{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:40:31Z","timestamp":1782506431528,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12105-019-01120-3","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T13:00:35Z","timestamp":1577970035000},"page":"1094-1104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adenoid Cystic Carcinoma with Transformation to High Grade Carcinomatous and Sarcomatoid Components: A Rare Case Report with Review of Literature"],"prefix":"10.1007","volume":"14","author":[{"given":"Anupurva","family":"Dutta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattatheyil","family":"Arun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-6757","authenticated-orcid":false,"given":"Indu","family":"Arun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"issue":"1","key":"1120_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/PCR.0000000000000076","volume":"20","author":"F Petersson","year":"2015","unstructured":"Petersson F. High-grade transformation (\u201cdedifferentiation\u201d)\u2014malignant progression of salivary gland neoplasms, including carcinoma ex pleomorphic adenoma. Pathol Case Rev. 2015;20(1):27\u201337.","journal-title":"Pathol Case Rev."},{"issue":"2","key":"1120_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/1097-0142(197108)28:2<461::AID-CNCR2820280227>3.0.CO;2-U","volume":"28","author":"DC Dahlin","year":"1971","unstructured":"Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer. 1971;28(2):461\u20136.","journal-title":"Cancer"},{"issue":"4","key":"1120_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/00000478-199904000-00012","volume":"23","author":"W Cheuk","year":"1999","unstructured":"Cheuk W, Chan JK, Ngan RK. Dedifferentiation in adenoid cystic carcinoma of salivary gland: an uncommon complication associated with an accelerated clinical course. Am J Surg Pathol. 1999;23(4):465\u201372.","journal-title":"Am J Surg Pathol."},{"issue":"11","key":"1120_CR4","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1097\/PAS.0b013e3180dc928c","volume":"31","author":"RR Seethala","year":"2007","unstructured":"Seethala RR, Hunt JL, Baloch ZW, LiVolsi VA, Leon BE. Adenoid cystic carcinoma with high-grade transformation. Am J Surg Pathol. 2007;31(11):1683\u201394.","journal-title":"Am J Surg Pathol."},{"issue":"5","key":"1120_CR5","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1097\/IOP.0b013e318201cb90","volume":"27","author":"JF Panarelli","year":"2011","unstructured":"Panarelli JF, Zoumalan CI, Mukkamala K, Maher EA, Iacob C, Della Rocca DA. Dedifferentiated adenoid cystic carcinoma of the lacrimal gland. Ophthalmic Plast Reconstr Surg. 2011;27(5):e119\u2013e12121.","journal-title":"Ophthalmic Plast Reconstr Surg."},{"issue":"2","key":"1120_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/pin.12624","volume":"68","author":"S Tando","year":"2018","unstructured":"Tando S, Nagao T, Kayano K, Fushiki S, Itoh K. High-grade transformation\/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma. Pathol Int. 2018;68(2):133\u20138.","journal-title":"Pathol Int."},{"issue":"11","key":"1120_CR7","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1001\/archotol.129.11.1193","volume":"129","author":"M-W Sung","year":"2003","unstructured":"Sung M-W, Kim KH, Kim J-W, Min Y-G, Seong W-J, Roh J-L, et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Neck Surg. 2003;129(11):1193.","journal-title":"Arch Otolaryngol Neck Surg."},{"key":"1120_CR8","first-page":"164","volume-title":"WHO classification of head and neck tumours","author":"AK El-Naggar","year":"2017","unstructured":"AK El-Naggar, JKC Chan, JR Grandis, Takashi TPJS. WHO classification of head and neck tumours, 4 ed - WHO. IARC, Lyon. 2017.p. 164\u20135.","edition":"4"},{"issue":"6","key":"1120_CR9","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/1097-0142(19840915)54:6<1062::AID-CNCR2820540622>3.0.CO;2-E","volume":"54","author":"PA Szanto","year":"1984","unstructured":"Szanto PA, Luna MA, Tortoledo ME, White RA. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54(6):1062\u20139.","journal-title":"Cancer"},{"issue":"4","key":"1120_CR10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s13402-011-0037-5","volume":"34","author":"AF Costa","year":"2011","unstructured":"Costa AF, Altemani A, V\u00e9kony H, Bloemena E, Fresno F, Su\u00e1rez C, et al. Genetic profile of adenoid cystic carcinomas (ACC) with high-grade transformation versus solid type. Cell Oncol. 2011;34(4):369\u201379.","journal-title":"Cell Oncol."},{"issue":"3","key":"1120_CR11","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s12325-016-0298-5","volume":"33","author":"H Hellquist","year":"2016","unstructured":"Hellquist H, Sk\u00e1lov\u00e1 A, Barnes L, Cardesa A, Thompson LDR, Triantafyllou A, et al. Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: a collective international review. Adv Ther. 2016;33(3):357\u201368.","journal-title":"Adv Ther."},{"issue":"4","key":"1120_CR12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12105-009-0122-5","volume":"3","author":"K Preet","year":"2009","unstructured":"Preet K, Ae M, Ae VA, Pandey R. High grade transformation in adenoid cystic carcinoma of the parotid: report of a case with cytologic, histologic and immunohistochemical study. Head Neck Pathol. 2009;3(4):310\u20134.","journal-title":"Head Neck Pathol."},{"issue":"7","key":"1120_CR13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/PAT.0000000000000012","volume":"45","author":"CK Ly","year":"2013","unstructured":"Ly CK, Cheng HM, Vermeulen T. High grade transformation in a case of adenoid cystic carcinoma associated with Epstein-Barr virus expression. Pathology. 2013;45(7):693\u20135.","journal-title":"Pathology."},{"issue":"3","key":"1120_CR14","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4103\/0973-1482.179522","volume":"14","author":"M Bhardwaj","year":"2018","unstructured":"Bhardwaj M, Gupta P. Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. J Cancer Res Ther. 2018;14(3):706.","journal-title":"J Cancer Res Ther."},{"issue":"4","key":"1120_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0964-1955(95)00059-3","volume":"32B","author":"G Seifert","year":"1996","unstructured":"Seifert G, Donath K. Hybrid tumours of salivary glands. Definition and classification of five rare cases. Eur J Cancer B Oral Oncol. 1996;32B(4):251\u20139.","journal-title":"Eur J Cancer B Oral Oncol."},{"issue":"12","key":"1120_CR16","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1097\/01.MP.0000097366.88165.08","volume":"16","author":"T Nagao","year":"2003","unstructured":"Nagao T, Gaffey TA, Serizawa H, Sugano I, Ishida Y, Yamazaki K, et al. Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. Mod Pathol. 2003;16(12):1265\u201372.","journal-title":"Mod Pathol."},{"issue":"2","key":"1120_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s00428-005-0054-8","volume":"448","author":"K Sato","year":"2006","unstructured":"Sato K, Ueda Y, Sakurai A, Ishikawa Y, Kaji S, Nojima T, et al. Adenoid cystic carcinoma of the maxillary sinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report with dedifferentiated carcinoma. Virchows Arch. 2006;448(2):204\u20138.","journal-title":"Virchows Arch."},{"issue":"3","key":"1120_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/BF02484288","volume":"17","author":"M Terasaki","year":"2000","unstructured":"Terasaki M, Tokutomi T, Maruiwa H, Sugita Y, Harada H, Shigemori M. High-grade adenoid cystic carcinoma originating from the lacrimal gland. Brain Tumor Pathol. 2000;17(3):159\u201363.","journal-title":"Brain Tumor Pathol."},{"issue":"1","key":"1120_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12105-012-0383-2","volume":"7","author":"PP Argyris","year":"2013","unstructured":"Argyris PP, Pambuccian SE, Cayci Z, Singh C, Tosios KI, Koutlas IG. Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature. Head Neck Pathol. 2013;7(1):85\u201392.","journal-title":"Head Neck Pathol."},{"issue":"1","key":"1120_CR20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5858\/arpa.2014-0167-RA","volume":"139","author":"S Zhu","year":"2015","unstructured":"Zhu S, Schuerch C, Hunt J. Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. Arch Pathol Lab Med. 2015;139(1):55\u201366.","journal-title":"Arch Pathol Lab Med."},{"issue":"1","key":"1120_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.oraloncology.2005.12.026","volume":"43","author":"MR Pfeffer","year":"2007","unstructured":"Pfeffer MR, Talmi Y, Catane R, Symon Z, Yosepovitch A, Levitt M. A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. Oral Oncol. 2007;43(1):33\u20136.","journal-title":"Oral Oncol."},{"issue":"44","key":"1120_CR22","doi-asserted-by":"publisher","first-page":"18740","DOI":"10.1073\/pnas.0909114106","volume":"106","author":"M Persson","year":"2009","unstructured":"Persson M, Andr\u00e9n Y, Mark J, Horlings HM, Persson F, Stenman G. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA. 2009;106(44):18740\u20134.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1120_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.5858\/arpa.2016-0259-SA","volume":"141","author":"CC Griffith","year":"2017","unstructured":"Griffith CC, Schmitt AC, Little JL, Magliocca KR. New developments in salivary gland pathology: clinically useful ancillary testing and new potentially targetable molecular alterations. Arch Pathol Lab Med. 2017;141(3):381\u201395.","journal-title":"Arch Pathol Lab Med."},{"issue":"2","key":"1120_CR24","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1097\/PAS.0000000000000980","volume":"42","author":"A Sk\u00e1lov\u00e1","year":"2018","unstructured":"Sk\u00e1lov\u00e1 A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, et al. The role of molecular testing in the differential diagnosis of salivary gland carcinomas. Am J Surg Pathol. 2018;42(2):e11\u2013e27.","journal-title":"Am J Surg Pathol."},{"issue":"40","key":"1120_CR25","doi-asserted-by":"publisher","first-page":"66239","DOI":"10.18632\/oncotarget.11288","volume":"7","author":"PT Wysocki","year":"2016","unstructured":"Wysocki PT, Izumchenko E, Meir J, Ha PK, Sidransky D, Brait M. Adenoid cystic carcinoma: emerging role of translocations and gene fusions. Oncotarget. 2016;7(40):66239\u201354.","journal-title":"Oncotarget."},{"issue":"10","key":"1120_CR26","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1158\/2159-8290.CD-13-0830","volume":"4","author":"A Stoeck","year":"2014","unstructured":"Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, et al. Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov. 2014;4(10):1154\u201367.","journal-title":"Cancer Discov."},{"issue":"2","key":"1120_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1079-2104(99)70114-9","volume":"88","author":"MAG Moles","year":"1999","unstructured":"Moles MAG, Avila IR, Archilla AR. Dedifferentiation occurring in adenoid cystic carcinoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 1999;88(2):177\u201380.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol."},{"issue":"12","key":"1120_CR28","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1053\/hupa.2001.28966","volume":"32","author":"Y Chau","year":"2001","unstructured":"Chau Y, Hongyo T, Aozasa K, Chan JK. Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation. Hum Pathol. 2001;32(12):1403\u20137.","journal-title":"Hum Pathol."},{"issue":"6","key":"1120_CR29","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/j.1365-2559.2003.01682.x","volume":"43","author":"F Ide","year":"2003","unstructured":"Ide F, Mishima K, Saito I. Small foci of high-grade carcinoma cells in adenoid cystic carcinoma represent an incipient phase of dedifferentiation. Histopathology. 