{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:51Z","timestamp":1791919071211,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12105-019-01099-x","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T13:03:11Z","timestamp":1574946191000},"page":"701-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Primary Thyroid Gland Alveolar Soft Part Sarcoma"],"prefix":"10.1007","volume":"14","author":[{"given":"Rumeal D.","family":"Whaley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3714-1432","authenticated-orcid":false,"given":"Lester D. R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"1099_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/jso.24183","volume":"113","author":"H Wang","year":"2016","unstructured":"Wang H, Jacobson A, Harmon DC, Choy E, Hornicek FJ, Raskin KA, Chebib IA, DeLaney TF, Chen YL. Prognostic factors in alveolar soft part sarcoma: a SEER analysis. J Surg Oncol. 2016;113:581\u20136.","journal-title":"J Surg Oncol."},{"key":"1099_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/sj.onc.1204074","volume":"20","author":"M Ladanyi","year":"2001","unstructured":"Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, Healey JH, Ueda T, Yoshikawa H, Meloni-Ehrig A, Sorensen PH, Mertens F, Mandahl N, van den Berghe H, Sciot R, Dal Cin P, Bridge J. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene. 2001;20:48\u201357.","journal-title":"Oncogene."},{"key":"1099_CR3","volume-title":"WHO classification of tumours of soft tissue and bone","author":"NG Ord\u00f3\u00f1ez","year":"2017","unstructured":"Ord\u00f3\u00f1ez NG, Ladanyi M. Alveolar soft part sarcoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. Lyon: IARC; 2017."},{"key":"1099_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/1097-0142(20010201)91:3<585::AID-CNCR1038>3.0.CO;2-0","volume":"91","author":"CA Portera Jr","year":"2001","unstructured":"Portera CA Jr, Ho V, Patel SR, Hunt KK, Feig BW, Respondek PM, Yasko AW, Benjamin RS, Pollock RE, Pisters PW. Alveolar soft part sarcoma: clinical course and patterns of metastasis in 70 patients treated at a single institution. Cancer. 2001;91:585\u201391.","journal-title":"Cancer."},{"key":"1099_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jpedsurg.2005.10.023","volume":"41","author":"ML Kayton","year":"2006","unstructured":"Kayton ML, Meyers P, Wexler LH, Gerald WL, LaQuaglia MP. Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. J Pediatr Surg. 2006;41:187\u201393.","journal-title":"J Pediatr Surg."},{"key":"1099_CR6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1365-2559.2004.01966.x","volume":"45","author":"JC Fanburg-Smith","year":"2004","unstructured":"Fanburg-Smith JC, Miettinen M, Folpe AL, Weiss SW, Childers EL. Lingual alveolar soft part sarcoma; 14 cases: novel clinical and morphological observations. Histopathology. 2004;45:526\u201337.","journal-title":"Histopathology."},{"key":"1099_CR7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1046\/j.1365-2559.1999.035005411.x","volume":"35","author":"YK Park","year":"1999","unstructured":"Park YK, Unni KK, Kim YW, Han CS, Yang MH, Wenger DE, Sim FH, Lucas DR, Ryan JR, Nadim YA, Nojima T, Fletcher CD. Primary alveolar soft part sarcoma of bone. Histopathology. 1999;35:411\u20137.","journal-title":"Histopathology."},{"key":"1099_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1177\/106689690501300112","volume":"13","author":"J Wu","year":"2005","unstructured":"Wu J, Brinker DA, Haas M, Montgomery EA, Argani P. Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy. Int J Surg Pathol. 2005;13:81\u20135.","journal-title":"Int J Surg Pathol."},{"key":"1099_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1097\/00004347-199510000-00001","volume":"14","author":"GP Nielsen","year":"1995","unstructured":"Nielsen GP, Oliva E, Young RH, Rosenberg AE, Dickersin GR, Scully RE. Alveolar soft-part sarcoma of the female genital tract: a report of nine cases and review of the literature. Int J Gynecol Pathol. 