{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:16:15Z","timestamp":1762866975896,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s12105-016-0769-7","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T09:47:31Z","timestamp":1479116851000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck"],"prefix":"10.1007","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-3866","authenticated-orcid":false,"given":"Julia","family":"Thierauf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A.","family":"Veit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen K.","family":"Lennerz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie E.","family":"Weissinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Affolter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"D\u00f6scher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Knopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Gr\u00fcnow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Gr\u00fcnm\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Mauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.","family":"Plinkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Hess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"769_CR1","first-page":"739","volume":"5","author":"M Mihajlovic","year":"2012","unstructured":"Mihajlovic M, Vlajkovic S, Jovanovic P, Stefanovic V. Primary mucosal melanomas: a comprehensive review. Int J Clin Exp Pathol. 2012;5:739\u201353.","journal-title":"Int J Clin Exp Pathol"},{"key":"769_CR2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/hed.20112","volume":"26","author":"ML Prasad","year":"2004","unstructured":"Prasad ML, et al. Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck. Head Neck. 2004;26:1053\u20137.","journal-title":"Head Neck"},{"key":"769_CR3","first-page":"9","volume":"48","author":"M Holmstrom","year":"1991","unstructured":"Holmstrom M, Lund VJ. Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde. Br J Ind Med. 1991;48:9\u201311.","journal-title":"Br J Ind Med"},{"key":"769_CR4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1080\/02841860500247461","volume":"44","author":"L Dahlgren","year":"2005","unstructured":"Dahlgren L, Schedvins K, Kanter-Lewensohn L, Dalianis T, Ragnarsson-Olding BK. Human papilloma virus (HPV) is rarely detected in malignant melanomas of sun sheltered mucosal membranes. Acta Oncol. 2005;44:694\u20139.","journal-title":"Acta Oncol"},{"key":"769_CR5","first-page":"3627","volume":"26","author":"R Lundberg","year":"2006","unstructured":"Lundberg R, et al. Human herpes virus DNA is rarely detected in non-UV light-associated primary malignant melanomas of mucous membranes. Anticancer Res. 2006;26:3627\u201331.","journal-title":"Anticancer Res."},{"key":"769_CR6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1055\/s-0035-1565056","volume":"94","author":"J Thierauf","year":"2015","unstructured":"Thierauf J, et al. Mucosal melanoma of the head and neck. Laryngorhinootologie. 2015;94:812\u20138.","journal-title":"Laryngorhinootologie"},{"key":"769_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23428","author":"JJ Liao","year":"2013","unstructured":"Liao JJ, et al. Fast neutron radiotherapy for primary mucosal melanomas of the head and neck. Head Neck. 2013. doi: 10.1002\/hed.23428 .","journal-title":"Head Neck"},{"key":"769_CR8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijrobp.2010.04.071","volume":"81","author":"S Zenda","year":"2011","unstructured":"Zenda S, et al. Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck: a pilot study. Int J Radiat Oncol Biol Phys. 2011;81:135\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"769_CR9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/CMR.0b013e3283457743","volume":"21","author":"JH Yi","year":"2011","unstructured":"Yi JH, et al. Dacarbazine-based chemotherapy as first-line treatment in noncutaneous metastatic melanoma: multicenter, retrospective analysis in Asia. Melanoma Res. 2011;21:223\u20137.","journal-title":"Melanoma Res"},{"key":"769_CR10","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1200\/JCO.2007.14.0707","volume":"26","author":"FS Hodi","year":"2008","unstructured":"Hodi FS, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008;26:2046\u201351.","journal-title":"J Clin Oncol"},{"key":"769_CR11","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1158\/1078-0432.CCR-11-1987","volume":"18","author":"DR Minor","year":"2012","unstructured":"Minor DR, et al. Sunitinib therapy for melanoma patients with KIT mutations. Clin Cancer Res. 2012;18:1457\u201363.","journal-title":"Clin Cancer Res"},{"key":"769_CR12","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000035","author":"SV Louren\u00e7o","year":"2014","unstructured":"Louren\u00e7o SV, et al. Head and neck mucosal melanoma: a review. Am J Dermatopathol. 2014. doi: 10.1097\/DAD.0000000000000035 .","journal-title":"Am J Dermatopathol"},{"key":"769_CR13","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000197","author":"J Thierauf","year":"2015","unstructured":"Thierauf J, et al. Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck. Melanoma Res. 2015. doi: 10.1097\/CMR.0000000000000197 .","journal-title":"Melanoma Res"},{"key":"769_CR14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2006.12.018","volume":"249","author":"M Paliouras","year":"2007","unstructured":"Paliouras M, Borgono C, Diamandis EP. Human tissue kallikreins: the cancer biomarker family. Cancer Lett. 2007;249:61\u201379.","journal-title":"Cancer Lett"},{"key":"769_CR15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0065-2423(04)39002-5","volume":"39","author":"GM Yousef","year":"2005","unstructured":"Yousef GM, et al. Human tissue kallikreins: from gene structure to function and clinical applications. Adv Clin Chem. 2005;39:11\u201379.","journal-title":"Adv Clin Chem"},{"key":"769_CR16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrd4534","volume":"14","author":"I Prassas","year":"2015","unstructured":"Prassas I, Eissa A, Poda G, Diamandis EP. Unleashing the therapeutic potential of human kallikrein-related serine proteases. Nat Rev Drug Discov. 