{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:18:44Z","timestamp":1782497924923,"version":"3.54.5"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In recent years, the list of tumor entities in the sinonasal tract has significantly expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old patient with an unusual NUT carcinoma originating in the maxillary sinus, which showed extensive well-differentiated, papillary squamous morphology, similar to the spectrum of the recently described <jats:italic>DEK::AFF2<\/jats:italic> fusion-associated carcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed immunohistochemical and molecular studies including EBV- and HPV-testing, as well as DNA\/RNA next generation sequencing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The tumor showed predominantly exophytic papillary growth with mature squamous differentiation. An additional component harbored atypical, less differentiated basaloid tumor cells with infiltration of the adjacent stroma. Conspicuous inflammation was evident. There was no evidence of HPV DNA or EBV RNA. Next-generation sequencing revealed a <jats:italic>NUT::NSD3<\/jats:italic> gene fusion corresponding to (\u201cspeckled-type\u201d) immunopositivity of NUT in the tumor cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We describe a <jats:italic>NUT::NSD3<\/jats:italic> gene fusion-associated NUT carcinoma of the sinonasal tract with a deceptively well-differentiated papillary growth pattern, thus expanding the morphological spectrum of this typically poorly differentiated neoplasm.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12105-023-01554-w","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T18:02:30Z","timestamp":1682704950000},"page":"803-807","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Differentiated Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a Sinonasal Carcinoma"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-3825","authenticated-orcid":false,"given":"Martin","family":"Wartenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara-Lynn","family":"Hool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marrazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Giger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels J.","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"1554_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12105-021-01406-5","volume":"16","author":"LDR Thompson","year":"2022","unstructured":"Thompson LDR, Bishop JA (2022) Update from the 5th Edition of the World health organization classification of head and neck tumors: nasal cavity paranasal sinuses and skull base. Head Neck Pathol 16:1\u201318. https:\/\/doi.org\/10.1007\/s12105-021-01406-5","journal-title":"Head Neck Pathol"},{"key":"1554_CR2","unstructured":"WHO Classification of Tumours Editorial Board. Head and neck tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 2022 12 19]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"key":"1554_CR3","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1038\/s41379-021-00846-2","volume":"34","author":"YJ Kuo","year":"2021","unstructured":"Kuo YJ, Lewis JS Jr, Zhai C, Chen YA, Chernock RD, Hsieh MS, Lan MY, Lee CK, Weinreb I, Hang JF (2021) DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology. Mod Pathol 34:1820\u20131830. https:\/\/doi.org\/10.1038\/s41379-021-00846-2","journal-title":"Mod Pathol"},{"key":"1554_CR4","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1097\/PAS.0000000000001741","volume":"45","author":"LM Rooper","year":"2021","unstructured":"Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA (2021) DEK-AFF2 carcinoma of the sinonasal region and skull base: detailed clinicopathologic characterization of a distinctive entity. Am J Surg Pathol 45:1682\u20131693. https:\/\/doi.org\/10.1097\/PAS.0000000000001741","journal-title":"Am J Surg Pathol"},{"key":"1554_CR5","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1158\/0008-5472.CAN-15-0340","volume":"75","author":"AM Udager","year":"2015","unstructured":"Udager AM, Rolland DCM, McHugh JB, Betz BL, Murga-Zamalloa C, Carey TE, Marentette LJ, Hermsen MA, DuRoss KE, Lim MS, Elenitoba-Johnson KSJ, Brown NA (2015) High-Frequency targetable EGFR mutations in sinonasal squamous cell carcinomas arising from inverted sinonasal papilloma. Cancer Res 75:2600\u20132606. https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-0340","journal-title":"Cancer Res"},{"key":"1554_CR6","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1158\/1078-0432.CCR-22-0591","volume":"28","author":"CA French","year":"2022","unstructured":"French CA, Cheng ML, Hanna GJ, DuBois SG, Chau NG, Hann CL, Storck S, Salgia R, Trucco M, Tseng J, Stathis A, Piekarz R, Lauer UM, Massard C, Bennett K, Coker S, Tontsch-Grunt U, Sos ML, Liao S, Wu CJ, Polyak K, Piha-Paul SA, Shapiro GI (2022) Report of the first international symposium on NUT carcinoma. Clin Cancer Res 28:2493\u20132505. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-0591","journal-title":"Clin Cancer Res"},{"key":"1554_CR7","doi-asserted-by":"publisher","first-page":"860830","DOI":"10.3389\/fonc.2022.860830","volume":"12","author":"V Moreno","year":"2022","unstructured":"Moreno V, Saluja K, Pina-Oviedo S (2022) NUT carcinoma: clinicopathologic features, molecular genetics and epigenetics. Front Oncol 12:860830. https:\/\/doi.org\/10.3389\/fonc.2022.860830","journal-title":"Front Oncol"},{"key":"1554_CR8","doi-asserted-by":"publisher","first-page":"pkz094","DOI":"10.1093\/jncics\/pkz094","volume":"4","author":"NG Chau","year":"2020","unstructured":"Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA (2020) An anatomical site and genetic-based prognostic model for patients with nuclear protein in testis (NUT) midline carcinoma: analysis of 124 patients. JNCI Cancer Spectr 4:pkz094. https:\/\/doi.org\/10.1093\/jncics\/pkz094","journal-title":"JNCI Cancer Spectr"},{"key":"1554_CR9","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s12022-021-09700-2","volume":"33","author":"DB Allison","year":"2022","unstructured":"Allison DB, Rueckert J, Cornea V, Lee CY, Dueber J, Bocklage T (2022) Thyroid carcinoma with NSD3::NUTM1 fusion: a Case with thyrocyte differentiation and colloid production. Endocr Pathol 33:315\u2013326. https:\/\/doi.org\/10.1007\/s12022-021-09700-2","journal-title":"Endocr Pathol"},{"key":"1554_CR10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001967","author":"JA Barletta","year":"2022","unstructured":"Barletta JA, Gilday SD, Afkhami M, Bell D, Bocklage T, Boisselier P, Chau NG, Cipriani NA, Costes-Martineau V, Ghossein RA, Hertzler HJ, Kramer AM, Limaye S, Lopez CA, Ng TL, Weissferdt A, Xu B, Zhang S, French CA (2022) NUTM1-rearranged carcinoma of the thyroid: a distinct subset of NUT carcinoma characterized by frequent NSD3-NUTM1 fusions. Am J Surg Pathol. https:\/\/doi.org\/10.1097\/PAS.0000000000001967","journal-title":"Am J Surg Pathol"},{"key":"1554_CR11","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/his.14421","volume":"79","author":"S Ihrler","year":"2021","unstructured":"Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L (2021) Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult? Histopathology 79:779\u2013790. https:\/\/doi.org\/10.1111\/his.14421","journal-title":"Histopathology"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-023-01554-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-023-01554-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-023-01554-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T12:22:26Z","timestamp":1695298946000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-023-01554-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1007\/s12105-023-01554-w","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"3 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest. The authors have no financial or non-financial interests that are directly or indirectly related to the work submitted for publication to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Written consent for publication was obtained from the patient. All procedures involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Consent for publication was obtained from every individual included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}