{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:59:11Z","timestamp":1790384351016,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Indian Journal of Pediatrics","award":["PG thesis grant 2024"],"award-info":[{"award-number":["PG thesis grant 2024"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Pediatr"],"DOI":"10.1007\/s12098-026-06409-0","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:40:20Z","timestamp":1790336420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Reconstitution in Pediatric Patients Post Autologous Stem Cell Transplantation"],"prefix":"10.1007","author":[{"given":"Nupur","family":"Bathwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyendra","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Kurup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdish Prasad","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Deepak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay","family":"Tanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepam","family":"Pushpam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Coshic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-8944","authenticated-orcid":false,"given":"Aditya Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"6409_CR1","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1056\/NEJMp078166","volume":"357","author":"FR Appelbaum","year":"2007","unstructured":"Appelbaum FR. Hematopoietic-cell transplantation at 50. N Engl J Med. 2007;357:1472\u20135.","journal-title":"N Engl J Med"},{"key":"6409_CR2","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","volume":"354","author":"EA Copelan","year":"2006","unstructured":"Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354:1813\u201326.","journal-title":"N Engl J Med"},{"key":"6409_CR3","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.bbmt.2015.07.032","volume":"21","author":"NS Majhail","year":"2015","unstructured":"Majhail NS, Farnia SH, Carpenter PA, et al. Indications for autologous and allogeneic hematopoietic cell transplantation: Guidelines from the American society for blood and marrow transplantation. Biol Blood Marrow Transpl. 2015;21:1863\u20139.","journal-title":"Biol Blood Marrow Transpl"},{"key":"6409_CR4","volume-title":"The EBMT handbook: Hematopoietic stem cell transplantation and cellular therapies","year":"2019","unstructured":"Carreras E, Dufour C, Mohty M, Kr\u00f6ger N, editors. The EBMT handbook: Hematopoietic stem cell transplantation and cellular therapies. 7th ed. Cham: Springer; 2019.","edition":"7"},{"key":"6409_CR5","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.bbmt.2009.06.019","volume":"15","author":"M Tomblyn","year":"2009","unstructured":"Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: A global perspective. Biol Blood Marrow Transpl. 2009;15:1143\u2013238.","journal-title":"Biol Blood Marrow Transpl"},{"key":"6409_CR6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/bmt.2009.263","volume":"44","author":"P Ljungman","year":"2009","unstructured":"Ljungman P, Cordonnier C, Einsele H et al. Center for International Blood and Marrow Transplant Research; National Marrow Donor Program; European Blood and Marrow Transplant Group; American Society of Blood and Marrow Transplantation; Canadian Blood and Marrow Transplant Group; Infectious Disease Society of America; Society for Healthcare Epidemiology of America. Association of Medical Microbiology and Infectious Diseases Canada; Centers for Disease Control and Prevention. Vaccination of hematopoietic cell transplant recipients. Bone Marrow Transpl. 2009;44:521\u20136.","journal-title":"Bone Marrow Transpl"},{"key":"6409_CR7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00281-008-0132-5","volume":"30","author":"J Storek","year":"2008","unstructured":"Storek J, Geddes M, Khan F, et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. Semin Immunopathol. 2008;30:425\u201337.","journal-title":"Semin Immunopathol"},{"key":"6409_CR8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.beha.2006.09.009","volume":"20","author":"M Geddes","year":"2007","unstructured":"Geddes M, Storek J. Immune reconstitution following hematopoietic stem-cell transplantation. Best Pract Res Clin Haematol. 2007;20:329\u201348.","journal-title":"Best Pract Res Clin Haematol"},{"key":"6409_CR9","doi-asserted-by":"publisher","first-page":"e302","DOI":"10.1097\/MPH.0000000000001340","volume":"41","author":"V Wiegering","year":"2019","unstructured":"Wiegering V, Eyrich M, Winkler B, Schlegel PG. Comparison of immune reconstitution after allogeneic versus autologous stem cell transplantation in 182 pediatric recipients. J Pediatr Hematol Oncol. 