{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:46:41Z","timestamp":1788511601321,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["PITN-GA-2013-ITN 606831"],"award-info":[{"award-number":["PITN-GA-2013-ITN 606831"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M021637\/1"],"award-info":[{"award-number":["BB\/M021637\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/J020192\/1"],"award-info":[{"award-number":["EP\/J020192\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biomol NMR Assign"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s12104-016-9720-9","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T13:49:35Z","timestamp":1481809775000},"page":"57-61","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["1H, 15N, 13C backbone resonance assignments of human soluble catechol O-methyltransferase in complex with S-adenosyl-l-methionine and 3,5-dinitrocatechol"],"prefix":"10.1007","volume":"11","author":[{"given":"Sylwia","family":"Czarnota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Cliff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Waltho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel S.","family":"Scrutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-0938","authenticated-orcid":false,"given":"Sam","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"9720_CR1","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1210\/jcem-34-4-736","volume":"34","author":"P Ball","year":"1972","unstructured":"Ball P, Knuppen R, Haupt M, Breuer H (1972) Interactions between estrogens and catechol amines III. Studies on the methylation of catechol estrogens, catechol amines and other catechols by the catechol-O-methyltransferase of human liver. J Clin Endocrinol Metab 34:736\u2013746. doi: 10.1210\/jcem-34-4-736","journal-title":"J Clin Endocrinol Metab"},{"key":"9720_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/B978-0-12-380002-2.50009-9","volume":"2","author":"RT Borchardt","year":"1980","unstructured":"Borchardt RT (1980) N-and O-methylation. Enzym Basis Detoxication 2:43\u201362","journal-title":"Enzym Basis Detoxication"},{"key":"9720_CR3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00004714-199908000-00008","volume":"19","author":"M Fava","year":"1999","unstructured":"Fava M et al (1999) Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder. J Clin Psychopharmacol 19:329\u2013335","journal-title":"J Clin Psychopharmacol"},{"key":"9720_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1146\/annurev.biophys.27.1.357","volume":"27","author":"KH Gardner","year":"1998","unstructured":"Gardner KH, Kay LE (1998) The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins. Annu Rev Biophys Biomol Struct 27:357\u2013406. doi: 10.1146\/annurev.biophys.27.1.357","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"9720_CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0031-6997(25)06681-5","volume":"27","author":"HC Guldberg","year":"1975","unstructured":"Guldberg HC, Marsden CA (1975) Catechol-O-methyl transferase: pharmacological aspects and physiological role. Pharmacol Rev 27:135\u2013206","journal-title":"Pharmacol Rev"},{"key":"9720_CR6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1021\/ml500502d","volume":"6","author":"ST Harrison","year":"2015","unstructured":"Harrison ST et al. (2015) Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT). ACS Med Chem Lett 6:318\u2013323 doi: 10.1021\/ml500502d","journal-title":"ACS Med Chem Lett"},{"key":"9720_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s10858-012-9698-2","volume":"55","author":"SG Hyberts","year":"2013","unstructured":"Hyberts SG, Robson SA, Wagner G (2013) Exploring signal-to-noise ratio and sensitivity in non-uniformly sampled multi-dimensional NMR spectra. J Biomol NMR 55:167\u2013178. doi: 10.1007\/s10858-012-9698-2","journal-title":"J Biomol NMR"},{"key":"9720_CR8","doi-asserted-by":"publisher","first-page":"8692","DOI":"10.1021\/jm500572b","volume":"57","author":"LE Kiss","year":"2014","unstructured":"Kiss LE, Soares-da-Silva P (2014) Medicinal chemistry of catechol O-methyltransferase (COMT) inhibitors and their therapeutic utility. J Med Chem 57:8692\u20138717. doi: 10.1021\/jm500572b","journal-title":"J Med Chem"},{"key":"9720_CR9","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/(SICI)1096-8628(19960920)67:5<468::AID-AJMG5>3.0.CO;2-G","volume":"67","author":"HM Lachman","year":"1996","unstructured":"Lachman HM et al (1996) Association of codon 108\/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet 67:468\u2013472. doi: 10.1002\/(SICI)1096-8628(19960920)67:5<468::AID-AJMG5>3.0.CO;2-G","journal-title":"Am J Med Genet"},{"key":"9720_CR10","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1021\/bi00013a008","volume":"34","author":"T Lotta","year":"1995","unstructured":"Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J (1995) Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34:4202\u20134210","journal-title":"Biochemistry"},{"key":"9720_CR11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0031-6997(24)01423-6","volume":"51","author":"PT Mannisto","year":"1999","unstructured":"Mannisto PT, Kaakkola S (1999) Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 51:593\u2013628","journal-title":"Pharmacol Rev"},{"key":"9720_CR12","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0022-2836(03)00625-9","volume":"330","author":"MA Reed","year":"2003","unstructured":"Reed MA et al (2003) Effects of domain dissection on the folding and stability of the 43\u00a0kDa protein PGK probed by NMR. J Mol Biol 330:1189\u20131201","journal-title":"J Mol Biol"},{"key":"9720_CR13","doi-asserted-by":"publisher","unstructured":"Rutherford K, Alphandery E, McMillan A, Daggett V, Parson WW (2008a) The V108M mutation decreases the structural stability of catechol O-methyltransferase. Biochim Biophys Acta 1784:1098\u20131105. doi: 10.1016\/j.bbapap.2008.04.006","DOI":"10.1016\/j.bbapap.2008.04.006"},{"key":"9720_CR14","doi-asserted-by":"publisher","unstructured":"Rutherford K, Le Trong I, Stenkamp RE, Parson WW (2008b) Crystal structures of human 108 V and 108 M catechol O-methyltransferase. J Mol Biol 380:120\u2013130. doi: 10.1016\/j.jmb.2008.04.040","DOI":"10.1016\/j.jmb.2008.04.040"},{"key":"9720_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10858-009-9333-z","volume":"44","author":"Y Shen","year":"2009","unstructured":"Shen Y, Delaglio F, Cornilescu G, Bax A (2009) TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR 44:213\u2013223. doi: 10.1007\/s10858-009-9333-z","journal-title":"J Biomol NMR"},{"key":"9720_CR16","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1432-1033.1994.tb19083.x","volume":"223","author":"J Tenhunen","year":"1994","unstructured":"Tenhunen J, Salminen M, Lundstrom K, Kiviluoto T, Savolainen R, Ulmanen I (1994) Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters. Eur J Biochem 223:1049\u20131059","journal-title":"Eur J Biochem"},{"key":"9720_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/368354a0","volume":"368","author":"J Vidgren","year":"1994","unstructured":"Vidgren J, Svensson LA, Liljas A (1994) Crystal structure of catechol O-methyltransferase. Nature 368:354\u2013358. doi: 10.1038\/368354a0","journal-title":"Nature"},{"key":"9720_CR18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/prot.20449","volume":"59","author":"WF Vranken","year":"2005","unstructured":"Vranken WF et al (2005) The CCPN data model for NMR spectroscopy: development of a software pipeline. Proteins 59:687\u2013696. doi: 10.1002\/prot.20449","journal-title":"Proteins"}],"container-title":["Biomolecular NMR Assignments"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12104-016-9720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12104-016-9720-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12104-016-9720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T17:19:10Z","timestamp":1749835150000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12104-016-9720-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9720"],"URL":"https:\/\/doi.org\/10.1007\/s12104-016-9720-9","relation":{},"ISSN":["1874-2718","1874-270X"],"issn-type":[{"value":"1874-2718","type":"print"},{"value":"1874-270X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}