{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:49:49Z","timestamp":1784310589797,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s12098-026-06194-w","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:02:09Z","timestamp":1779087729000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Prospective Model for Detecting Missed Appendicitis in Low-Risk Pediatric Patients"],"prefix":"10.1007","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-816X","authenticated-orcid":false,"given":"Mohamed","family":"Zouari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Belhajmansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Laadhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Karim","family":"Tounsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Hbaieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumaima","family":"Jarboui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi Ben","family":"Dhaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Mhiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"6194_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/jpc.16748","volume":"61","author":"M Paran","year":"2025","unstructured":"Paran M, Dreznik Y, Totah M, Nevo A, Kravarusic D, Samuk I. Diagnostic challenges of acute appendicitis in preschool children: a comprehensive case-control study. J Paediatr Child Health. 2025;61:369\u201375.","journal-title":"J Paediatr Child Health"},{"key":"6194_CR2","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/wjs.70015","volume":"49","author":"M Zouari","year":"2025","unstructured":"Zouari M, Rhaiem W, Belhajmansour M, et al. Risk factors for postoperative complications following emergency abdominal surgery: a prospective pediatric cohort. World J Surg. 2025;49:2531\u20139.","journal-title":"World J Surg"},{"key":"6194_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s13312-025-00217-z","volume":"63","author":"P Pan","year":"2026","unstructured":"Pan P. Validation of pediatric appendicitis score in suspected acute appendicitis. Indian Pediatr. 2026;63:201\u20134.","journal-title":"Indian Pediatr"},{"key":"6194_CR4","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s13312-022-2620-4","volume":"59","author":"SM Salahuddin","year":"2022","unstructured":"Salahuddin SM, Ayaz O, Jaffer M, Naeem R, Tikmani SS, Mian AI. Pediatric appendicitis score for identifying acute appendicitis in children presenting with acute abdominal pain to the emergency department. Indian Pediatr. 2022;59:774\u20137.","journal-title":"Indian Pediatr"},{"key":"6194_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4103\/ijpvm.ijpvm_539_21","volume":"14","author":"R Raeisi","year":"2023","unstructured":"Raeisi R, Azizi M, Amiri J, Ghorbanpour M, Esna-Ashari F. Accuracy evaluation of pediatric appendicitis scoring (PAS) method in differentiating nonspecific abdominal pain from appendicitis. Int J Prev Med. 2023;14:40.","journal-title":"Int J Prev Med"},{"key":"6194_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13017-020-00306-3","volume":"15","author":"S Di Saverio","year":"2020","unstructured":"Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020;15:27.","journal-title":"World J Emerg Surg"},{"key":"6194_CR7","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1007\/s12098-022-04226-9","volume":"90","author":"R Nandan","year":"2023","unstructured":"Nandan R, Samie AU, Acharya SK, et al. Pediatric appendicitis score or ultrasonography? In search of a better diagnostic tool in Indian children with lower abdominal pain. Indian J Pediatr. 2023;90:1204\u20139.","journal-title":"Indian J Pediatr"},{"key":"6194_CR8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1055\/s-0040-1710534","volume":"31","author":"J Gudjonsdottir","year":"2021","unstructured":"Gudjonsdottir J, Marklund E, Hagander L, Sal\u00f6 M. Clinical prediction scores for pediatric appendicitis. Eur J Pediatr Surg. 2021;31:252\u201360.","journal-title":"Eur J Pediatr Surg"},{"key":"6194_CR9","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/acem.14985","volume":"31","author":"WH Lee","year":"2024","unstructured":"Lee WH, O\u2019Brien S, McKinnon E, et al. Study of pediatric appendicitis scores and management strategies: A prospective observational feasibility study. Acad Emerg Med. 2024;31:1089\u201399.","journal-title":"Acad Emerg Med"},{"key":"6194_CR10","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.3390\/medicina61071308","volume":"61","author":"SK Oh","year":"2025","unstructured":"Oh SK. Diagnostic accuracy of non-radiologist-performed ultrasound for diagnosing acute appendicitis in pediatric patients: a systematic review and meta-analysis. Medicina. 2025;61:1308.","journal-title":"Medicina"},{"key":"6194_CR11","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1111\/acem.70118","volume":"320","author":"N Aljahdali","year":"2025","unstructured":"Aljahdali N, Doria AS, Man C, et al. Identification of children with a positive ultrasound and appendicitis using the pediatric appendicitis risk calculator: retrospective cohort study. Acad Emerg Med. 2025;320:1084\u201391.","journal-title":"Acad Emerg Med"},{"key":"6194_CR12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-0040-1718406","volume":"31","author":"AE Fuhrer","year":"2021","unstructured":"Fuhrer AE, Sukhotnik I, Ben-Shahar Y, Weinberg M, Koppelmann T. Predictive value of Alvarado score and pediatric appendicitis score in the success of nonoperative management for simple acute appendicitis in children. Eur J Pediatr Surg. 2021;31:95\u2013101.","journal-title":"Eur J Pediatr Surg"},{"key":"6194_CR13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1089\/sur.2023.295","volume":"25","author":"M Zouari","year":"2024","unstructured":"Zouari M, Issaoui A, Hbaieb M. Predictive factors of acute appendicitis in children with non-visualized appendix on ultrasound: a prospective cohort study. Surg Infect. 