{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:56:54Z","timestamp":1791309414440,"version":"4.3.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-023-01524-2","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T22:15:18Z","timestamp":1675721718000},"page":"467-478","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-0199","authenticated-orcid":false,"given":"Simmi","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail I.","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassem M.","family":"Bastaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon I.","family":"Chiosea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aatur D.","family":"Singhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja R.","family":"Seethala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"issue":"5","key":"1524_CR1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/PAS.0000000000000413","volume":"39","author":"L Williams","year":"2015","unstructured":"Williams L, Thompson LD, Seethala RR, Weinreb I, Assaad AM, Tuluc M et al (2015) Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression. Am J Surg Pathol 39(5):705\u2013713","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1524_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00795-011-0554-3","volume":"45","author":"K Kusafuka","year":"2012","unstructured":"Kusafuka K, Maeda M, Honda M, Nakajima T (2012) Mucin-rich salivary duct carcinoma with signet-ring cell feature ex pleomorphic adenoma of the submandibular gland: a case report of an unusual histology with immunohistochemical analysis and review of the literature. Med Mol Morphol 45(1):45\u201352","journal-title":"Med Mol Morphol"},{"issue":"3","key":"1524_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1365-2559.2010.03639.x","volume":"57","author":"E Yakirevich","year":"2010","unstructured":"Yakirevich E, Sabo E, Klorin G, Alos L, Cardesa A, Ellis GL et al (2010) Primary mucin-producing tumours of the salivary glands: a clinicopathological and morphometric study. Histopathology 57(3):395\u2013409","journal-title":"Histopathology"},{"issue":"8","key":"1524_CR4","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1097\/00000478-200308000-00004","volume":"27","author":"RH Simpson","year":"2003","unstructured":"Simpson RH, Prasad AR, Lewis JE, Skalova A, David L (2003) Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol 27(8):1070\u20131079","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"1524_CR5","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1097\/PAS.0000000000000676","volume":"40","author":"RR Seethala","year":"2016","unstructured":"Seethala RR, Chiosea SI (2016) MAML2 status in mucoepidermoid carcinoma can no longer be considered a prognostic marker. Am J Surg Pathol 40(8):1151\u20131153","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"1524_CR6","doi-asserted-by":"publisher","first-page":"e80","DOI":"10.1097\/PAI.0000000000000320","volume":"24","author":"F Petersson","year":"2016","unstructured":"Petersson F, Michal M, Kazakov DV, Grossmann P, Michal M (2016) A new hitherto unreported histopathologic manifestation of mammary analogue secretory carcinoma: \u201cmasked MASC\u201d associated with low-grade mucinous adenocarcinoma and low-grade in situ carcinoma components. Appl Immunohistochem Mol Morphol 24(9):e80\u2013e85","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"8","key":"1524_CR7","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1097\/PAS.0000000000001273","volume":"43","author":"JA Bishop","year":"2019","unstructured":"Bishop JA, Weinreb I, Swanson D, Westra WH, Qureshi HS, Sciubba J et al (2019) Microsecretory adenocarcinoma: a novel salivary gland tumor characterized by a recurrent MEF2C-SS18 fusion. Am J Surg Pathol 43(8):1023\u20131032","journal-title":"Am J Surg Pathol"},{"key":"1524_CR8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001980","author":"I Weinreb","year":"2022","unstructured":"Weinreb I, Hahn E, Dickson BC, Rooper LM, Rupp NJ, Freiberger SN et al (2022) Microcribriform adenocarcinoma of salivary glands: a unique tumor entity characterized by an SS18::ZBTB7A fusion. Am J Surg Pathol. https:\/\/doi.org\/10.1097\/PAS.0000000000001980","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"1524_CR9","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1097\/PAS.0000000000001688","volume":"45","author":"LM Rooper","year":"2021","unstructured":"Rooper LM, Argyris PP, Thompson LDR, Gagan J, Westra WH, Jordan RC et al (2021) Salivary mucinous adenocarcinoma is a histologically diverse single entity with recurrent AKT1 E17K mutations: clinicopathologic and molecular characterization with proposal for a unified classification. Am J Surg Pathol 45(10):1337\u20131347","journal-title":"Am J Surg Pathol"},{"issue":"8","key":"1524_CR10","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1097\/PAS.0000000000001080","volume":"42","author":"A Agaimy","year":"2018","unstructured":"Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A et al (2018) Intraductal papillary mucinous neoplasms of minor salivary glands with AKT1 p.Glu17Lys mutation. Am J Surg Pathol 42(8):1076\u20131082","journal-title":"Am J Surg Pathol"},{"key":"1524_CR11","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1007\/s12105-022-01471-4","volume":"16","author":"M