1995;14:283\u201392.","journal-title":"Int J Gynecol Pathol."},{"key":"1099_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2350\/06-12-0199.1","volume":"11","author":"J Luo","year":"2008","unstructured":"Luo J, Melnick S, Rossi A, Burke RP, Pfeifer JD, Dehner LP. Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration. Pediatr Dev Pathol. 2008;11:142\u20137.","journal-title":"Pediatr Dev Pathol."},{"key":"1099_CR11","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1002\/hed.20766","volume":"30","author":"K Kusafuka","year":"2008","unstructured":"Kusafuka K, Muramatsu K, Yabuzaki T, Ishiki H, Asano R, Kamijo T, Iida Y, Ebihara M, Onitsuka T, Kameya T. Alveolar soft part sarcoma of the larynx: a case report of an unusual location with immunohistochemical and ultrastructural analyses. Head Neck. 2008;30:1257\u201363.","journal-title":"Head Neck."},{"key":"1099_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/000313480807400109","volume":"74","author":"KK Shaddix","year":"2008","unstructured":"Shaddix KK, Fakhre GP, Nields WW, Steers JL, Hewitt WR, Menke DM. Primary alveolar soft-part sarcoma of the liver: anomalous presentation of a rare disease. Am Surg. 2008;74:43\u20136.","journal-title":"Am Surg."},{"key":"1099_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/106689699400200110","volume":"2","author":"H Sonobe","year":"1994","unstructured":"Sonobe H, Ro JY, Mackay B, Ord\u00f3\u00f1ez NG, Rundell MM, Ayala AG. Primary pulmonary alveolar soft-part sarcoma: report of a case. Int J Surg Pathol. 1994;2:57\u201361.","journal-title":"Int J Surg Pathol."},{"key":"1099_CR14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0344-0338(00)80054-0","volume":"196","author":"H Yaziji","year":"2000","unstructured":"Yaziji H, Ranaldi R, Verdolini R, Morroni M, Haggitt R, Bearzi I. Primary alveolar soft part sarcoma of the stomach: a case report and review. Pathol Res Pract. 2000;196:519\u201325.","journal-title":"Pathol Res Pract."},{"key":"1099_CR15","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1097\/01.pas.0000213298.34520.2b","volume":"30","author":"MB Amin","year":"2006","unstructured":"Amin MB, Patel RM, Oliveira P, Cabrera R, Carneiro V, Preto M, Balzer B, Folpe AL. Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence: a unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3. Am J Surg Pathol. 2006;30:1322\u20135.","journal-title":"Am J Surg Pathol."},{"key":"1099_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1097-0142(19890101)63:1<1::AID-CNCR2820630102>3.0.CO;2-E","volume":"63","author":"PH Lieberman","year":"1989","unstructured":"Lieberman PH, Brennan MF, Kimmel M, Erlandson RA, Garin-Chesa P, Flehinger BY. Alveolar soft-part sarcoma. A clinico-pathologic study of half a century. Cancer. 1989;63:1\u201313.","journal-title":"Cancer."},{"key":"1099_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22803","author":"BC Dickson","year":"2019","unstructured":"Dickson BC, Chung CT, Hurlbut DJ, Marrano P, Shago M, Sung YS, Swanson D, Zhang L, Antonescu CR. Genetic diversity in alveolar soft part sarcoma: a subset contain variant fusion genes, highlighting broader molecular kinship with other MiT family tumors. Genes Chromosom Cancer. 2019. https:\/\/doi.org\/10.1002\/gcc.22803.","journal-title":"Genes Chromosom Cancer."},{"key":"1099_CR18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/modpathol.2013.208","volume":"27","author":"CL Ellis","year":"2014","unstructured":"Ellis CL, Eble JN, Subhawong AP, Martignoni G, Zhong M, Ladanyi M, Epstein JI, Netto GJ, Argani P. Clinical heterogeneity of Xp11 translocation renal cell carcinoma: impact of fusion subtype, age, and stage. Mod Pathol. 2014;27:875\u201386.","journal-title":"Mod Pathol."},{"key":"1099_CR19","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1097\/PAS.0b013e3181f17ac0","volume":"34","author":"P Argani","year":"2010","unstructured":"Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW. A distinctive subset of PEComas harbors TFE3 gene fusions. Am J Surg Pathol. 