2015;14:183\u2013202.","journal-title":"Nat Rev Drug Discov"},{"key":"769_CR17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1515\/cclm.2011.750","volume":"50","author":"J Bayani","year":"2012","unstructured":"Bayani J, Diamandis EP. The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6). Clin Chem Lab Med. 2012;50:211\u201333.","journal-title":"Clin Chem Lab Med"},{"key":"769_CR18","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/jid.2011.190","volume":"131","author":"S Krenzer","year":"2011","unstructured":"Krenzer S, et al. Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Investig Dermatol. 2011;131:2281\u20138.","journal-title":"J Investig Dermatol"},{"key":"769_CR19","first-page":"299","volume":"391","author":"K Oikonomopoulou","year":"2010","unstructured":"Oikonomopoulou K, Diamandis EP, Hollenberg MD. Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier. Biol Chem. 2010;391:299\u2013310.","journal-title":"Biol Chem"},{"key":"769_CR20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/neuonc\/nos313","volume":"15","author":"KL Drucker","year":"2013","unstructured":"Drucker KL, et al. Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma. Neuro Oncol. 2013;15:305\u201318.","journal-title":"Neuro Oncol"},{"key":"769_CR21","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1158\/0008-5472.CAN-08-1976","volume":"69","author":"G Pampalakis","year":"2009","unstructured":"Pampalakis G, et al. A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition. Cancer Res. 2009;69:3779\u201387.","journal-title":"Cancer Res"},{"key":"769_CR22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-015-0381-6","volume":"14","author":"CH Schrader","year":"2015","unstructured":"Schrader CH, et al. Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients. Mol Cancer. 2015;14:107.","journal-title":"Mol Cancer"},{"key":"769_CR23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.molonc.2008.01.001","volume":"1","author":"M Paliouras","year":"2008","unstructured":"Paliouras M, Diamandis EP. Androgens act synergistically to enhance estrogen-induced upregulation of human tissue kallikreins 10, 11, and 14 in breast cancer cells via a membrane bound androgen receptor. Mol Oncol. 2008;1:413\u201324.","journal-title":"Mol Oncol"},{"key":"769_CR24","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.0022-202x.2001.01437.x","volume":"117","author":"U Breitenbach","year":"2001","unstructured":"Breitenbach U, et al. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. J Investig Dermatol. 2001;117:634\u201340.","journal-title":"J Investig Dermatol"},{"key":"769_CR25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mc.20008","volume":"39","author":"NA Ignatenko","year":"2004","unstructured":"Ignatenko NA, et al. The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells. Mol Carcinog. 2004;39:221\u201333.","journal-title":"Mol Carcinog"},{"key":"769_CR26","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/pmic.201100371","volume":"12","author":"U Kuzmanov","year":"2012","unstructured":"Kuzmanov U, et al. Separation of kallikrein 6 glycoprotein subpopulations in biological fluids by anion-exchange chromatography coupled to ELISA and identification by mass spectrometry. Proteomics. 2012;12:799\u2013809.","journal-title":"Proteomics"},{"key":"769_CR27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1515\/BC.2008.071","volume":"389","author":"TF Chow","year":"2008","unstructured":"Chow TF, et al. Kallikreins as microRNA targets: an in silico and experimental-based analysis. Biol Chem. 2008;389:731\u20138.","journal-title":"Biol Chem"},{"key":"769_CR28","doi-asserted-by":"crossref","first-page":"8198","DOI":"10.1158\/0008-5472.CAN-07-0607","volume":"67","author":"B Klucky","year":"2007","unstructured":"Klucky B, et al. Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion. Cancer Res. 2007;67:8198\u2013206.","journal-title":"Cancer Res"},{"key":"769_CR29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.50.10.801","volume":"50","author":"PJ Diest van","year":"1997","unstructured":"van Diest PJ, et al. A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group. J Clin Pathol. 1997;50:801\u20134.","journal-title":"J Clin Pathol"},{"key":"769_CR30","first-page":"350","volume":"60","author":"A Qureshi","year":"2010","unstructured":"Qureshi A, Pervez S. Allred scoring for ER reporting and it\u2019s impact in clearly distinguishing ER negative from ER positive breast cancers. J Pak Med Assoc. 2010;60:350\u20133.","journal-title":"J Pak Med Assoc"},{"key":"769_CR31","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/BF03401646","volume":"2","author":"A Anisowicz","year":"1996","unstructured":"Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R. A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med. 1996;2:624\u201336.","journal-title":"Mol Med"},{"key":"769_CR32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1515\/hsz-2011-0264","volume":"393","author":"L Seiz","year":"2012","unstructured":"Seiz L, et al. Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biol Chem. 2012;393:391\u2013401.","journal-title":"Biol Chem"},{"key":"769_CR33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1515\/bc.2010.025","volume":"391","author":"M Gabril","year":"2010","unstructured":"Gabril M, et al. Immunohistochemical analysis of kallikrein-related peptidases in the normal kidney and renal tumors: potential clinical implications. Biol Chem. 2010;391:403\u20139.","journal-title":"Biol Chem"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-016-0769-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-016-0769-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-016-0769-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T08:58:02Z","timestamp":1657702682000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-016-0769-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["769"],"URL":"https:\/\/doi.org\/10.1007\/s12105-016-0769-7","relation":{},"ISSN":["1936-055X","1936-0568"],"issn-type":[{"type":"print","value":"1936-055X"},{"type":"electronic","value":"1936-0568"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}