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As\n                    <jats:italic>COL11A1<\/jats:italic>\n                    expression correlates with adverse prognosis and is implicated in chemoresistance, it is a promising putative target. For the first time, we used RNA in-situ hybridization to systematically identify the cells that produce\n                    <jats:italic>COL11A1<\/jats:italic>\n                    in the ten most prevalent carcinoma types, lymphomas (n\u2009=\u2009275) and corresponding normal tissue (n\u2009=\u200955; panCancer cohort). Moreover, as most salivary gland carcinomas (SGC) display distinct stromal architectures, we also analysed 110 SGC. The corresponding protein formation of\n                    <jats:italic>COL11A1<\/jats:italic>\n                    was determined by MALDI-TOF\u2013MS-Imaging. We report that colon, breast and salivary duct carcinomas are highly infiltrated by\n                    <jats:italic>COL11A1<\/jats:italic>\n                    positive CAFs (CAFs\n                    <jats:sub>\n                      <jats:italic>COL11A1<\/jats:italic>\n                    <\/jats:sub>\n                    ) and might thus be promising candidates for antidesmoplastic or\n                    <jats:italic>COL11A1<\/jats:italic>\n                    -targeted therapies. The amount of CAFs\n                    <jats:sub>\n                      <jats:italic>COL11A1<\/jats:italic>\n                    <\/jats:sub>\n                    correlated significantly with tumour grade, tumour stage and nodal spread in the panCancer cohort. Significant associations between CAFs\n                    <jats:sub>\n                      <jats:italic>COL11A1<\/jats:italic>\n                    <\/jats:sub>\n                    and vascular invasion, perineural spread and nodal spread were observed in the SGC cohort. Also, we discovered that tumour cells of intercalated duct derived SGC and CAFs produce\n                    <jats:italic>COL11A1<\/jats:italic>\n                    in a mutually exclusive manner. Our findings represent a novel mode of extracellular matrix production in carcinomas and could be highly relevant in the future. Our findings elucidate the mode of\n                    <jats:italic>COL11A1<\/jats:italic>\n                    expression in very different carcinoma types and may aid to categorise tumours in the setting of possible future\n                    <jats:italic>COL11A1<\/jats:italic>\n                    -related therapies.\n                  <\/jats:p>","DOI":"10.1007\/s12105-021-01370-0","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T15:02:30Z","timestamp":1628607750000},"page":"394-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2285","authenticated-orcid":false,"given":"Christoph","family":"Arolt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nachtsheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Wolber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"von Eggeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Quaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Klu\u00dfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"1370_CR1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/ijc.30067","volume":"139","author":"SK Priya","year":"2016","unstructured":"Priya SK, Nagare RP, Sneha VS, Sidhanth C, Bindhya S, Manasa P, et al. 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