{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:18:07Z","timestamp":1791483487179,"version":"4.3.4"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Oral soft tissue and jawbone sarcomas (OSTJS) are rare neoplasms accounting for only 1% of all intraoral malignancies. As a result, robust epidemiologic data pertaining to OSTJS are limited. Here, we present a collaborative, retrospective analysis of the clinicopathologic characteristics of 128 cases of OSTJS, together with a comprehensive review of the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Archived OSTJS cases (2000\u20132022) were retrieved from the electronic laboratory databases of the oral pathology services at The Ohio State University and University of Minnesota. Patient age and sex, anatomic site and histopathologic diagnosis were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 128 OSTJS, 123 (96.1%) were primary and 5 (3.9%) metastatic (M: F\u2009=\u20091.5:1; mean age\u2009=\u200943.7 years, range\u2009=\u20094-102 years). Most OSTJS presented in adults (113, 88.3%; mean age\u2009=\u200947.8 years) with only 15 pediatric cases (11.7%; mean age\u2009=\u200913 years). Favored sites included the mandible (48, 37.5%), maxilla (39, 30.4%), gingiva (15, 11.7%), palate (13, 10.2%), and tongue (4, 3.1%). In adults, osteosarcoma represented the predominant OSTJS (58, 51.3%), followed by Kaposi sarcoma (18, 15.9%), leiomyosarcoma (7, 6.2%), chondrosarcoma (6, 5.3%), low-grade myofibroblastic sarcoma (5, 4.4%), and 4 each (3.5%) of angiosarcoma, rhabdomyosarcoma and undifferentiated pleomorphic sarcoma. Similarly, osteosarcoma comprised the most common OSTJS histotype in the pediatric population (8, 53.3%), followed by Ewing sarcoma (4, 26.7%) and 1 each (6.7%) of\n                      <jats:italic>TFCP2::EWSR1<\/jats:italic>\n                      -rearranged rhabdomyosarcoma, mesenchymal chondrosarcoma, and alveolar soft part sarcoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OSTJS represent an uncommon, histopathologically diverse, subset of mesenchymal malignancies. In our series, most patients were adults in their 4th \u2212\u20095th decade with a broad age range and a slight male predilection. Overall, jawbone osteosarcoma and Kaposi sarcoma accounted for two-thirds of OSTJS cases in this cohort. While the diagnosis of OSTJS relies heavily on routine light microscopic findings, ancillary immunohistochemistry and\/or cytogenetic studies are frequently warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12105-025-01811-0","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:40:20Z","timestamp":1750149620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Soft Tissue and Jawbone Sarcomas: A Retrospective Clinicopathologic Analysis of 128 Cases from Two Institutions and Comprehensive Literature Review"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-6181","authenticated-orcid":false,"given":"Prokopios P.","family":"Argyris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle R.","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaram","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis G.","family":"Koutlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin K.