"},{"key":"5469_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jpeds.2013.10.007","volume":"164","author":"R Francavilla","year":"2014","unstructured":"Francavilla R, Cristofori F, Castellaneta S, et al. Clinical, serologic, and histologic features of gluten sensitivity in children. J Pediatr. 2014;164:463-7.e1.","journal-title":"J Pediatr"},{"key":"5469_CR33","first-page":"CD012849","volume":"2","author":"C Wallace","year":"2023","unstructured":"Wallace C, Gordon M, Sinopoulou V, Akobeng AK. Probiotics for management of functional abdominal pain disorders in children. Cochrane Database Syst Rev. 2023;2:CD012849.","journal-title":"Cochrane Database Syst Rev"},{"key":"5469_CR34","first-page":"CD010972","volume":"3","author":"TV Newlove-Delgado","year":"2017","unstructured":"Newlove-Delgado TV, Martin AE, Abbott RA, et al. Dietary interventions for recurrent abdominal pain in childhood. Cochrane Database Syst Rev. 2017;3:CD010972.","journal-title":"Cochrane Database Syst Rev"},{"key":"5469_CR35","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1136\/archdischild-2012-302906","volume":"98","author":"JM Rutten","year":"2013","unstructured":"Rutten JM, Reitsma JB, Vlieger AM, Benninga MA. Gut-directed hypnotherapy for functional abdominal pain or irritable bowel syndrome in children: A systematic review. Arch Dis Child. 2013;98:252\u20137.","journal-title":"Arch Dis Child"},{"key":"5469_CR36","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1097\/j.pain.0000000000000800","volume":"158","author":"RL Levy","year":"2017","unstructured":"Levy RL, Langer SL, van Tilburg MAL, et al. Brief telephone-delivered cognitive behavioral therapy targeted to parents of children with functional abdominal pain: A randomized controlled trial. Pain. 2017;158:618\u201328.","journal-title":"Pain"},{"key":"5469_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1067\/mpd.2001.109606","volume":"138","author":"RM Kline","year":"2001","unstructured":"Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr. 2001;138:125\u20138.","journal-title":"J Pediatr"},{"key":"5469_CR38","doi-asserted-by":"publisher","first-page":"e23844","DOI":"10.5812\/ircmj.17(4)2015.23844","volume":"17","author":"M Asgarshirazi","year":"2015","unstructured":"Asgarshirazi M, Shariat M, Dalili H. Comparison of the effects of pH-dependent peppermint oil and synbiotic lactol (Bacillus coagulans\u2009+\u2009Fructooligosaccharides) on childhood functional abdominal pain: A randomized placebo-controlled study. Iran Red Crescent Med J. 2015;17:e23844.","journal-title":"Iran Red Crescent Med J"},{"key":"5469_CR39","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s13312-015-0730-y","volume":"52","author":"M Narang","year":"2015","unstructured":"Narang M, Shah D, Akhtar H. Efficacy and safety of Drotaverine hydrochloride in children with recurrent abdominal pain: A randomized placebo controlled trial. Indian Pediatr. 2015;52:847\u201351.","journal-title":"Indian Pediatr"},{"key":"5469_CR40","doi-asserted-by":"publisher","first-page":"191026","DOI":"10.1155\/2014\/191026","volume":"2014","author":"Z Pourmoghaddas","year":"2014","unstructured":"Pourmoghaddas Z, Saneian H, Roohafza H, Gholamrezaei A. Mebeverine for pediatric functional abdominal pain: A randomized, placebo-controlled trial. Biomed Res Int. 2014;2014:191026.","journal-title":"Biomed Res Int"},{"key":"5469_CR41","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1053\/j.gastro.2009.06.060","volume":"137","author":"M Saps","year":"2009","unstructured":"Saps M, Youssef N, Miranda A, et al. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional Gastrointestinal disorders. Gastroenterology. 2009;137:1261\u20139.","journal-title":"Gastroenterology"},{"key":"5469_CR42","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.jpeds.2007.10.012","volume":"152","author":"RJ Bahar","year":"2008","unstructured":"Bahar RJ, Collins BS, Steinmetz B, Ament ME. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J Pediatr. 2008;152:685\u20139.","journal-title":"J Pediatr"},{"key":"5469_CR43","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/jgh.15765","volume":"37","author":"J Seetharaman","year":"2022","unstructured":"Seetharaman J, Poddar U, Yachha SK, Srivastava A, Sen Sarma M. Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial. J Gastroenterol Hepatol. 2022;37:685\u201391.","journal-title":"J Gastroenterol Hepatol"},{"key":"5469_CR44","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/01.chi.0000136563.31709.b0","volume":"43","author":"JV Campo","year":"2004","unstructured":"Campo JV, Perel J, Lucas A, et al. Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. J Am Acad Child Adolesc Psychiatry. 2004;43:1234\u201342.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"5469_CR45","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1111\/nmo.12444","volume":"26","author":"H Roohafza","year":"2014","unstructured":"Roohafza H, Pourmoghaddas Z, Saneian H, Gholamrezaei A. Citalopram for pediatric functional abdominal pain: A randomized, placebo-controlled trial. Neurogastroenterol Motil. 2014;26:1642\u201350.","journal-title":"Neurogastroenterol Motil"},{"key":"5469_CR46","first-page":"CD011194","volume":"3","author":"MI Pinto-Sanchez","year":"2017","unstructured":"Pinto-Sanchez MI, Yuan Y, Bercik P, Moayyedi P. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017;3:CD011194.","journal-title":"Cochrane Database Syst Rev"},{"key":"5469_CR47","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1097\/MPG.0000000000001819","volume":"66","author":"A Karunanayake","year":"2018","unstructured":"Karunanayake A, Devanarayana NM, de Silva A, Gunawardena S, Rajindrajith S. Randomized controlled clinical trial on value of Domperidone in functional abdominal pain in children. J Pediatr Gastroenterol Nutr. 2018;66:725\u201331.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"5469_CR48","first-page":"1367","volume":"60","author":"M Sadeghian","year":"2008","unstructured":"Sadeghian M, Farahmand F, Fallahi GH, Abbasi A. Cyproheptadine for the treatment of functional abdominal pain in childhood: A double-blinded randomized placebo-controlled trial. Minerva Pediatr. 2008;60:1367\u201374.","journal-title":"Minerva Pediatr"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-025-05469-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-025-05469-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-025-05469-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:02:29Z","timestamp":1744869749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-025-05469-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["5469"],"URL":"https:\/\/doi.org\/10.1007\/s12098-025-05469-y","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"29 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}