{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:43:26Z","timestamp":1777009406142,"version":"3.51.4"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["14\/50943-1"],"award-info":[{"award-number":["14\/50943-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Brazilian National Research Council","award":["465682\/2014-6"],"award-info":[{"award-number":["465682\/2014-6"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-024-01629-2","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T19:02:31Z","timestamp":1713985351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Aspects of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of the Salivary Gland"],"prefix":"10.1007","volume":"18","author":[{"given":"Raisa Ferreira","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolinne Alves","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gatha Nagli de Mello","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Vanessa","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Malheiros","family":"Coutinho-Camillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"1629_CR1","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.3390\/cancers12113107","volume":"12","author":"C Porccheri","year":"2020","unstructured":"Porccheri C, Meisel CT, Mitsiadis TA (2020) Molecular and Cellular Modelling of Salivary Gland Tumors Open New landscapes in diagnosis and treatment. Cancer 12:3107. https:\/\/doi.org\/10.3390\/cancers12113107","journal-title":"Cancer"},{"key":"1629_CR2","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/joor.12664","volume":"45","author":"AML Pedersen","year":"2018","unstructured":"Pedersen AML, S\u00f8rensen CE, Proctor GB, Carpenter GH, Ekstr\u00f6m J (2018) Salivary secretion in health and disease. J Oral Rehabil 45:730\u2013746. https:\/\/doi.org\/10.1111\/joor.12664","journal-title":"J Oral Rehabil"},{"key":"1629_CR3","volume-title":"StatPearls [Internet]","author":"MG Ghannam","year":"2022","unstructured":"Ghannam MG, Singh P (2022) Anatomy, Head and Neck, salivary glands. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)"},{"key":"1629_CR4","unstructured":"El-Naggar AK, Chan JKC, Grandis JR et al (2017) WHO classification of head and neck tumours. In: World Health Organization classification of tumours. 4th edition. Lyon (France): International Agency for Research on Cancer (IARC), pp 163\u201384"},{"key":"1629_CR5","doi-asserted-by":"publisher","first-page":"102959","DOI":"10.1016\/j.critrevonc.2020.102959","volume":"152","author":"G Gatta","year":"2020","unstructured":"Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ (2020) Major and minor salivary gland tumours. Crit Rev Oncol Hematol 152:102959. https:\/\/doi.org\/10.1016\/j.critrevonc.2020.102959","journal-title":"Crit Rev Oncol Hematol"},{"key":"1629_CR6","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00405-020-06205-2","volume":"278","author":"M Westergaard-Nielsen","year":"2021","unstructured":"Westergaard-Nielsen M, Godballe C, Eriksen JG et al (2021) Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome. Eur Arch Otorhinolaryngol 278:1179\u20131188. https:\/\/doi.org\/10.1007\/s00405-020-06205-2","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1629_CR7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.suc.2021.12.008","volume":"102","author":"J Pang","year":"2022","unstructured":"Pang J, Houlton JJ (2022) Management of malignant salivary gland conditions. SurgClin North Am 102:325\u2013333. https:\/\/doi.org\/10.1016\/j.suc.2021.12.008","journal-title":"SurgClin North Am"},{"key":"1629_CR8","doi-asserted-by":"publisher","unstructured":"Lima SS, Soares AF, de Amorim RF (2005) Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases. Braz J Otorhinolaryngol 71. https:\/\/doi.org\/10.1016\/s1808-8694(15)31332-x. :335\u2009\u2013\u200940","DOI":"10.1016\/s1808-8694(15)31332-x"},{"key":"1629_CR9","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2147\/CMAR.S233431","volume":"12","author":"I Kordzi\u0144ska-Cisek","year":"2020","unstructured":"Kordzi\u0144ska-Cisek I, Cisek P, Grzybowska-Szatkowska L (2020) The role of prognostic factors in salivary gland tumors treated by surgery and adjuvant radio- or chemoradiotherapy - A single Institution experience. CancerManag Res 12:1047\u20131067. https:\/\/doi.org\/10.2147\/CMAR.S233431","journal-title":"CancerManag Res"},{"key":"1629_CR10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12105-009-0139-9","volume":"3","author":"FA de Oliveira","year":"2009","unstructured":"de Oliveira FA, Duarte EC, Taveira CT et al (2009) Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol 3:271\u2013275. https:\/\/doi.org\/10.1007\/s12105-009-0139-9","journal-title":"Head Neck Pathol"},{"key":"1629_CR11","volume-title":"StatPearls [Internet]","author":"A Young","year":"2022","unstructured":"Young A, Okuyemi OT (2022) Malignant salivary gland tumors. StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)"},{"key":"1629_CR12","doi-asserted-by":"publisher","first-page":"103352","DOI":"10.1016\/j.critrevonc.2021.103352","volume":"162","author":"ES Dos Santos","year":"2021","unstructured":"Dos Santos ES, Rodrigues-Fernandes CI, Speight PM et al (2021) Impact of tumor site on the prognosis of salivary gland neoplasms: a systematic review and meta-analysis. Crit Rev Oncol\/Hematol 162:103352. https:\/\/doi.org\/10.1016\/j.critrevonc.2021.103352","journal-title":"Crit Rev Oncol\/Hematol"},{"key":"1629_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4322\/acr.2016.056","volume":"6","author":"CP Nagano","year":"2016","unstructured":"Nagano CP, Coutinho-Camillo CM, Pinto CA et al (2016) Cytokeratin immunoprofile of primary and metastatic adenoid cystic carcinoma of salivary glands: a report of two cases. Autops Case Rep 6:57\u201363. https:\/\/doi.org\/10.4322\/acr.2016.056","journal-title":"Autops Case Rep"},{"key":"1629_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1097\/01.pap.0000213058.74509.d3","volume":"272","author":"A Coca-Pelaz","year":"2015","unstructured":"Coca-Pelaz A, Rodrigo JP, Triantafyllou A et al (2015) Salivary mucoepidermoid carcinoma revisited. Eur Arch Otorhinolaryngol 272:799\u2013819. https:\/\/doi.org\/10.1097\/01.pap.0000213058.74509.d3","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1629_CR15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/hed.23256","volume":"36","author":"MM