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Kalmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"1811_CR1","doi-asserted-by":"publisher","unstructured":"Lahat G, Lazar A, Lev D (2008) Sarcoma epidemiology and etiology: potential environmental and genetic factors. Surg Clin North Am.;88(3):451\u2013\u200981, v. https:\/\/doi.org\/10.1016\/j.suc.2008.03.006","DOI":"10.1016\/j.suc.2008.03.006"},{"issue":"1","key":"1811_CR2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2045-3329-2-14","volume":"2","author":"Z Burningham","year":"2012","unstructured":"Burningham Z, Hashibe M, Spector L, Schiffman JD (2012) The epidemiology of sarcoma. Clin Sarcoma Res 2(1):14. https:\/\/doi.org\/10.1186\/2045-3329-2-14","journal-title":"Clin Sarcoma Res"},{"issue":"5","key":"1811_CR3","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.suc.2016.05.005","volume":"96","author":"JY Hui","year":"2016","unstructured":"Hui JY (2016) Epidemiology and etiology of sarcomas. Surg Clin North Am 96(5):901\u2013914. https:\/\/doi.org\/10.1016\/j.suc.2016.05.005","journal-title":"Surg Clin North Am"},{"key":"1811_CR4","unstructured":"American Cancer Society. Cancer Facts & Figs (2025) Atlanta: American Cancer Society; 2025. Available at https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/allcancer-facts-figures\/2025-cancer-facts-figures.html"},{"issue":"3","key":"1811_CR5","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1097\/SLA.0000000000000869","volume":"260","author":"MF Brennan","year":"2014","unstructured":"Brennan MF, Antonescu CR, Moraco N, Singer S (2014) Lessons learned from the study of 10,000 patients with soft tissue sarcoma. Ann Surg 260(3):416\u2013421 discussion 21\u2013\u20092. https:\/\/doi.org\/10.1097\/SLA.0000000000000869","journal-title":"Ann Surg"},{"issue":"3","key":"1811_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2214\/AJR.18.19894","volume":"212","author":"CL Scelsi","year":"2019","unstructured":"Scelsi CL, Wang A, Garvin CM, Bajaj M, Forseen SE, Gilbert BC (2019) Head and neck sarcomas: A review of clinical and imaging findings based on the 2013 world health organization classification. AJR Am J Roentgenol 212(3):644\u2013654. https:\/\/doi.org\/10.2214\/AJR.18.19894","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"1811_CR7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1177\/0194599814545747","volume":"151","author":"KA Peng","year":"2014","unstructured":"Peng KA, Grogan T, Wang MB (2014) Head and neck sarcomas: analysis of the SEER database. Otolaryngol Head Neck Surg 151(4):627\u2013633. https:\/\/doi.org\/10.1177\/0194599814545747","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"1811_CR8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3390\/cancers5030890","volume":"5","author":"MA Tejani","year":"2013","unstructured":"Tejani MA, Galloway TJ, Lango M, Ridge JA, von Mehren M (2013) Head and neck sarcomas: a comprehensive cancer center experience. Cancers (Basel) 5(3):890\u2013900. https:\/\/doi.org\/10.3390\/cancers5030890","journal-title":"Cancers (Basel)"},{"issue":"5","key":"1811_CR9","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00405-020-05834-x","volume":"277","author":"DGL Moreira","year":"2020","unstructured":"Moreira DGL, da Silva LP, de Morais EF, Queiroz S, de Moura Santos E, de Souza LB et al (2020) The occurrence and pattern of head and neck sarcomas: a comprehensive cancer center experience. Eur Arch Otorhinolaryngol 277(5):1473\u20131480. https:\/\/doi.org\/10.1007\/s00405-020-05834-x","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1811_CR10","doi-asserted-by":"publisher","unstructured":"Alaggio A, Magro G et al (2021) Pediatric Surgical Pathology of Sarcomas of the Head and Neck. In: P. Campisi (eds.), Pediatric Head and Neck Textbook.; pp.743\u2013783. https:\/\/doi.org\/10.1007\/978-3-030-59265-3_31","DOI":"10.1007\/978-3-030-59265-3_31"},{"issue":"4","key":"1811_CR11","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s13193-012-0127-5","volume":"2","author":"AS Aljabab","year":"2011","unstructured":"Aljabab AS, Nason RW, Kazi R, Pathak KA (2011) Head and