2010;34:1395\u2013406.","journal-title":"Am J Surg Pathol."},{"key":"1099_CR20","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.humpath.2013.12.021","volume":"45","author":"BK Chamberlain","year":"2014","unstructured":"Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM. Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study. Hum Pathol. 2014;45:1039\u201344.","journal-title":"Hum Pathol."},{"key":"1099_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/PAT.0b013e32834d7ba4","volume":"44","author":"B Rekhi","year":"2012","unstructured":"Rekhi B, Ingle A, Agarwal M, Puri A, Laskar S, Jambhekar NA. Alveolar soft part sarcoma \u2018revisited\u2019: clinicopathological review of 47 cases from a tertiary cancer referral centre, including immunohistochemical expression of TFE3 in 22 cases and 21 other tumours. Pathology. 2012;44:11\u20137.","journal-title":"Pathology."},{"key":"1099_CR22","first-page":"895","volume":"36","author":"K Ogawa","year":"1986","unstructured":"Ogawa K, Nakashima Y, Yamabe H, Hamashima Y. Alveolar soft part sarcoma, granular cell tumor, and paraganglioma. An immunohistochemical comparative study. Acta Pathol Jpn. 1986;36:895\u2013904.","journal-title":"Acta Pathol Jpn."},{"key":"1099_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/ajcp\/aqx142","volume":"149","author":"G Harrison","year":"2017","unstructured":"Harrison G, Hemmerich A, Guy C, Perkinson K, Fleming D, McCall S, Cardona D, Zhang X. Overexpression of SOX11 and TFE3 in solid-pseudopapillary neoplasms of the pancreas. Am J Clin Pathol. 2017;149:67\u201375.","journal-title":"Am J Clin Pathol."},{"key":"1099_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00428-010-1039-9","volume":"458","author":"A Williams","year":"2011","unstructured":"Williams A, Bartle G, Sumathi VP, Meis JM, Mangham DC, Grimer RJ, Kindblom LG. Detection of ASPL\/TFE3 fusion transcripts and the TFE3 antigen in formalin-fixed, paraffin-embedded tissue in a series of 18 cases of alveolar soft part sarcoma: useful diagnostic tools in cases with unusual histological features. Virchows Arch. 2011;458:291\u2013300.","journal-title":"Virchows Arch."},{"key":"1099_CR25","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/PAS.0000000000000511","volume":"40","author":"LA Doyle","year":"2016","unstructured":"Doyle LA, Fletcher CD, Hornick JL. Nuclear expression of CAMTA1 distinguishes epithelioid hemangioendothelioma from histologic mimics. Am J Surg Pathol. 2016;40:94\u2013102.","journal-title":"Am J Surg Pathol."},{"key":"1099_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0002-9440(10)61684-7","volume":"159","author":"P Argani","year":"2001","unstructured":"Argani P, Antonescu CR, Illei PB, Lui MY, Timmons CF, Newbury R, Reuter VE, Garvin AJ, Perez-Atayde AR, Fletcher JA, Beckwith JB, Bridge JA, Ladanyi M. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol. 2001;159:179\u201392.","journal-title":"Am J Pathol."},{"key":"1099_CR27","volume-title":"WHO classification of tumours of endocrine organs","author":"V LiVolsi","year":"2017","unstructured":"LiVolsi V, Abdulkader Nallib I, Baloch ZW, Bartolazzi A, Chan JKC, DeLellis RA, El-Naggar AK. Follicular thyroid carcinoma. In: Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J, editors. WHO classification of tumours of endocrine organs. Lyon: IARC; 2017."},{"key":"1099_CR28","volume-title":"WHO classification of tumours of endocrine organs","author":"RA DeLellis","year":"2017","unstructured":"DeLellis RA, Al Ghuzlan A, Albores Saavedra J, Baloch ZW, Basolo F, Elisei R, Kaserer K, LiVolsi V, Matias-Guiu X, Mete O, Moley JF, Nikiforov YE, Nos\u00e9 V, Pinto AE. Medullary thyroid carcinoma. In: Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J, editors. WHO classification of tumours of endocrine organs. Lyon: IARC; 2017."