Chen","year":"2014","unstructured":"Chen MM, Roman SA, Sosa JA et al (2014) Histologic grade as prognostic indicator for mucoepidermoid carcinoma: a population-level analysis of 2400 patients. Head Neck 36:158\u2013163. https:\/\/doi.org\/10.1002\/hed.23256","journal-title":"Head Neck"},{"key":"1629_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/PAP.0000000000000298","volume":"28","author":"A Skalova","year":"2021","unstructured":"Skalova A, Leivo I, Hellquist H et al (2021) High-grade Transformation\/Dedifferentiation in Salivary Gland carcinomas: occurrence across subtypes and clinical significance. Adv Anat Pathol 28:107\u2013118. https:\/\/doi.org\/10.1097\/PAP.0000000000000298","journal-title":"Adv Anat Pathol"},{"key":"1629_CR17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s12325-016-0298-5","volume":"33","author":"H Hellquist","year":"2016","unstructured":"Hellquist H, Sk\u00e1lov\u00e1 A, Barnes L et al (2016) Cervical lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: a collective International Review. Adv Ther 33:357\u2013368. https:\/\/doi.org\/10.1007\/s12325-016-0298-5","journal-title":"Adv Ther"},{"key":"1629_CR18","doi-asserted-by":"publisher","first-page":"4138","DOI":"10.1158\/1078-0432.CCR-16-2942","volume":"23","author":"PM Dillon","year":"2017","unstructured":"Dillon PM, Petroni GR, Horton BJ et al (2017) A phase II study of dovitinib in patients with recurrent or metastatic adenoid cystic carcinoma. Clin Cancer Res 23:4138\u20134145. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-2942","journal-title":"Clin Cancer Res"},{"key":"1629_CR19","doi-asserted-by":"publisher","first-page":"100602","DOI":"10.1016\/j.esmoop.2022.100602","volume":"7","author":"C Van Herpen","year":"2022","unstructured":"Van Herpen C, Vander Poorten V, Skalova A et al (2022) Salivary gland cancer: ESMO-European Reference Network on Rare Adult Solid Cancers (EURACAN) Clinical Practice Guideline for diagnosis, treatment, and follow-up. ESMO Open 7:100602. https:\/\/doi.org\/10.1016\/j.esmoop.2022.100602","journal-title":"ESMO Open"},{"key":"1629_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.oraloncology.2016.12.016","volume":"66","author":"S Alfieri","year":"2017","unstructured":"Alfieri S, Granata R, Bergamini C et al (2017) Systemic therapy in metastatic salivary gland carcinomas: a pathology-driven paradigm? Oral Oncol 66:58\u201363. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.12.016","journal-title":"Oral Oncol"},{"key":"1629_CR21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ejca.2020.05.013","volume":"136","author":"S Cavalieri","year":"2020","unstructured":"Cavalieri S, Mariani L, Vander Poorten V et al (2020) Prognostic nomogram in patients with metastatic adenoid cystic carcinoma of the salivary glands. Eur J Cancer 136:35\u201342. https:\/\/doi.org\/10.1016\/j.ejca.2020.05.013","journal-title":"Eur J Cancer"},{"key":"1629_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2014.05.003","author":"A Namboodiripad","year":"2014","unstructured":"Namboodiripad A (2014) A review: immunological markers for malignant salivary gland tumours. J Oral BiolCraniofac Res. https:\/\/doi.org\/10.1016\/j.jobcr.2014.05.003. 4:127\u2009\u2013\u200934","journal-title":"J Oral BiolCraniofac Res"},{"key":"1629_CR23","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.3390\/ijms22136771","volume":"22","author":"MT Meyer","year":"2021","unstructured":"Meyer MT, Watermann C, Dreyer T et al (2021) 2021 update on diagnostic markers and translocation in salivary gland tumors. Int J MolSci 22:6771. https:\/\/doi.org\/10.3390\/ijms22136771","journal-title":"Int J MolSci"},{"key":"1629_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1177\/0194599813489659","volume":"149","author":"SA Byrd","year":"2013","unstructured":"Byrd SA, Spector ME, Carey TE et al (2013) Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma. Otolaryngol Head Neck Surg 149:402\u2013408. https:\/\/doi.org\/10.1177\/0194599813489659","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1629_CR25","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.jormas.2020.06.003","volume":"121","author":"A Peraza","year":"2020","unstructured":"Peraza A, G\u00f3mez R, Beltran J et al (2020) Mucoepidermoid carcinoma. An update and review of the literature. J Stomatol Oral Maxillofac Surg 121:713\u2013720. https:\/\/doi.org\/10.1016\/j.jormas.2020.06.003","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"1629_CR26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.14639\/0392-100X-N1379","volume":"41","author":"G Cant\u00f9","year":"2021","unstructured":"Cant\u00f9 G (2021) Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from a etiopathogenesis to diagnosis. ActaOtorhinolaryngolItal 41:206\u2013214. https:\/\/doi.org\/10.14639\/0392-100X-N1379","journal-title":"ActaOtorhinolaryngolItal"},{"issue":"15","key":"1629_CR27","doi-asserted-by":"publisher","first-page":"14071","DOI":"10.1007\/s00432-023-05224-w","volume":"149","author":"D He","year":"2023","unstructured":"He D, Zhu S, Zhao Q, Chang H, Li G, Shao Q, Zhang C, Wu P (2023) Epidemiology of and factors associated with overall survival for patients with head and neck adenoid cystic carcinoma. J Cancer Res Clin Oncol 149(15):14071\u201314080. https:\/\/doi.org\/10.1007\/s00432-023-05224-w","journal-title":"J Cancer Res Clin Oncol"},{"key":"1629_CR28","doi-asserted-by":"publisher","unstructured":"Califf RM (2018) Biomarker definitions and their applications. Exp Biol Med (Maywood) 243:213\u2013221. https:\/\/doi.org\/10.1177\/1535370217750088","DOI":"10.1177\/1535370217750088"},{"key":"1629_CR29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/PAP.0000000000000291","volume":"28","author":"MH Toper","year":"2021","unstructured":"Toper MH, Sarioglu S (2021) Molecular Pathology of Salivary Gland neoplasms: Diagnostic, Prognostic, and predictive perspective. Adv Anat Pathol 28:81\u201393. https:\/\/doi.org\/10.1097\/PAP.0000000000000291","journal-title":"Adv Anat Pathol"},{"key":"1629_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-1-0716-0247-8_4","volume":"2108","author":"A Li","year":"2020","unstructured":"Li A, Yang DH (2020) Application of immunohistochemistry in Basic and Clinical studies. Methods