{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:51:25Z","timestamp":1792792285262,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004077","name":"Kocaeli \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA-2024-3720"],"award-info":[{"award-number":["TSA-2024-3720"]}],"id":[{"id":"10.13039\/501100004077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12098-026-06319-1","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:25:10Z","timestamp":1785482710000},"page":"1046-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Cytokine Profiles in Enthesitis-Related Arthritis and Adult Spondyloarthritis"],"prefix":"10.1007","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-4140","authenticated-orcid":false,"given":"Nebahat Zeynep","family":"\u00d6zaslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-0457","authenticated-orcid":false,"given":"Mehtap Kal\u00e7\u0131k","family":"Unan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-2977","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Uzuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-9933","authenticated-orcid":false,"given":"Gamze","family":"Dilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-6952","authenticated-orcid":false,"given":"Nihal","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-5284","authenticated-orcid":false,"given":"Aynur","family":"Karadenizli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-493X","authenticated-orcid":false,"given":"Neslihan","family":"G\u00f6k\u00e7en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-0851","authenticated-orcid":false,"given":"Kemal","family":"Nas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-3068","authenticated-orcid":false,"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"6319_CR1","first-page":"294","volume":"11","author":"M Mahmoudi","year":"2012","unstructured":"Mahmoudi M, Jamshidi AR, Amirzargar AA, et al. Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran. Iran J Allergy Asthma Immunol. 2012;11:294\u2013300.","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"6319_CR2","unstructured":"Tse SM, Colbert RA. Enthesitis related arthritis. In: Petty RE, Laxer R, Lindsley C, Wedderburn L, Mellins ED, Fuhlbrigge RC, editors. Textbook of Pediatric Rheumatology. 8th ed. Philadelphia: Elsevier; 2021. p. 250\u201367."},{"key":"6319_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/ard.2010.133645","volume":"70","author":"M Rudwaleit","year":"2011","unstructured":"Rudwaleit M, van der Heijde D, Landew\u00e9 R, et al. The assessment of Spondyloarthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis. 2011;70:25\u201331.","journal-title":"Ann Rheum Dis"},{"key":"6319_CR4","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.pcl.2018.03.006","volume":"65","author":"PF Weiss","year":"2018","unstructured":"Weiss PF, Colbert RA. Juvenile spondyloarthritis: a distinct form of juvenile arthritis. Pediatr Clin North Am. 2018;65:675\u201390.","journal-title":"Pediatr Clin North Am"},{"key":"6319_CR5","doi-asserted-by":"publisher","first-page":"680916","DOI":"10.3389\/fmed.2021.680916","volume":"8","author":"JA Smith","year":"2021","unstructured":"Smith JA, Burgos-Vargas R. Outcomes in juvenile-onset spondyloarthritis. Front Med. 2021;8:680916.","journal-title":"Front Med"},{"key":"6319_CR6","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3390\/ph15111370","volume":"15","author":"PA Shesternya","year":"2022","unstructured":"Shesternya PA, Savchenko AA, Gritsenko OD, et al. Features of peripheral blood Th-cell subset composition and serum cytokine level in patients with activity-driven ankylosing spondylitis. Pharmaceuticals. 2022;15:1370.","journal-title":"Pharmaceuticals"},{"key":"6319_CR7","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.biopha.2018.01.108","volume":"100","author":"A Rezaiemanesh","year":"2018","unstructured":"Rezaiemanesh A, Abdolmaleki M, Abdolmohammadi K, et al. Immune cells involved in the pathogenesis of ankylosing spondylitis. Biomed Pharmacother. 2018;100:198\u2013204.","journal-title":"Biomed Pharmacother"},{"key":"6319_CR8","doi-asserted-by":"publisher","first-page":"e42953","DOI":"10.1097\/MD.0000000000042953","volume":"104","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Zhou BH, Hu L, Li MC, Chang D, Dou X. Relationship between biologic therapy and cytokine levels in patients with inflammatory arthritis. Medicine. 