{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:01:21Z","timestamp":1785535281530,"version":"3.56.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073237"],"award-info":[{"award-number":["82073237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-025-01799-7","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:15:54Z","timestamp":1747732554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["DEK::AFF2-Associated Papillary Squamous Cell Carcinoma of the Sinonasal Tract: Clinicopathologic Characterization of 9 Cases"],"prefix":"10.1007","volume":"19","author":[{"given":"Ye","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"1799_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/PAP.0000000000000376","volume":"30","author":"K Ruangritchankul","year":"2023","unstructured":"Ruangritchankul K, Sandison A (2023) DEK::AFF2 fusion carcinomas of head and neck. Adv Anat Pathol 30:86","journal-title":"Adv Anat Pathol"},{"key":"1799_CR2","doi-asserted-by":"crossref","unstructured":"Agarwal A, Bhatt AA, Bathla G, Kanekar S, Soni N, Murray J, et al. (2023) Update from the 5th edition of the who classification of nasal, paranasal, and skull base tumors imaging overview with histopathologic and genetic correlation. Am J Neuroradiol 44: 1116\u201325.","DOI":"10.3174\/ajnr.A7960"},{"key":"1799_CR3","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1038\/s41379-021-00846-2","volume":"34","author":"Y Kuo","year":"2021","unstructured":"Kuo Y, Lewis JS, Zhai C, Chen Y, Chernock RD, Hsieh M et al (2021) DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology. Modern Pathol 34:1820\u20131830","journal-title":"Modern Pathol"},{"key":"1799_CR4","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1097\/PAS.0000000000001741","volume":"45","author":"LM Rooper","year":"2021","unstructured":"Rooper LM, Agaimy A, Dickson BC, Dueber JC (2021) DEK-AFF2 carcinoma of the sinonasal region and skull base. Surg Pathol 45:1682\u20131692","journal-title":"Surg Pathol"},{"key":"1799_CR5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/PAS.0000000000002335","volume":"49","author":"SA Hart","year":"2025","unstructured":"Hart SA, Hang J, Chernock RD, Mikula MW, Rooper L, Amin SE et al (2025) DEK\u202f: AFF2 fusion sinonasal and skull base nonkeratinizing squamous cell carcinoma\u202f: a clinical outcome study compared with conventional sinonasal squamous cell carcinoma. Am J Surg Pathol 49:130\u2013137","journal-title":"Am J Surg Pathol"},{"key":"1799_CR6","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1097\/PAS.0000000000001498","volume":"44","author":"E Todorovic","year":"2020","unstructured":"Todorovic E, Truong T, Eskander A, Lin V, Swanson D, Dickson BC et al (2020) Middle ear and temporal bone nonkeratinizing squamous cell carcinomas with DEK-AFF2 fusion: an emerging entity. Am J Surg Pathol 44:1244\u20131250","journal-title":"Am J Surg Pathol"},{"key":"1799_CR7","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1097\/PAS.0000000000001596","volume":"45","author":"E Yakirevich","year":"2021","unstructured":"Yakirevich E, Pavlivk DC, Perrino CM, Stanton M, Lu S (2021) Nonkeratinizing squamouscell carcinoma of the sinonasal tract with DEK-AFF2: further solidifying an emerging entity. Surg Pathol 45:718","journal-title":"Surg Pathol"},{"key":"1799_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-023-01334-8","author":"S Yuzawa","year":"2023","unstructured":"Yuzawa S, Michizuka T, Kakisaka R, Ono Y, Hayashi M, Takahara M et al (2023) Low-grade papillary Schneiderian carcinoma with TP53 mutation: a case report and review of the literature. Diagn Pathol. https:\/\/doi.org\/10.1186\/s13000-023-01334-8","journal-title":"Diagn Pathol"},{"key":"1799_CR9","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1097\/PAS.0000000000000390","volume":"39","author":"JS Lewis","year":"2015","unstructured":"Lewis JS, Chernock RD, Haynes W, El-Mofty SK (2015) Low-grade papillary schneiderian carcinoma, a unique and deceptively bland malignant neoplasm: report of a case. Am J Surg Pathol 39:714\u2013721","journal-title":"Am J Surg Pathol"},{"key":"1799_CR10","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1038\/s41379-022-01117-4","volume":"35","author":"YJ Kuo","year":"2022","unstructured":"Kuo YJ, Lewis JJ, Truong T, Yeh YC, Chernock RD, Zhai C et al (2022) Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract. Modern Pathol 35:1587\u20131595","journal-title":"Modern Pathol"},{"key":"1799_CR11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s12105-023-01538-w","volume":"17","author":"D Holliday","year":"2023","unstructured":"Holliday D, Mehrad M, Ely KA, Tong F, Wang X, Hang J et al (2023) Sinonasal adenosquamous carcinoma\u2014morphology and genetic drivers including low- and high-risk human papillomavirus mRNA, DEK::AFF2 Fusion, and MAML2 rearrangement. Head Neck Pathol 17:487\u2013497","journal-title":"Head Neck Pathol"},{"key":"1799_CR12","doi-asserted-by":"publisher","first-page":"23414","DOI":"10.18632\/oncotarget.15582","volume":"8","author":"EA Smith","year":"2017","unstructured":"Smith EA, Kumar B, Komurov K, Smith SM, Brown NV, Zhao S et al (2017) DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma. Oncotarget 8:23414\u201323426","journal-title":"Oncotarget"},{"key":"1799_CR13","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.jtho.2022.05.009","volume":"17","author":"O Savari","year":"2022","unstructured":"Savari O, Chang JC, Bishop JA, Sakthivel MK, Askin FB, Rekhtman N (2022) First report of thoracic carcinoma with DEK::AFF2 rearrangement: a case report. J Thorac Oncol 17:1050\u20131053","journal-title":"J Thorac Oncol"},{"key":"1799_CR14","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1007\/s12105-022-01432-x","volume":"16","author":"DL Miller","year":"2022","unstructured":"Miller DL, Palsgrove DN, Rijal A, Hathuc V, Chernock