neck soft tissue sarcoma. Indian J Surg Oncol 2(4):286\u2013290. https:\/\/doi.org\/10.1007\/s13193-012-0127-5","journal-title":"Indian J Surg Oncol"},{"issue":"3","key":"1811_CR12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/01.coc.0000158440.27229.d6","volume":"28","author":"SA Chen","year":"2005","unstructured":"Chen SA, Morris CG, Amdur RJ, Werning JW, Villaret DB, Mendenhall WM (2005) Adult head and neck soft tissue sarcomas. Am J Clin Oncol 28(3):259\u2013263. https:\/\/doi.org\/10.1097\/01.coc.0000158440.27229.d6","journal-title":"Am J Clin Oncol"},{"issue":"1","key":"1811_CR13","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1097\/SCS.0000000000010783","volume":"36","author":"MV Dimitrijevic","year":"2025","unstructured":"Dimitrijevic MV, Tomic AMM, Todorovic NR, Dimitrijevic AM, Kablar DB (2025) Sarcomas of the head and neck region. J Craniofac Surg 36(1):e75\u2013e7. https:\/\/doi.org\/10.1097\/SCS.0000000000010783","journal-title":"J Craniofac Surg"},{"key":"1811_CR14","volume-title":"Oral and maxillofacial pathology","author":"BW Neville","year":"2024","unstructured":"Neville BW, Damm DD, Allen CM, Chi AC (2024) Oral and maxillofacial pathology, 5th edn. Saunders Elsevier, Philadelphia, PA","edition":"5"},{"key":"1811_CR15","unstructured":"WHO Classification of Tumours Editorial Board Head and neck tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2023 [cited on 04\/15\/2025]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52"},{"key":"1811_CR16","doi-asserted-by":"publisher","unstructured":"Jacob DS, Raghu B et al (2021) Sarcoma of the Maxillofacial\/Head and Neck Region. In: K. Bonanthaya (eds.), Oral and Maxillofacial Surgery for the Clinician.; pp.1893\u20131902. https:\/\/doi.org\/10.1007\/978-981-15-1346-6_83","DOI":"10.1007\/978-981-15-1346-6_83"},{"key":"1811_CR17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.oraloncology.2016.12.005","volume":"65","author":"LV Vassiliou","year":"2017","unstructured":"Vassiliou LV, Lalabekyan B, Jay A, Liew C, Whelan J, Newman L et al (2017) Head and neck sarcomas: A single Institute series. Oral Oncol 65:16\u201322. https:\/\/doi.org\/10.1016\/j.oraloncology.2016.12.005","journal-title":"Oral Oncol"},{"issue":"2","key":"1811_CR18","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/1097-0142(19940715)74:2<697::aid-cncr2820740224>3.0.co;2-a","volume":"74","author":"DH Kraus","year":"1994","unstructured":"Kraus DH, Dubner S, Harrison LB, Strong EW, Hajdu SI, Kher U et al (1994) Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas. Cancer 74(2):697\u2013702. https:\/\/doi.org\/10.1002\/1097-0142(19940715)74:2%3C;697::aid-cncr2820740224%3E;3.0.co;2-a","journal-title":"Cancer"},{"issue":"7","key":"1811_CR19","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.clon.2024.04.009","volume":"36","author":"RG Hikmet","year":"2024","unstructured":"Hikmet RG, Klug TE, Gade SD, Sandfeld-Paulsen B, Aggerholm-Pedersen N (2024) A retrospective study of 291 patients with head and neck sarcomas: treatment, outcomes, and prognostic factors. Clin Oncol (R Coll Radiol) 36(7):409\u2013419. https:\/\/doi.org\/10.1016\/j.clon.2024.04.009","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"4","key":"1811_CR20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S1368-8375(98)80010-9","volume":"34","author":"M Gorsky","year":"1998","unstructured":"Gorsky M, Epstein JB (1998) Head and neck and intra-oral soft tissue sarcomas. Oral Oncol 34(4):292\u2013296","journal-title":"Oral Oncol"},{"issue":"2","key":"1811_CR21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/ejso.1999.0758","volume":"26","author":"M Pandey","year":"2000","unstructured":"Pandey