2003;43(6):604\u20136.","journal-title":"Histopathology"},{"issue":"2B","key":"1120_CR30","first-page":"1321","volume":"25","author":"S Brackrock","year":"2019","unstructured":"Brackrock S, Kr\u00fcll A, R\u00f6ser K, Schwarz R, Riethdorf L, Alberti W. Neutron therapy, prognostic factors and dedifferentiation of adenoid cystic carcinomas (ACC) of salivary glands. Anticancer Res. 2019;25(2B):1321\u20136.","journal-title":"Anticancer Res."},{"issue":"11","key":"1120_CR31","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1016\/j.oraloncology.2009.04.010","volume":"45","author":"A Handra-Luca","year":"2009","unstructured":"Handra-Luca A, Planchard D, Fouret P. Docetaxel-cisplatin-radiotherapy in adenoid cystic carcinoma with high-grade transformation. Oral Oncol. 2009;45(11):e208\u2013e209209.","journal-title":"Oral Oncol."},{"issue":"7","key":"1120_CR32","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1136\/jcp.2010.075390","volume":"63","author":"VL Bonfitto","year":"2010","unstructured":"Bonfitto VL, Demasi AP, Costa AF, Bonfitto JF, Araujo VC, Altemani A. High-grade transformation of adenoid cystic carcinomas: a study of the expression of GLUT1 glucose transporter and of mitochondrial antigen. J Clin Pathol. 2010;63(7):615\u20139.","journal-title":"J Clin Pathol."},{"issue":"4","key":"1120_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/modpathol.2011.186","volume":"25","author":"JM Boland","year":"2012","unstructured":"Boland JM, McPhail ED, Garc\u00eda JJ, Lewis JE, Schembri-Wismayer DJ. Detection of human papilloma virus and p16 expression in high-grade adenoid cystic carcinoma of the head and neck. Mod Pathol. 2012;25(4):529\u201336.","journal-title":"Mod Pathol."},{"issue":"3","key":"1120_CR34","doi-asserted-by":"publisher","first-page":"474","DOI":"10.4103\/0973-029X.125225","volume":"17","author":"R Bavle","year":"2013","unstructured":"Bavle R, D\u2032Mello S, Makarla S, Hosthor S. Dedifferentiation in adenoid cystic carcinoma. J Oral Maxillofac Pathol. 2013;17(3):474.","journal-title":"J Oral Maxillofac Pathol."},{"key":"1120_CR35","doi-asserted-by":"publisher","first-page":"333","DOI":"10.5152\/balkanmedj.2013.7220","volume":"30","author":"H Sayar","year":"2013","unstructured":"Sayar H, Sar\u0131o\u011flu S, Bakari\u015f S, Y\u0131ld\u0131r\u0131m \u0130, \u00d6ztarak\u00e7\u0131 H. High-grade transformation of adenoid cystic carcinoma delineated with a fibrous rim: a case report. Balkan Med J. 2013;30:333\u20136.","journal-title":"Balkan Med J."},{"issue":"1","key":"1120_CR36","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1746-1596-8-113","volume":"8","author":"K Kusafuka","year":"2013","unstructured":"Kusafuka K, Miki T, Nakajima T. Salivary adenoid cystic carcinoma with an early phase of high-grade transformation: case report with an immunohistochemical analysis. Diagn Pathol. 2013;8(1):113.","journal-title":"Diagn Pathol."},{"issue":"3","key":"1120_CR37","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1016\/j.oooo.2014.07.165","volume":"119","author":"Y Noda","year":"2015","unstructured":"Noda Y, Hori Y, Kishino M, Satou S, Ogawa Y, Harada H, et al. A case of dedifferentiated adenoid cystic carcinoma in submandibular gland: morphological and immunohistochemical features. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(3):e140.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01120-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-019-01120-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-019-01120-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T01:25:08Z","timestamp":1609464308000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-019-01120-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,2]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1120"],"URL":"https:\/\/doi.org\/10.1007\/s12105-019-01120-3","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,2]]},"assertion":[{"value":"4 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}