},{"key":"1099_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12022-011-9146-y","volume":"22","author":"M Bowry","year":"2011","unstructured":"Bowry M, Almeida B, Jeannon JP. Granular cell tumour of the thyroid gland: a case report and review of the literature. Endocr Pathol. 2011;22:1\u20135.","journal-title":"Endocr Pathol."},{"key":"1099_CR30","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1097\/PAS.0b013e3181e8ce5b","volume":"34","author":"P Argani","year":"2010","unstructured":"Argani P, Hicks J, De Marzo AM, Albadine R, Illei PB, Ladanyi M, Reuter VE, Netto GJ. Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers. Am J Surg Pathol. 2010;34:1295\u2013303.","journal-title":"Am J Surg Pathol."},{"key":"1099_CR31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/COC.0000000000000295","volume":"41","author":"MR Pelizzo","year":"2018","unstructured":"Pelizzo MR, Conti C, Pennelli G, Bellan E, Cook GJ, Wong KK, Colletti PM, Merante Boschin I, Rubello D. Thyroid Paraganglioma: our experience and systematic review of the literature on a rare tumor. Am J Clin Oncol. 2018;41:416\u201323.","journal-title":"Am J Clin Oncol."},{"key":"1099_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humpath.2009.05.011","volume":"41","author":"AL Folpe","year":"2010","unstructured":"Folpe AL, Kwiatkowski DJ. Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol. 2010;41:1\u201315.","journal-title":"Hum Pathol."},{"key":"1099_CR33","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1600-0560.2007.00891.x","volume":"35","author":"SJ Ohsie","year":"2008","unstructured":"Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35:433\u201344.","journal-title":"J Cutan Pathol."},{"key":"1099_CR34","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12105-011-0326-3","volume":"6","author":"S Dogan","year":"2012","unstructured":"Dogan S, Barnes L, Cruz-Vetrano WP. Crystal-storing histiocytosis: report of a case, review of the literature (80 cases) and a proposed classification. Head Neck Pathol. 2012;6:111\u201320.","journal-title":"Head Neck Pathol."},{"key":"1099_CR35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/jcp.56.6.412","volume":"56","author":"NJ Sebire","year":"2003","unstructured":"Sebire NJ, Malone M. Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. J Clin Pathol. 2003;56:412\u20136.","journal-title":"J Clin Pathol."},{"key":"1099_CR36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/dc.21033","volume":"37","author":"B Jin","year":"2009","unstructured":"Jin B, Saleh H. Pitfalls in the diagnosis of adult rhabdomyoma by fine needle aspiration: report of a case and a brief literature review. Diagn Cytopathol. 2009;37:483\u20136.","journal-title":"Diagn Cytopathol."},{"key":"1099_CR37","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/cncr.10901","volume":"95","author":"CS Heffess","year":"2002","unstructured":"Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer. 2002;95:1869\u201378.","journal-title":"Cancer."}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01099-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-019-01099-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01099-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T10:00:31Z","timestamp":1612692031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-019-01099-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1099"],"URL":"https:\/\/doi.org\/10.1007\/s12105-019-01099-x","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,28]]},"assertion":[{"value":"21 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare that they have no conflict of interest as it relates to this research project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this case report involving human participants were in accordance with the ethical standards of the institutional review board (IRB #5968), which did not require informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}