Nakaguro","year":"2022","unstructured":"Nakaguro M, Sadow PM, Hu R, Hattori H, Kuwabara K, Tsuzuki T et al (2022) NKX3.1 Expression in salivary gland \u201cintraductal\u201d papillary mucinous neoplasm: a low-grade subtype of salivary gland mucinous adenocarcinoma. Head Neck Pathol 16:1114","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1524_CR12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00000478-200401000-00010","volume":"28","author":"JE Ghannoum","year":"2004","unstructured":"Ghannoum JE, Freedman PD (2004) Signet-ring cell (mucin-producing) adenocarcinomas of minor salivary glands. Am J Surg Pathol 28(1):89\u201393","journal-title":"Am J Surg Pathol"},{"issue":"Suppl 1","key":"1524_CR13","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1007\/s12105-013-0464-x","volume":"7","author":"DR Gnepp","year":"2013","unstructured":"Gnepp DR (2013) Mucinous myoepithelioma, a recently described new myoepithelioma variant. Head Neck Pathol 7(Suppl 1):S85\u2013S89","journal-title":"Head Neck Pathol"},{"issue":"3","key":"1524_CR14","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s12105-014-0518-8","volume":"8","author":"JM Bastaki","year":"2014","unstructured":"Bastaki JM, Purgina BM, Dacic S, Seethala RR (2014) Secretory myoepithelial carcinoma: a histologic and molecular survey and a proposed nomenclature for mucin producing signet ring tumors. Head Neck Pathol 8(3):250\u2013260","journal-title":"Head Neck Pathol"},{"issue":"1\u20132","key":"1524_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0925-4773(00)00355-5","volume":"95","author":"A Schneider","year":"2000","unstructured":"Schneider A, Brand T, Zweigerdt R, Arnold H (2000) Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech Dev 95(1\u20132):163\u2013174","journal-title":"Mech Dev"},{"issue":"8","key":"1524_CR16","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/PAS.0b013e3181e6cbf3","volume":"34","author":"B Gurel","year":"2010","unstructured":"Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M et al (2010) NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol 34(8):1097\u20131105","journal-title":"Am J Surg Pathol"},{"key":"1524_CR17","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.humpath.2018.09.009","volume":"84","author":"RK Yang","year":"2019","unstructured":"Yang RK, Zhao P, Lu C, Luo J, Hu R (2019) Expression pattern of androgen receptor and AR-V7 in androgen-deprivation therapy-naive salivary duct carcinomas. Hum Pathol 84:173\u2013182","journal-title":"Hum Pathol"},{"issue":"1","key":"1524_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1159\/000504810","volume":"87","author":"N Takada","year":"2020","unstructured":"Takada N, Nishida H, Oyama Y, Kusaba T, Kadowaki H, Arakane M et al (2020) Immunohistochemical reactivity of prostate-specific markers for salivary duct carcinoma. Pathobiology 87(1):30\u201336","journal-title":"Pathobiology"},{"issue":"8","key":"1524_CR19","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1097\/PAS.0b013e3181de3021","volume":"34","author":"RR Seethala","year":"2010","unstructured":"Seethala RR, Dacic S, Cieply K, Kelly LM, Nikiforova MN (2010) A reappraisal of the MECT1\/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol 34(8):1106\u20131121","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1524_CR20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/PAS.0000000000000410","volume":"39","author":"SI Chiosea","year":"2015","unstructured":"Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE et al (2015) Molecular characterization of apocrine salivary duct carcinoma. Am J Surg Pathol 39(6):744\u2013752","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"1524_CR21","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/his.12398","volume":"65","author":"DP Boyle","year":"2014","unstructured":"Boyle DP, McArt DG, Irwin G, Wilhelm-Benartzi CS, Lioe TF, Sebastian E et al (2014) The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer. Histopathology 65(3):340\u2013352","journal-title":"Histopathology"},{"issue":"12","key":"1524_CR22","first-page":"3545","volume":"50","author":"RA McClelland","year":"1990","unstructured":"McClelland RA, Finlay P, Walker KJ, Nicholson D, Robertson JF, Blamey RW et al (1990) Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer. Cancer Res 50(12):3545\u20133550","journal-title":"Cancer Res"},{"issue":"4","key":"1524_CR23","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00428-022-03359-8","volume":"481","author":"S Patel","year":"2022","unstructured":"Patel S, Snyderman CH, Muller SK, Agaimy A, Seethala RR (2022) Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations\u2014sinonasal analogues to the sialadenoma papilliferum family tumors. Virchows Arch. 481(4):565\u2013574","journal-title":"Virchows Arch."