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Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.<\/jats:p>","DOI":"10.1007\/s12105-021-01299-4","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T02:22:38Z","timestamp":1613701358000},"page":"1385-1390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-4195","authenticated-orcid":false,"given":"Costantino","family":"Ricci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Chiarucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-1115","authenticated-orcid":false,"given":"Francesca","family":"Ambrosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Balbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Corti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"Piccin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-0387","authenticated-orcid":false,"given":"Ernesto","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-7260","authenticated-orcid":false,"given":"Maria Pia","family":"Foschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"1299_CR1","volume-title":"WHO Classification of Head and Neck Tumours","year":"2017","unstructured":"El-Naggar AK, Chan JKC, Grandis JR, et al editors. 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The remaining Authors declare that they have no conflict of interest related to the present work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study and involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. According to the Italian legislation, etichs approval by ethics committee is not required for this type of study (Case Report). Authors are responsible for correctness of the statements provided in the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent to participate was obtained from all individual participants included in the study (by Patient #1 and by the wife of Patient #2).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Although this paper does not contain data that can identify the single patients and therefore \u201cconsent to publish\u201d is not needed, the \u201cinformed consent to publish\u201d was obtained from all individual participants included in the study (by Patient #1 and by the wife of Patient #2).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}}]}}