{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:56:01Z","timestamp":1767588961055,"version":"3.48.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We present the case of a patient with acinic cell carcinoma of the parotid gland who was found to have metastasis to the left atrium of the heart. The pathologic findings and prior reports of metastasis of acinic cell carcinoma are discussed in this article. Grading of acinic cell carcinoma and utility of immunohistochemical study using NOR-1 is discussed.<\/jats:p>","DOI":"10.1007\/s12105-025-01808-9","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T03:50:36Z","timestamp":1751860236000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Acinic Cell Carcinoma Metastasizing to the Heart"],"prefix":"10.1007","volume":"19","author":[{"given":"Aniqa Nuzhat","family":"Chowdhury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayna","family":"DeSando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima Zahra","family":"Aly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"1808_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S1658-3876(09)50035-0","volume":"2","author":"N Al-Zaher","year":"2009","unstructured":"Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS (2009) Acinic cell carcinoma of the salivary glands: A literature review. Hematol Oncol Stem Cell Ther 2:259\u2013264","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"1808_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5306\/wjco.v11.i1.11","volume":"11","author":"SA Ali","year":"2020","unstructured":"Ali SA et al (2020) Predictors of distant metastasis in acinic cell carcinoma of the Parotid gland. WJCO 11:11\u201319","journal-title":"WJCO"},{"key":"1808_CR3","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1002\/cncr.32792","volume":"126","author":"X Mimica","year":"2020","unstructured":"Mimica X et al (2020) Distant metastasis of salivary gland cancer: incidence, management, and outcomes. Cancer 126:2153\u20132162","journal-title":"Cancer"},{"key":"1808_CR4","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1245\/s10434-015-4454-y","volume":"22","author":"S Ali","year":"2015","unstructured":"Ali S et al (2015) Distant metastases in patients with carcinoma of the major salivary glands. Ann Surg Oncol 22:4014\u20134019","journal-title":"Ann Surg Oncol"},{"key":"1808_CR5","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1007\/s00405-020-05998-6","volume":"277","author":"M Cavaliere","year":"2020","unstructured":"Cavaliere M, De Luca P, Scarpa A et al (2020) Acinic cell carcinoma of the Parotid gland: from pathogenesis to management: a literature review. Eur Arch Otorhinolaryngol 277:2673\u20132679. https:\/\/doi.org\/10.1007\/s00405-020-05998-6","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1808_CR6","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.3390\/jcm8091315","volume":"8","author":"S Grasl","year":"2019","unstructured":"Grasl S et al (2019) Nodal metastases in acinic cell carcinoma of the Parotid gland. JCM 8:1315","journal-title":"JCM"},{"key":"1808_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humpath.2020.05.001","volume":"102","author":"L Nguyen","year":"2020","unstructured":"Nguyen L et al (2020) NOR-1 distinguishes acinic cell carcinoma from its mimics on fine-needle aspiration biopsy specimens. Hum Pathol 102:1\u20136","journal-title":"Hum Pathol"},{"key":"1808_CR8","first-page":"e13","volume":"48","author":"S Vidyadhara","year":"2007","unstructured":"Vidyadhara S, Shetty AP, Rajasekaran S (2007) Widespread metastases from acinic cell carcinoma of Parotid gland. Singap Med J 48:e13\u201315","journal-title":"Singap Med J"},{"key":"1808_CR9","first-page":"232470961667474","volume":"4","author":"Y Khelfa","year":"2016","unstructured":"Khelfa Y et al (2016) Relapsed acinic cell carcinoma of the Parotid gland with diffuse distant metastasis: case report with literature review. J Investig Med High Impact Case Rep 4:232470961667474","journal-title":"J Investig Med High Impact Case Rep"},{"key":"1808_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1177\/019459988809800210","volume":"98","author":"RJ Stanley","year":"1988","unstructured":"Stanley RJ, Weiland LH, Olsen KD, Pearson BW (1988) Dedifferentiated acinic cell (Acinous) carcinoma of the Parotid gland. Otolaryngol --head Neck Surg 98:155\u2013161","journal-title":"Otolaryngol - -head Neck Surg"},{"key":"1808_CR11","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1097\/PAS.0000000000001867","volume":"46","author":"B Xu","year":"2022","unstructured":"Xu B et al (2022) Head and neck acinic cell carcinoma: A new grading system proposal and diagnostic utility of NR4A3 immunohistochemistry. Am J Surg Pathol 46:933\u2013941","journal-title":"Am J Surg Pathol"},{"key":"1808_CR12","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.3390\/cancers15133373","volume":"15","author":"J Khan","year":"2023","unstructured":"Khan J et al (2023) Acinic cell carcinoma in the 21st century: A Population-Based study from the SEER database and review of recent molecular genetic advances. Cancers 15:3373","journal-title":"Cancers"},{"key":"1808_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.30699\/ijp.2021.530574.2645","volume":"17","author":"E Mirzaian","year":"2022","unstructured":"Mirzaian E, Asgarikarchekani S, Abdoli AA (2022) Rare case of brain metastasis from dedifferentiated acinic cell carcinoma of Parotid gland and review of the literature. Iran J Pathol 17:97\u2013103","journal-title":"Iran J Pathol"},{"key":"1808_CR14","doi-asserted-by":"publisher","first-page":"780","DOI":"10.5858\/2005-129-780-IEOACC","volume":"129","author":"ML Spencer","year":"2005","unstructured":"Spencer ML, Neto G, Fuller A, G. N., Luna MA (2005) Intracranial extension of acinic cell carcinoma of the Parotid gland. Arch Pathol Lab Med 129:780\u2013782","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"1808_CR15","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1001\/archopht.121.12.1783","volume":"121","author":"TA