{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:51:25Z","timestamp":1777125085896,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-024-01726-2","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T05:35:35Z","timestamp":1730698535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Malignant Salivary Gland Neoplasm of the Tongue Base with EWSR1::BEND2 Fusion: An Unusual Case with Literature Review"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7713-5113","authenticated-orcid":false,"given":"Yuan-Dong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Yan","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Rong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4138-8115","authenticated-orcid":false,"given":"Xu-Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"1726_CR1","unstructured":"Board WCoTE. Head and Neck Tumours WHO Classification of Tumours, 5th Edition, Volume 9. LYON, France: International Agency for Research on Cancer; 2024."},{"issue":"1","key":"1726_CR2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","volume":"16","author":"A Sk\u00e1lov\u00e1","year":"2022","unstructured":"Sk\u00e1lov\u00e1 A, Hyrcza MD, Leivo I (2022) Update from the 5th edition of the World Health Organization classification of head and neck tumors: salivary glands. Head Neck Pathol 16(1):40\u201353","journal-title":"Head Neck Pathol"},{"issue":"2","key":"1726_CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00428-023-03731-2","volume":"484","author":"A Sk\u00e1lov\u00e1","year":"2024","unstructured":"Sk\u00e1lov\u00e1 A, Bradov\u00e1 M, Michal M Jr et al (2024) Molecular pathology in diagnosis and prognostication of head and neck tumors. Virchows Archiv: Int J Pathol 484(2):215\u2013231","journal-title":"Virchows Archiv: Int J Pathol"},{"issue":"2","key":"1726_CR4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12105-020-01140-4","volume":"14","author":"E Todorovic","year":"2020","unstructured":"Todorovic E, Dickson BC, Weinreb I (2020) Salivary gland cancer in the era of routine next-generation sequencing. Head Neck Pathol 14(2):311\u2013320","journal-title":"Head Neck Pathol"},{"issue":"11","key":"1726_CR5","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/PAS.0000000000001744","volume":"45","author":"Y Li","year":"2021","unstructured":"Li Y, Xi SY, Yong JJ, Wu XY, Yang XH, Wang F (2021) Morphologic, immunohistochemical, and genetic differences between high-grade and low-grade fetal adenocarcinomas of the lung. Am J Surg Pathol 45(11):1464\u20131475","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"1726_CR6","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1097\/PAS.0000000000002298","volume":"48","author":"L Fu","year":"2024","unstructured":"Fu L, Lao IW, Huang L, Ou L, Yuan L, Li Z, Li S, Hu W, Xi S (2024) Spinal cord Astroblastoma With EWSR1-BEND2 fusion in female patients: a report of four cases from china and a comprehensive literature review. Am J Surg Pathol 48(11):1372\u20131380","journal-title":"Am J Surg Pathol"},{"issue":"7643","key":"1726_CR7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature21063","volume":"543","author":"A Scarpa","year":"2017","unstructured":"Scarpa A, Chang DK, Nones K et al (2017) Whole-genome landscape of pancreatic neuroendocrine tumours. Nature 543(7643):65\u201371","journal-title":"Nature"},{"issue":"3","key":"1726_CR8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00428-022-03484-4","volume":"482","author":"A Agaimy","year":"2023","unstructured":"Agaimy A, Kasajima A, Stoehr R et al (2023) Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts. Virchows Arch 482(3):507\u2013516","journal-title":"Virchows Arch"},{"key":"1726_CR9","doi-asserted-by":"crossref","first-page":"101795","DOI":"10.1016\/j.tranon.2023.101795","volume":"38","author":"V Walker","year":"2023","unstructured":"Walker V, Jin DX, Millis SZ et al (2023) Gene partners of the EWSR1 fusion may represent molecularly distinct entities. Transl Oncol 38:101795","journal-title":"Transl Oncol"},{"issue":"2","key":"1726_CR10","first-page":"1908","volume":"33","author":"M Aldulescu","year":"2020","unstructured":"Aldulescu M (2020) Should all ewsr1-rearranged neoplasms be classified and treated as ewing sarcoma? abstracts from USCAP 2020: pediatric and