{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:16:03Z","timestamp":1778757363467,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s12105-015-0670-9","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T03:51:36Z","timestamp":1447732296000},"page":"354-361","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Parotid Sebaceous Carcinoma in Patient with Muir Torre Syndrome, Caused by MSH2 Mutation"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-0002","authenticated-orcid":false,"given":"Iyer Vishwas","family":"Neelakantan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Di Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E. T.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"McCoombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"issue":"3","key":"670_CR1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/bjs.1800540309","volume":"54","author":"EG Muir","year":"1967","unstructured":"Muir EG, Bell AJ, Barlow KA. Multiple primary carcinomata of the colon, duodenum, and larynx associated with keratoacanthoma of the face. Br J Surg. 1967;54(3):191\u20135.","journal-title":"Br J Surg"},{"issue":"5","key":"670_CR2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1001\/archderm.98.5.549","volume":"98","author":"D Torre","year":"1968","unstructured":"Torre D. Multiple sebaceous adenomas. Arch Dermatol. 1968;98(5):549\u201351.","journal-title":"Arch Dermatol"},{"key":"670_CR3","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.5858\/arpa.2013-0301-RS","volume":"138","author":"F Bhaijee","year":"2014","unstructured":"Bhaijee F, Brown AS. Muir Torre syndrome. Arch Pathol Lab Med. 2014;138:1685\u20139.","journal-title":"Arch Pathol Lab Med"},{"issue":"5","key":"670_CR4","first-page":"4","volume":"12","author":"D Navi","year":"2006","unstructured":"Navi D, wadhera A, Fung MA, Fazel N. Muir Torre syndrome. Dermatol Online J. 2006;12(5):4.","journal-title":"Dermatol Online J"},{"issue":"4","key":"670_CR5","first-page":"252","volume":"82","author":"HH Hare","year":"2008","unstructured":"Hare HH, Mahendraker N, Sarwate S, Tangella K. Muir Torre syndrome: rare but important disorder. Cutis. 2008;82(4):252\u20136.","journal-title":"Cutis"},{"issue":"3","key":"670_CR6","first-page":"149","volume":"75","author":"AA Pettey","year":"2005","unstructured":"Pettey AA, Walsh JS. Muir-Torre syndrome: a case report and review of the literature. Cutis. 2005;75(3):149\u201355.","journal-title":"Cutis"},{"key":"670_CR7","first-page":"8","volume":"2","author":"JH Heather","year":"2009","unstructured":"Heather JH, Melissa V, Jean MH. Muir Torre syndrome: a case report. J Clin Aesthet Dermatol. 2009;2:8.","journal-title":"J Clin Aesthet Dermatol"},{"key":"670_CR8","first-page":"4836","volume":"56","author":"SN Thibodeau","year":"1996","unstructured":"Thibodeau SN, French AJ, Roche PC, et al. Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res. 1996;56:4836\u201340.","journal-title":"Cancer Res"},{"key":"670_CR9","first-page":"1784","volume":"6","author":"MM Entius","year":"2000","unstructured":"Entius MM, Keller JJ, Drillenburg P, Kuypers KC, Giardiello FM, Offerhaus GJ. Microsatellite instability and expression of hMLH-1 and hMSH-2 in sebaceous gland carcinomas as markers for Muir-Torre syndrome. Clin Cancer Res. 2000;6:1784\u20139.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"670_CR10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1046\/j.1523-1747.2003.12125.x","volume":"120","author":"R Kruse","year":"2003","unstructured":"Kruse R, Rutten A, Schweiger N, et al. Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias. J Invest Dermatol. 2003;120(5):858\u201364.","journal-title":"J Invest Dermatol"},{"key":"670_CR11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/jnci\/djm291","volume":"100","author":"DS Christopher","year":"2008","unstructured":"Christopher DS, Heather H, Ilene C, Judith AW, Wendy LF, Albert C. The frequency of Muir-Torre syndrome among Lynch syndrome families. J Natl Cancer Inst. 2008;100:277\u201381.","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"670_CR12","first-page":"736","volume":"59","author":"B Bapat","year":"1996","unstructured":"Bapat B, Xia L, Madlensky L, et al. The genetic basis of Muir-Torre syndrome includes the hMLH1 locus. Am J Hum Genet. 