},{"issue":"4","key":"1524_CR24","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s12105-015-0615-3","volume":"9","author":"B Purgina","year":"2015","unstructured":"Purgina B, Bastaki JM, Duvvuri U, Seethala RR (2015) A subset of sinonasal non-intestinal type adenocarcinomas are truly seromucinous adenocarcinomas: a morphologic and immunophenotypic assessment and description of a novel pitfall. Head Neck Pathol 9(4):436\u2013446","journal-title":"Head Neck Pathol"},{"issue":"9","key":"1524_CR25","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/s41379-022-01068-w","volume":"35","author":"LM Rooper","year":"2022","unstructured":"Rooper LM, Thompson LDR, Gagan J, Hwang JSG, London NR, Mikula MW et al (2022) Low-grade non-intestinal-type sinonasal adenocarcinoma: a histologically distinctive but molecularly heterogeneous entity. Mod Pathol 35(9):1160\u20131167","journal-title":"Mod Pathol"},{"issue":"6","key":"1524_CR26","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1097\/PAS.0000000000001441","volume":"44","author":"KI Yoshida","year":"2020","unstructured":"Yoshida KI, Machado I, Motoi T, Parafioriti A, Lacambra M, Ichikawa H et al (2020) NKX3-1 Is a useful immunohistochemical marker of EWSR1-NFATC2 sarcoma and mesenchymal chondrosarcoma. Am J Surg Pathol 44(6):719\u2013728","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1524_CR27","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/PAS.0000000000001627","volume":"45","author":"A Yoshida","year":"2021","unstructured":"Yoshida A, Hashimoto T, Ryo E, Yoshida KI, Motoi T, Yatabe Y et al (2021) Confirmation of NKX3-1 expression in EWSR1-NFATC2 sarcoma and mesenchymal chondrosarcoma using monoclonal antibody immunohistochemistry, RT-PCR, and RNA in situ hybridization. Am J Surg Pathol 45(4):578\u2013582","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"1524_CR28","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1007\/s12105-021-01331-7","volume":"15","author":"JA Bishop","year":"2021","unstructured":"Bishop JA, Sajed DP, Weinreb I, Dickson BC, Bilodeau EA, Agaimy A et al (2021) Microsecretory adenocarcinoma of salivary glands: an expanded series of 24 cases. Head Neck Pathol 15(4):1192\u20131201","journal-title":"Head Neck Pathol"},{"issue":"10","key":"1524_CR29","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1158\/2159-8290.CD-13-0830","volume":"4","author":"A Stoeck","year":"2014","unstructured":"Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C et al (2014) Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. Cancer Discov 4(10):1154\u20131167","journal-title":"Cancer Discov"},{"issue":"12","key":"1524_CR30","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1038\/nm.2580","volume":"17","author":"DR Robinson","year":"2011","unstructured":"Robinson DR, Kalyana-Sundaram S, Wu YM, Shankar S, Cao X, Ateeq B et al (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nat Med 17(12):1646\u20131651","journal-title":"Nat Med"},{"issue":"2","key":"1524_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/bcr3122","volume":"14","author":"PA Edwards","year":"2012","unstructured":"Edwards PA, Howarth KD (2012) Are breast cancers driven by fusion genes? Breast Cancer Res 14(2):303","journal-title":"Breast Cancer Res"},{"issue":"7","key":"1524_CR32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/ng.2643","volume":"45","author":"AS Ho","year":"2013","unstructured":"Ho AS, Kannan K, Roy DM, Morris LG, Ganly I, Katabi N et al (2013) The mutational landscape of adenoid cystic carcinoma. Nat Genet 45(7):791\u2013798","journal-title":"Nat Genet"},{"issue":"3","key":"1524_CR33","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1200\/JCO.2016.67.5264","volume":"35","author":"R Ferrarotto","year":"2017","unstructured":"Ferrarotto R, Mitani Y, Diao L, Guijarro I, Wang J, Zweidler-McKay P et al (2017) Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to Notch1 inhibitors. J Clin Oncol 35(3):352\u2013360","journal-title":"J Clin Oncol"},{"issue":"8","key":"1524_CR34","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s11864-022-01001-y","volume":"23","author":"LG de Sousa","year":"2022","unstructured":"de Sousa LG, Jovanovic K, Ferrarotto R (2022) Metastatic adenoid cystic carcinoma: genomic landscape and emerging treatments. Curr Treat Options Oncol 23(8):1135\u20131150","journal-title":"Curr Treat Options Oncol"},{"key":"1524_CR35","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1365-2559.2013.04352.x","volume":"62","author":"A Altemani","year":"2012","unstructured":"Altemani A, Costa AF, Montalli V, Mosqueda-Taylor A, de Almeida OP, Leon JE et al (2012) Signet-ring cell change in adenoid cystic carcinoma: a clinicopathologic and immunohistochemical study of four cases. Histopathology 62:531","journal-title":"Histopathology"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-023-01524-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-023-01524-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-023-01524-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T06:31:18Z","timestamp":1687761078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-023-01524-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["1524"],"URL":"https:\/\/doi.org\/10.1007\/s12105-023-01524-2","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]},"assertion":[{"value":"1 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"This study has obtained IRB approval from (University of Pittsburgh Human Research Protection Office) and the need for informed consent was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"For this type of study consent for publication is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}