perinatal pathology (1842\u20131868). Modern Pathol 33(2):1908\u20131933","journal-title":"Modern Pathol"},{"issue":"2","key":"1726_CR11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12105-023-01527-z","volume":"17","author":"DN Palsgrove","year":"2023","unstructured":"Palsgrove DN, Manucha V, Park JY, Bishop JA (2023) A low-grade sinonasal sarcoma harboring EWSR1::BEND2: expanding the differential diagnosis of sinonasal spindle cell neoplasms. Head Neck Pathol 17(2):571\u2013575","journal-title":"Head Neck Pathol"},{"issue":"3","key":"1726_CR12","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3390\/ijms25031735","volume":"25","author":"C Salguero-Aranda","year":"2024","unstructured":"Salguero-Aranda C, Di Blasi E, Gal\u00e1n L, Zaldumbide L, Civantos G, Marcilla D, de \u00c1lava E, D\u00edaz-Mart\u00edn J (2024) Identification of novel\/rare EWSR1 fusion partners in undifferentiated mesenchymal neoplasms. Int J Mol Sci 25(3):1735","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1726_CR13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1148\/rg.2021200062","volume":"41","author":"T Hiyama","year":"2021","unstructured":"Hiyama T, Kuno H, Sekiya K, Oda S, Kobayashi T (2021) Imaging of malignant minor salivary gland tumors of the head and neck. Radiographics 41(1):175\u2013191","journal-title":"Radiographics"},{"issue":"3","key":"1726_CR14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijom.2016.09.021","volume":"46","author":"M Gao","year":"2017","unstructured":"Gao M, Hao Y, Huang MX et al (2017) Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases. Int J Oral Maxillofac Surg 46(3):343\u2013349","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"1726_CR15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijom.2009.10.016","volume":"39","author":"Z Tian","year":"2010","unstructured":"Tian Z, Li L, Wang L, Hu Y, Li J (2010) Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 39(3):235\u2013242","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"2","key":"1726_CR16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0002-9440(10)64862-6","volume":"160","author":"E R\u00f6ijer","year":"2002","unstructured":"R\u00f6ijer E, Nordkvist A, Str\u00f6m AK et al (2002) Translocation, deletion\/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. Am J Pathol 160(2):433\u2013440","journal-title":"Am J Pathol"},{"issue":"1","key":"1726_CR17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/gcc.20619","volume":"48","author":"F Persson","year":"2009","unstructured":"Persson F, Andr\u00e9n Y, Winnes M et al (2009) High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. Genes Chromosom Cancer 48(1):69\u201382","journal-title":"Genes Chromosom Cancer"},{"issue":"5","key":"1726_CR18","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ophtha.2013.11.037","volume":"121","author":"SL von Holstein","year":"2014","unstructured":"von Holstein SL, Fehr A, Persson M et al (2014) Lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma: genomic profiles, gene fusions, and clinical characteristics. Ophthalmology 121(5):1125\u20131133","journal-title":"Ophthalmology"},{"issue":"20","key":"1726_CR19","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/cncr.30179","volume":"122","author":"SI Chiosea","year":"2016","unstructured":"Chiosea SI, Thompson LD, Weinreb I et al (2016) Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations. Cancer 122(20):3136\u20133144","journal-title":"Cancer"},{"key":"1726_CR20","doi-asserted-by":"crossref","first-page":"106112","DOI":"10.1016\/j.oraloncology.2022.106112","volume":"134","author":"F Titinchi","year":"2022","unstructured":"Titinchi F, Sallies M, Wu HT (2022) Mucoepidermoid carcinoma ex pleomorphic adenoma: a rare diagnostically challenging entity. Oral Oncol 134:106112","journal-title":"Oral Oncol"},{"issue":"40","key":"1726_CR21","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1038\/sj.onc.1204598","volume":"20","author":"A Arvand","year":"2001","unstructured":"Arvand A, Denny CT (2001) Biology of EWS\/ETS fusions in Ewing\u2019s family tumors. Oncogene 20(40):5747\u20135754","journal-title":"Oncogene"},{"issue":"6","key":"1726_CR22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/diagnostics11061093","volume":"11","author":"U