{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:55:59Z","timestamp":1779335759927,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12105-020-01268-3","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T17:14:03Z","timestamp":1609780443000},"page":"1322-1327","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Not All K\u00fcttner Tumors Are IgG4-Related Disease (IgG4-RD)"],"prefix":"10.1007","volume":"15","author":[{"given":"Kathryn S.","family":"Marcus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry T.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-5217","authenticated-orcid":false,"given":"Anand","family":"Rajan KD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"issue":"9","key":"1268_CR1","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","volume":"25","author":"V Deshpande","year":"2012","unstructured":"Deshpande V, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181\u201392.","journal-title":"Mod Pathol"},{"issue":"1","key":"1268_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/art.41120","volume":"72","author":"ZS Wallace","year":"2020","unstructured":"Wallace ZS, et al. The 2019 American College of Rheumatology\/European League against rheumatism classification criteria for IgG4-related disease. Arthritis Rheumatol. 2020;72(1):7\u201319.","journal-title":"Arthritis Rheumatol"},{"key":"1268_CR3","first-page":"815","volume":"15","author":"H K\u00fcttner","year":"1896","unstructured":"K\u00fcttner H. Uber entzundiche Tumoren der Submaaxillar-speicheldruse. Beitr\u00e4ge zur klinischen Chirurgie. 1896;15:815\u201334.","journal-title":"Beitr\u00e4ge zur klinischen Chirurgie"},{"issue":"2","key":"1268_CR4","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/PAS.0b013e3181c811ad","volume":"34","author":"JT Geyer","year":"2010","unstructured":"Geyer JT, et al. Chronic sclerosing sialadenitis (Kuttner tumor) is an IgG4-associated disease. Am J Surg Pathol. 2010;34(2):202\u201310.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1268_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/01676830.2013.842252","volume":"33","author":"RM Verdijk","year":"2014","unstructured":"Verdijk RM, et al. Raised numbers of IgG4-positive plasma cells are a common histopathological finding in orbital xanthogranulomatous disease. Orbit. 2014;33(1):17\u201322.","journal-title":"Orbit"},{"issue":"2","key":"1268_CR6","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1309\/AJCPTMWTCN04GSJH","volume":"141","author":"JS Lehman","year":"2014","unstructured":"Lehman JS, Smyrk TC, Pittelkow MR. Increased immunoglobulin (Ig) G4-positive plasma cell density and IgG4\/IgG ratio are not specific for IgG4-related disease in the skin. Am J Clin Pathol. 2014;141(2):234\u20138.","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"1268_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMra1104650","volume":"366","author":"JH Stone","year":"2012","unstructured":"Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366(6):539\u201351.","journal-title":"N Engl J Med"},{"issue":"7","key":"1268_CR8","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/art.39132","volume":"67","author":"A Khosroshahi","year":"2015","unstructured":"Khosroshahi A, et al. International consensus guidance statement on the management and treatment of IgG4-related disease. Arthritis Rheumatol. 2015;67(7):1688\u201399.","journal-title":"Arthritis Rheumatol"},{"issue":"10","key":"1268_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.joms.2003.12.033","volume":"62","author":"AD Rapidis","year":"2004","unstructured":"Rapidis AD, et al. Tumors of the submandibular gland: clinicopathologic analysis of 23 patients. J Oral Maxillofac Surg. 2004;62(10):1203\u20138.","journal-title":"J Oral Maxillofac Surg"},{"issue":"2","key":"1268_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bjoms.2016.10.021","volume":"55","author":"X Hong","year":"2017","unstructured":"Hong X, et al. Differential diagnosis of IgG4-related sialadenitis, primary Sjogren syndrome, and chronic obstructive submandibular sialadenitis. Br J Oral Maxillofac Surg. 2017;55(2):179\u201384.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"2","key":"1268_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2350\/11-04-1023-OA.1","volume":"15","author":"JC Melo","year":"2012","unstructured":"Melo JC, Kitsko D, Reyes-M\u00fagica M. Pediatric chronic sclerosing sialadenitis: K\u00fcttner tumor. Pediatr Dev Pathol. 