MolBiol 2108:43\u201355. https:\/\/doi.org\/10.1007\/978-1-0716-0247-8_4","journal-title":"Methods MolBiol"},{"key":"1629_CR31","doi-asserted-by":"publisher","first-page":"14891","DOI":"10.3390\/ijms232314891","volume":"23","author":"R Cleymaet","year":"2022","unstructured":"Cleymaet R, Vermassen T, Coopman R et al (2022) The Therapeutic Landscape of Salivary Gland malignancies-where are we now? Int J MolSci 23:14891. https:\/\/doi.org\/10.3390\/ijms232314891","journal-title":"Int J MolSci"},{"key":"1629_CR32","doi-asserted-by":"publisher","unstructured":"Adelstein DJ, Koyfman SA, El-Naggar AK et al (2012) Biology and management of salivary gland cancers. https:\/\/doi.org\/10.1016\/j.semradonc.2012.03.009. SeminRadiatOncol 22:245\u2009\u2013\u200953","DOI":"10.1016\/j.semradonc.2012.03.009"},{"key":"1629_CR33","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1354\/vp.42-4-405","volume":"42","author":"JA Ramos-Vara","year":"2005","unstructured":"Ramos-Vara JA (2005) Technical aspects of immunohistochemistry. Vet Pathol 42:405\u2013426. https:\/\/doi.org\/10.1354\/vp.42-4-405","journal-title":"Vet Pathol"},{"key":"1629_CR34","doi-asserted-by":"publisher","unstructured":"Sukswai N, Khoury JD (2019) Immunohistochemistry innovations for diagnosis and tissue-based biomarker detection. CurrHematolMalig Rep 14. https:\/\/doi.org\/10.1007\/s11899-019-00533-9. :368\u2009\u2013\u200975","DOI":"10.1007\/s11899-019-00533-9"},{"key":"1629_CR35","doi-asserted-by":"publisher","first-page":"e0171341","DOI":"10.1371\/journal.pone.0171341","volume":"12","author":"XL Gao","year":"2017","unstructured":"Gao XL, Wu JS, Cao MX et al (2017) Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma. PLoS ONE 12:e0171341. https:\/\/doi.org\/10.1371\/journal.pone.0171341","journal-title":"PLoS ONE"},{"key":"1629_CR36","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/1066896918813678","volume":"27","author":"LN Teixeira","year":"2019","unstructured":"Teixeira LN, Janner \u00c9C, Teixeira T et al (2019) Comparison of p63\/p40 expression with myoepithelial markers in minor salivary gland tumors. Int J SurgPathol 27:360\u2013371. https:\/\/doi.org\/10.1177\/1066896918813678","journal-title":"Int J SurgPathol"},{"key":"1629_CR37","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/j.1600-0714.2012.01148.x","volume":"41","author":"SR Larsen","year":"2012","unstructured":"Larsen SR, Bj\u00f8rndal K, Godballe C, Krogdahl A (2012) Prognostic significance of Ki-67 in salivary gland carcinomas. J Oral Pathol Med 41:598\u2013602. https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01148.x","journal-title":"J Oral Pathol Med"},{"key":"1629_CR38","doi-asserted-by":"publisher","first-page":"EC01","DOI":"10.7860\/JCDR\/2015\/11690.5604","volume":"9","author":"BB Bagulkar","year":"2015","unstructured":"Bagulkar BB, Gawande M, Chaudhary M et al (2015) XIAP and Ki-67: a correlation BetweenAntiapoptotic and proliferative marker expression in Benign and Malignant tumours of salivary gland: an immunohistochemical study. J ClinDiagn Res 9:EC01\u20134. https:\/\/doi.org\/10.7860\/JCDR\/2015\/11690.5604","journal-title":"J ClinDiagn Res"},{"key":"1629_CR39","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.oraloncology.2013.08.004","volume":"49","author":"KA Warner","year":"2013","unstructured":"Warner KA, Adams A, Bernardi L et al (2013) Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol 49:1059\u20131066. https:\/\/doi.org\/10.1016\/j.oraloncology.2013.08.004","journal-title":"Oral Oncol"},{"key":"1629_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.47162\/RJME.61.1.20","volume":"61","author":"IC Belulescu","year":"2020","unstructured":"Belulescu IC, M\u0103rg\u0103ritescu C, Dumitrescu CI et al (2020) Immunophenotypical alterations with impact on the epithelial-mesenchymal transition (EMT) process in salivary gland adenoid cystic carcinomas. Rom J MorpholEmbryol 61:175\u2013187. https:\/\/doi.org\/10.47162\/RJME.61.1.20","journal-title":"Rom J MorpholEmbryol"},{"key":"1629_CR41","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/hed.26026","volume":"42","author":"A Moore","year":"2020","unstructured":"Moore A, Bar Y, Maurice-Dror C et al (2020) Next-generation sequencing in salivary gland carcinoma: targetable alterations lead to a therapeutic advantage-multicenter experience. Head Neck 42:599\u2013607. https:\/\/doi.org\/10.1002\/hed.26026","journal-title":"Head Neck"},{"key":"1629_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000479070","volume":"85","author":"M Rito","year":"2018","unstructured":"Rito M, Fonseca I (2018) Salivary gland neoplasms: does morphological diversity reflect Tumor Heterogeneity. Pathobiol 85:85\u201395. https:\/\/doi.org\/10.1159\/000479070","journal-title":"Pathobiol"},{"key":"1629_CR43","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1158\/1078-0432.CCR-20-1192","volume":"27","author":"R Ferrarotto","year":"2021","unstructured":"Ferrarotto R, Mitani Y, McGrail DJ et al (2021) Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas defines molecular subtypes and identifies therapeutic targets. Clin Cancer Res 27:852\u2013864. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-1192","journal-title":"Clin Cancer Res"},{"key":"1629_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s10637-019-00739-x","volume":"38","author":"C Even","year":"2020","unstructured":"Even C, Lassen U, Merchan J et al (2020) Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma. Invest New Drugs 38:402\u2013409. https:\/\/doi.org\/10.1007\/s10637-019-00739-x","journal-title":"Invest New Drugs"},{"key":"1629_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02971-w","author":"H Majewska","year":"2021","unstructured":"Majewska H, Gorczy\u0144ski A, Czapiewski P et al (2021) ALK alterations in salivary gland carcinomas. Virchows Arch. https:\/\/doi.org\/10.1007\/s00428-020-02971-w. 478:933\u2009\u2013\u200941","journal-title":"Virchows Arch"},{"key":"1629_CR46","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1111\/odi.13253","volume":"26","author":"ES Dos Santos","year":"2020","unstructured":"Dos Santos ES, Ramos JC, Normando AGC et al (2020) Epigenetic alterations in salivary gland tumors. Oral Dis 26:1610\u20131618. https:\/\/doi.org\/10.1111\/odi.13253","journal-title":"Oral