M, Thomas G, Mathew A, Abraham EK, Somanathan T, Ramadas K et al (2000) Sarcoma of the oral and maxillofacial soft tissue in adults. Eur J Surg Oncol 26(2):145\u2013148. https:\/\/doi.org\/10.1053\/ejso.1999.0758","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"1811_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s00784-003-0233-4","volume":"8","author":"S Yamaguchi","year":"2004","unstructured":"Yamaguchi S, Nagasawa H, Suzuki T, Fujii E, Iwaki H, Takagi M et al (2004) Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig 8(2):52\u201355. https:\/\/doi.org\/10.1007\/s00784-003-0233-4","journal-title":"Clin Oral Investig"},{"issue":"4","key":"1811_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.bjoms.2005.11.008","volume":"45","author":"MM Chidzonga","year":"2007","unstructured":"Chidzonga MM, Mahomva L (2007) Sarcomas of the oral and maxillofacial region: a review of 88 cases in Zimbabwe. Br J Oral Maxillofac Surg 45(4):317\u2013318. https:\/\/doi.org\/10.1016\/j.bjoms.2005.11.008","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"8","key":"1811_CR24","first-page":"4551","volume":"35","author":"T Sumida","year":"2015","unstructured":"Sumida T, Otawa N, Kamata YU, Yamada T, Uchida K, Nakano H et al (2015) A clinical investigation of oral sarcomas at Multi-institutions over the past 30 years. Anticancer Res 35(8):4551\u20134555","journal-title":"Anticancer Res"},{"issue":"2","key":"1811_CR25","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s12253-018-0510-9","volume":"25","author":"P Kumar","year":"2019","unstructured":"Kumar P, Surya V, Urs AB, Augustine J, Mohanty S, Gupta S (2019) Sarcomas of the oral and maxillofacial region: analysis of 26 cases with emphasis on diagnostic challenges. Pathol Oncol Res 25(2):593\u2013601. https:\/\/doi.org\/10.1007\/s12253-018-0510-9","journal-title":"Pathol Oncol Res"},{"issue":"1","key":"1811_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/odi.13211","volume":"26","author":"WRS de Carvalho","year":"2020","unstructured":"de Carvalho WRS, de Souza LL, Pontes FSC, Uchoa DCC, Correa DL, de Caceres C et al (2020) A multicenter study of oral sarcomas in Brazil. Oral Dis 26(1):43\u201352. https:\/\/doi.org\/10.1111\/odi.13211","journal-title":"Oral Dis"},{"key":"1811_CR27","doi-asserted-by":"crossref","unstructured":"Bisio PM, Olvi LG, Carrizo F, Paparella ML (2020) Sarcomas of the oral cavity: a study of a series of 22 cases. Oral Surg Oral Med Oral Pathol Oral Radiol 129(1):e24\u2013e25","DOI":"10.1016\/j.oooo.2019.06.048"},{"key":"1811_CR28","doi-asserted-by":"crossref","unstructured":"Pina PSS, Bergamini ML, Coracin FL, de Sousa SCOM (2021) Nov Oral soft-tissue sarcomas diagnosed in an oral pathology service: a 16year experience. Clin Lab Res Dent [Internet]. 10 [cited 2025 Mar. 25];. Available from: https:\/\/www.revistas.usp.br\/clrd\/article\/view\/184424","DOI":"10.11606\/issn.2357-8041.clrd.2021.184424"},{"key":"1811_CR29","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3332\/ecancer.2016.665","volume":"10","author":"TD Silva","year":"2016","unstructured":"Silva TD, Ferreira CB, Leite GB, de Menezes Pontes JR, Antunes HS (2016) Oral manifestations of lymphoma: a systematic review. Ecancermedicalscience 10:665. https:\/\/doi.org\/10.3332\/ecancer.2016.665","journal-title":"Ecancermedicalscience"},{"issue":"3","key":"1811_CR30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.oooo.2013.06.014","volume":"116","author":"PP Argyris","year":"2013","unstructured":"Argyris PP, Dolan M, Piperi E, Tosios KI, Pambuccian SE, Koutlas IG (2013) Oral follicular lymphomas. A short report of 8 cases with assessment of the IGH\/BCL2 