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To the best of our knowledge, this is the first report of such a tumor. A 43-year old male presented with acute and severe abdominal pain due to acute pancreatitis. On physical examination a painless lump in the right neck was detected and laboratory analyses revealed hyperparathyroidism (parathormone: 146\u00a0pmol\/L, normal range 1.05\u20136.83) and hypercalcemia (calcium level: 3.02\u00a0mg\/dL, normal range 2.25\u20132.5), which fell to 2.55\u00a0mg\/dL after parathyroidectomy. Histologically, the tumor was a parathyroid carcinoma associated with a mucous secreting adenocarcinoma also confirmed by histochemical (Alcian blue\u2014periodic acid Schiff) and immunohistochemical stainings. The present case expands the spectrum of MiNENs that can be found in endocrine organs.<\/jats:p>","DOI":"10.1007\/s12105-020-01178-4","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T19:02:25Z","timestamp":1591470145000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does Mixed Neuroendocrine-Nonneuroendocrine Neoplasm (MiNEN) of the Parathyroid Gland Exist? First Description of a Possible Case"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-1771","authenticated-orcid":false,"given":"Silvana","family":"Di Palma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonim","family":"Mufaddal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwas","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Sciarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"1178_CR1","volume-title":"WHO classification of tumours of endocrine organs","author":"RV Lloyd","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel G, Rosai J. 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Cancers. 2012;4:11\u201330.","journal-title":"Cancers"},{"key":"1178_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000375449","volume":"101","author":"M Volante","year":"2015","unstructured":"Volante M, Monica V, Birocco N, Brizzi MP, Busso S, Daniele L, La Rosa S, Righi L, Sapino A, Berruti A, Scagliotti GV, Papotti M. Expression analysis of genes involved in DNA repair or synthesis in mixed neuroendocrine\/nonneuroendocrine carcinomas. Neuroendocrinology. 2015;101:151\u201360.","journal-title":"Neuroendocrinology"},{"key":"1178_CR7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000369071","volume":"100","author":"M Scardoni","year":"2014","unstructured":"Scardoni M, Vittoria E, Volante M, Rusev B, Bersani S, Mafficini A, Gottardi M, Giandomenico V, Malleo G, Butturini G, Cingarlini S, Fassan M, Scarpa A. Scarpa A Mixed adenoneuroendocrine carcinomas of the gastrointestinal tract: targeted next-generation sequencing suggests a monoclonal origin of the two components. Neuroendocrinology. 2014;100:310\u20136.","journal-title":"Neuroendocrinology"},{"key":"1178_CR8","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/modpathol.2016.220","volume":"30","author":"M Jesinghaus","year":"2017","unstructured":"Jesinghaus M, Konukiewitz B, Keller G, Kloor M, Steiger K, Reiche M, Penzel R, Endris V, Arsenic R, Hermann G, Stenzinger A, Weichert W, Pfarr N, Kl\u00f6ppel G. Kl\u00f6ppel G Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas. 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