{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:19:47Z","timestamp":1792995587487,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s12105-020-01140-4","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T13:03:08Z","timestamp":1583154188000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Salivary Gland Cancer in the Era of Routine Next-Generation Sequencing"],"prefix":"10.1007","volume":"14","author":[{"given":"Emilija","family":"Todorovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-3549","authenticated-orcid":false,"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"1140_CR1","unstructured":"World Health Organization classification of tumours: pathology and genetics of head and neck tumours. 4th Edition [press release]. Lyon2017."},{"issue":"6","key":"1140_CR2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/1097-0142(195311)6:6<1065::AID-CNCR2820060602>3.0.CO;2-0","volume":"6","author":"FW Foote Jr","year":"1953","unstructured":"Foote FW Jr, Frazell EL. Tumors of the major salivary glands. Cancer. 1953;6(6):1065\u2013133.","journal-title":"Cancer"},{"issue":"2","key":"1140_CR3","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/PAS.0000000000000980","volume":"42","author":"A Skalova","year":"2018","unstructured":"Skalova A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, et al. The role of molecular testing in the differential diagnosis of salivary gland carcinomas. Am J Surg Pathol. 2018;42(2):e11\u2013e27.","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"1140_CR4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5858\/arpa.2016-0259-SA","volume":"141","author":"CC Griffith","year":"2017","unstructured":"Griffith CC, Schmitt AC, Little JL, Magliocca KR. New developments in salivary gland pathology: clinically useful ancillary testing and new potentially targetable molecular alterations. Arch Pathol Lab Med. 2017;141(3):381\u201395.","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"1140_CR5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/gcc.22690","volume":"58","author":"BC Dickson","year":"2019","unstructured":"Dickson BC, Swanson D. Targeted RNA sequencing: A routine ancillary technique in the diagnosis of bone and soft tissue neoplasms. Genes Chromosomes Cancer. 2019;58(2):75\u2013877.","journal-title":"Genes Chromosomes Cancer"},{"issue":"8","key":"1140_CR6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/PAS.0000000000001273","volume":"43","author":"JA Bishop","year":"2019","unstructured":"Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J, et al. Microsecretory adenocarcinoma: a novel salivary gland tumor characterized by a recurrent MEF2C-SS18 fusion. Am J Surg Pathol. 2019;43(8):1023\u201332.","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"1140_CR7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/PAS.0000000000001252","volume":"43","author":"NA Cipriani","year":"2019","unstructured":"Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, et al. Mucoepidermoid Carcinoma: A Comparison Of Histologic grading systems and relationship to MAML2 rearrangement and prognosis. Am J Surg Pathol. 2019;43(7):885\u201397.","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"1140_CR8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gcc.20881","volume":"50","author":"CR Antonescu","year":"2011","unstructured":"Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50(7):559\u201370.","journal-title":"Genes Chromosomes Cancer"},{"issue":"12","key":"1140_CR9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41571-018-0113-0","volume":"15","author":"E Cocco","year":"2018","unstructured":"Cocco E, Scaltriti M, Drilon A. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol. 2018;15(12):731\u201347.","journal-title":"Nat Rev Clin Oncol"},{"key":"1140_CR10","doi-asserted-by":"crossref","unstructured":"Santana T, Pavel A, Martinek P, Steiner P, Grossmann P, Baneckova M, et al. Biomarker Immunoprofile and molecular characteristics in salivary duct carcinoma: Clinicopathologic and prognostic implications. Hum Pathol. 2019.","DOI":"10.1016\/j.humpath.2019.08.009"},{"key":"1140_CR11","doi-asserted-by":"crossref","unstructured":"Thierauf J, Ramamurthy N, Jo VY, Robinson H, Frazier RP, Gonzalez J, et al. Clinically integrated molecular diagnostics in adenoid cystic carcinoma. Oncologist. 