{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:45:13Z","timestamp":1784735113022,"version":"3.55.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12105-021-01374-w","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T12:04:47Z","timestamp":1629374687000},"page":"416-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sclerosing Polycystic Adenoma: Conclusive Clinical and Molecular Evidence of Its Neoplastic Nature"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-4649","authenticated-orcid":false,"given":"Juan C.","family":"Hernandez-Prera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryoush","family":"Saeed-Vafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Heidarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Gewandter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Wenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"issue":"2","key":"1374_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/00000478-199602000-00004","volume":"20","author":"BC Smith","year":"1996","unstructured":"Smith BC, Ellis GL, Slater LJ, Foss RD. Sclerosing polycystic adenosis of major salivary glands., A clinicopathologic analysis of nine cases. Am J Surg Pathol. 1996;20(2):161\u201370.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1374_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s004280100481","volume":"440","author":"A Skalova","year":"2002","unstructured":"Skalova A, Michal M, Simpson R, Starek I, P\u0159\u00e1dn\u00e1 J, Pfaltz M. Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ. Virchows Arch. 2002;440(1):29\u201335.","journal-title":"Virchows Arch"},{"issue":"4","key":"1374_CR3","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/00125480-200307000-00005","volume":"10","author":"DR Gnepp","year":"2003","unstructured":"Gnepp DR. Sclerosing polycystic adenosis of the salivary gland: a lesion that may be associated with dysplasia and carcinoma in situ: on: sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ: report of three cases with immunohistochemical and ultrastructural examination. Skalova A, Michal M, Simpson RHW, et al. Virchows Arch 2002. Adv Anatomic Pathol. 2003;10(4):218\u201322.","journal-title":"Adv Anatomic Pathol."},{"issue":"2","key":"1374_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/01.pas.0000186394.64840.1d","volume":"30","author":"DR Gnepp","year":"2006","unstructured":"Gnepp DR, Wang LJ, Brandwein-Gensler M, Slootweg P, Gill M, Hille J. Sclerosing polycystic adenosis of the salivary gland: a report of 16 cases. Am J Surg Pathol. 2006;30(2):154\u201364.","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"1374_CR5","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1097\/00000478-200608000-00002","volume":"30","author":"A Sk\u00e1lov\u00e1","year":"2006","unstructured":"Sk\u00e1lov\u00e1 A, Gnepp DR, Simpson RH, Lewis JE, Janssen D, Sima R, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30(8):939\u201344.","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1374_CR6","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00428-014-1551-4","volume":"464","author":"RC Marques","year":"2014","unstructured":"Marques RC, F\u00e9lix A. Invasive carcinoma arising from sclerosing polycystic adenosis of the salivary gland. Virchows Arch. 2014;464(5):621\u20135.","journal-title":"Virchows Arch"},{"key":"1374_CR7","first-page":"195","volume-title":"WHO classification of head and neck tumours","author":"R Seethala","year":"2017","unstructured":"Seethala R, Gnepp DR, Skalova A, Slater L, Williams MD. Sclerosing polycystic adenosis. In: El-Naggar AKCJ, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. 4th ed. Lyon: IARC Press; 2017. p. 195.","edition":"4"},{"issue":"3","key":"1374_CR8","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s12105-019-01088-0","volume":"14","author":"JA Bishop","year":"2020","unstructured":"Bishop JA, Gagan J, Baumhoer D, McLean-Holden AL, Oliai BR, Couce M, et al. Sclerosing polycystic \u201cadenosis\u201d of salivary glands: a neoplasm characterized by PI3K pathway alterations more correctly named sclerosing polycystic adenoma. Head Neck Pathol. 2020;14(3):630\u20136.","journal-title":"Head Neck Pathol"},{"key":"1374_CR9","doi-asserted-by":"publisher","first-page":"503830","DOI":"10.3389\/fgene.2021.503830","volume":"12","author":"TA Boyle","year":"2021","unstructured":"Boyle TA, Mondal AK, Saeed-Vafa D, Ananth S, Ahluwalia P, Kothapalli R, et al. Guideline-adherent clinical validation of a comprehensive 170-gene DNA\/RNA Panel for determination of small variants, copy number variations, splice variants, and fusions on a next-generation sequencing platform in the CLIA setting. Front Genet. 