R, Gagan J et al (2022) Unclassified neuroendocrine tumor with a novel CHD4::AFF2 fusion: expanding the family of AFF2-rearranged head and neck malignancies. Head Neck Pathol 16:928\u2013933","journal-title":"Head Neck Pathol"},{"key":"1799_CR15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/s41591-019-0434-2","volume":"25","author":"W Yang","year":"2019","unstructured":"Yang W, Lee K, Srivastava RM, Kuo F, Krishna C, Chowell D et al (2019) Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nat Med 25:767\u2013775","journal-title":"Nat Med"},{"key":"1799_CR16","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s12105-021-01335-3","volume":"15","author":"MW Saab-Chalhoub","year":"2021","unstructured":"Saab-Chalhoub MW, Guo X, Shi Q, Chernock RD, Lewis JS (2021) Low grade papillary sinonasal (Schneiderian) carcinoma: a series of five cases of a unique malignant neoplasm with comparison to inverted papilloma and conventional nonkeratinizing squamous cell carcinoma. Head Neck Pathol 15:1221\u20131234","journal-title":"Head Neck Pathol"},{"key":"1799_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009999","author":"YH Im","year":"2024","unstructured":"Im YH, Choi D, Nam I (2024) Low-grade papillary schneiderian carcinoma in the nasal cavity. J Craniofac Surg. https:\/\/doi.org\/10.1097\/SCS.0000000000009999","journal-title":"J Craniofac Surg"},{"key":"1799_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0103-5","author":"H Wang","year":"2016","unstructured":"Wang H, Chang Y, To K, Hwang JSG, Mai H, Feng Y et al (2016) A new prognostic histopathologic classification of nasopharyngeal carcinoma. Chin J Cancer. https:\/\/doi.org\/10.1186\/s40880-016-0103-5","journal-title":"Chin J Cancer"},{"key":"1799_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","volume":"394","author":"Y Chen","year":"2019","unstructured":"Chen Y, Chan ATC, Le Q, Blanchard P, Sun Y, Ma J (2019) Nasopharyngeal carcinoma. Lancet 394:64\u201380","journal-title":"Lancet"},{"key":"1799_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00292-023-01202-8","volume":"44","author":"A Agaimy","year":"2023","unstructured":"Agaimy A (2023) Sinonasal neoplasms: Update from the WHO 2022. Pathologie (Heidelb) 44:233\u2013239","journal-title":"Pathologie (Heidelb)"},{"key":"1799_CR21","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.939244","author":"NM AlMadan","year":"2023","unstructured":"AlMadan NM, AlEssa EA, AlGhamdi DA (2023) SMARCB1-deficient sinonasal carcinoma: case report and review of the literature. Am J Case Rep. https:\/\/doi.org\/10.12659\/AJCR.939244","journal-title":"Am J Case Rep"},{"key":"1799_CR22","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1097\/PAS.0000000000000460","volume":"39","author":"JA Bishop","year":"2015","unstructured":"Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR (2015) Adamantinoma-like ewing family tumors of the head and neck. Am J Surg Pathol 39:1267","journal-title":"Am J Surg Pathol"},{"key":"1799_CR23","doi-asserted-by":"publisher","unstructured":"Rooper LM, Bishop JA (2020) Soft tissue special issue: adamantinoma-like ewing sarcoma of the head and neck: a practical review of a challenging emerging entity. Head Neck Pathol 14(1):59\u201369. https:\/\/doi.org\/10.1007\/s12105019-01098-y","DOI":"10.1007\/s12105019-01098-y"},{"key":"1799_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fonc.2017.00072","volume":"7","author":"A Argiris","year":"2017","unstructured":"Argiris A, Harrington KJ, Tahara M, Schulten J, Chomette P, Ferreira Castro A et al (2017) Evidence-based treatment options in recurrent and\/or metastatic squamous cell carcinoma of the head and neck. Front Oncol 7:72","journal-title":"Front Oncol"},{"issue":"1","key":"1799_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12943-023-01725-x","volume":"22","author":"H Zhang","year":"2023","unstructured":"Zhang H, Liu L, Liu J, Dang P, Hu S, Yuan W, Sun Z, Liu Y, Wang C (2023) Roles of tumor-associated macrophages in anti-PD-1\/PD-L1 immunotherapy for solid cancers. Mol Cancer 22(1):58","journal-title":"Mol Cancer"},{"issue":"22","key":"1799_CR26","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1056\/NEJMoa1809615","volume":"379","author":"P Schmid","year":"2018","unstructured":"Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Di\u00e9ras V, Hegg R, Im SA, Shaw Wright G, Henschel V (2018) Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer. N Engl J Med 379(22):2108-2121","journal-title":"N Engl J Med"},{"key":"1799_CR27","first-page":"195","volume":"191","author":"DGSSAD Pfister","year":"2024","unstructured":"Pfister DGSSAD (2024) Head and neck cancers, version 4.2024. J Natl Compr Cancer Netw 191:195","journal-title":"J Natl Compr Cancer Netw"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01799-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01799-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01799-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:48Z","timestamp":1767588828000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01799-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1799"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01799-7","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"25 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The use of clinical tissue specimens for this study was approved by the ethics committee of Nanfang Hospital, Southern Medical University (Guangzhou, China; No. NFEC-2025-023). All of the patients signed an informed consent form before their clinical materials were used for research purposes. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964\u00a0Helsinki declaration\u00a0and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Consent for publication was obtained for every individual person\u2019s data included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"66"}}