{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:20:08Z","timestamp":1781929208784,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008938","name":"Gertrude von Meissner-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008938","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the cranio-facial skeleton, a heterogeneous group of well characterized fibro-osseous lesions can be distinguished. Whereas fibrous dysplasia can affect any skeletal bone, ossifying fibroma and cemento-osseous dysplasia exclusively develop in the cranio-facial region, with most subtypes restricted to the tooth bearing areas of the jaws. Herein we present a series of 20 fibro-osseous lesions that developed mostly in the frontal bone and in the mandible, presenting as expansile intramedullary tumors with a unique histologic appearance and an indolent clinical course. We provide evidence that these tumors are distinct from the categories included in the WHO classification and are therefore currently unclassifiable. The definition of cemento-ossifying fibroma as an odontogenic neoplasm developing only in close proximity to teeth should be re-considered and incorporate also extragnathic lesions as shown here.<\/jats:p>","DOI":"10.1007\/s12105-021-01351-3","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T12:02:40Z","timestamp":1624708960000},"page":"257-267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ossifying Fibroma of Non-odontogenic Origin: A Fibro-osseous Lesion in the Craniofacial Skeleton to be (Re-)considered"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-7507","authenticated-orcid":false,"given":"Daniel","family":"Baumhoer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Haefliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Ameline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Amary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"Cleven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester D. R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Harder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"1351_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.rcl.2017.08.007","volume":"56","author":"M Ahmad","year":"2018","unstructured":"Ahmad M, Gaalaas L. Fibro-osseous and other lesions of bone in the jaws. Radiol Clin N Am. 2018;56:91\u2013104.","journal-title":"Radiol Clin N Am"},{"key":"1351_CR2","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3171\/2015.7.PEDS1521","volume":"17","author":"C Barrena Lopez","year":"2016","unstructured":"Barrena Lopez C, Bollar Zabala A, Urculo Bareno E. Cranial juvenile psammomatoid ossifying fibroma: case report. J Neurosurg Pediatr. 2016;17:318\u201323.","journal-title":"J Neurosurg Pediatr"},{"key":"1351_CR3","doi-asserted-by":"publisher","first-page":"105050","DOI":"10.1016\/j.oraloncology.2020.105050","volume":"113","author":"RS Desai","year":"2021","unstructured":"Desai RS, Bansal S, Shirsat PM, Prasad P, Sattar S. Cemento-ossifying fibroma and juvenile ossifying fibroma: clarity in terminology. Oral Oncol. 2021;113:105050.","journal-title":"Oral Oncol"},{"key":"1351_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s12105-014-0590-0","volume":"8","author":"SK El-Mofty","year":"2014","unstructured":"El-Mofty SK. Fibro-osseous lesions of the craniofacial skeleton: an update. Head Neck Pathol. 2014;8:432\u201344.","journal-title":"Head Neck Pathol"},{"key":"1351_CR5","first-page":"253","volume-title":"WHO classification of head and neck tumours","author":"SK El-Mofty","year":"2017","unstructured":"El-Mofty SK, Nelson B, Toyosawa S. Fibrous dysplasia. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. Lyon: IARC Press; 2017. p. 253\u20134."},{"key":"1351_CR6","first-page":"251","volume-title":"WHO classification of head and neck tumours","author":"SK El-Mofty","year":"2017","unstructured":"El-Mofty SK, Nelson B, Toyosawa S. Ossifying fibroma. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. Lyon: IARC Press; 2017. p. 251\u20132."},{"key":"1351_CR7","first-page":"254","volume-title":"WHO classification of head and neck tumours","author":"SK El-Mofty","year":"2017","unstructured":"El-Mofty SK, Nelson B, Toyosawa S, Wright JM. Cemento-osseous dysplasia. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. Lyon: IARC Press; 2017. p. 254\u20135."},{"key":"1351_CR8","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41467-020-20603-4","volume":"12","author":"C Koelsche","year":"2021","unstructured":"Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig CE, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler KW, Reinhardt A, Wefers AK, Sievers P, Ebrahimi A, Suwala A, Fernandez-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss FKF, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik AE, Kool M, Romero-Perez L, Grunewald TGP, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers YMH, Weidema ME, Mentzel T, Griewank K, De Alava E, Martin JD, MaI G, Chang KT, Low SYY, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schuller U, Mautner VF, Schittenhelm J, Serrano J, Snuderl M, Buttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens WNM, Brandner S, Jaunmuktane Z, Lyskjaer I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado OM, Sainz-Jaspeado M, Mora J, Alonso J, Del Muro XG, Moran S, Esteller M, Benhamida JK, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones DTW, Frohling S, Pfister SM, Von Deimling A. Sarcoma classification by DNA methylation profiling. Nat Commun. 2021;12:498.","journal-title":"Nat Commun"},{"key":"1351_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s12105-013-0430-7","volume":"7","author":"EF Mccarthy","year":"2013","unstructured":"Mccarthy EF. Fibro-osseous lesions of the maxillofacial bones. Head Neck Pathol. 2013;7:5\u201310.","journal-title":"Head Neck Pathol"},{"key":"1351_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jop.12797","volume":"48","author":"T Pereira","year":"2019","unstructured":"Pereira T, Gomes CC, Brennan PA, Fonseca FP, Gomez RS. Fibrous dysplasia of the jaws: integrating molecular pathogenesis with clinical, radiological, and histopathological features. 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J Stomatol Oral Maxillofac Surg. 2021. https:\/\/doi.org\/10.1016\/j.jormas.2021.04.008.","journal-title":"J Stomatol Oral Maxillofac Surg"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-021-01351-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01351-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T11:08:48Z","timestamp":1650452928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-021-01351-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1351"],"URL":"https:\/\/doi.org\/10.1007\/s12105-021-01351-3","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"25 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest as it relates to this research project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This clinical investigation was conducted in accordance and compliance with all statutes, directives, and guidelines of an Internal Review Board authorization involving a retrospective\/prospective data analysis involving human subjects in research with appropriate informed consent and consent to publish (\u201cEthikkommission beider Basel\u201d ref. 274\/12).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Informed Consent"}}]}}