2021;12:503830.","journal-title":"Front Genet"},{"issue":"6","key":"1374_CR10","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/iub.1389","volume":"67","author":"F Pan","year":"2015","unstructured":"Pan F, Weeks O, Yang FC, Xu M. The TET2 interactors and their links to hematological malignancies. IUBMB Life. 2015;67(6):438\u201345.","journal-title":"IUBMB Life"},{"issue":"5","key":"1374_CR11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2174\/138920207782446160","volume":"8","author":"A Arcaro","year":"2007","unstructured":"Arcaro A, Guerreiro AS. The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics. 2007;8(5):271\u2013306.","journal-title":"Curr Genomics"},{"issue":"5573","key":"1374_CR12","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","volume":"296","author":"LC Cantley","year":"2002","unstructured":"Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296(5573):1655\u20137.","journal-title":"Science"},{"issue":"7","key":"1374_CR13","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc839","volume":"2","author":"I Vivanco","year":"2002","unstructured":"Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2(7):489\u2013501.","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"1374_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/sj.bjc.6602970","volume":"94","author":"B Karakas","year":"2006","unstructured":"Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer. 2006;94(4):455\u20139.","journal-title":"Br J Cancer"},{"issue":"3","key":"1374_CR15","doi-asserted-by":"publisher","first-page":"689","DOI":"10.4143\/crt.2019.497","volume":"52","author":"S Guo","year":"2020","unstructured":"Guo S, Loibl S, von Minckwitz G, Darb-Esfahani S, Lederer B, Denkert C. PIK3CA H1047R mutation associated with a lower pathological complete response rate in triple-negative breast cancer patients treated with anthracycline-taxane-based neoadjuvant chemotherapy. Cancer Res Treat. 2020;52(3):689\u201396.","journal-title":"Cancer Res Treat"},{"key":"1374_CR16","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1038\/ncomms5846","volume":"5","author":"N Stransky","year":"2014","unstructured":"Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun. 2014;5:4846.","journal-title":"Nat Commun"},{"issue":"13","key":"1374_CR17","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.1073\/pnas.1217197110","volume":"110","author":"C Beetz","year":"2013","unstructured":"Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, et al. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. Proc Natl Acad Sci USA. 2013;110(13):5091\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1374_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1006\/geno.1997.4625","volume":"41","author":"M Mencinger","year":"1997","unstructured":"Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P. Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. Genomics. 1997;41(3):327\u201331.","journal-title":"Genomics"},{"issue":"11","key":"1374_CR19","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1128\/MCB.15.11.6118","volume":"15","author":"A Greco","year":"1995","unstructured":"Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, et al. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol. 1995;15(11):6118\u201327.","journal-title":"Mol Cell Biol"},{"issue":"4","key":"1374_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/gcc.20044","volume":"40","author":"M Hisaoka","year":"2004","unstructured":"Hisaoka M, Ishida T, Imamura T, Hashimoto H. TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes Cancer. 2004;40(4):325\u20138.","journal-title":"Genes Chromosomes Cancer"},{"key":"1374_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.pathol.4.110807.092311","volume":"4","author":"N Chalhoub","year":"2009","unstructured":"Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 2009;4:127\u201350.","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"1374_CR22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/1097-0215(20010101)91:1<22::AID-IJC1002>3.0.CO;2-S","volume":"91","author":"HB Salvesen","year":"2001","unstructured":"Salvesen HB, MacDonald N, Ryan A, Jacobs IJ, Lynch ED, Akslen LA, et al. PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. Int J Cancer. 2001;91(1):22\u20136.","journal-title":"Int J Cancer"},{"issue":"9","key":"1374_CR23","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1158\/0008-5472.CAN-2401-2","volume":"64","author":"A Goel","year":"2004","unstructured":"Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 2004;64(9):3014\u201321.","journal-title":"Cancer Res"},{"issue":"17","key":"1374_CR24","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.1158\/1078-0432.CCR-09-2990","volume":"16","author":"S Zhang","year":"2010","unstructured":"Zhang S, Yu D. PI(3)king apart PTEN\u2019s role in cancer. Clin Cancer Res. 2010;16(17):4325\u201330.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"1374_CR25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/modpathol.2011.208","volume":"25","author":"B Djordjevic","year":"2012","unstructured":"Djordjevic B, Hennessy BT, Li J, Barkoh BA, Luthra R, Mills GB, et al. