{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:27:45Z","timestamp":1787696865025,"version":"build-2784847793"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"Abstract<\/jats:title>\n \n Case presentation:<\/jats:title>\n \n A 30-year-old man presented with a multilobulated left parotid mass measuring 5.2\u2009\u00d7\u20094.1\u2009\u00d7\u20092.4\u00a0cm by imaging, and numerous enlarged left cervical lymph nodes, suspicious for metastasis. FNA cytopathology of the mass showed loose clusters of large cells displaying increased N\/C ratios and ample granular oncocytic cytoplasm. A superficial left parotidectomy with radical resection of the cheek and cervical lymphadenectomy was performed. Histopathologic examination disclosed a circumscribed, unencapsulated neoplasm exhibiting a solid growth pattern composed of infiltrative islands and nests of cohesive, polygonal, oncocytoid cells in a densely fibrous stroma. Lesional cells exhibited enlarged, oval, open-face nuclei with coarse chromatin and a single acidophilic macronucleolus, voluminous eosinophilic granular cytoplasm and distinct cell membrane borders. Mitotic activity and necrosis were absent. Microcystic architecture was noted solely in a single tumor nest at the periphery. These spaces contained mucinous secretions and were lined by cuboidal oncocytic and intermediate cells with interspersed mucocytes, highlighted by mucicarmine stain. Immunohistochemically, oncocytic cells were strongly and diffusely positive for cytokeratin AE1\/AE3, p63 and p40, and uniformly negative for androgen receptor, GATA3, S100, SOX10 and Her-2. A\n MAML2<\/jats:italic>\n rearrangement was identified by FISH, thus confirming the diagnosis of oncocytic variant of mucoepidermoid carcinoma.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In this illustrative example, we present the clinicoradiologic, cytologic, histopathologic, and immunophenotypic characteristics of this rare variant of mucoepidermoid carcinoma, together with molecular documentation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s12105-025-01768-0","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T01:13:08Z","timestamp":1742001188000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncocytic Mucoepidermoid Carcinoma of the Parotid Gland"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-6181","authenticated-orcid":false,"given":"Prokopios P.","family":"Argyris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Wakely Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"1768_CR1","unstructured":"Leivo IBJ, Inagaki H, Vielh P, Cipriani NA, Costes-Martineau V Mucoepidermoid carcinoma. In: WHO Classification of Tumours Editorial Board. Head and neck tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2023 [cited 2025 Feb 19]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52"},{"issue":"2","key":"1768_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/his.15289","volume":"86","author":"RA Wolk","year":"2025","unstructured":"Wolk RA, Cipriani NA (2025) Update of newly-recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance. Histopathology 86(2):183\u2013198. https:\/\/doi.org\/10.1111\/his.15289","journal-title":"Histopathology"},{"issue":"2","key":"1768_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/his.14817","volume":"82","author":"JA Bishop","year":"2023","unstructured":"Bishop JA, Thompson LDR, Siegele B, Gagan J, Mansour M, Chernock RD et al (2023) Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours. Histopathology 82(2):305\u2013313. https:\/\/doi.org\/10.1111\/his.14817","journal-title":"Histopathology"},{"issue":"7","key":"1768_CR4","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/his.14911","volume":"82","author":"IG Koutlas","year":"2023","unstructured":"Koutlas IG, Argyris PP (2023) Low-grade cystic mucoepidermoid carcinoma of the oral mucosa: report of two puzzling examples with molecular confirmation. Histopathology 82(7):1112\u20131114. https:\/\/doi.org\/10.1111\/his.14911","journal-title":"Histopathology"},{"issue":"1","key":"1768_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s12105-024-01622-9","volume":"18","author":"N Katabi","year":"2024","unstructured":"Katabi N (2024) Oncocytoid salivary tumors: Differential diagnosis and utility of newly described immunohistochemistry. Head Neck Pathol 18(1):20. https:\/\/doi.org\/10.1007\/s12105-024-01622-9","journal-title":"Head Neck Pathol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01768-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:28Z","timestamp":1767588808000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01768-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,15]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1768"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01768-0","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,15]]},"assertion":[{"value":"24 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"30"}}