Dis"},{"key":"1629_CR47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3892\/ijo.2022.5465","volume":"62","author":"Y Li","year":"2023","unstructured":"Li Y, Gu F, He Y et al (2023) MicroRNA in adenoid cystic carcinoma (review). Int J Oncol 62:17. https:\/\/doi.org\/10.3892\/ijo.2022.5465","journal-title":"Int J Oncol"},{"key":"1629_CR48","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4103\/0973-029X.140732","volume":"18","author":"J Salehinejad","year":"2014","unstructured":"Salehinejad J, Mohtasham N, Bagherpour A et al (2014) Evaluation of c-kit protein (CD117) expression in common salivary gland neoplasms. J Oral Maxillofac Pathol 18:177\u2013182. https:\/\/doi.org\/10.4103\/0973-029X.140732","journal-title":"J Oral MaxillofacPathol"},{"key":"1629_CR49","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1097\/DAD.0000000000000301","volume":"37","author":"H Nishida","year":"2015","unstructured":"Nishida H, Daa T, Kashima K et al (2015) KIT (CD117) expression in Benign and malignant sweat gland tumors. Am J Dermatopathol 37:898\u2013805. https:\/\/doi.org\/10.1097\/DAD.0000000000000301","journal-title":"Am J Dermatopathol"},{"key":"1629_CR50","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.12669\/pjms.336.13373","volume":"33","author":"H Tariq","year":"2017","unstructured":"Tariq H, Anjum S, Din HU et al (2017) Diagnostic utility of C-kit protein (CD117) expression in differentiating adenoid cystic carcinoma and polymorphous low-grade Adenocarcinoma. Pak J Med Sci 33:1376\u20131380. https:\/\/doi.org\/10.12669\/pjms.336.13373","journal-title":"Pak J Med Sci"},{"key":"1629_CR51","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.18632\/oncotarget.1606","volume":"5","author":"YL Tang","year":"2014","unstructured":"Tang YL, Fan YL, Jiang J et al (2014) C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression. Oncotarget 5:1491\u20131501. https:\/\/doi.org\/10.18632\/oncotarget.1606","journal-title":"Oncotarget"},{"key":"1629_CR52","doi-asserted-by":"publisher","unstructured":"Phuchareon J, van Zante A, Overdevest JB et al (2014) c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands. Transl Oncol 7: 537\u2009\u2013\u200945. https:\/\/doi.org\/10.1016\/j.tranon.2014.07.006","DOI":"10.1016\/j.tranon.2014.07.006"},{"key":"1629_CR53","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.21037\/tcr-20-637","volume":"9","author":"H Hou","year":"2020","unstructured":"Hou H, Jia D, Yan W et al (2020) KIT\/PDGFRA\/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors. Transl Cancer Res 9:4703\u20134714. https:\/\/doi.org\/10.21037\/tcr-20-637","journal-title":"Transl Cancer Res"},{"key":"1629_CR54","doi-asserted-by":"publisher","unstructured":"Freiberger SN, Brada M, Fritz C et al (2021) SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets. Neoplasia 23:473\u2013487. https:\/\/doi.org\/10.1016\/j.neo.2021.03.008","DOI":"10.1016\/j.neo.2021.03.008"},{"key":"1629_CR55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/1756-0500-7-131","volume":"7","author":"J Fukai","year":"2014","unstructured":"Fukai J, Fujita K, Yamoto T et al (2014) Intracranial extension of adenoid cystic carcinoma: potential involvement of EphA2 expression and epithelial-mesenchymal transition in tumor metastasis: a case report. BMC Res Notes 7:131. https:\/\/doi.org\/10.1186\/1756-0500-7-131","journal-title":"BMC Res Notes"},{"key":"1629_CR56","doi-asserted-by":"publisher","first-page":"105213","DOI":"10.1016\/j.oraloncology.2021.105213","volume":"115","author":"L Lorini","year":"2021","unstructured":"Lorini L, Ardighieri L, Bozzola A et al (2021) Prognosis and management of recurrent and\/or metastatic head and neck adenoid cystic carcinoma. Oral Oncol 115:105213. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105213","journal-title":"Oral Oncol"},{"key":"1629_CR57","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1172\/JCI128227","volume":"129","author":"AS Ho","year":"2019","unstructured":"Ho AS, Ochoa A, Jayakumaran G et al (2019) Genetic hallmarks of recurrent\/metastatic adenoid cystic carcinoma. J Clin Invest 129:4276\u20134289. https:\/\/doi.org\/10.1172\/JCI128227","journal-title":"J Clin Invest"},{"key":"1629_CR58","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.3390\/cancers14153691","volume":"14","author":"M Persson","year":"2022","unstructured":"Persson M, Andersson MK, Mitani Y, Brandwein-Weber MS, Frierson HF Jr, Moskaluk C, Fonseca I, Ferrarotto R, Boecker W, Loening T, El-Naggar AK, Stenman G (2022) Rearrangements, expression, and clinical significance of MYB and MYBL1 in adenoid cystic carcinoma: a multi-institutional study. Cancers (Basel) 14:3691. https:\/\/doi.org\/10.3390\/cancers14153691","journal-title":"Cancers (Basel)"},{"key":"1629_CR59","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1200\/JCO.2016.67.5264","volume":"35","author":"R Ferrarotto","year":"2017","unstructured":"Ferrarotto R, Mitani Y, Diao L et al (2017) Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic Carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to Notch1 inhibitors. J Clin Oncol 35:352\u2013360. https:\/\/doi.org\/10.1200\/JCO.2016.67.5264","journal-title":"J ClinOncol"},{"key":"1629_CR60","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1093\/annonc\/mdy171","volume":"29","author":"R Ferrarotto","year":"2018","unstructured":"Ferrarotto R, Eckhardt G, Patnaik A, LoRusso P, Faoro L, Heymach JV, Kapoun AM, Xu L, Munster P (2018) A phase 1 dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors. Ann Oncol 29:1561\u20131568. https:\/\/doi.org\/10.1093\/annonc\/mdy171","journal-title":"Ann Oncol"},{"key":"1629_CR61","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1158\/1078-0432.CCR-20-4071","volume":"27","author":"TV Karpinets","year":"2021","unstructured":"Karpinets TV, Mitani Y, Liu B et al (2021) Whole-genome sequencing of Common Salivary Gland carcinomas: Subtype-Restricted and Shared genetic alterations. Clin Cancer Res 27:3960\u20133969. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-4071","journal-title":"Clin Cancer Res"},{"key":"1629_CR62","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.3390\/cancers14092263","volume":"14","author":"JO Humtsoe","year":"2022","unstructured":"Humtsoe JO, Kim HS, Jones L, Cevallos J, Boileau P, Kuo F, Morris LGT, Ha P (2022) Development and characterization of MYB-NFIB Fusion expression in Adenoid cystic carcinoma. Cancers (Basel) 14:2263. https:\/\/doi.org\/10.3390\/cancers14092263","journal-title":"Cancers (Basel)"},{"key":"1629_CR63","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/lio2.139","volume":"3","author":"K Yan","year":"2018","unstructured":"Yan K, Yesensky J, Hasina R et al (2018) Genomics of mucoepidermoid and adenoid cystic carcinomas. Laryngoscope Investig Otolaryngol 3:56\u201361. https:\/\/doi.org\/10.1002\/lio2.139","journal-title":"Laryngoscope InvestigOtolaryngol"},{"key":"1629_CR64","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/his.13281","volume":"71","author":"K Fujii","year":"2017","unstructured":"Fujii K, Murase T, Beppu S et al (2017) MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. Histopathology 71:823\u2013834. https:\/\/doi.org\/10.1111\/his.13281","journal-title":"Histopathology"},{"key":"1629_CR65","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.oooo.2021.03.020","volume":"132","author":"E Shibata","year":"2021","unstructured":"Shibata E, Morita KI, Kayamori K et al (2021) Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol 132:426\u2013433. https:\/\/doi.org\/10.1016\/j.oooo.2021.03.020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1629_CR66","first-page":"764","volume":"4","author":"GT Yu","year":"2014","unstructured":"Yu GT, Bu LL, Zhao YY et al (2014) Inhibition of mTOR reduce Stat3 and PAI related angiogenesis in salivary gland adenoid cystic carcinoma. Am J Cancer Res 4:764\u2013775","journal-title":"Am J Cancer Res"},{"key":"1629_CR67","doi-asserted-by":"publisher","first-page":"37117","DOI":"10.18632\/oncotarget.5076","volume":"6","author":"YK Chae","year":"2015","unstructured":"Chae YK, Chung SY, Davis AA et al (2015) Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling. Oncotarget 6:37117\u201337134. https:\/\/doi.org\/10.18632\/oncotarget.5076","journal-title":"Oncotarget"},{"key":"1629_CR68","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1590\/1414-431X20133231","volume":"47","author":"LC Jiang","year":"2014","unstructured":"Jiang LC, Huang SY, Zhang DS et al (2014) Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis. Braz J Med Biol Res 47:252\u2013258. https:\/\/doi.org\/10.1590\/1414-431X20133231","journal-title":"Braz J Med Biol Res"},{"key":"1629_CR69","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1158\/1078-0432.CCR-16-1235","volume":"23","author":"F N\u00f6r","year":"2018","unstructured":"N\u00f6r F, Warner KA, Zhang Z et al (2018) Therapeutic inhibition of the MDM2-p53 Interaction prevents recurrence of adenoid cystic carcinomas. CQn Cancer Res 23:1036\u20131048. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-1235","journal-title":"CQn Cancer Res"},{"key":"1629_CR70","doi-asserted-by":"publisher","first-page":"29458","DOI":"10.18632\/oncotarget.15297","volume":"8","author":"Q Li","year":"2017","unstructured":"Li Q, Huang P, Zheng C et al (2017) Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis. Oncotarget 8:29458\u201329473. https:\/\/doi.org\/10.18632\/oncotarget.15297","journal-title":"Oncotarget"},{"key":"1629_CR71","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1158\/0008-5472.CAN-20-1780","volume":"81","author":"JO Humtsoe","year":"2021","unstructured":"Humtsoe JO, Kim HS, Leonard B et al (2021) Newly identified members of FGFR1 splice variants engage in cross-talk with AXL\/AKT Axis in Salivary Adenoid cystic carcinoma. Cancer Res 81:1001\u20131013. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-1780","journal-title":"Cancer Res"},{"key":"1629_CR72","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/bjc.2011.605","volume":"106","author":"T Ettl","year":"2012","unstructured":"Ettl T, Baader K, Stiegler C et al (2012) Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. Br J Cancer 106:719\u2013726. https:\/\/doi.org\/10.1038\/bjc.2011.605","journal-title":"Br J Cancer"},{"key":"1629_CR73","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3892\/or.2018.6931","volume":"41","author":"Y Cao","year":"2019","unstructured":"Cao Y, Liu H, Xia SL et al (2019) PTEN downregulates WD repeat containing protein 66 in salivary adenoid cystic carcinoma. Oncol Rep 41:1827\u20131836. https:\/\/doi.org\/10.3892\/or.2018.6931","journal-title":"Oncol Rep"},{"key":"1629_CR74","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/hed.26529","volume":"43","author":"E Guazzo","year":"2021","unstructured":"Guazzo E, Cooper C, Wilkinson L et al (2021) Therapeutic implications of immune-profiling and EGFR expression in salivary gland carcinoma. Head Neck 43:768\u2013777. https:\/\/doi.org\/10.1002\/hed.26529","journal-title":"Head Neck"},{"key":"1629_CR75","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.3892\/mmr.2015.3815","volume":"12","author":"WM Wang","year":"2015","unstructured":"Wang WM, Zhao ZL, Zhang WF et al (2015) Role of hypoxia-inducible factor-1\u03b1 and CD146 in epidermal growth factor receptor-mediated angiogenesis in salivary gland adenoid cystic carcinoma. Mol Med Rep 12:3432\u20133438. https:\/\/doi.org\/10.3892\/mmr.2015.3815","journal-title":"Mol Med Rep"},{"key":"1629_CR76","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1080\/15384101.2018.1489177","volume":"17","author":"Y Wang","year":"2018","unstructured":"Wang Y, Hu J, Wang Y et al (2018) EGFR activation induced snail-dependent EMT and myc-dependent PD-L1 in human salivary adenoid cystic carcinoma cells. Cell Cycle 17:1457\u20131470. https:\/\/doi.org\/10.1080\/15384101.2018.1489177","journal-title":"Cell Cycle"},{"key":"1629_CR77","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.5858\/arpa.2012-0704-OA","volume":"137","author":"R Xia","year":"2013","unstructured":"Xia R, Zhou R, Tian Z et al (2013) High expression of H3K9me3 is a strong predictor of poor survival in patients with salivary adenoid cystic carcinoma. Arch Pathol Lab Med 137:1761\u20131769. https:\/\/doi.org\/10.5858\/arpa.2012-0704-OA","journal-title":"Arch Pathol Lab Med"},{"key":"1629_CR78","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1600-0463.2008.00773.x","volume":"116","author":"T Daa","year":"2008","unstructured":"Daa T, Kashima K, Kondo Y et al (2008) Aberrant methylation in promoter regions of cyclin-dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland. APMIS 