{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:22:49Z","timestamp":1789762969376,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12105-020-01165-9","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T11:02:49Z","timestamp":1588158169000},"page":"966-973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?"],"prefix":"10.1007","volume":"14","author":[{"given":"Jefree J.","family":"Schulte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Steinmetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa V.","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya N.","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Lingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"issue":"6","key":"1165_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492.","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"1165_CR2","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/JTO.0b013e3182208e58","volume":"6","author":"M Casiraghi","year":"2011","unstructured":"Casiraghi M, De Pas T, Maisonneuve P, Brambilla D, Ciprandi B, Galetta D, et al. A 10-year single-center experience on 708 lung metastasectomies: the evidence of the \"international registry of lung metastases\". J Thoracic Oncol. 2011;6(8):1373\u20138. https:\/\/doi.org\/10.1097\/JTO.0b013e3182208e58.","journal-title":"J Thoracic Oncol"},{"issue":"9","key":"1165_CR3","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/hed.24687","volume":"39","author":"F Duprez","year":"2017","unstructured":"Duprez F, Berwouts D, De Neve W, Bonte K, Boterberg T, Deron P, et al. Distant metastases in head and neck cancer. Head Neck. 2017;39(9):1733\u201343. https:\/\/doi.org\/10.1002\/hed.24687.","journal-title":"Head Neck"},{"key":"1165_CR4","unstructured":"WHO classification of tumours of the lung, pleura, thymus, and heart. Lyon: 2015."},{"issue":"5","key":"1165_CR5","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1001\/jamaoto.2015.136","volume":"141","author":"SJ Trosman","year":"2015","unstructured":"Trosman SJ, Koyfman SA, Ward MC, Al-Khudari S, Nwizu T, Greskovich JF, et al. Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy. JAMA Otolaryngol Head Neck Surg. 2015;141(5):457\u201362. https:\/\/doi.org\/10.1001\/jamaoto.2015.136.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"10","key":"1165_CR6","first-page":"5499","volume":"35","author":"S Wiegand","year":"2015","unstructured":"Wiegand S, Zimmermann A, Wilhelm T, Werner JA. Survival after distant metastasis in head and neck cancer. Anticancer Res. 2015;35(10):5499\u2013502.","journal-title":"Anticancer Res"},{"issue":"1","key":"1165_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","volume":"11","author":"P Goldstraw","year":"2016","unstructured":"Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer. J Thoracic Oncol. 2016;11(1):39\u201351. https:\/\/doi.org\/10.1016\/j.jtho.2015.09.009.","journal-title":"J Thoracic Oncol"},{"issue":"5","key":"1165_CR8","doi-asserted-by":"publisher","first-page":"559","DOI":"10.5858\/arpa.2017-0286-CP","volume":"142","author":"JS Lewis Jr","year":"2018","unstructured":"Lewis JS Jr, Beadle B, Bishop JA, Chernock RD, Colasacco C, Lacchetti C, et al. Human papillomavirus testing in head and neck carcinomas: guideline from the College of American Pathologists. Arch Pathol Lab Med. 2018;142(5):559\u201397. https:\/\/doi.org\/10.5858\/arpa.2017-0286-CP.","journal-title":"Arch Pathol Lab Med"},{"issue":"31","key":"1165_CR9","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1200\/jco.18.00684","volume":"36","author":"C Fakhry","year":"2018","unstructured":"Fakhry C, Lacchetti C, Rooper LM, Jordan RC, Rischin D, Sturgis EM, et al. Human papillomavirus testing in head and neck carcinomas: ASCO clinical practice guideline endorsement of the college of american pathologists guideline. J Clin Oncol. 2018;36(31):3152\u201361. https:\/\/doi.org\/10.1200\/jco.18.00684.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1165_CR10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1136\/jcp.57.1.58","volume":"57","author":"V Esposito","year":"2004","unstructured":"Esposito V, Baldi A, Tonini G, Vincenzi B, Santini M, Ambrogi V, et al. Analysis of cell cycle regulator proteins in non-small cell lung cancer. J Clin Pathol. 2004;57(1):58\u201363. https:\/\/doi.org\/10.1136\/jcp.57.1.58.","journal-title":"J Clin Pathol"},{"key":"1165_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01117-y","author":"JS Lewis Jr","year":"2020","unstructured":"Lewis JS Jr. Human papillomavirus testing in head and neck squamous cell carcinoma in 2020: where are we now and where are we going? Head Neck Pathol. 