2019.","DOI":"10.1634\/theoncologist.2018-0515"},{"issue":"8","key":"1140_CR12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1056\/NEJMoa1714448","volume":"378","author":"A Drilon","year":"2018","unstructured":"Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, et al. Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med. 2018;378(8):731\u20139.","journal-title":"N Engl J Med"},{"issue":"4","key":"1140_CR13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S1470-2045(15)00583-5","volume":"17","author":"A Italiano","year":"2016","unstructured":"Italiano A, Di Mauro I, Rapp J, Pierron G, Auger N, Alberti L, et al. Clinical effect of molecular methods in sarcoma diagnosis (GENSARC): a prospective, multicentre, observational study. Lancet Oncol. 2016;17(4):532\u20138.","journal-title":"Lancet Oncol"},{"key":"1140_CR14","first-page":"10","volume":"99","author":"S Dogan","year":"2019","unstructured":"Dogan S. Novel rearrangements in salivary gland tumors detected by an RNA-based targeted next-generation sequencing assay. Lab Investig. 2019;99:10.","journal-title":"Lab Investig"},{"key":"1140_CR15","doi-asserted-by":"crossref","unstructured":"Solomon JP, Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, et al. NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls. Mod Pathol. 2019.","DOI":"10.1038\/s41379-019-0324-7"},{"issue":"13","key":"1140_CR16","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1158\/0008-5472.CAN-19-0372","volume":"79","author":"JP Solomon","year":"2019","unstructured":"Solomon JP, Hechtman JF. Detection of NTRK fusions: merits and limitations of current diagnostic platforms. Cancer Res. 2019;79(13):3163\u20138.","journal-title":"Cancer Res"},{"issue":"1","key":"1140_CR17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jmoldx.2016.10.002","volume":"19","author":"MM Li","year":"2017","unstructured":"Li MM, Datto M, Duncavage EJ, Kulkarni S, Lindeman NI, Roy S, et al. Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the association for molecular pathology, american society of clinical oncology, and college of american pathologists. J Mol Diagn. 2017;19(1):4\u201323.","journal-title":"J Mol Diagn"},{"issue":"2","key":"1140_CR18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/PAS.0000000000000538","volume":"40","author":"R Alaggio","year":"2016","unstructured":"Alaggio R, Zhang L, Sung YS, Huang SC, Chen CL, Bisogno G, et al. A molecular study of pediatric spindle and sclerosing rhabdomyosarcoma: identification of novel and recurrent VGLL2-related fusions in infantile cases. Am J Surg Pathol. 2016;40(2):224\u201335.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1140_CR19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/path.2327","volume":"215","author":"E Moller","year":"2008","unstructured":"Moller E, Stenman G, Mandahl N, Hamberg H, Molne L, van den Oord JJ, et al. POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol. 2008;215(1):78\u201386.","journal-title":"J Pathol"},{"issue":"12","key":"1140_CR20","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.humpath.2011.02.028","volume":"42","author":"JJ Garcia","year":"2011","unstructured":"Garcia JJ, Hunt JL, Weinreb I, McHugh JB, Barnes EL, Cieply K, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagnostic test. Hum Pathol. 2011;42(12):2001\u20139.","journal-title":"Hum Pathol"},{"issue":"1","key":"1140_CR21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/PAS.0000000000000932","volume":"42","author":"JA Bishop","year":"2018","unstructured":"Bishop JA, Cowan ML, Shum CH, Westra WH. MAML2 rearrangements in variant forms of mucoepidermoid carcinoma: ancillary diagnostic testing for the ciliated and warthin-like variants. Am J Surg Pathol. 