2019;41:e302\u20137.","journal-title":"J Pediatr Hematol Oncol"},{"key":"6409_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1056\/NEJM199501193320303","volume":"332","author":"CL Mackall","year":"1995","unstructured":"Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4\u2009+\u2009T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 1995;332:143\u20139.","journal-title":"N Engl J Med"},{"key":"6409_CR11","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1182\/blood.V89.10.3700","volume":"89","author":"CL Mackall","year":"1997","unstructured":"Mackall CL, Fleisher TA, Brown MR, et al. Distinctions between CD8\u2009+\u2009and CD4\u2009+\u2009T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 1997;89:3700\u20137.","journal-title":"Blood"},{"key":"6409_CR12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1046\/j.1365-2141.2002.03560.x","volume":"118","author":"K Kalwak","year":"2002","unstructured":"Kalwak K, Gorczy\u0144ska E, Toporski J, et al. Immune reconstitution after haematopoietic cell transplantation in children: Immunophenotype analysis with regard to factors affecting the speed of recovery. Br J Haematol. 2002;118:74\u201389.","journal-title":"Br J Haematol"},{"key":"6409_CR13","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/bmt.2013.76","volume":"48","author":"H Frangoul","year":"2013","unstructured":"Frangoul H, Min E, Wang W, et al. Incidence and risk factors for hypogammaglobulinemia in pediatric patients following allo-SCT. Bone Marrow Transpl. 2013;48:1456\u20139.","journal-title":"Bone Marrow Transpl"},{"key":"6409_CR14","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/sj.bmt.1704196","volume":"32","author":"J Machatschek","year":"2003","unstructured":"Machatschek J, Duda J, Matthay K, Cowan M, Horn B. Immune reconstitution, infectious complications and post transplant supportive care measures after autologous blood and marrow transplantation in children. Bone Marrow Transpl. 2003;32:687\u201393.","journal-title":"Bone Marrow Transpl"},{"key":"6409_CR15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0025-6196(11)62388-4","volume":"76","author":"LF Porrata","year":"2001","unstructured":"Porrata LF, Litzow MR, Markovic SN. Immune reconstitution after autologous hematopoietic stem cell transplantation. Mayo Clin Proc. 2001;76:407\u201312.","journal-title":"Mayo Clin Proc"},{"key":"6409_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1182\/blood-2014-02-514778","volume":"124","author":"B Gyurkocza","year":"2014","unstructured":"Gyurkocza B, Sandmaier BM. Conditioning regimens for hematopoietic cell transplantation: One size does not fit all. Blood. 2014;124:344\u201353.","journal-title":"Blood"},{"key":"6409_CR17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1200\/JCO.1995.13.3.588","volume":"13","author":"W Mills","year":"1995","unstructured":"Mills W, Chopra R, McMillan A, Pearce R, Linch DC, Goldstone AH. BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin\u2019s lymphoma. J Clin Oncol. 1995;13:588\u201395.","journal-title":"J Clin Oncol"},{"key":"6409_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S1470-2045(17)30070-0","volume":"18","author":"R Ladenstein","year":"2017","unstructured":"Ladenstein R, P\u00f6tschger U, Pearson ADJ, et al. Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1\/SIOPEN): An international, randomised, multi-arm, open-label, phase 3 trial. Lancet Oncol. 2017;18:500\u201314.","journal-title":"Lancet Oncol"},{"key":"6409_CR19","first-page":"25","volume":"7","author":"AK Gupta","year":"2024","unstructured":"Gupta AK, Meena JP, Seth R, Naranje P, Mohanty S, Coshic P. Autologous hematopoietic stem cell transplant at a tertiary care centre in India: Achieving comparable outcomes with adaptations. Blood Cell Ther. 2024;7:25\u201332.","journal-title":"Blood Cell Ther"},{"key":"6409_CR20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/sj.bmt.1703831","volume":"31","author":"S Hoepfner","year":"2003","unstructured":"Hoepfner S, Haut PR, O\u2019Gorman M, Kletzel M. Rapid immune reconstitution following autologous hematopoietic stem cell transplantation in children: A single institution experience. Bone Marrow Transpl. 2003;31:285\u201390.","journal-title":"Bone Marrow Transpl"},{"key":"6409_CR21","first-page":"1","volume":"113","author":"C Parra","year":"1999","unstructured":"Parra C, Rold\u00e1n E, Rodr\u00edguez C, et al. Reconstituci\u00f3n de los linfocitos de sangre perif\u00e9rica en pacientes tratados con trasplante de m\u00e9dula \u00f3sea: comparaci\u00f3n entre el trasplante alog\u00e9nico y el aut\u00f3logo [Reconstitution of peripheral blood lymphocytes in patients treated with bone marrow transplantation: Comparison between allogeneic and autologous transplantation]. Med Clin (Barc). 1999;113:1\u20135.","journal-title":"Med Clin (Barc)"}],"container-title":["Indian Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06409-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12098-026-06409-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12098-026-06409-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:03:07Z","timestamp":1790380987000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12098-026-06409-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":21,"alternative-id":["6409"],"URL":"https:\/\/doi.org\/10.1007\/s12098-026-06409-0","relation":{},"ISSN":["0019-5456","0973-7693"],"issn-type":[{"value":"0019-5456","type":"print"},{"value":"0973-7693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"27 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}