2025;104:e42953.","journal-title":"Medicine"},{"key":"6319_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.expneurol.2018.01.002","volume":"302","author":"B Paramo","year":"2018","unstructured":"Paramo B, Wyatt S, Davies AM. An essential role for neuregulin-4 in the growth and elaboration of developing neocortical pyramidal dendrites. Exp Neurol. 2018;302:85\u201392.","journal-title":"Exp Neurol"},{"key":"6319_CR10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10067-012-2119-9","volume":"32","author":"FL Yuan","year":"2013","unstructured":"Yuan FL, Li X, Lu WG, Sun JM, Jiang DL, Xu RS. Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis. Clin Rheumatol. 2013;32:289\u201392.","journal-title":"Clin Rheumatol"},{"key":"6319_CR11","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/acr.22411","volume":"66","author":"PF Weiss","year":"2014","unstructured":"Weiss PF, Colbert RA, Xiao R. Development and retrospective validation of the juvenile spondyloarthritis disease activity index. Arthritis Care Res. 2014;66:1775\u201382.","journal-title":"Arthritis Care Res"},{"key":"6319_CR12","first-page":"2286","volume":"21","author":"S Garrett","year":"1994","unstructured":"Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity index. J Rheumatol. 1994;21:2286\u201391.","journal-title":"J Rheumatol"},{"key":"6319_CR13","doi-asserted-by":"publisher","first-page":"110530","DOI":"10.1016\/j.intimp.2023.110530","volume":"121","author":"N Bao","year":"2023","unstructured":"Bao N, Fu B, Zhong X, et al. Role of the CXCR6\/CXCL16 axis in autoimmune diseases. Int Immunopharmacol. 2023;121:110530.","journal-title":"Int Immunopharmacol"},{"key":"6319_CR14","doi-asserted-by":"publisher","first-page":"111697","DOI":"10.1016\/j.intimp.2024.111697","volume":"129","author":"HY Muhsin","year":"2024","unstructured":"Muhsin HY, Khazaal AQ, Ismaeel HM, Alosami MH, Ad\u2019hiah AH. Evaluation of interleukins (IL-1\u03b1, IL-1Ra, IL-12, IL-17A, IL-31, and IL-33) and chemokines (CXCL10 and CXCL16) in the serum of male patients with ankylosing spondylitis. Int Immunopharmacol. 2024;129:111697.","journal-title":"Int Immunopharmacol"},{"key":"6319_CR15","doi-asserted-by":"publisher","first-page":"368","DOI":"10.46497\/ArchRheumatol.2024.10360","volume":"39","author":"R Ko\u00e7ak Ulucak\u00f6y","year":"2024","unstructured":"Ko\u00e7ak Ulucak\u00f6y R, K\u0131l\u0131\u00e7 A, Bat\u0131bay S, et al. Can serum granulocyte-macrophage colony-stimulating factor and CCL17 levels be a marker of disease activation in spondyloarthritis? Arch Rheumatol. 2024;39:368\u201374.","journal-title":"Arch Rheumatol"},{"key":"6319_CR16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s13075-022-02888-6","volume":"24","author":"C Papagoras","year":"2022","unstructured":"Papagoras C, Tsiami S, Chrysanthopoulou A, Mitroulis I, Baraliakos X. Serum granulocyte-macrophage colony-stimulating factor (GM-CSF) is increased in patients with active radiographic axial spondyloarthritis and persists despite anti-TNF treatment. Arthritis Res Ther. 2022;24:195.","journal-title":"Arthritis Res Ther"},{"key":"6319_CR17","doi-asserted-by":"publisher","first-page":"1106380","DOI":"10.3389\/fphys.2022.1106380","volume":"13","author":"Y Liu","year":"2023","unstructured":"Liu Y, Chen M. Neuregulin 4 as a novel adipokine in energy metabolism. Front Physiol. 2023;13:1106380.","journal-title":"Front Physiol"},{"key":"6319_CR18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.gendis.2023.03.021","volume":"11","author":"M Chen","year":"2023","unstructured":"Chen M, Zhu J, Luo H, Mu W, Guo L. The journey towards physiology and pathology: tracing the path of neuregulin 4. Genes Dis. 2023;11:687\u2013700.","journal-title":"Genes Dis"},{"key":"6319_CR19","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1152\/ajpgi.00296.2020","volume":"320","author":"MA Schumacher","year":"2021","unstructured":"Schumacher MA, Dennis IC, Liu CY, et al. NRG4-ErbB4 signaling represses proinflammatory macrophage activity. Am J Physiol Gastrointest Liver Physiol. 2021;320:990\u20131001.