gene fusion with fluorescence in situ hybridization. Oral Surg Oral Med Oral Pathol Oral Radiol 116(3):343\u2013347. https:\/\/doi.org\/10.1016\/j.oooo.2013.06.014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"3","key":"1811_CR31","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12105-016-0693-x","volume":"10","author":"MH Smith","year":"2016","unstructured":"Smith MH, Bhattacharyya I, Cohen DM, Islam NM, Fitzpatrick SG, Montague LJ et al (2016) Melanoma of the oral cavity: an analysis of 46 new cases with emphasis on clinical and histopathologic characteristics. Head Neck Pathol 10(3):298\u2013305. https:\/\/doi.org\/10.1007\/s12105-016-0693-x","journal-title":"Head Neck Pathol"},{"issue":"3","key":"1811_CR32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/hed.10019","volume":"24","author":"SG Patel","year":"2002","unstructured":"Patel SG, Prasad ML, Escrig M, Singh B, Shaha AR, Kraus DH et al (2002) Primary mucosal malignant melanoma of the head and neck. Head Neck 24(3):247\u2013257","journal-title":"Head Neck"},{"issue":"2","key":"1811_CR33","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S1368-8375(99)00085-8","volume":"36","author":"MJ Hicks","year":"2000","unstructured":"Hicks MJ, Flaitz CM (2000) Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 36(2):152\u2013169","journal-title":"Oral Oncol"},{"key":"1811_CR34","doi-asserted-by":"publisher","DOI":"10.1111\/his.14843","author":"PP Argyris","year":"2022","unstructured":"Argyris PP, Naumann J, Jarvis MC, Wilkinson PE, Ho DP, Islam MN et al (2022) Primary mucosal melanomas of the head and neck are characterized by overexpression of the DNA mutating enzyme APOBEC3B. Histopathology. https:\/\/doi.org\/10.1111\/his.14843","journal-title":"Histopathology"},{"key":"1811_CR35","unstructured":"WHO Classification of Tumours Editorial Board Soft tissue and bone tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2020 [cited on 04\/15\/2025]. (WHO classification of tumours series, 5th ed.; vol. 3). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/33"},{"key":"1811_CR36","doi-asserted-by":"publisher","unstructured":"Suk R, White DL, Knights S, Nijhawan A, Deshmukh AA, Chiao EY (2022) Incidence trends of Kaposi sarcoma among young Non-Hispanic black men by US regions, 2001\u20132018. JNCI Cancer Spectr 6(6). https:\/\/doi.org\/10.1093\/jncics\/pkac078","DOI":"10.1093\/jncics\/pkac078"},{"issue":"10","key":"1811_CR37","doi-asserted-by":"publisher","first-page":"e1566","DOI":"10.1016\/S2214-109X(23)00349-2","volume":"11","author":"L Fu","year":"2023","unstructured":"Fu L, Tian T, Wang B, Lu Z, Gao Y, Sun Y et al (2023) Global patterns and trends in Kaposi sarcoma incidence: a population-based study. Lancet Glob Health 11(10):e1566\u2013e75. https:\/\/doi.org\/10.1016\/S2214-109X(23)00349-2","journal-title":"Lancet Glob Health"},{"issue":"1","key":"1811_CR38","doi-asserted-by":"publisher","first-page":"e77213","DOI":"10.7759\/cureus.77213","volume":"17","author":"D Balasubramanian","year":"2025","unstructured":"Balasubramanian D, Srinivasan S, Paul PM, Ko N, Garlapati S (2025) A retrospective study on the incidence of Kaposi sarcoma in the united States from 1999 to 2020 using the centers for disease control and prevention Wide-Ranging online data for epidemiological research (CDC WONDER) database. Cureus 17(1):e77213. https:\/\/doi.org\/10.7759\/cureus.77213","journal-title":"Cureus"},{"issue":"4","key":"1811_CR39","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.oooo.2014.12.013","volume":"119","author":"HW Wang","year":"2015","unstructured":"Wang HW, Qin XJ, Yang WJ, Xu LQ, Ji T, Zhang CP (2015) Alveolar soft part sarcoma of the