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The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and\/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a retrospective study of 160 patients with T1\/T2N0 tumours staged using TNM7 treated surgically. Histology of the primary tumour was re-reviewed as appropriate to assess for the presence of WPOI-5 parameters. Univariate and multivariate analysis assessing impact of pathological features on survival outcomes was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>On univariate analysis, WPOI-5 and its 3 constituent components of satellite nodules, extratumoural PNI and extratumoural LVI were all significantly associated with disease-specific survival (DSS) and overall survival (OS). On multivariate analysis, satellite nodules (odds ratio 6.61, 95% CI 2.83\u201315.44, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and extratumoural LVI (odds ratio 9.97, 95% CI 2.19\u201345.35, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) were independently associated with OS. Postoperative radiotherapy (odds ratio 0.40, 95% CI 0.19\u20130.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and non-tongue subsite (odds ratio 3.03, 95% CI 1.70\u20135.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.0002) were also significantly associated with OS on multivariate analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Satellite nodules and extratumoural LVI correlated significantly with survival outcomes in our early-stage OSCC cohort. Further study is required to investigate the benefit of adjuvant treatment in these cases and to ascertain if WPOI-5 parameters including satellite nodules should be mandatory reporting data elements.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12105-023-01571-9","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T08:02:32Z","timestamp":1690185752000},"page":"679-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma"],"prefix":"10.1007","volume":"17","author":[{"given":"Shima","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan O\u2019","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Callanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sheahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-8253","authenticated-orcid":false,"given":"Linda","family":"Feeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"issue":"2","key":"1571_CR1","first-page":"122","volume":"67","author":"WM Lydiatt","year":"2017","unstructured":"Lydiatt WM, Patel SG, Sullivan B, Brandwein MS, Ridge JA, Migliacci JC et al (2017) Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. 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