2018;42(1):130\u20136.","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"1140_CR22","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/PAS.0b013e3181de3021","volume":"34","author":"RR Seethala","year":"2010","unstructured":"Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN. A reappraisal of the MECT1\/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 2010;34(8):1106\u201321.","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1140_CR23","first-page":"530","volume":"121","author":"PP Luk","year":"2016","unstructured":"Luk PP, Wykes J, Selinger CI, Ekmejian R, Tay J, Gao K, et al. Diagnostic and prognostic utility of Mastermind-like 2 (MAML2) gene rearrangement detection by fluorescent in situ hybridization (FISH) in mucoepidermoid carcinoma of the salivary glands. Oral Surg. 2016;121(5):530\u201341.","journal-title":"Oral Surg"},{"issue":"1","key":"1140_CR24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1158\/1078-0432.CCR-16-0720","volume":"23","author":"H Kang","year":"2017","unstructured":"Kang H, Tan M, Bishop JA, Jones S, Sausen M, Ha PK, et al. Whole-exome sequencing of salivary gland mucoepidermoid carcinoma. Clin Cancer Res. 2017;23(1):283\u20138.","journal-title":"Clin Cancer Res"},{"key":"1140_CR25","doi-asserted-by":"crossref","unstructured":"Lee H, Roh JL, Choi YJ, Choi J, Cho KJ. High grade transformation in mucoepidermoid carcinoma of the minor salivary gland with polyploidy of the rearranged MAML2 gene. Head Neck Pathol. 2019.","DOI":"10.1007\/s12105-019-01064-8"},{"issue":"7","key":"1140_CR26","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/j.bjoms.2012.07.010","volume":"51","author":"S Doumas","year":"2013","unstructured":"Doumas S, Barrett AW, Carrillo M, Tighe JV. Synchronous metastatic adenoid cystic and squamous cell carcinoma of the cervical lymph nodes 31 years after ablation of the primary palatal tumour. Br J Oral Maxillofac Surg. 2013;51(7):e190\u2013e191191.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"10","key":"1140_CR27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-0714.1994.tb00445.x","volume":"23","author":"JE van der Wal","year":"1994","unstructured":"van der Wal JE, Snow GB, Karim AB, van der Waal I. Adenoid cystic carcinoma of the palate with squamous metaplasia or basaloid-squamous carcinoma? Report of a case. J Oral Pathol Med. 1994;23(10):461\u20134.","journal-title":"J Oral Pathol Med"},{"issue":"7","key":"1140_CR28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","volume":"51","author":"A Coca-Pelaz","year":"2015","unstructured":"Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL, et al. Adenoid cystic carcinoma of the head and neck\u2014An update. Oral Oncol. 2015;51(7):652\u201361.","journal-title":"Oral Oncol"},{"issue":"5","key":"1140_CR29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/PAS.0b013e3181d9efcc","volume":"34","author":"A Skalova","year":"2010","unstructured":"Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34(5):599\u2013608.","journal-title":"Am J Surg Pathol"},{"key":"1140_CR30","doi-asserted-by":"publisher","DOI":"10.1111\/his.13981","author":"B Xu","year":"2019","unstructured":"Xu B, Haroon Al Rasheed MR, Antonescu CR, Alex D, Frosina D, Ghossein R, et al. Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool in diagnosing secretory carcinoma of salivary gland and detecting ETV6-NTRK3 fusion. Histopathology. 2019. https:\/\/doi.org\/10.1111\/his.13981.","journal-title":"Histopathology"},{"issue":"18","key":"1140_CR31","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1158\/1078-0432.CCR-16-0637","volume":"22","author":"MG Dalin","year":"2016","unstructured":"Dalin MG, Desrichard A, Katabi N, Makarov V, Walsh LA, Lee KW, et al. comprehensive molecular characterization of salivary duct carcinoma reveals actionable targets and similarity to apocrine breast cancer. Clin Cancer Res. 2016;22(18):4623\u201333.","journal-title":"Clin Cancer Res"},{"issue":"7643","key":"1140_CR32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature21063","volume":"543","author":"A Scarpa","year":"2017","unstructured":"Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, et al. Whole-genome landscape of pancreatic neuroendocrine tumours. Nature. 2017;543(7643):65\u201371.","journal-title":"Nature"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01140-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12105-020-01140-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01140-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:48:14Z","timestamp":1614646094000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12105-020-01140-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1140"],"URL":"https:\/\/doi.org\/10.1007\/s12105-020-01140-4","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]},"assertion":[{"value":"2 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"No conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}