1996;59(3):736\u20139.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"670_CR13","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/j.1365-2133.2005.06506.x","volume":"152","author":"G Ponti","year":"2005","unstructured":"Ponti G, Ponz de Leon M, Losi L, et al. Different phenotypes in Muir-Torre syndrome: clinical and biomolecular characterization in two Italian families. Br J Dermatol. 2005;152(6):1335\u20138.","journal-title":"Br J Dermatol"},{"key":"670_CR14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jmg.2003.012997","volume":"41","author":"C Pagenstecher","year":"2004","unstructured":"Pagenstecher C, Mangold E, Leister M, et al. A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome. J Med Genet. 2004;41:567\u201372.","journal-title":"J Med Genet"},{"issue":"7","key":"670_CR15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1034\/j.1600-0560.2002.290705.x","volume":"29","author":"P Machin","year":"2002","unstructured":"Machin P, Catasus L, Pons C, et al. Microsatellite instability and immunostaining for MSH-2 and MLH-1 in cutaneous and internal tumors from patients with the Muir-Torre syndrome. J Cutan Pathol. 2002;29(7):415\u201320.","journal-title":"J Cutan Pathol"},{"key":"670_CR16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1529-8019.2008.00247.x","volume":"21","author":"W Buitrago","year":"2008","unstructured":"Buitrago W, Joseph AK. Sebaceous carcinoma: the great masquerader, emerging concepts in diagnosis and treatment. Dermatol Therapy. 2008;21:459\u201366.","journal-title":"Dermatol Therapy"},{"key":"670_CR17","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1470-2045(05)70465-4","volume":"6","author":"G Ponti","year":"2005","unstructured":"Ponti G, Ponz de Leon M. Muir-Torre syndrome. Lancet Oncol. 2005;6:980\u20137.","journal-title":"Lancet Oncol"},{"issue":"5","key":"670_CR18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0190-9622(99)70001-0","volume":"41","author":"S Akhtar","year":"1999","unstructured":"Akhtar S, Oza KK, Khan SA, Wright J. Muir-Torre syndrome: case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature. J Am Acad Dermatol. 1999;41(5):681\u20136.","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"670_CR19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/jmedgenet-2015-103216","volume":"52","author":"EF Harkness","year":"2015","unstructured":"Harkness EF, Barrow E, Newton K, Green K, Clancy T, Lalloo F, Hill J, Evans GD. Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study. J Med Genet. 2015;52(8):553\u20136.","journal-title":"J Med Genet"},{"issue":"3","key":"670_CR20","first-page":"227","volume":"43","author":"D Akbari","year":"2005","unstructured":"Akbari D, Naraghi Z, Emadi N, Ghaninejad H. Extraocular Sebaceous carcinoma arising from nevus sebaceous. Acta Med Iran. 2005;43(3):227\u20139.","journal-title":"Acta Med Iran"},{"issue":"1","key":"670_CR21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0190-9622(95)90017-9","volume":"33","author":"RA Schwartz","year":"1995","unstructured":"Schwartz RA, Torre DP. The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol. 1995;33(1):90\u2013104.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"670_CR22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0733-8635(18)30110-4","volume":"13","author":"PR Cohen","year":"1995","unstructured":"Cohen PR, Kohn SR, Davis DA, Kurzrock R. Muir-Torre syndrome. Dermatol Clin. 1995;13(1):79\u201389.","journal-title":"Dermatol Clin"},{"issue":"12","key":"670_CR23","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1002\/cncr.23963","volume":"113","author":"GM Dores","year":"2008","unstructured":"Dores GM, Curtis RE, Toro JR, Devesa SS, Fraumeni JF. Incidence of cutaneous sebaceous carcinoma and risk associated neoplasms: insight into Muir Torre syndrome. Cancer. 2008;113(12):3372\u201381.","journal-title":"Cancer"},{"issue":"1","key":"670_CR24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2559.2009.03454.x","volume":"56","author":"SC Shalin","year":"2010","unstructured":"Shalin SC, Lyle S, Calonje E, Lazar AJF. Sebaceous neoplasia and Muir Torre syndrome: important connection with clinical implication. Histopathology. 