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No conflicts of interest are present in relation to editorial board membership, funding, employment, financial or non-financial interests in any material discussed in this article. No funding was received to assist with the preparation of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The study is based on biologic material from human participants. Conduct of the study was approved by the University of Iowa Human Subjects Office following review by the institutional review board (IRB ID: 202,108,465) and was conducted in accordance the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. 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