Flucke","year":"2021","unstructured":"Flucke U, van Noesel MM, Siozopoulou V, Creytens D, Tops BB, van Gorp JM, Hiemcke-Jiwa LS (2021) EWSR1\u2014the most common rearranged gene in soft tissue lesions, which also occurs in different bone lesions: an updated review. Diagnostics 11(6):1093","journal-title":"Diagnostics"},{"issue":"4","key":"1726_CR23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/PAS.0b013e3182772a15","volume":"37","author":"AA Shah","year":"2013","unstructured":"Shah AA, LeGallo RD, van Zante A et al (2013) EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol 37(4):571\u2013578","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"1726_CR24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/PAS.0000000000000364","volume":"39","author":"A Sk\u00e1lov\u00e1","year":"2015","unstructured":"Sk\u00e1lov\u00e1 A, Weinreb I, Hyrcza M et al (2015) Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol 39(3):338\u2013348","journal-title":"Am J Surg Pathol"},{"issue":"1\u20133","key":"1726_CR25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/21541264.2022.2105128","volume":"13","author":"F Kurniawan","year":"2022","unstructured":"Kurniawan F, Prasanth SG (2022) A BEN-domain protein and polycomb complex work coordinately to regulate transcription. Transcription 13(1\u20133):82\u201387","journal-title":"Transcription"},{"issue":"21","key":"1726_CR26","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1126\/sciadv.abn1606","volume":"8","author":"L Ma","year":"2022","unstructured":"Ma L, Xie D, Luo M et al (2022) Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis. Sci Adv 8(21):1606","journal-title":"Sci Adv"},{"issue":"1","key":"1726_CR27","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1038\/s41467-022-29302-8","volume":"13","author":"NL Lehman","year":"2022","unstructured":"Lehman NL, Spassky N, Sak M et al (2022) Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes. Nat Commun 13(1):2083","journal-title":"Nat Commun"},{"issue":"Supplement_5","key":"1726_CR28","doi-asserted-by":"crossref","first-page":"v20","DOI":"10.1093\/noajnl\/vdad141.081","volume":"5","author":"R Yamamoto","year":"2023","unstructured":"Yamamoto R, Nakashima T, Sugihara Y et al (2023) 10206-GGE-21 molecular landscape and tumor evolution in astroblastoma. Neuro-Oncol Adv 5(Supplement_5):v20\u2013v21","journal-title":"Neuro-Oncol Adv"},{"issue":"1","key":"1726_CR29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00401-021-02388-y","volume":"143","author":"CG Lucas","year":"2022","unstructured":"Lucas CG, Gupta R, Wu J et al (2022) EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma. Acta Neuropathol 143(1):109\u2013113","journal-title":"Acta Neuropathol"},{"issue":"4","key":"1726_CR30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10014-021-00412-3","volume":"38","author":"T Tsutsui","year":"2021","unstructured":"Tsutsui T, Arakawa Y, Makino Y et al (2021) Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report. Brain Tumor Pathol 38(4):283\u2013289","journal-title":"Brain Tumor Pathol"},{"key":"1726_CR31","unstructured":"Smith-Cohn MA, Abdullaev Z, Aldape KD, et al. Molecular clarification of brainstem astroblastoma with EWSR1-BEND2 fusion in a 38-year-old man. Free Neuropathol. 2021;2."},{"issue":"2","key":"1726_CR32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/nan.12593","volume":"46","author":"K Yamasaki","year":"2020","unstructured":"Yamasaki K, Nakano Y, Nobusawa S et al (2020) Spinal cord astroblastoma with an EWSR1-BEND2 fusion classified as a high-grade neuroepithelial tumour with MN1 alteration. Neuropathol Appl Neurobiol 46(2):190\u2013193","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"7","key":"1726_CR33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gcc.20881","volume":"50","author":"CR Antonescu","year":"2011","unstructured":"Antonescu CR, Katabi N, Zhang L et al (2011) EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosom Cancer 50(7):559\u2013570","journal-title":"Genes Chromosom Cancer"},{"issue":"10","key":"1726_CR34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/gcc.22979","volume":"60","author":"J Bubola","year":"2021","unstructured":"Bubola J, MacMillan CM, Demicco EG et al (2021) Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors. Genes