{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:41:03Z","timestamp":1784893263331,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007833","name":"Hamad Medical Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007833","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Myxoid liposarcoma (ML)-like changes can seldom occur in some cases of WDL, which makes the diagnosis of WDL more challenging. Amplification of <jats:italic>DDIT3<\/jats:italic> gene in a subset of cases of WDL has shown to be associated with such unique morphology. Herein, we present a case of a 36-year-old gentleman who presented with difficulty in breathing and swallowing for 3\u00a0months duration. CT scan of the neck revealed a lesion along the posterior wall of the hypopharynx measuring 3.5\u00a0cm. Histopathologic examination revealed a tumor composed of lobules of oval to spindle cells in a prominent myxoid stroma with delicate chicken-wire vasculature. In the vicinity, there were lobules composed of variably sized adipocytes separated by thick fibrous septa that contains atypical hyperchromatic spindle cells. By immunohistochemistry, the tumor cells in both components were immunoreactive for CDK4, but negative for MDM2. Fluorescence in-situ hybridization (FISH) confirmed the presence of <jats:italic>MDM2<\/jats:italic> gene amplification. There was no evidence of <jats:italic>FUS-DDIT3<\/jats:italic> gene rearrangement, however, <jats:italic>DDIT3<\/jats:italic> gene was also amplified. The diagnosis of well-differentiated liposarcoma with prominent myxoid stroma was rendered. This is the first documentation of WDL with ML-like morphology harboring co-amplification of <jats:italic>MDM2<\/jats:italic> and <jats:italic>DDIT3<\/jats:italic> in the hypopharynx.<\/jats:p>","DOI":"10.1007\/s12105-021-01341-5","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T16:03:02Z","timestamp":1622822582000},"page":"288-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-363X","authenticated-orcid":false,"given":"Khaled A.","family":"Murshed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayan","family":"Abo Samra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adham","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"1341_CR1","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"WHO Classification of Tumours Editorial Board. 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Atypical lipomatous tumour\/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged \u2264 40 years: a study of 116 patients. Histopathology. 2019;75(6):833\u201342.","journal-title":"Histopathology"},{"issue":"2","key":"1341_CR4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/00000478-199002000-00005","volume":"14","author":"BM Wenig","year":"1990","unstructured":"Wenig BM, Weiss SW, Gnepp DR. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol. 1990;14(2):134\u201341.","journal-title":"Am J Surg Pathol"},{"key":"1341_CR5","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1288\/00005537-199507000-00013","volume":"105","author":"BM Wenig","year":"1995","unstructured":"Wenig BM, Heffner DK. Liposarcomas of the larynx and hypopharynx: a clinicopathologic study of eight new cases and a review of literature. 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