oral and maxillofacial region: clinical analysis in a series of 18 patients. Oral Surg Oral Med Oral Pathol Oral Radiol 119(4):396\u2013401. https:\/\/doi.org\/10.1016\/j.oooo.2014.12.013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"1","key":"1811_CR40","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12105-012-0395-y","volume":"7","author":"PP Argyris","year":"2013","unstructured":"Argyris PP, Reed RC, Manivel JC, Lopez-Terrada D, Jakacky J, Cayci Z et al (2013) Oral alveolar soft part sarcoma in childhood and adolescence: report of two cases and review of literature. Head Neck Pathol 7(1):40\u201349. https:\/\/doi.org\/10.1007\/s12105-012-0395-y","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1811_CR41","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s12105-022-01505-x","volume":"17","author":"A Aksionau","year":"2023","unstructured":"Aksionau A, Dela Cruz NE, Meram AT, Cuellar-Saenz H, Aveni JR, Takei H (2023) Lingual alveolar soft part sarcoma in a 78-Year-Old woman: A case report and comprehensive review of the literature from 1952 to 2022. Head Neck Pathol 17(1):265\u2013274. https:\/\/doi.org\/10.1007\/s12105-022-01505-x","journal-title":"Head Neck Pathol"},{"issue":"2","key":"1811_CR42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/PAS.0000000000002334","volume":"49","author":"A Agaimy","year":"2025","unstructured":"Agaimy A, Michal M, Abdelsatir A, Abdelsatir AA, Abdulrahim S, Laco J et al (2025) TFE3 -rearranged head and neck neoplasms: Twenty-two cases spanning the morphologic continuum between alveolar soft part sarcoma and pecoma and highlighting genotypic diversity. Am J Surg Pathol 49(2):104\u2013112. https:\/\/doi.org\/10.1097\/PAS.0000000000002334","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"1811_CR43","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/PAS.0000000000001439","volume":"44","author":"B Xu","year":"2020","unstructured":"Xu B, Chang K, Folpe AL, Kao YC, Wey SL, Huang HY et al (2020) Head and neck mesenchymal neoplasms with GLI1 gene alterations: A pathologic entity with distinct histologic features and potential for distant metastasis. Am J Surg Pathol 44(6):729\u2013737. https:\/\/doi.org\/10.1097\/PAS.0000000000001439","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"1811_CR44","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1016\/j.oooo.2021.10.007","volume":"134","author":"H Zhong","year":"2022","unstructured":"Zhong H, Xu C, Chen X, Guo X, Yang S (2022) GLI1-altered epithelioid soft tissue tumor: A newly described entity with a predilection for the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol 134(1):e14\u2013e22. https:\/\/doi.org\/10.1016\/j.oooo.2021.10.007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"10","key":"1811_CR45","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1136\/jcp.50.10.869","volume":"50","author":"X Leroy","year":"1997","unstructured":"Leroy X, Delobelle A, Lefebvre JL, Cabaret V, Bloget F, Vilain MO (1997) Epithelioid sarcoma of the tongue. J Clin Pathol 50(10):869\u2013870. https:\/\/doi.org\/10.1136\/jcp.50.10.869","journal-title":"J Clin Pathol"},{"issue":"4","key":"1811_CR46","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1177\/0003489420952473","volume":"130","author":"AA Kazi","year":"2021","unstructured":"Kazi AA, Vahidi NA, Wiles AB, Reiter ER (2021) Epithelioid sarcoma of the tongue: an unusual tumor mimic for squamous cell carcinoma. Ann Otol Rhinol Laryngol 130(4):416\u2013419. https:\/\/doi.org\/10.1177\/0003489420952473","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1811_CR47","doi-asserted-by":"publisher","unstructured":"Argyris PPRA, Bilodeau EA, Koutlas IG (2024) Epithelioid sarcoma of the oral cavity: A retrospective clinicopathologic study of three rare cases. oral surgery, oral medicine, oral pathology and oral radiology. 