2020. https:\/\/doi.org\/10.1007\/s12105-019-01117-y.","journal-title":"Head Neck Pathol"},{"issue":"s1","key":"1165_CR12","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1038\/modpathol.2016.152","volume":"30","author":"JS Lewis Jr","year":"2017","unstructured":"Lewis JS Jr. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can! Mod Pathol. 2017;30(s1):S44\u2013s53. https:\/\/doi.org\/10.1038\/modpathol.2016.152.","journal-title":"Mod Pathol"},{"issue":"10","key":"1165_CR13","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1136\/jclinpath-2018-205216","volume":"71","author":"S Serra","year":"2018","unstructured":"Serra S, Chetty R. p16. J Clin Pathol. 2018;71(10):853\u20138. https:\/\/doi.org\/10.1136\/jclinpath-2018-205216.","journal-title":"J Clin Pathol."},{"issue":"3","key":"1165_CR14","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1200\/jco.1998.16.3.1197","volume":"16","author":"WH Liggett Jr","year":"1998","unstructured":"Liggett WH Jr, Sidransky D. Role of the p16 tumor suppressor gene in cancer. J Clin Oncol. 1998;16(3):1197\u2013206. https:\/\/doi.org\/10.1200\/jco.1998.16.3.1197.","journal-title":"J Clin Oncol"},{"issue":"2","key":"1165_CR15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbagrm.2019.01.001","volume":"1862","author":"D Estevao","year":"2019","unstructured":"Estevao D, Costa NR, Gil da Costa RM, Medeiros R. Hallmarks of HPV carcinogenesis: the role of E6, E7 and E5 oncoproteins in cellular malignancy. Biochim Biophys Acta Gene Regul Mech. 2019;1862(2):153\u201362. https:\/\/doi.org\/10.1016\/j.bbagrm.2019.01.001.","journal-title":"Biochim Biophys Acta Gene Regul Mech."},{"key":"1165_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.oraloncology.2016.01.002","volume":"54","author":"PP Sedghizadeh","year":"2016","unstructured":"Sedghizadeh PP, Billington WD, Paxton D, Ebeed R, Mahabady S, Clark GT, et al. Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis. Oral Oncol. 2016;54:15\u201327. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.01.002.","journal-title":"Oral Oncol"},{"issue":"1","key":"1165_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","volume":"363","author":"KK Ang","year":"2010","unstructured":"Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tan PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24\u201335. https:\/\/doi.org\/10.1056\/NEJMoa0912217.","journal-title":"N Engl J Med"},{"issue":"2","key":"1165_CR18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/annonc\/mdy522","volume":"30","author":"TY Seiwert","year":"2019","unstructured":"Seiwert TY, Foster CC, Blair EA, Karrison TG, Agrawal N, Melotek JM, et al. OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer. Ann Oncol. 2019;30(2):297\u2013302. https:\/\/doi.org\/10.1093\/annonc\/mdy522.","journal-title":"Ann Oncol"},{"issue":"22","key":"1165_CR19","first-page":"3007","volume":"17","author":"JG Li","year":"2013","unstructured":"Li JG, Li L, Zhang SW. Different expression of p16INK4a and p14ARF in cervical and lung cancers. Eur Rev Med Pharmacol Sci. 2013;17(22):3007\u2013111.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"1165_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/s1010-7940(02)00749-2","volume":"23","author":"YL Cheng","year":"2003","unstructured":"Cheng YL, Lee SC, Harn HJ, Chen CJ, Chang YC, Chen JC, et al. Prognostic prediction of the immunohistochemical expression of p53 and p16 in resected non-small cell lung cancer. Eur J Cardio-Thoracic Surg. 2003;23(2):221\u20138. https:\/\/doi.org\/10.1016\/s1010-7940(02)00749-2.","journal-title":"Eur J Cardio-Thoracic Surg"},{"issue":"2","key":"1165_CR21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1054\/bjoc.1999.0929","volume":"82","author":"CI Huang","year":"2000","unstructured":"Huang CI, Taki T, Higashiyama M, Kohno N, Miyake M. p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung. Br J Cancer. 