Chromosom Cancer 60(10):695\u2013708","journal-title":"Genes Chromosom Cancer"},{"key":"1726_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2022.02.002","volume":"123","author":"L Sun","year":"2022","unstructured":"Sun L, Petrone JS, McNulty SN et al (2022) Comparison of gene fusion detection methods in salivary gland tumors. Hum Pathol 123:1\u201310","journal-title":"Hum Pathol"},{"issue":"5","key":"1726_CR36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/his.14971","volume":"83","author":"MD Lanic","year":"2023","unstructured":"Lanic MD, Gu\u00e9rin R, Wassef M et al (2023) Detection of salivary gland and sinonasal fusions by a next-generation sequencing based, ligation-dependent, multiplex RT-PCR assay. Histopathology 83(5):685\u2013699","journal-title":"Histopathology"},{"issue":"1","key":"1726_CR37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jso.24266","volume":"114","author":"T Mukaigawa","year":"2016","unstructured":"Mukaigawa T, Hayashi R, Hashimoto K, Ugumori T, Hato N, Fujii S (2016) Programmed death ligand-1 expression is associated with poor disease free survival in salivary gland carcinomas. J Surg Oncol 114(1):36\u201343","journal-title":"J Surg Oncol"},{"key":"1726_CR38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.oraloncology.2019.01.015","volume":"90","author":"T Nakano","year":"2019","unstructured":"Nakano T, Takizawa K, Uezato A, Taguchi K, Toh S, Masuda M (2019) Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas. Oral Oncol 90:30\u201337","journal-title":"Oral Oncol"},{"key":"1726_CR39","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.2147\/OTT.S134589","volume":"10","author":"H Chang","year":"2017","unstructured":"Chang H, Kim JS, Choi YJ et al (2017) Overexpression of PD-L2 is associated with shorter relapse-free survival in patients with malignant salivary gland tumors. Onco Targets Ther 10:2983\u20132992","journal-title":"Onco Targets Ther"},{"issue":"3","key":"1726_CR40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11912-022-01356-3","volume":"25","author":"PF Moretz-Sohn","year":"2023","unstructured":"Moretz-Sohn PF, Dias FL, de Carvalho Marques CM (2023) Minor salivary gland cancer of the head and neck: a review of epidemiologic aspects, prognostic factors, and outcomes. Curr Oncol Rep 25(3):173\u2013179","journal-title":"Curr Oncol Rep"},{"issue":"Suppl. 1","key":"1726_CR41","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.5301\/TJ.5000688","volume":"103","author":"R Accorona","year":"2017","unstructured":"Accorona R, Barbieri D, Farina D, Lombardi D, Bussi M, Nicolai P (2017) Intracapsular carcinoma ex-pleomorphic adenoma of the parapharyngeal space: report of two cases and review of the literature. Tumori 103(Suppl. 1):e73\u2013e77","journal-title":"Tumori"},{"issue":"1","key":"1726_CR42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/hed.23258","volume":"36","author":"NL Villanueva","year":"2014","unstructured":"Villanueva NL, de Almeida JR, Sikora AG, Miles BA, Genden EM (2014) Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck 36(1):28\u201333","journal-title":"Head Neck"},{"issue":"10","key":"1726_CR43","doi-asserted-by":"crossref","first-page":"e26760","DOI":"10.1371\/journal.pone.0026760","volume":"6","author":"RK Kancha","year":"2011","unstructured":"Kancha RK, von Bubnoff N, Bartosch N, Peschel C, Engh RA, Duyster J (2011) Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS ONE 6(10):e26760","journal-title":"PLoS ONE"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-024-01726-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-024-01726-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-024-01726-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:06:59Z","timestamp":1736348819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-024-01726-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1726"],"URL":"https:\/\/doi.org\/10.1007\/s12105-024-01726-2","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"4 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"For this type of study formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Consent for publication was obtained for every individual person\u2019s data included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"118"}}