116:21\u201326. https:\/\/doi.org\/10.1111\/j.1600-0463.2008.00773.x","journal-title":"APMIS"},{"key":"1629_CR79","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3892\/ijo.2016.3532","volume":"49","author":"S Ling","year":"2016","unstructured":"Ling S, Rettig EM, Tan M et al (2016) Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. Int J Oncol 49:225\u2013234. https:\/\/doi.org\/10.3892\/ijo.2016.3532","journal-title":"Int J Oncol"},{"key":"1629_CR80","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/jop.12894","volume":"48","author":"AL Brown","year":"2019","unstructured":"Brown AL, Al-Samadi A, Sperandio M et al (2019) MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma. J Oral Pathol Med 48:840\u2013845. https:\/\/doi.org\/10.1111\/jop.12894","journal-title":"J Oral Pathol Med"},{"key":"1629_CR81","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00428-018-2423-0","volume":"473","author":"S Andreasen","year":"2018","unstructured":"Andreasen S, Tan Q, Agander TK et al (2018) MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study. Virchows Arch 473:329\u2013340. https:\/\/doi.org\/10.1007\/s00428-018-2423-0","journal-title":"Virchows Arch"},{"key":"1629_CR82","doi-asserted-by":"publisher","first-page":"e66778","DOI":"10.1371\/journal.pone.0066778","volume":"8","author":"Y Mitani","year":"2013","unstructured":"Mitani Y, Roberts DB, Fatani H, Weber RS, Kies MS, Lippman SM, El-Naggar AK (2013) MicroRNA profiling of salivary adenoid cystic carcinoma: association of mir-17-92 upregulation with poor outcome. PLoS ONE 8:e66778. https:\/\/doi.org\/10.1371\/journal.pone.0066778","journal-title":"PLoS ONE"},{"key":"1629_CR83","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1007\/s11033-021-07033-1","volume":"49","author":"LE Kerche","year":"2022","unstructured":"Kerche LE, de Sousa EA, Squarize CH et al (2022) EMT in salivary gland tumors: the expression of microRNAs miR-155 and miR-200c is associated with clinical-pathological parameters. Mol Biol Rep 49:2157\u20132167. https:\/\/doi.org\/10.1007\/s11033-021-07033-1","journal-title":"MolBiol Rep"},{"issue":"2","key":"1629_CR84","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1600-0714.2012.01189.x","volume":"42","author":"L Liu","year":"2013","unstructured":"Liu L, Hu Y, Fu J, Yang X, Zhang Z (2013) MicroRNA155 in the growth and invasion of salivary adenoid cystic carcinoma. J Oral Pathol Med 42(2):140\u2013147. https:\/\/doi.org\/10.1111\/j.1600-0714.2012.01189.x","journal-title":"J Oral Pathol Med"},{"key":"1629_CR85","doi-asserted-by":"publisher","first-page":"101573","DOI":"10.1016\/j.tranon.2022.101573","volume":"27","author":"P Kumar","year":"2023","unstructured":"Kumar P, Kumawat RK, Uttam V et al (2023) The imminent role of microRNAs in salivary adenoid cystic carcinoma. Transl Oncol 27:101573. https:\/\/doi.org\/10.1016\/j.tranon.2022.101573","journal-title":"TranslOncol"},{"key":"1629_CR86","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/his.13944","volume":"75","author":"B Xu","year":"2019","unstructured":"Xu B, Jungbluth AA, Frosina D et al (2019) The immune microenvironment and expression of PD-L1, PD-1, PRAME and MHC I in salivary duct carcinoma. Histopathology 75:672\u2013682. https:\/\/doi.org\/10.1111\/his.13944","journal-title":"Histopathology"},{"key":"1629_CR87","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12885-018-4069-3","volume":"18","author":"K Harada","year":"2018","unstructured":"Harada K, Ferdous T, Ueyama Y (2018) PD-L1 expression in malignant salivary gland tumors. BMC Cancer 18:156. https:\/\/doi.org\/10.1186\/s12885-018-4069-3","journal-title":"BMC Cancer"},{"key":"1629_CR88","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/jso.24266","volume":"114","author":"T Mukaigawa","year":"2016","unstructured":"Mukaigawa T, Hayashi R, Hashimoto K et al (2016) Programmed death ligand-1 expression is associated with poor disease-free survival in salivary gland carcinomas. J Surg Oncol 114:36\u201343. https:\/\/doi.org\/10.1002\/jso.24266","journal-title":"J SurgOncol"},{"key":"1629_CR89","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.oraloncology.2018.11.028","volume":"88","author":"C Mosconi","year":"2019","unstructured":"Mosconi C, de Arruda JAA, de Farias ACR et al (2019) Immune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glands. Oral Oncol 88:95\u2013101. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.11.028","journal-title":"Oral Oncol"},{"key":"1629_CR90","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.oraloncology.2019.01.015","volume":"90","author":"T Nakano","year":"2019","unstructured":"Nakano T, Takizawa K, Uezato A et al (2019) Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas. Oral Oncol 90:30\u201337. https:\/\/doi.org\/10.1016\/j.oraloncology.2019.01.015","journal-title":"Oral Oncol"},{"key":"1629_CR91","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/his.14100","volume":"76","author":"M Morita","year":"2020","unstructured":"Morita M, Murase T, Okumura Y et al (2020) Clinicopathological significance of EGFR pathway gene mutations and CRTC1\/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma. Histopathology 76:1013\u20131022. https:\/\/doi.org\/10.1111\/his.14100","journal-title":"Histopathology"},{"key":"1629_CR92","doi-asserted-by":"publisher","first-page":"e139497","DOI":"10.1172\/jci.insight.139497","volume":"6","author":"Z Chen","year":"2021","unstructured":"Chen Z, Ni W, Li JL et al (2021) The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma. JCI Insight 6:e139497. https:\/\/doi.org\/10.1172\/jci.insight.139497","journal-title":"JCI Insight"},{"key":"1629_CR93","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1038\/s41388-017-0104-0","volume":"37","author":"Z Chen","year":"2018","unstructured":"Chen Z, Lin S, Li JL et al (2018) CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells. Oncogene 37:1885\u20131895. https:\/\/doi.org\/10.1038\/s41388-017-0104-0","journal-title":"Oncogene"},{"key":"1629_CR94","doi-asserted-by":"publisher","first-page":"786150","DOI":"10.3389\/fonc.2021.786150","volume":"11","author":"E Naakka","year":"2022","unstructured":"Naakka E, Barros-Filho MC, Adnan-Awad S et al (2022) miR-22 and miR-205 Drive Tumor aggressiveness of Mucoepidermoid carcinomas of salivary