2010;56(1):133\u201347.","journal-title":"Histopathology"},{"key":"670_CR25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12105-012-0343-x","volume":"6","author":"DR Gnepp","year":"2012","unstructured":"Gnepp DR. My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol. 2012;6:101\u201310.","journal-title":"Head Neck Pathol"},{"key":"670_CR26","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/1097-0142(19840515)53:10<2155::AID-CNCR2820531026>3.0.CO;2-F","volume":"53","author":"DR Gnepp","year":"1984","unstructured":"Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer. 1984;53:2155\u201370.","journal-title":"Cancer"},{"key":"670_CR27","unstructured":"Mill SE, Carter D, Greenson JK, Reutor VE, Stoler MH. Sternberg\u2019s diagnostic surgical pathology. 5th ed. Wolter Kluwer\/Lippincot Williams and Wilkins; 2010."},{"key":"670_CR28","volume-title":"Pathology and genetics of head neck tumours","author":"L Barnes","year":"2005","unstructured":"Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and genetics of head neck tumours. 3rd ed. Geneva: WHO Press; 2005.","edition":"3"},{"key":"670_CR29","doi-asserted-by":"crossref","DOI":"10.3109\/9781420020373","volume-title":"Surgical pathology of head and neck","author":"L Barnes","year":"2008","unstructured":"Barnes L. Surgical pathology of head and neck. 3rd ed. London: Taylor and Francis Inc; 2008.","edition":"3"},{"key":"670_CR30","doi-asserted-by":"crossref","unstructured":"Di Palma S, Skalova A, Simpson R, Leivo IS, Fonseca I. Major and minor salivary glands. Pathology of the head and neck. Chapter 5. 2nd ed. Springer; 2015 (in press).","DOI":"10.1007\/978-3-662-49672-5_5"},{"issue":"10","key":"670_CR31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/00000478-198910000-00008","volume":"13","author":"FM Madrigal","year":"1989","unstructured":"Madrigal FM, Micheau C. Histology of major salivary glands. Am J Surg Pathol. 1989;13(10):879\u201399.","journal-title":"Am J Surg Pathol"},{"key":"670_CR32","first-page":"6","volume-title":"Oral and maxillofacial pathology 2","author":"BW Neville","year":"2002","unstructured":"Neville BW, Damm DD, Allen CM, et al. Oral and maxillofacial pathology 2. Philadelphia: W. B Saunders; 2002. p. 6\u20137."},{"key":"670_CR33","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1136\/gut.2005.064881","volume":"54","author":"C Felice De","year":"2005","unstructured":"De Felice C, Parrini S, Chitano G, Gentile M, Dipaola L, Latini G. Fordyce granules and hereditary non-polyposis colorectal cancer syndrome. Gut. 2005;54:1279\u201382.","journal-title":"Gut"},{"key":"670_CR34","first-page":"161","volume":"96","author":"M Akhtar","year":"1973","unstructured":"Akhtar M, Gosalbez TG. Primary sebaceous carcinoma of Parotid Gland. Arch Pathol. 1973;96:161\u20133.","journal-title":"Arch Pathol"},{"key":"670_CR35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1001\/archotol.1973.00780020431015","volume":"98","author":"J Shulman","year":"1973","unstructured":"Shulman J, Waisman J, Morledge D. Sebaceous carcinoma of parotid gland. Arch Otolaryngol. 1973;98:417\u201321.","journal-title":"Arch Otolaryngol"},{"key":"670_CR36","doi-asserted-by":"crossref","unstructured":"Siriwardena BSMS, Tilakaratne WM, Rajapakshe RMSK. A case of sebaceous carcinoma of the parotid gland. J Oral Pathol Med; 32:121\u2013123.","DOI":"10.1034\/j.1600-0714.2003.00037.x"},{"key":"670_CR37","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/1097-0142(196612)19:12<1773::AID-CNCR2820191203>3.0.CO;2-Q","volume":"19","author":"H Silver","year":"1966","unstructured":"Silver H, Goldstein MA. Sebaceous cell carcinoma of the parotid gland. Cancer. 