Saleh","year":"2003","unstructured":"Saleh TA, Hakin KN, Davidson MJ (2003) Metastasis of acinic cell carcinoma of the Parotid gland to the contralateral orbit. Arch Ophthalmol 121(12):1783\u20131786. https:\/\/doi.org\/10.1001\/archopht.121.12.1783","journal-title":"Arch Ophthalmol"},{"key":"1808_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.oraloncology.2018.05.002","volume":"82","author":"C Scherl","year":"2018","unstructured":"Scherl C et al (2018) Outcomes and prognostic factors for Parotid acinic cell carcinoma: A National Cancer database study of 2362 cases. Oral Oncol 82:53\u201360","journal-title":"Oral Oncol"},{"key":"1808_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jasc.2022.07.001","volume":"11","author":"V Krishnan","year":"2022","unstructured":"Krishnan V et al (2022) NOR-1 (NR4A3) immunostaining on cytologic preparations for the preoperative diagnosis of acinic cell carcinoma of the salivary gland. J Am Soc Cytopathol 11:352\u2013358","journal-title":"J Am Soc Cytopathol"},{"key":"1808_CR18","doi-asserted-by":"publisher","first-page":"100150","DOI":"10.1016\/j.modpat.2023.100150","volume":"36","author":"S Dogan","year":"2023","unstructured":"Dogan S et al (2023) Loss of CDKN2A\/B is a molecular marker of High-grade histology and is associated with aggressive behavior in acinic cell carcinoma. Mod Pathol 36:100150","journal-title":"Mod Pathol"},{"key":"1808_CR19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/lary.24231","volume":"124","author":"NR Patel","year":"2014","unstructured":"Patel NR et al (2014) Demographic trends and disease-specific survival in salivary acinic cell carcinoma: an analysis of 1129 cases. Laryngoscope 124:172\u2013178","journal-title":"Laryngoscope"},{"key":"1808_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.5858\/arpa.2021-0418-OA","volume":"147","author":"LM Nova-Camacho","year":"2023","unstructured":"Nova-Camacho LM et al (2023) Cardiac metastasis from solid cancers: A 35-Year Single-Center autopsy study. Arch Pathol Lab Med 147:177\u2013184","journal-title":"Arch Pathol Lab Med"},{"key":"1808_CR21","doi-asserted-by":"publisher","DOI":"10.29011\/AMCO-128.000128","author":"J Foglietta","year":"2021","unstructured":"Foglietta J, Cardona AA (2021) Rare case of a minor salivary gland carcinoma with a voluminous cardiac metastasis. Ann Med Clin Oncol. https:\/\/doi.org\/10.29011\/AMCO-128.000128","journal-title":"Ann Med Clin Oncol"},{"key":"1808_CR22","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s12885-018-4070-x","volume":"18","author":"I Burazor","year":"2018","unstructured":"Burazor I et al (2018) Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment. BMC Cancer 18:202","journal-title":"BMC Cancer"},{"key":"1808_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.case.2021.09.012","volume":"6","author":"L Buchanan","year":"2022","unstructured":"Buchanan L et al (2022) Metastatic carcinoma to the right heart: the complementary utility of Contrast-Enhanced echocardiography and cardiac positron emission tomography\/computed tomography. CASE (Phila) 6:3\u20137","journal-title":"CASE (Phila)"},{"key":"1808_CR24","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.anl.2021.02.016","volume":"49","author":"T Kishida","year":"2022","unstructured":"Kishida T et al (2022) Pericardial metastasis of Parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy. Auris Nasus Larynx 49:727\u2013732","journal-title":"Auris Nasus Larynx"},{"key":"1808_CR25","first-page":"258","volume":"39","author":"ZT Demirozu","year":"2012","unstructured":"Demirozu ZT, Ho JK, Sarwar AB, Delgado RM, Frazier OH (2012) Adenocarcinoma of the Parotid gland metastatic to the ventricular septum and right ventricular wall. Tex Heart Inst J 39:258\u2013260","journal-title":"Tex Heart Inst J"},{"key":"1808_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1477-7819-1-20","volume":"1","author":"NG Barbetakis","year":"2003","unstructured":"Barbetakis NG, Vassiliadis M, Krikeli M, Antoniadis T, Tsilikas C (2003) Cardiac tamponade secondary to metastasis from adenocarcinoma of the Parotid gland. World J Surg Oncol 1:20","journal-title":"World J Surg Oncol"},{"key":"1808_CR27","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/hed.2890040413","volume":"4","author":"A Sulkes","year":"1982","unstructured":"Sulkes A, Weshler Z, Dolberg L, Biran S (1982) Isolated pericardial metastasis of Parotid tumor origin. Head Neck Surg 4:344\u2013348","journal-title":"Head Neck Surg"},{"key":"1808_CR28","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1002\/1097-0142(197509)36:3<1080::AID-CNCR2820360336>3.0.CO;2-V","volume":"36","author":"SN Becker","year":"1975","unstructured":"Becker SN, Reza MJ, Greenberg SH, Stein JJ (1975) Pericardial effusion secondary to mucoepidermoid carcinoma of the Parotid gland. A report of an unusual case. Cancer 36:1080\u20131085","journal-title":"Cancer"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01808-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:31Z","timestamp":1767588811000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01808-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1808"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01808-9","relation":{},"ISSN":["1936-0568"],"issn-type":[{"type":"electronic","value":"1936-0568"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"25 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For this type of study formal consent is not required. This study was approved by the Institutional Review Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"This study has obtained IRB approval from Atrium Health Wake Forest Baptist hospital and the need for informed consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Consent for publication was obtained for every individual person\u2019s data included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"82"}}