{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:25:43Z","timestamp":1782753943742,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12105-018-0963-x","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T08:49:42Z","timestamp":1536223782000},"page":"313-317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Epstein\u2013Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature"],"prefix":"10.1007","volume":"13","author":[{"given":"Zhenjian","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel I.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-019X","authenticated-orcid":false,"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"963_CR1","volume-title":"WHO classification of head and neck tumours","author":"AK EL-Naggar","year":"2017","unstructured":"EL-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg P. WHO classification of head and neck tumours. 4th ed. Lyon: IAPR Press; 2017.","edition":"4"},{"issue":"1","key":"963_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12105-007-0004-7","volume":"1","author":"I Weinreb","year":"2007","unstructured":"Weinreb I, Perez-Ordo\u00f1ez B. Non-small cell neuroendocrine carcinoma of the sinonasal tract and nasopharynx. Report of 2 cases and review of the literature. Head Neck Pathol. 2007;1(1):21\u20136.","journal-title":"Head Neck Pathol"},{"issue":"2","key":"963_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1177\/1066896908316904","volume":"19","author":"LY Lee","year":"2011","unstructured":"Lee LY, Chang KP, Hsu CL, Chen TC, Kuo TT. Small-cell neuroendocrine carcinoma of the nasopharynx: report of a rare case lacking association with Epstein-Barr virus. Int J Surg Pathol. 2011;19(2):199\u2013202.","journal-title":"Int J Surg Pathol"},{"issue":"2","key":"963_CR4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/00016480500401027","volume":"127","author":"IH Lin","year":"2007","unstructured":"Lin IH, Hwang CF, Huang HY, Chien CY. Small cell carcinoma of the nasopharynx. Acta Otolaryngol. 2007;127(2):206\u20138.","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"963_CR5","first-page":"147","volume":"6","author":"V Vandist","year":"2010","unstructured":"Vandist V, Deridder F, Waelput W, Parizel PM, Van de Heyning P, Van Laer C. A neuroendocrine tumour of the sphenoid sinus and nasopharynx: a case report. B ENT. 2010;6(2):147\u201351.","journal-title":"B ENT"},{"issue":"11","key":"963_CR6","first-page":"E1","volume":"87","author":"S Deviprasad","year":"2008","unstructured":"Deviprasad S, Rajeshwari A, Tahir M, Adarsha TV, Gangadhara S. Small-cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. Ear Nose Throat J. 2008;87(11):E1\u20133.","journal-title":"Ear Nose Throat J"},{"issue":"3","key":"963_CR7","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.canrad.2014.03.003","volume":"18","author":"F Elloumi","year":"2014","unstructured":"Elloumi F, Fourati N, Siala W, Ghorbell L, Jlidi R, Ghorbel A, Frikha M, Daoud J. Large cell neuroendocrine carcinoma of the nasopharynx: a case report. Cancer Radiother. 2014;18(3):208\u201310.","journal-title":"Cancer Radiother"},{"key":"963_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0883-1","author":"JK Wasserman","year":"2018","unstructured":"Wasserman JK, Papp S, Hope AJ, Perez-Ord\u00f3\u00f1ez B. Epstein-Barr virus-positive large cell neuroendocrine carcinoma of the nasopharynx: report of a case with complete clinical and radiological response after combined chemoradiotherapy. Head Neck Pathol. 2018. https:\/\/doi.org\/10.1007\/s12105-017-0883-1","journal-title":"Head Neck Pathol"},{"key":"963_CR9","first-page":"231070","volume":"2015","author":"CD Sturgis","year":"2015","unstructured":"Sturgis CD, Burkey BB, Momin S, Hoschar AP. High grade (large cell) neuroendocrine carcinoma of the nasopharynx: novel case report with touch preparation cytology and positive EBV encoded early RNA. Case Rep Pathol. 2015;2015:231070.","journal-title":"Case Rep Pathol"},{"issue":"6","key":"963_CR10","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/MPH.0000000000000334","volume":"37","author":"C Dumars","year":"2015","unstructured":"Dumars C, Thebaud E, Joubert M, Renaudin K, Cariou-Patron G, Heymann MF. Large cell neuroendocrine carcinoma of the nasopharynx: a pediatric case. J Pediatr Hematol Oncol. 2015;37(6):474\u20136.","journal-title":"J Pediatr Hematol Oncol"},{"key":"963_CR11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cca.2017.06.016","volume":"471","author":"C Guo","year":"2017","unstructured":"Guo C, Pan Q, Su M, Li R. Clinical immunophenotype of nasopharyngeal neuroendocrine carcinoma with metastatic liver cancer. Clin Chim Acta. 2017;471:283\u20135.","journal-title":"Clin Chim Acta"},{"issue":"12","key":"963_CR12","first-page":"E14","volume":"87","author":"AR Mohebbi","year":"2008","unstructured":"Mohebbi AR, Daneshi A, Emami AR. Nasopharyngeal neuroendocrine carcinoma: a case report. Ear Nose Throat J. 2008;87(12):E14.","journal-title":"Ear Nose Throat J"},{"issue":"1","key":"963_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/1871526516666160407113536","volume":"16","author":"OO Ozoya","year":"2016","unstructured":"Ozoya OO, Sokol L, Dalia S. EBV-related malignancies, outcomes and novel prevention strategies. Infect Disord Drug Targets. 2016;16(1):4\u201321.","journal-title":"Infect Disord Drug Targets"},{"issue":"3","key":"963_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s12105-010-0188-0","volume":"4","author":"JS Lewis Jr","year":"2010","unstructured":"Lewis JS Jr, Spence DC, Chiosea S, Barnes EL Jr, Brandwein-Gensler M, El-Mofty SK. Large cell neuroendocrine carcinoma of the larynx: definition of an entity. Head Neck Pathol. 2010;4(3):198\u2013207.","journal-title":"Head Neck Pathol"},{"issue":"5","key":"963_CR15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/PAS.0000000000001037","volume":"42","author":"LM Rooper","year":"2018","unstructured":"Rooper LM, Bishop JA, Westra WH. INSM1 is a sensitive and specific marker of neuroendocrine differentiation in head and neck tumors. Am J Surg Pathol. 2018;42(5):665\u201371.","journal-title":"Am J Surg Pathol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-018-0963-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-018-0963-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-018-0963-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T20:43:31Z","timestamp":1661978611000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-018-0963-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["963"],"URL":"https:\/\/doi.org\/10.1007\/s12105-018-0963-x","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]},"assertion":[{"value":"16 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None of the authors have any conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}