glands. Front Oncol 11:786150. https:\/\/doi.org\/10.3389\/fonc.2021.786150","journal-title":"Front Oncol"},{"key":"1629_CR95","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/cancers14010054","volume":"14","author":"T Yoshimura","year":"2021","unstructured":"Yoshimura T, Higashi S, Yamada S et al (2021) PCP4\/PEP19 and HER2 are novel prognostic markers in Mucoepidermoid Carcinoma of the salivary gland. Cancers (Basel) 14:54. https:\/\/doi.org\/10.3390\/cancers14010054","journal-title":"Cancers (Basel)"},{"key":"1629_CR96","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000488669","volume":"11","author":"TS Corr\u00eaa","year":"2018","unstructured":"Corr\u00eaa TS, Matos GDR, Segura M et al (2018) Second-line treatment of HER2-Positive salivary gland tumor: Ado-TrastuzumabEmtansine (T-DM1) after progression on Trastuzumab. Case Rep Oncol 11:252\u2013257. https:\/\/doi.org\/10.1159\/000488669","journal-title":"Case Rep Oncol"},{"key":"1629_CR97","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.oooo.2017.09.013","volume":"125","author":"N Nikolic","year":"2018","unstructured":"Nikolic N, Carkic J, IlicDimitrijevic I et al (2018) P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. Oral Surg Oral Med Oral Pathol Oral Radiol 125:52\u201358. https:\/\/doi.org\/10.1016\/j.oooo.2017.09.013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1629_CR98","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0720","author":"H Kang","year":"2017","unstructured":"Kang H, Tan M, Bishop JA et al (2017) Whole-exome sequencing of salivary gland Mucoepidermoid Carcinoma. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0720. 23:283\u2009\u2013\u200988","journal-title":"Clin Cancer Res"},{"key":"1629_CR99","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/sj.bjc.6605788","volume":"103","author":"B Lujan","year":"2010","unstructured":"Lujan B, Hakim S, Moyano S, Nadal A, Caballero M, Diaz A, Valera A, Carrera M, Cardesa A, Alos L (2010) Activation of the EGFR\/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands. Br J Cancer 103:510\u2013516. https:\/\/doi.org\/10.1038\/sj.bjc.6605788","journal-title":"Br J Cancer"},{"key":"1629_CR100","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/odi.12800","volume":"24","author":"NO Binmadi","year":"2018","unstructured":"Binmadi NO, Basile JR, Perez P et al (2018) miRNA expression profile of mucoepidermoid carcinoma. Oral Dis 24:537\u2013543. https:\/\/doi.org\/10.1111\/odi.12800","journal-title":"Oral Dis"},{"key":"1629_CR101","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00428-016-2049-z","volume":"470","author":"BC Flores","year":"2017","unstructured":"Flores BC, Louren\u00e7o SV, Damascena AS et al (2017) Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. Virchows Arch 470:291\u2013299. https:\/\/doi.org\/10.1007\/s00428-016-2049-z","journal-title":"Virchows Arch"},{"key":"1629_CR102","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/1472-6882-13-322","volume":"13","author":"XF Xu","year":"2013","unstructured":"Xu XF, Zhang TL, Jin S, Wang R, Xiao X, Zhang WD, Wang PY, Wang XJ (2013) Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells. BMC Complement Altern Med 13:322. https:\/\/doi.org\/10.1186\/1472-6882-13-322","journal-title":"BMC Complement Altern Med"},{"key":"1629_CR103","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s12935-021-02134-0","volume":"21","author":"SJ Choi","year":"2021","unstructured":"Choi SJ, Ahn CH, Hong KO et al (2021) Molecular mechanism underlying the apoptotic modulation by ethanol extract of Pseudolarixkaempferi in mucoepidermoid carcinoma of the salivary glands. Cancer Cell Int 21:427. https:\/\/doi.org\/10.1186\/s12935-021-02134-0","journal-title":"Cancer Cell Int"},{"key":"1629_CR104","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3390\/biomedicines11020519","volume":"11","author":"M BouZerdan","year":"2023","unstructured":"BouZerdan M, Kumar PA, Zaccarini D et al (2023) Molecular targets in salivary gland cancers: a comprehensive genomic analysis of 118 mucoepidermoid carcinoma tumors. Biomedicines 11:519. https:\/\/doi.org\/10.3390\/biomedicines11020519","journal-title":"Biomedicines"},{"key":"1629_CR105","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1002\/hed.25763","volume":"41","author":"GM da Silva","year":"2019","unstructured":"da Silva GM, Saavedra V, Ianez RCF et al (2019) Apoptotic signaling in salivary mucoepidermoid carcinoma. Head Neck 41:2904\u20132913. https:\/\/doi.org\/10.1002\/hed.25763","journal-title":"Head Neck"},{"key":"1629_CR106","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0220-5","author":"D Bell","year":"2012","unstructured":"Bell D, Hanna EY (2012) Salivary gland cancers: biology and molecular targets for therapy. CurrOncol Rep. https:\/\/doi.org\/10.1007\/s11912-012-0220-5. 14:166\u2009\u2013\u200974","journal-title":"CurrOncol Rep"},{"key":"1629_CR107","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s41199-016-0011-z","volume":"1","author":"AV Chintakuntlawar","year":"2016","unstructured":"Chintakuntlawar AV, Okuno SH, Price K (2016) Systemic therapy for recurrent or metastatic salivary gland malignancies. Cancers Head Neck 1:11. https:\/\/doi.org\/10.1186\/s41199-016-0011-z","journal-title":"Cancers Head Neck"},{"key":"1629_CR108","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.annonc.2019.11.018","volume":"31","author":"R Kurzrock","year":"2020","unstructured":"Kurzrock R, Bowles DW, Kang H et al (2020) Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study. Ann Oncol 31:412\u2013421. https:\/\/doi.org\/10.1016\/j.annonc.2019.11.018","journal-title":"Ann Oncol"},{"key":"1629_CR109","doi-asserted-by":"publisher","unstructured":"Andersson MK, Afshari MK, Andr\u00e9n Y et al (2017) Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid cystic carcinoma by inhibition of IGF1R\/AKT signaling. J Natl Cancer Inst 109. https:\/\/doi.org\/10.1093\/jnci\/djx017","DOI":"10.1093\/jnci\/djx017"},{"issue":"16","key":"1629_CR110","doi-asserted-by":"publisher","first-page":"6885","DOI":"10.18632\/oncotarget.2321","volume":"5","author":"BH Su","year":"2014","unstructured":"Su BH, Qu J, Song M, Huang XY, Hu XM, Xie J, Zhao Y, Ding LC, She L, Chen J, Lin LS, Lin X, Zheng DL, Lu YG (2014) NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma. Oncotarget 