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing. Mod Pathol. 2012;25(5):699\u2013708.","journal-title":"Mod Pathol"},{"key":"1374_CR26","doi-asserted-by":"crossref","unstructured":"Uemura A, Bandoh N, Goto T, Sato R, Suzuki S, Kubota A, et al. Sclerosing polycystic adenosis arising in the parotid gland without PI3K pathway mutations. Head Neck Pathol. 2021.","DOI":"10.1007\/s12105-021-01339-z"},{"issue":"1","key":"1374_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3109\/02841860903107890","volume":"49","author":"SW Park","year":"2010","unstructured":"Park SW, Kang MR, Eom HS, Han JY, Ahn CH, Kim SS, et al. Somatic mutation of PIK3R1 gene is rare in common human cancers. Acta Oncol. 2010;49(1):125\u20137.","journal-title":"Acta Oncol"},{"issue":"5670","key":"1374_CR28","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.1096502","volume":"304","author":"Y Samuels","year":"2004","unstructured":"Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science. 2004;304(5670):554.","journal-title":"Science"},{"key":"1374_CR29","unstructured":"COSMIC, the Catalogue Of Somatic Mutations In Cancer. https:\/\/cancer.sanger.ac.uk\/"},{"issue":"2","key":"1374_CR30","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1158\/1078-0432.CCR-12-1842","volume":"19","author":"V Nardi","year":"2013","unstructured":"Nardi V, Sadow PM, Juric D, Zhao D, Cosper AK, Bergethon K, et al. Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment. Clin Cancer Res. 2013;19(2):480\u201390.","journal-title":"Clin Cancer Res"},{"issue":"8","key":"1374_CR31","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1097\/PAS.0b013e3182880d5a","volume":"37","author":"CC Griffith","year":"2013","unstructured":"Griffith CC, Seethala RR, Luvison A, Miller M, Chiosea SI. PIK3CA mutations and PTEN loss in salivary duct carcinomas. Am J Surg Pathol. 2013;37(8):1201\u20137.","journal-title":"Am J Surg Pathol"},{"issue":"18","key":"1374_CR32","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1002\/cncr.31600","volume":"124","author":"P Saintigny","year":"2018","unstructured":"Saintigny P, Mitani Y, Pytynia KB, Ferrarotto R, Roberts DB, Weber RS, et al. Frequent PTEN loss and differential HER2\/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Cancer. 2018;124(18):3693\u2013705.","journal-title":"Cancer"},{"issue":"6","key":"1374_CR33","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/PAS.0000000000000410","volume":"39","author":"SI Chiosea","year":"2015","unstructured":"Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE, et al. Molecular characterization of apocrine salivary duct carcinoma. Am J Surg Pathol. 2015;39(6):744\u201352.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1374_CR34","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/PAS.0000000000000952","volume":"42","author":"I Weinreb","year":"2018","unstructured":"Weinreb I, Bishop JA, Chiosea SI, Seethala RR, Perez-Ordonez B, Zhang L, et al. Recurrent RET gene rearrangements in intraductal carcinomas of salivary gland. Am J Surg Pathol. 2018;42(4):442\u201352.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1374_CR35","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s12105-020-01128-0","volume":"14","author":"JA Bishop","year":"2020","unstructured":"Bishop JA, Gagan J, Krane JF, Jo VY. Low-grade apocrine intraductal carcinoma: expanding the morphologic and molecular spectrum of an enigmatic salivary gland tumor. Head Neck Pathol. 2020;14(4):869\u201375.","journal-title":"Head Neck Pathol"},{"issue":"5","key":"1374_CR36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1053\/hupa.2001.24327","volume":"32","author":"C Leal","year":"2001","unstructured":"Leal C, Henrique R, Monteiro P, Lopes C, Bento MJ, De Sousa CP, et al. Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. Hum Pathol. 2001;32(5):487\u201393.","journal-title":"Hum Pathol"},{"issue":"5","key":"1374_CR37","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1097\/PAS.0b013e3181590ba4","volume":"32","author":"A Robson","year":"2008","unstructured":"Robson A, Lazar AJ, Ben Nagi J, Hanby A, Grayson W, Feinmesser M, et al. Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases. Am J Surg Pathol. 2008;32(5):682\u201390.","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"1374_CR38","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.humpath.2015.05.017","volume":"46","author":"S Vranic","year":"2015","unstructured":"Vranic S, Marchi\u00f2 C, Castellano I, Botta C, Scalzo MS, Bender RP, et al. Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast. Hum Pathol. 2015;46(9):1350\u20139.","journal-title":"Hum Pathol"},{"issue":"5","key":"1374_CR39","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/modpathol.2016.39","volume":"29","author":"PS Weisman","year":"2016","unstructured":"Weisman PS, Ng CK, Brogi E, Eisenberg RE, Won HH, Piscuoglio S, et al. Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology. Mod Pathol. 