2012;15(2):165\u20139.","journal-title":"Pediatr Dev Pathol"},{"issue":"3","key":"1268_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1046\/j.1365-2559.1997.2530856.x","volume":"31","author":"JD Harrison","year":"1997","unstructured":"Harrison JD, Epivatianos A, Bhatia SN. Role of microliths in the aetiology of chronic submandibular sialadenitis: a clinicopathological investigation of 154 cases. Histopathology. 1997;31(3):237\u201351.","journal-title":"Histopathology"},{"issue":"4","key":"1268_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00125480-199807000-00004","volume":"5","author":"JK Chan","year":"1998","unstructured":"Chan JK. Kuttner tumor (chronic sclerosing sialadenitis) of the submandibular gland: an underrecognized entity. Adv Anat Pathol. 1998;5(4):239\u201351.","journal-title":"Adv Anat Pathol"},{"issue":"6","key":"1268_CR14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/01.pas.0000164031.59940.fc","volume":"29","author":"S Kitagawa","year":"2005","unstructured":"Kitagawa S, et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (K\u00fcttner\u2019s tumor). Am J Surg Pathol. 2005;29(6):783\u201391.","journal-title":"Am J Surg Pathol"},{"issue":"1\u20132","key":"1268_CR15","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000090033","volume":"6","author":"T Kamisawa","year":"2006","unstructured":"Kamisawa T, et al. IgG4-related sclerosing disease incorporating sclerosing pancreatitis, cholangitis, sialadenitis and retroperitoneal fibrosis with lymphadenopathy. Pancreatology. 2006;6(1\u20132):132\u20137.","journal-title":"Pancreatology"},{"issue":"7","key":"1268_CR16","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1148\/rg.327125032","volume":"32","author":"A Fujita","year":"2012","unstructured":"Fujita A, et al. IgG4-related disease of the head and neck: CT and MR imaging manifestations. Radiographics. 2012;32(7):1945\u201358.","journal-title":"Radiographics"},{"issue":"8","key":"1268_CR17","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00234-012-1012-1","volume":"54","author":"M Katsura","year":"2012","unstructured":"Katsura M, et al. Radiological features of IgG4-related disease in the head, neck, and brain. Neuroradiology. 2012;54(8):873\u201382.","journal-title":"Neuroradiology"},{"key":"1268_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41379-019-0395-5","volume":"33","author":"E Peuraharju","year":"2019","unstructured":"Peuraharju E, et al. Sclerosing sialadenitis of the submandibular gland is rarely an immunoglobulin G4-related disease in the Finnish population. Mod Pathol. 2019;33:551\u20139.","journal-title":"Mod Pathol"},{"issue":"1","key":"1268_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/his.12122","volume":"63","author":"JD Harrison","year":"2013","unstructured":"Harrison JD, Rodriguez-Justo M. IgG4-related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis. Histopathology. 2013;63(1):96\u2013102.","journal-title":"Histopathology"},{"issue":"3","key":"1268_CR20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1136\/jcp.2010.085613","volume":"64","author":"JD Strehl","year":"2011","unstructured":"Strehl JD, Hartmann A, Agaimy A. Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic inflammatory conditions and need to be distinguished from IgG4-related systemic disorders. J Clin Pathol. 2011;64(3):237\u201343.","journal-title":"J Clin Pathol"},{"issue":"3","key":"1268_CR21","first-page":"634","volume":"59","author":"Y Liu","year":"2020","unstructured":"Liu Y, et al. Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients. Rheumatology (Oxford). 2020;59(3):634\u201340.","journal-title":"Rheumatology (Oxford)"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01268-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-020-01268-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-020-01268-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T06:35:57Z","timestamp":1638340557000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-020-01268-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1268"],"URL":"https:\/\/doi.org\/10.1007\/s12105-020-01268-3","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"7 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Kathryn S. Marcus, BS: No conflict of interest to disclose; Henry T. Hoffman, MD: Research consultant for COOK Medical; contributing author for UpToDate; research consultant for IotaMotion\u00ae; Anand Rajan KD, MBBS: No conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was determined to meet the regulatory requirements for the protection of human subjects and approved by the University of Iowa Human Subjects Office\/Institutional Review Board (IRB ID #: 201906740).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}