5(16):6885\u20136895. https:\/\/doi.org\/10.18632\/oncotarget.2321","journal-title":"Oncotarget"},{"issue":"11","key":"1629_CR111","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1097\/PAS.0000000000000945","volume":"41","author":"DP Sajed","year":"2017","unstructured":"Sajed DP, Faquin WC, Carey C, Severson EA, Afrogheh H, Johnson AA, Blacklow C, Chau SC, Lin NG, Krane DT, Jo JF, Garcia VY, Sholl JJ, Aster LM JC (2017) Diffuse staining for activated NOTCH1 correlates with NOTCH1 mutation status and is Associated with worse outcome in Adenoid cystic carcinoma. Am J Surg Pathol 41(11):1473\u20131482. https:\/\/doi.org\/10.1097\/PAS.0000000000000945","journal-title":"Am J SurgPathol"},{"issue":"2","key":"1629_CR112","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/modpathol.2012.154","volume":"26","author":"KJ Jee","year":"2013","unstructured":"Jee KJ, Persson M, Heikinheimo K, Passador-Santos F, Aro K, Knuutila S, Odell EW, M\u00e4kitie A, Sundelin K, Stenman G, Leivo I (2013) Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. Mod Pathol 26(2):213\u2013222. https:\/\/doi.org\/10.1038\/modpathol.2012.154","journal-title":"ModPathol"},{"issue":"5","key":"1629_CR113","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1158\/1078-0432.CCR-17-2730","volume":"25","author":"A Andrews","year":"2019","unstructured":"Andrews A, Warner K, Rodriguez-Ramirez C, Pearson AT, N\u00f6r F, Zhang Z, Kerk S, Kulkarni A, Helman JI, Brenner JC, Wicha MS, Wang S, N\u00f6r JE (2019) Ablation of Cancer Stem cells by therapeutic inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. Clin Cancer Res 25(5):1588\u20131600. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-2730","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1629_CR114","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/2231-0770.102282","volume":"2","author":"B Firwana","year":"2012","unstructured":"Firwana B, Atassi B, Hasan R, Hasan N, Sukari A (2012) Trastuzumab for Her2\/neu-positive metastatic salivary gland carcinoma: case report and review of the literature. Avicenna J Med 2(3):71\u201373. https:\/\/doi.org\/10.4103\/2231-0770.102282","journal-title":"Avicenna J Med"},{"key":"1629_CR115","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41419-022-05133-9","volume":"13","author":"R Ferrarotto","year":"2022","unstructured":"Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E (2022) AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis 13:678. https:\/\/doi.org\/10.1038\/s41419-022-05133-9","journal-title":"Cell Death Dis"},{"key":"1629_CR116","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1200\/JCO.22.02221","volume":"41","author":"R Ferrarotto","year":"2023","unstructured":"Ferrarotto R, Sousa LG, Feng L, Mott F, Blumenschein G, Altan M, Bell D, Bonini F, Li K, Marques-Piubelli ML, Dal Lago EA, Johnson JJ, Mitani Y, Godoy M, Lee A, Kupferman M, Hanna E, Glisson BS, Elamin Y, El-Naggar A (2023) Phase II clinical trial of Axitinib and Avelumab in patients with Recurrent\/Metastatic adenoid cystic carcinoma. J Clin Oncol 41:2843\u20132851. https:\/\/doi.org\/10.1200\/JCO.22.02221","journal-title":"J Clin Oncol"},{"key":"1629_CR117","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1200\/JCO.2021.39.15_suppl.3020","volume":"39","author":"EL Miranda","year":"2021","unstructured":"Miranda EL, Stathis A, Hess D, Racca F, Quon D, Rodon J, Gadea OSS, Garcia JMP, Nuciforo P, Vivancos A, Cortes J, Ferrarotto R, Sch\u00f6nborn-Kellenberger O, Vigolo M, Bobadilla M, Beni L, Lehal R, Bauer MP, Vogl FD, Garralda E (2021) Phase 1 study of CB-103, a novel first-in-class inhibitor of the CSL-NICD gene transcription factor complex in human cancers. J Clin Oncol 39:3020\u20133020. https:\/\/doi.org\/10.1200\/JCO.2021.39.15_suppl.3020","journal-title":"J Clin Oncol"},{"key":"1629_CR118","doi-asserted-by":"publisher","first-page":"4897","DOI":"10.1158\/1538-7445.AM2023-4897","volume":"83","author":"V Mishra","year":"2023","unstructured":"Mishra V, Singh A, Chen X, Korzinkin M, Wing C, Sarkisova V, Ozerova A, Glushchenko O, Thodima V, Ito K, Scherle P, Lingen M, Hasina R, Pearson A, Rosenberg A, Zhavoronkov A, Ruggeri B, Agrawal N, Izumchenko E (2023) PRT543, a methyl transferase inhibitor, has potent anti-tumor activity against adenoid cystic carcinoma of salivary glands. Cancer Res 83:4897. https:\/\/doi.org\/10.1158\/1538-7445.AM2023-4897","journal-title":"Cancer Res"},{"key":"1629_CR119","doi-asserted-by":"publisher","first-page":"TPS3146","DOI":"10.1200\/JCO.2019.37.15_suppl.TPS3146","volume":"37","author":"V Chung","year":"2019","unstructured":"Chung V, Wang L, Fletcher MS, Massarelli E, Reckamp KL, Cristea MC, Prajapati N, Parikh N, Whiting A, Wang RL, Wu M J (2019) First-time in-human study of VMD-928, an allosteric and irreversible TrkA selective inhibitor, in patients with solid tumors or lymphoma. J Clin Oncol 37:TPS3146\u2013TPS3146. https:\/\/doi.org\/10.1200\/JCO.2019.37.15_suppl.TPS3146","journal-title":"J Clin Oncol"},{"key":"1629_CR120","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1200\/JCO.2021.39.15_suppl.1024","volume":"39","author":"X Hu","year":"2021","unstructured":"Hu X, Zhang J, Liu R, Gao S, Qing Y, Yi S, Yuan J, Chen H, Fan B, Zheng H, Wang J (2021) Phase I study of A166 in patients with HER2-expressing locally advanced or metastatic solid tumors. J Clin Oncol 39:1024\u20131024. https:\/\/doi.org\/10.1200\/JCO.2021.39.15_suppl.1024","journal-title":"J Clin Oncol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-024-01629-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-024-01629-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-024-01629-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:21:40Z","timestamp":1736349700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-024-01629-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":120,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1629"],"URL":"https:\/\/doi.org\/10.1007\/s12105-024-01629-2","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]},"assertion":[{"value":"8 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"For this type of study consent for publication is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"For this type of study informed consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"34"}}