2024;25:26\u201331.","journal-title":"Surg Infect"},{"key":"6194_CR14","doi-asserted-by":"publisher","first-page":"583719","DOI":"10.3389\/fped.2021.583719","volume":"9","author":"J Lan","year":"2021","unstructured":"Lan J, Zhu H, Liu Q, Guo C. Inflammatory markers and duration of symptoms have a close connection with diagnosis and staging of acute appendicitis in children. Front Pediatr. 2021;9:583719.","journal-title":"Front Pediatr"},{"key":"6194_CR15","doi-asserted-by":"publisher","first-page":"e056854","DOI":"10.1136\/bmjopen-2021-056854","volume":"12","author":"D Fawkner-Corbett","year":"2022","unstructured":"Fawkner-Corbett D, Hayward G, Alkhmees M, Van Den Bruel A, Ord\u00f3\u00f1ez-Mena JM, Holtman GA. Diagnostic accuracy of blood tests of inflammation in paediatric appendicitis: a systematic review and meta-analysis. BMJ Open. 2022;12:e056854.","journal-title":"BMJ Open"},{"key":"6194_CR16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3390\/jcm15010393","volume":"15","author":"A Alper","year":"2026","unstructured":"Alper A, Galor A, Lerner M, Levy O, Zmora O. CLR (CRP to lymphocytes) score for differentiating simple and complicated appendicitis in pediatric patients. J Clin Med. 2026;15:393.","journal-title":"J Clin Med"},{"key":"6194_CR17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ajem.2015.10.004","volume":"34","author":"M Zouari","year":"2016","unstructured":"Zouari M, Jallouli M, Louati H, et al. Predictive value of C-reactive protein, ultrasound and Alvarado score in acute appendicitis: a prospective pediatric cohort. Am J Emerg Med. 2016;34:189\u201392.","journal-title":"Am J Emerg Med"},{"key":"6194_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jpedsurg.2023.10.028","volume":"59","author":"K Roberts","year":"2024","unstructured":"Roberts K, Moore H, Raju M, et al. Diagnostic ultrasound for acute appendicitis: the gold standard. J Pediatr Surg. 2024;59:235\u20139.","journal-title":"J Pediatr Surg"},{"key":"6194_CR19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1308\/rcsann.2021.0326","volume":"105","author":"AR Darbyshire","year":"2023","unstructured":"Darbyshire AR, Towers A, Harrison R, et al. Routine ultrasound for suspected appendicitis in children: a single-centre retrospective cohort study. Ann R Coll Surg Engl. 2023;105:72\u20136.","journal-title":"Ann R Coll Surg Engl"},{"key":"6194_CR20","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00383-024-05880-0","volume":"40","author":"M Badlis","year":"2024","unstructured":"Badlis M, Amari K, Alkheshi M, Alolaby K, Alsaid B. Ultrasound and computed tomography in differentiating between simple and complicated appendicitis in pediatric patients. Pediatr Surg Int. 2024;40:299.","journal-title":"Pediatr Surg Int"},{"key":"6194_CR21","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1089\/sur.2023.370","volume":"25","author":"M Zouari","year":"2024","unstructured":"Zouari M, Hbaieb M, Issaoui A, et al. Ultrasound assessment in children with suspected appendicitis: time to revise diagnostic criteria: a prospective cohort study. Surg Infect. 2024;25:300\u20136.","journal-title":"Surg Infect"},{"key":"6194_CR22","doi-asserted-by":"publisher","unstructured":"Hu H, Lin M, Li W, Chen J, Su C, Wang C, Li Y, Li J, Huang J, Luo Y. The significance of combined detection of ultrasonography, pediatric appendicitis score, and C-reactive protein in the diagnosis and pathological type of acute appendicitis in children. Clin Pediatr (Phila). 2026;99228251414473. https:\/\/doi.org\/10.1177\/00099228251414473.","DOI":"10.1177\/00099228251414473"},{"key":"6194_CR23","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.4240\/wjgs.v16.i8.2565","volume":"16","author":"LM Guo","year":"2024","unstructured":"Guo LM, Jiang ZH, Liu HZ. Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis. World J Gastrointest Surg. 2024;16:2565\u201373.","journal-title":"World J Gastrointest Surg"},{"key":"6194_CR24","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.3390\/diagnostics13132275","volume":"13","author":"K Bekiaridou","year":"2023","unstructured":"Bekiaridou K, Kambouri K, Giatromanolaki A, et al. Predicting complicated appendicitis in children: pros and cons of a new score combining clinical signs, laboratory values, and ultrasound images (CLU score). Diagnostics. 2023;13:2275.","journal-title":"Diagnostics"},{"key":"6194_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00383-023-05463-5","volume":"39","author":"J Arredondo Montero","year":"2023","unstructured":"Arredondo Montero J, Bardaj\u00ed Pascual C, Antona G, Ros Briones R, L\u00f3pez-Andr\u00e9s N, Mart\u00edn-Calvo N. The BIDIAP index: a clinical, analytical and ultrasonographic score for the diagnosis of acute appendicitis in children. Pediatr Surg Int. 2023;39:175.","journal-title":"Pediatr Surg Int"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06194-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-026-06194-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06194-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:00:33Z","timestamp":1782799233000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-026-06194-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["6194"],"URL":"https:\/\/doi.org\/10.1007\/s12098-026-06194-w","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"15 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}