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"6319_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00223-021-00897-2","volume":"110","author":"L Shi","year":"2022","unstructured":"Shi L, Xu X, Meng B, et al. Neuregulin 4 attenuates osteoarthritis progression by inhibiting inflammation and apoptosis of chondrocytes in mice. Calcif Tissue Int. 2022;110:131\u201342.","journal-title":"Calcif Tissue Int"},{"key":"6319_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/ijlh.14075","volume":"45","author":"A Greinacher","year":"2023","unstructured":"Greinacher A, Warkentin TE. Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity. Int J Lab Hematol. 2023;45:11\u201322.","journal-title":"Int J Lab Hematol"},{"key":"6319_CR22","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1161\/ATVBAHA.124.320149","volume":"44","author":"A Mack","year":"2024","unstructured":"Mack A, Vanden Hoek T, Du X. Thromboinflammation and the role of platelets. Arterioscler Thromb Vasc Biol. 2024;44:1175\u201380.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6319_CR23","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12975-021-00938-w","volume":"13","author":"AM Kollikowski","year":"2022","unstructured":"Kollikowski AM, Pham M, M\u00e4rz AG, et al. Platelet activation and chemokine release are related to local neutrophil-dominant inflammation during hyperacute human stroke. Transl Stroke Res. 2022;13:364\u20139.","journal-title":"Transl Stroke Res"},{"key":"6319_CR24","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/jre.12448","volume":"52","author":"M Javaid","year":"2017","unstructured":"Javaid M, Bi J, Biddle C, Tsai CM, H\u00e4kkinen L, Kim H. Platelet factor 4 upregulates matrix metalloproteinase-1 production in gingival fibroblasts. J Periodontal Res. 2017;52:787\u201392.","journal-title":"J Periodontal Res"},{"key":"6319_CR25","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.2147\/JIR.S504673","volume":"18","author":"Y Ji","year":"2025","unstructured":"Ji Y, Zhang Q, Li H, Chen L, Wu Y, Lin S. Platelet factor 4: a mysterious chemokine in inflammatory regulation diseases. J Inflamm Res. 2025;18:4481\u201395.","journal-title":"J Inflamm Res"},{"key":"6319_CR26","first-page":"17362","volume":"8","author":"W Liu","year":"2015","unstructured":"Liu W, Wu YH, Zhang L, et al. Elevated serum levels of IL-6 and IL-17 may associate with the development of ankylosing spondylitis. Int J Clin Exp Med. 2015;8:17362\u201376.","journal-title":"Int J Clin Exp Med"},{"key":"6319_CR27","doi-asserted-by":"publisher","first-page":"818413","DOI":"10.3389\/fimmu.2022.818413","volume":"13","author":"H Zhang","year":"2022","unstructured":"Zhang H, Jiang HL, Dai SM. No significant effects of IL-23 on initiating and perpetuating the axial spondyloarthritis: the reasons for the failure of IL-23 inhibitors. Front Immunol. 2022;13:818413.","journal-title":"Front Immunol"},{"key":"6319_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1136\/ard-2022-223595","volume":"82","author":"D van der Heijde","year":"2023","unstructured":"van der Heijde D, Deodhar A, Baraliakos X, et al. Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials. Ann Rheum Dis. 2023;82:515\u201326.","journal-title":"Ann Rheum Dis"},{"key":"6319_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/ard-2022-223296","volume":"82","author":"S Ramiro","year":"2023","unstructured":"Ramiro S, Nikiphorou E, Sepriano A, et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann Rheum Dis. 2023;82:19\u201334.","journal-title":"Ann Rheum Dis"},{"key":"6319_CR30","doi-asserted-by":"publisher","first-page":"1759720X2412848","DOI":"10.1177\/1759720X241284869","volume":"16","author":"J So","year":"2024","unstructured":"So J, Tam LS. Precision medicine in axial spondyloarthritis: current opportunities and future perspectives. Ther Adv Musculoskelet Dis. 2024;16:1759720X241284869.","journal-title":"Ther Adv Musculoskelet Dis"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06319-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-026-06319-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06319-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:43:08Z","timestamp":1790822588000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-026-06319-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["6319"],"URL":"https:\/\/doi.org\/10.1007\/s12098-026-06319-1","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"23 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}