{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:30:27Z","timestamp":1778200227910,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s12105-019-01055-9","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T15:55:57Z","timestamp":1564415757000},"page":"554-558","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-3456","authenticated-orcid":false,"given":"Niels J.","family":"Rupp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Brada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Sk\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina A.","family":"Broglie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire B.","family":"Morand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rechsteiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra N.","family":"Freiberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"issue":"1","key":"1055_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/01.pas.0000213314.74423.d8","volume":"31","author":"RR Seethala","year":"2007","unstructured":"Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31(1):44\u201357. \nhttps:\/\/doi.org\/10.1097\/01.pas.0000213314.74423.d8\n\n.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1055_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1159\/000331363","volume":"43","author":"GC Yang","year":"1999","unstructured":"Yang GC, Soslow RA. Epithelial-myoepithelial carcinoma of the parotid. A case of ductal-predominant presentation with cytologic, histologic and ultrastructural correlations. Acta Cytol. 1999;43(6):1113\u20138. \nhttps:\/\/doi.org\/10.1159\/000331363\n\n.","journal-title":"Acta Cytol"},{"issue":"1","key":"1055_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/PAS.0000000000000933","volume":"42","author":"S El Hallani","year":"2018","unstructured":"El Hallani S, Udager AM, Bell D, Fonseca I, Thompson LDR, Assaad A, et al. Epithelial-myoepithelial carcinoma: frequent morphologic and molecular evidence of preexisting pleomorphic adenoma, common HRAS mutations in PLAG1-intact and HMGA2-intact cases, and occasional TP53, FBXW7, and SMARCB1 alterations in high-grade cases. Am J Surg Pathol. 2018;42(1):18\u201327. \nhttps:\/\/doi.org\/10.1097\/PAS.0000000000000933\n\n.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1055_CR4","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1043\/1543-2165-133.6.950","volume":"133","author":"RR Seethala","year":"2009","unstructured":"Seethala RR, Richmond JA, Hoschar AP, Barnes EL. New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine. Arch Pathol Lab Med. 2009;133(6):950\u20139. \nhttps:\/\/doi.org\/10.1043\/1543-2165-133.6.950\n\n.","journal-title":"Arch Pathol Lab Med"},{"issue":"Suppl 1","key":"1055_CR5","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1007\/s12105-013-0461-0","volume":"7","author":"RR Seethala","year":"2013","unstructured":"Seethala RR. Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor. Head Neck Pathol. 2013;7(Suppl 1):S77\u201384. \nhttps:\/\/doi.org\/10.1007\/s12105-013-0461-0\n\n.","journal-title":"Head Neck Pathol."},{"issue":"2","key":"1055_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s12105-013-0506-4","volume":"8","author":"SI Chiosea","year":"2014","unstructured":"Chiosea SI, Miller M, Seethala RR. HRAS mutations in epithelial-myoepithelial carcinoma. Head Neck Pathol. 2014;8(2):146\u201350. \nhttps:\/\/doi.org\/10.1007\/s12105-013-0506-4\n\n.","journal-title":"Head Neck Pathol."},{"key":"1055_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001258","author":"M Urano","year":"2019","unstructured":"Urano M, Nakaguro M, Yamamoto Y, Hirai H, Tanigawa M, Saigusa N, et al. Diagnostic significance of HRAS mutations in epithelial-myoepithelial carcinomas exhibiting a broad histopathologic spectrum. Am J Surg Pathol. 2019. \nhttps:\/\/doi.org\/10.1097\/PAS.0000000000001258\n\n.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1055_CR8","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1038\/s41467-018-04128-5","volume":"9","author":"FC Geyer","year":"2018","unstructured":"Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, et al. Recurrent hotspot mutations in HRAS Q61 and PI3\u00a0K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018;9(1):1816. \nhttps:\/\/doi.org\/10.1038\/s41467-018-04128-5\n\n.","journal-title":"Nat Commun."},{"key":"1055_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41523-018-0101-7","volume":"5","author":"F Pareja","year":"2019","unstructured":"Pareja F, Geyer FC, Brown DN, Sebastiao APM, Gularte-Merida R, Li A, et al. Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas. NPJ Breast Cancer. 2019;5:6. \nhttps:\/\/doi.org\/10.1038\/s41523-018-0101-7\n\n.","journal-title":"NPJ Breast Cancer."},{"issue":"1","key":"1055_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1158\/2159-8290.CD-12-0361","volume":"3","author":"JN Wu","year":"2013","unstructured":"Wu JN, Roberts CW. ARID1A mutations in cancer: another epigenetic tumor suppressor? Cancer Discov. 2013;3(1):35\u201343. \nhttps:\/\/doi.org\/10.1158\/2159-8290.CD-12-0361\n\n.","journal-title":"Cancer Discov"},{"issue":"16","key":"1055_CR11","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1056\/NEJMoa1008433","volume":"363","author":"KC Wiegand","year":"2010","unstructured":"Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med. 2010;363(16):1532\u201343. \nhttps:\/\/doi.org\/10.1056\/NEJMoa1008433\n\n.","journal-title":"N Engl J Med"},{"issue":"10","key":"1055_CR12","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/gcc.22195","volume":"53","author":"I Weinreb","year":"2014","unstructured":"Weinreb I, Zhang L, Tirunagari LM, Sung YS, Chen CL, Perez-Ordonez B, et al. Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. Genes Chromosomes Cancer. 2014;53(10):845\u201356. \nhttps:\/\/doi.org\/10.1002\/gcc.22195\n\n.","journal-title":"Genes Chromosomes Cancer"},{"key":"1055_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/his.13854","author":"APM Sebastiao","year":"2019","unstructured":"Sebastiao APM, Pareja F, Kumar R, Brown DN, Silveira C, da Silva EM, et al. Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinomas. Histopathology. 2019. \nhttps:\/\/doi.org\/10.1111\/his.13854\n\n.","journal-title":"Histopathology"},{"issue":"6","key":"1055_CR14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nm.4333","volume":"23","author":"A Zehir","year":"2017","unstructured":"Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017;23(6):703\u201313. \nhttps:\/\/doi.org\/10.1038\/nm.4333\n\n.","journal-title":"Nat Med"},{"issue":"6001","key":"1055_CR15","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1126\/science.1196333","volume":"330","author":"S Jones","year":"2010","unstructured":"Jones S, Wang TL, Shih Ie M, Mao TL, Nakayama K, Roden R, et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 2010;330(6001):228\u201331. \nhttps:\/\/doi.org\/10.1126\/science.1196333\n\n.","journal-title":"Science"},{"key":"1055_CR16","doi-asserted-by":"publisher","first-page":"13837","DOI":"10.1038\/ncomms13837","volume":"7","author":"CT Williamson","year":"2016","unstructured":"Williamson CT, Miller R, Pemberton HN, Jones SE, Campbell J, Konde A, et al. ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Nat Commun. 2016;7:13837. \nhttps:\/\/doi.org\/10.1038\/ncomms13837\n\n.","journal-title":"Nat Commun."},{"issue":"7","key":"1055_CR17","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1158\/2159-8290.CD-14-0849","volume":"5","author":"J Shen","year":"2015","unstructured":"Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, et al. ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors. Cancer Discov. 2015;5(7):752\u201367. \nhttps:\/\/doi.org\/10.1158\/2159-8290.CD-14-0849\n\n.","journal-title":"Cancer Discov"},{"issue":"14","key":"1055_CR18","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.18632\/oncotarget.2092","volume":"5","author":"EP Samartzis","year":"2014","unstructured":"Samartzis EP, Gutsche K, Dedes KJ, Fink D, Stucki M, Imesch P. Loss of ARID1A expression sensitizes cancer cells to PI3\u00a0K- and AKT-inhibition. Oncotarget. 2014;5(14):5295\u2013303. \nhttps:\/\/doi.org\/10.18632\/oncotarget.2092\n\n.","journal-title":"Oncotarget."}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01055-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-019-01055-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01055-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:17:15Z","timestamp":1594682235000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-019-01055-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1055"],"URL":"https:\/\/doi.org\/10.1007\/s12105-019-01055-9","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]},"assertion":[{"value":"2 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that no competing financial interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The patient provided a written informed consent in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}