2016;29(5):476\u201388.","journal-title":"Mod Pathol"},{"issue":"2","key":"1374_CR40","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/00000478-200402000-00017","volume":"28","author":"W Cheuk","year":"2004","unstructured":"Cheuk W, Miliauskas JR, Chan JK. Intraductal carcinoma of the oral cavity: a case report and a reappraisal of the concept of pure ductal carcinoma in situ in salivary duct carcinoma. Am J Surg Pathol. 2004;28(2):266\u201370.","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1374_CR41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/j.1365-2559.2008.03135.x","volume":"53","author":"RH Simpson","year":"2008","unstructured":"Simpson RH, Desai S, Di Palma S. Salivary duct carcinoma in situ of the parotid gland. Histopathology. 2008;53(4):416\u201325.","journal-title":"Histopathology"},{"issue":"11","key":"1374_CR42","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1097\/PAS.0000000000001133","volume":"42","author":"A Sk\u00e1lov\u00e1","year":"2018","unstructured":"Sk\u00e1lov\u00e1 A, Vanecek T, Uro-Coste E, Bishop JA, Weinreb I, Thompson LDR, et al. Molecular profiling of salivary gland intraductal carcinoma revealed a subset of tumors harboring NCOA4-RET and novel TRIM27-RET fusions: a report of 17 cases. Am J Surg Pathol. 2018;42(11):1445\u201355.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"1374_CR43","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/PAS.0000000000001301","volume":"43","author":"A Sk\u00e1lov\u00e1","year":"2019","unstructured":"Sk\u00e1lov\u00e1 A, Pt\u00e1kov\u00e1 N, Santana T, Agaimy A, Ihrler S, Uro-Coste E, et al. NCOA4-RET and TRIM27-RET are characteristic gene fusions in salivary intraductal carcinoma, including invasive and metastatic tumors: is \u201cIntraductal\u201d correct? Am J Surg Pathol. 2019;43(10):1303\u201313.","journal-title":"Am J Surg Pathol"},{"key":"1374_CR44","doi-asserted-by":"crossref","unstructured":"Bishop JA, Nakaguro M, Whaley RD, Ogura K, Imai H, Laklouk I, et al. Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33-RET fusions and BRAF V600E mutations. Histopathology. 2020.","DOI":"10.1111\/his.14296"},{"issue":"1","key":"1374_CR45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.humpath.2014.08.017","volume":"46","author":"N Katabi","year":"2015","unstructured":"Katabi N, Ghossein R, Ho A, Dogan S, Zhang L, Sung YS, et al. Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts. Hum Pathol. 2015;46(1):26\u201333.","journal-title":"Hum Pathol"},{"issue":"20","key":"1374_CR46","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1002\/cncr.30179","volume":"122","author":"SI Chiosea","year":"2016","unstructured":"Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, et al. Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations. Cancer. 2016;122(20):3136\u201344.","journal-title":"Cancer"},{"issue":"5","key":"1374_CR47","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/PAS.0000000000000413","volume":"39","author":"L Williams","year":"2015","unstructured":"Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M, et al. Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression. Am J Surg Pathol. 2015;39(5):705\u201313.","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"1374_CR48","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/his.12152","volume":"63","author":"A Bahrami","year":"2013","unstructured":"Bahrami A, Perez-Ordonez B, Dalton JD, Weinreb I. An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions. Histopathology. 2013;63(2):250\u201362.","journal-title":"Histopathology"},{"issue":"3","key":"1374_CR49","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF00496559","volume":"390","author":"G Seifert","year":"1981","unstructured":"Seifert G, Thomsen S, Donath K. Bilateral dysgenetic polycystic parotid glands. Morphological analysis and differential diagnosis of a rare disease of the salivary glands. Virchows Arch A. 1981;390(3):273\u201388.","journal-title":"Virchows Arch A."},{"issue":"10","key":"1374_CR50","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1001\/archotol.1988.01860220080029","volume":"114","author":"JG Batsakis","year":"1988","unstructured":"Batsakis JG, Bruner JM, Luna MA. Polycystic (dysgenetic) disease of the parotid glands. Arch Otolaryngol Head Neck Surg. 1988;114(10):1146\u20138.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1374_CR51","doi-asserted-by":"crossref","unstructured":"Hernandez-Prera JC, Sk\u00e1lov\u00e1 A, Franchi A, Rinaldo A, Vander Poorten V, Zb\u00e4ren P, et al. Pleomorphic adenoma: the great mimicker of malignancy. Histopathology. 2020.","DOI":"10.1111\/his.14322"},{"issue":"2","key":"1374_CR52","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s12105-020-01213-4","volume":"15","author":"KS Wong","year":"2021","unstructured":"Wong KS, Mari\u00f1o-Enriquez A, Hornick JL, Jo VY. NR4A3 immunohistochemistry reliably discriminates acinic cell carcinoma from mimics. Head Neck Pathol. 