1966;19:1773\u20139.","journal-title":"Cancer"},{"key":"670_CR38","doi-asserted-by":"crossref","unstructured":"MacFarlane JK, Viloria JB, Palmer JD. Sebaceous cell carcinoma of Parotid Gland. Am J Surg; 130:499\u2013501.","DOI":"10.1016\/0002-9610(75)90494-8"},{"key":"670_CR39","first-page":"141","volume":"69","author":"TP Grieve","year":"1986","unstructured":"Grieve TP, Saragas E, Mannell A. Sebaceous carcinoma of parotid gland in a black patient. S Afr Med J. 1986;69:141\u20132.","journal-title":"S Afr Med J"},{"key":"670_CR40","first-page":"1","volume":"9","author":"M Warman","year":"2008","unstructured":"Warman M, Mozes M, Halperin D. Sebaceous Adenocarcinoma of the Parotid Gland: a case report and review of literature. Internet J Otorhinolaryngol. 2008;9:1\u20132.","journal-title":"Internet J Otorhinolaryngol"},{"key":"670_CR41","first-page":"122","volume":"12","author":"K Das","year":"2014","unstructured":"Das K, Karmakar A. Sebaceous Carcinoma of parotid Gland. Gomal Jo Med Sci. 2014;12:122\u20133.","journal-title":"Gomal Jo Med Sci"},{"key":"670_CR42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1259\/dmfr.25.1.9084287","volume":"25","author":"AJ Mighell","year":"1996","unstructured":"Mighell AJ, Stassen LFA, Soames JV. Sebaceous carcinoma of parotid gland. Dentalmaxillofac. Radiol. 1996;25:51\u20134.","journal-title":"Dentalmaxillofac. Radiol"},{"key":"670_CR43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000379742","volume":"8","author":"Y Takada","year":"2015","unstructured":"Takada Y, Kawamoto K, Baba S, Takada T, Inoue T, Tomoda K. Sebaceous carcinoma of parotid gland: a case report. Case Rep Oncol. 2015;8:106\u201312.","journal-title":"Case Rep Oncol"},{"key":"670_CR44","first-page":"1","volume":"6","author":"M Alexander","year":"2014","unstructured":"Alexander M, Seth Z, Vivian G. Sebaceous carcinoma of parotid gland. A case report and review of literature. ENT J. 2014;6:1\u20136.","journal-title":"ENT J"},{"key":"670_CR45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00718631","volume":"414","author":"T Takata","year":"1989","unstructured":"Takata T, Ogawa I, Nikai H. Sebaceous Carcinoma of parotid gland. An Immunohistochemical and ultrastructural study. Virchows Archiv A Pathol Anat. 1989;414:459\u201364.","journal-title":"Virchows Archiv A Pathol Anat"},{"issue":"5","key":"670_CR46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archinte.1981.00340050059016","volume":"141","author":"HT Lynch","year":"1981","unstructured":"Lynch HT, Lynch PM, Pester J, Fusaro RM. The cancer family syndrome. Rare cutaneous phenotypic linkage of Torre\u2019s syndrome. Arch Intern Med. 1981;141(5):607\u201311.","journal-title":"Arch Intern Med"},{"key":"670_CR47","unstructured":"http:\/\/www.cancer.net\/cancer-types\/muir-torre-syndrome . Accessed 11 Aug 2015."},{"key":"670_CR48","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00000478-200203000-00007","volume":"26","author":"M Mathiak","year":"2002","unstructured":"Mathiak M, Rutten A, Mangold E, Fisher HP, et al. Loss of DNA mismatch repair proteins in skin tumours from patients with Muir-Torre syndrome and MSH2 or MLH1 germline mutations: establishment of immunohistochemical analysis as a screening test. Am J Surg Pathol. 2002;26:338\u201343.","journal-title":"Am J Surg Pathol"},{"key":"670_CR49","volume-title":"Grays anatomy","author":"S Standring","year":"2009","unstructured":"Standring S. Grays anatomy. 40th ed. London: Churchill Livingstone; 2009.","edition":"40"},{"issue":"12","key":"670_CR50","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/hed.22009","volume":"34","author":"G Tryggvason","year":"2012","unstructured":"Tryggvason G, Bayon R, Pagedar NA. Epidemiology of sebaceous carcinoma of the head and neck: implications for lymph node management. Head Neck. 2012;34(12):1765\u20138.","journal-title":"Head Neck"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-015-0670-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-015-0670-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-015-0670-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T12:10:17Z","timestamp":1567339817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-015-0670-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,17]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1007\/s12105-015-0670-9","relation":{},"ISSN":["1936-055X","1936-0568"],"issn-type":[{"value":"1936-055X","type":"print"},{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,17]]}}}