{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:57:38Z","timestamp":1786982258640,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12105-021-01385-7","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T13:20:04Z","timestamp":1634390404000},"page":"466-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Frozen-Permanent Section Discrepancy Rate in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-0667","authenticated-orcid":false,"given":"Serenella","family":"Serinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P. A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Marzouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Zaccarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"key":"1385_CR1","volume-title":"WHO classification of head and neck tumours","author":"AK El-Naggar","year":"2017","unstructured":"El-Naggar AK, Chan JK, Grandis JR, et al. WHO classification of head and neck tumours. 4th ed. Lyon: IARC; 2017.","edition":"4"},{"issue":"8","key":"1385_CR2","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1002\/lary.25899","volume":"126","author":"E Du","year":"2016","unstructured":"Du E, Ow TJ, Lo Y, Gersten A, et al. Refining the utility and role of frozen section in head and neck squamous cell carcinoma resection. Laryngoscope. 2016;126(8):1768\u201375.","journal-title":"Laryngoscope"},{"issue":"3","key":"1385_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/jso.24134","volume":"113","author":"HM Baddour Jr","year":"2016","unstructured":"Baddour HM Jr, Magliocca KR, Chen AY. The importance of margins in head and neck cancer. J Surg Oncol. 2016;113(3):248\u201355.","journal-title":"J Surg Oncol"},{"key":"1385_CR4","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1002\/cncr.22347","volume":"107","author":"C Black","year":"2006","unstructured":"Black C, Marotti J, Zarovnaya E, et al. Critical evaluation of frozen section margins in head and neck cancer resections. Cancer. 2006;107:2792\u2013800.","journal-title":"Cancer"},{"issue":"12","key":"1385_CR5","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jamaoto.2015.1351","volume":"141","author":"JH Maxwell","year":"2015","unstructured":"Maxwell JH, Thompson LD, Brandwein-Gensler MS, et al. Early oral tongue squamous cell carcinoma: sampling of margins from tumor bed and worse local control. JAMA Otolaryngol-Head Neck Surg. 2015;141(12):1104\u201310.","journal-title":"JAMA Otolaryngol-Head Neck Surg"},{"issue":"1","key":"1385_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.path.2016.10.002","volume":"10","author":"SI Chiosea","year":"2017","unstructured":"Chiosea SI. Intraoperative margin assessment in early oral squamous cell carcinoma. Surg Pathol Clin. 2017;10(1):1\u201314.","journal-title":"Surg Pathol Clin"},{"key":"1385_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.oraloncology.2017.10.013","volume":"75","author":"AV Prabhu","year":"2017","unstructured":"Prabhu AV, Sturgis CD, Lai C, et al. Improving margin revision: characterization of tumor bed margins in early oral tongue cancer. Oral Oncol. 2017;75:184\u20138.","journal-title":"Oral Oncol"},{"issue":"2","key":"1385_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s12105-019-01121-2","volume":"14","author":"MW Kubik","year":"2020","unstructured":"Kubik MW, Sridharan S, Varvares MA, et al. Intraoperative margin assessment in head and neck cancer: a case of misuse and abuse? Head Neck Pathol. 2020;14(2):291\u2013302.","journal-title":"Head Neck Pathol"},{"key":"1385_CR9","volume-title":"AJCC cancer staging manual","author":"American Joint Committee on Cancer","year":"2018","unstructured":"American Joint Committee on Cancer. AJCC cancer staging manual. 8th ed. New York: Springer; 2018.","edition":"8"},{"key":"1385_CR10","volume-title":"Diagnostic pathology: intraoperative consultation","author":"SC Lester","year":"2018","unstructured":"Lester SC. Diagnostic pathology: intraoperative consultation. 2nd ed. Amsterdam: Elsevier; 2018.","edition":"2"},{"key":"1385_CR11","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1097\/00005537-200010000-00039","volume":"110","author":"LJ DiNardo","year":"2000","unstructured":"DiNardo LJ, Lin J, Karageorge LS, et al. Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery. Laryngoscope. 2000;110:1773\u20136.","journal-title":"Laryngoscope"},{"issue":"4","key":"1385_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1288\/00005537-198404000-00017","volume":"94","author":"KA Remsen","year":"1984","unstructured":"Remsen KA, Lucente FE, Biller HF. Reliability of frozen section diagnosis in head and neck neoplasms. Laryngoscope. 1984;94(4):519\u201324.","journal-title":"Laryngoscope"},{"issue":"4","key":"1385_CR13","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/hed.2880120404","volume":"12","author":"K Ikemura","year":"1990","unstructured":"Ikemura K, Ohya R. The accuracy and usefulness of frozen-section diagnosis. Head Neck. 1990;12(4):298\u2013302.","journal-title":"Head Neck"},{"issue":"1","key":"1385_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/hed.2880150108","volume":"15","author":"RF Gandour-Edwards","year":"1993","unstructured":"Gandour-Edwards RF, Donald PJ, Wiese DA. Accuracy of intraoperative frozen section diagnosis in head and neck surgery: experience at a university medical center. Head Neck. 1993;15(1):33\u20138.","journal-title":"Head Neck"},{"key":"1385_CR15","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0278-2391(97)90570-X","volume":"55","author":"RA Ord","year":"1997","unstructured":"Ord RA, Aisner S. Accuracy of frozen sections in assessing margins in oral cancer resection. J Oral Maxillofac Surg. 1997;55:663\u20139.","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"1385_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/modpathol.2010.233","volume":"24","author":"SM Olson","year":"2011","unstructured":"Olson SM, Hussaini M, Lewis JS. Frozen section analysis of margins for head and neck tumor resections: reduction of sampling errors with a third histologic level. Mod Pathol. 2011;24(5):665\u201370.","journal-title":"Mod Pathol"},{"issue":"210","key":"1385_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.31729\/jnma.3545","volume":"56","author":"P Adhikari","year":"2018","unstructured":"Adhikari P, Upadhyaya P, Karki S, et al. Accuracy of frozen section with histopathological report in an institute. JNMA J Nepal Med Assoc. 2018;56(210):572\u20137.","journal-title":"JNMA J Nepal Med Assoc"},{"issue":"2","key":"1385_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12105-017-0846-6","volume":"12","author":"EM Layfield","year":"2018","unstructured":"Layfield EM, Schmidt RL, Esebua M, et al. Frozen section evaluation of margin status in primary squamous cell carcinomas of the head and neck: a correlation study of frozen section and final diagnoses. Head Neck Pathol. 2018;12(2):175\u201380.","journal-title":"Head Neck Pathol"},{"issue":"3","key":"1385_CR19","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.1503\/cjs.011112","volume":"56","author":"E Mahe","year":"2013","unstructured":"Mahe E, Ara S, Bishara M, et al. Intraoperative pathology consultation: error, cause and impact. Can J Surg. 2013;56(3):E13\u20138.","journal-title":"Can J Surg"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01385-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-021-01385-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-021-01385-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T12:47:02Z","timestamp":1654865222000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-021-01385-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,16]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1385"],"URL":"https:\/\/doi.org\/10.1007\/s12105-021-01385-7","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,16]]},"assertion":[{"value":"20 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest\/competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from the IRB of SUNY Upstate Medical University, Syracuse, NY.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}