2021;15(2):425\u201332.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1374_CR53","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12105-013-0432-5","volume":"7","author":"D Bell","year":"2013","unstructured":"Bell D, El-Naggar AK. Molecular heterogeneity in mucoepidermoid carcinoma: conceptual and practical implications. Head Neck Pathol. 2013;7(1):23\u20137.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1374_CR54","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ajhg.2010.11.013","volume":"88","author":"MH Tan","year":"2011","unstructured":"Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, et al. A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands. Am J Hum Genet. 2011;88(1):42\u201356.","journal-title":"Am J Hum Genet"},{"issue":"4","key":"1374_CR55","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s10689-011-9472-8","volume":"10","author":"H Villeneuve","year":"2011","unstructured":"Villeneuve H, Tremblay S, Galiatsatos P, Hamel N, Guertin L, Morency R, et al. Acinic cell carcinoma of the retromolar trigone region: expanding the tumor phenotype in Cowden syndrome? Fam Cancer. 2011;10(4):691\u20134.","journal-title":"Fam Cancer"},{"key":"1374_CR56","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/1742-6413.141815","volume":"11","author":"T Jazaerly","year":"2014","unstructured":"Jazaerly T, Bandyopadhyay S, Almardini N, Husain M. Diagnosis of sebaceous lymphadenoma by fine needle aspiration in a patient with Cowden syndrome: case report and review of the literature. Cytojournal. 2014;11:25.","journal-title":"Cytojournal"},{"issue":"1","key":"1374_CR57","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/dc.24602","volume":"49","author":"K Viswanathan","year":"2021","unstructured":"Viswanathan K, Maleki Z, Pantanowitz L, Cantley R, Faquin WC. Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: a multi-institutional study. Diagn Cytopathol. 2021;49(1):83\u201395.","journal-title":"Diagn Cytopathol"},{"key":"1374_CR58","unstructured":"Yehia L, Eng C. PTEN Hamartoma Tumor Syndrome. 2001 Nov 29 [Updated 2021 Feb 11]. In: GeneReviews. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1488\/."},{"key":"1374_CR59","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1146\/annurev-med-052218-125823","volume":"71","author":"L Yehia","year":"2020","unstructured":"Yehia L, Keel E, Eng C. The clinical spectrum of PTEN mutations. Annu Rev Med. 2020;71:103\u201316.","journal-title":"Annu Rev Med"},{"issue":"D1","key":"1374_CR60","doi-asserted-by":"publisher","first-page":"D835","DOI":"10.1093\/nar\/gkz972","volume":"48","author":"MJ Landrum","year":"2020","unstructured":"Landrum MJ, Chitipiralla S, Brown GR, Chen C, Gu B, Hart J, et al. ClinVar: improvements to accessing data. Nucleic Acids Res. 2020;48(D1):D835\u201344.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"1374_CR61","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.prp.2014.01.006","volume":"210","author":"S Manojlovi\u0107","year":"2014","unstructured":"Manojlovi\u0107 S, Virag M, Milenovi\u0107 A, Manojlovi\u0107 L, \u0160alek Z, Sk\u00e1lov\u00e1 A. Sclerosing polycystic adenosis of parotid gland: a unique report of two cases occurring in two sisters. Pathology-Res Pract. 2014;210(6):342\u20135.","journal-title":"Pathology-Res Pract"},{"issue":"10","key":"1374_CR62","doi-asserted-by":"publisher","first-page":"e2019452","DOI":"10.1001\/jamanetworkopen.2020.19452","volume":"3","author":"SE Lincoln","year":"2020","unstructured":"Lincoln SE, Nussbaum RL, Kurian AW, Nielsen SM, Das K, Michalski S, et al. Yield and utility of germline testing following tumor sequencing in patients with cancer. JAMA Netw Open. 2020;3(10):e2019452.","journal-title":"JAMA Netw Open"},{"key":"1374_CR63","unstructured":"National Comprehensive Cancer Network. TGenetic\/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic (Version 1.2021). www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_screening.pdf."}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01374-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-021-01374-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01374-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T17:22:41Z","timestamp":1654881761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-021-01374-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1374"],"URL":"https:\/\/doi.org\/10.1007\/s12105-021-01374-w","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,19]]},"assertion":[{"value":"19 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest as it relates to this research project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance and compliance with all statutes, directives, and guidelines of an Internal Review Board authorization (IRB# Pro00044135) involving retrospective data analysis, which did not require informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}