2000;82(2):374\u201380. https:\/\/doi.org\/10.1054\/bjoc.1999.0929.","journal-title":"Br J Cancer"},{"issue":"9","key":"1165_CR22","doi-asserted-by":"publisher","first-page":"761","DOI":"10.2217\/bmm-2018-0441","volume":"13","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Hoti N, Ao M, Zhang Z, Zhu H, Li L, et al. Expression of p16 and p53 in non-small-cell lung cancer: clinicopathological correlation and potential prognostic impact. Biomarkers Med. 2019;13(9):761\u201371. https:\/\/doi.org\/10.2217\/bmm-2018-0441.","journal-title":"Biomarkers Med"},{"issue":"10","key":"1165_CR23","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1097\/JTO.0b013e3182295745","volume":"6","author":"W Sterlacci","year":"2011","unstructured":"Sterlacci W, Tzankov A, Veits L, Zelger B, Bihl MP, Foerster A, et al. A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas. J Thoracic Oncol. 2011;6(10):1649\u201357. https:\/\/doi.org\/10.1097\/JTO.0b013e3182295745.","journal-title":"J Thoracic Oncol"},{"issue":"2","key":"1165_CR24","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0169-5002(01)00225-2","volume":"34","author":"M Jin","year":"2001","unstructured":"Jin M, Inoue S, Umemura T, Moriya J, Arakawa M, Nagashima K, et al. Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II. Lung Cancer (Amsterdam, Netherlands). 2001;34(2):207\u201318. https:\/\/doi.org\/10.1016\/s0169-5002(01)00225-2.","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"issue":"8","key":"1165_CR25","first-page":"3085","volume":"32","author":"LB Gatta","year":"2012","unstructured":"Gatta LB, Balzarini P, Tironi A, Berenzi A, Benetti A, Angiero F, et al. Human papillomavirus DNA and p16 gene in squamous cell lung carcinoma. Anticancer Res. 2012;32(8):3085\u20139.","journal-title":"Anticancer Res"},{"issue":"1","key":"1165_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/01.pgp.0000101084.35393.03","volume":"23","author":"JA Plaza","year":"2004","unstructured":"Plaza JA, Ramirez NC, Nuovo GJ. Utility of HPV analysis for evaluation of possible metastatic disease in women with cervical cancer. Int J Gynecol Pathol. 2004;23(1):7\u201312. https:\/\/doi.org\/10.1097\/01.pgp.0000101084.35393.03.","journal-title":"Int J Gynecol Pathol"},{"issue":"1","key":"1165_CR27","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/PAS.0b013e3182395c7b","volume":"36","author":"JA Bishop","year":"2012","unstructured":"Bishop JA, Ogawa T, Chang X, Illei PB, Gabrielson E, Pai SI, et al. HPV analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Am J Surg Pathol. 2012;36(1):142\u20138. https:\/\/doi.org\/10.1097\/PAS.0b013e3182395c7b.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"1165_CR28","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/carcin\/bgp177","volume":"30","author":"M Srinivasan","year":"2009","unstructured":"Srinivasan M, Taioli E, Ragin CC. Human papillomavirus type 16 and 18 in primary lung cancers\u2014a meta-analysis. Carcinogenesis. 2009;30(10):1722\u20138. https:\/\/doi.org\/10.1093\/carcin\/bgp177.","journal-title":"Carcinogenesis"},{"key":"1165_CR29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jcv.2014.09.014","volume":"63","author":"K Zhai","year":"2015","unstructured":"Zhai K, Ding J, Shi HZ. HPV and lung cancer risk: a meta-analysis. J Clin Virol. 2015;63:84\u201390. https:\/\/doi.org\/10.1016\/j.jcv.2014.09.014.","journal-title":"J Clin Virol"},{"issue":"56","key":"1165_CR30","doi-asserted-by":"publisher","first-page":"96419","DOI":"10.18632\/oncotarget.21682","volume":"8","author":"WM Xiong","year":"2017","unstructured":"Xiong WM, Xu QP, Li X, Xiao RD, Cai L, He F. The association between human papillomavirus infection and lung cancer: a system review and meta-analysis. Oncotarget. 2017;8(56):96419\u201332. https:\/\/doi.org\/10.18632\/oncotarget.21682.","journal-title":"Oncotarget"},{"issue":"8","key":"1165_CR31","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1007\/s00432-019-02960-w","volume":"145","author":"MM Tsyganov","year":"2019","unstructured":"Tsyganov MM, Pevzner AM, Ibragimova MK, Deryusheva IV, Litviakov NV. Human papillomavirus and lung cancer: an overview and a meta-analysis. J Cancer Res Clin Oncol. 2019;145(8):1919\u201337. https:\/\/doi.org\/10.1007\/s00432-019-02960-w.","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01165-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-020-01165-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01165-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:22:00Z","timestamp":1619655720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-020-01165-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1165"],"URL":"https:\/\/doi.org\/10.1007\/s12105-020-01165-9","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"22 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}