138(2):e50\u2013e1. https:\/\/doi.org\/10.1016\/j.oooo.2024.04.063","DOI":"10.1016\/j.oooo.2024.04.063"},{"issue":"3","key":"1811_CR48","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1007\/s12105-022-01451-8","volume":"16","author":"DP Ho","year":"2022","unstructured":"Ho DP, Wilkinson PE, Vogel RI, Gopalakrishnan R, Argyris PP (2022) Metastatic tumors to the oral soft tissues and jawbones: A retrospective analysis of 40 cases and review of the literature. Head Neck Pathol 16(3):802\u2013813. https:\/\/doi.org\/10.1007\/s12105-022-01451-8","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1811_CR49","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/0973-029X.110737","volume":"17","author":"G Kumar","year":"2013","unstructured":"Kumar G, Manjunatha B (2013) Metastatic tumors to the jaws and oral cavity. J Oral Maxillofac Pathol 17(1):71\u201375. https:\/\/doi.org\/10.4103\/0973-029X.110737","journal-title":"J Oral Maxillofac Pathol"},{"issue":"8","key":"1811_CR50","doi-asserted-by":"publisher","first-page":"151448","DOI":"10.1016\/j.acthis.2019.151448","volume":"121","author":"I Kaplan","year":"2019","unstructured":"Kaplan I, Raiser V, Shuster A, Shlomi B, Rosenfeld E, Greenberg A et al (2019) Metastatic tumors in oral mucosa and jawbones: unusual primary origins and unusual oral locations. Acta Histochem 121(8):151448. https:\/\/doi.org\/10.1016\/j.acthis.2019.151448","journal-title":"Acta Histochem"},{"issue":"4","key":"1811_CR51","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12105-014-0591-z","volume":"8","author":"A Hirshberg","year":"2014","unstructured":"Hirshberg A, Berger R, Allon I, Kaplan I (2014) Metastatic tumors to the jaws and mouth. Head Neck Pathol 8(4):463\u2013474. https:\/\/doi.org\/10.1007\/s12105-014-0591-z","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1811_CR52","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1902\/jop.2013.130118","volume":"85","author":"I Allon","year":"2014","unstructured":"Allon I, Pessing A, Kaplan I, Allon DM, Hirshberg A (2014) Metastatic tumors to the gingiva and the presence of teeth as a contributing factor: a literature analysis. J Periodontol 85(1):132\u2013139. https:\/\/doi.org\/10.1902\/jop.2013.130118","journal-title":"J Periodontol"},{"issue":"2","key":"1811_CR53","doi-asserted-by":"publisher","first-page":"101656","DOI":"10.1016\/j.jormas.2023.101656","volume":"125","author":"S Atarbashi-Moghadam","year":"2024","unstructured":"Atarbashi-Moghadam S, Atarbashi-Moghadam F, Niazmand M, Shahrabi-Farahani S (2024) Metastatic sarcomas of the oral cavity: A systematic review. J Stomatol Oral Maxillofac Surg 125(2):101656. https:\/\/doi.org\/10.1016\/j.jormas.2023.101656","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"1","key":"1811_CR54","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/his.12298","volume":"64","author":"M Miettinen","year":"2014","unstructured":"Miettinen M (2014) Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers. Histopathology 64(1):101\u2013118. https:\/\/doi.org\/10.1111\/his.12298","journal-title":"Histopathology"},{"issue":"4","key":"1811_CR55","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1177\/10668969211056013","volume":"30","author":"H Cheng","year":"2022","unstructured":"Cheng H, Yihebali C, Zhang H, Guo L, Shi S (2022) Clinical characteristics, pathology and outcome of 237 patients with synovial sarcoma: single center experience. Int J Surg Pathol 30(4):360\u2013369. https:\/\/doi.org\/10.1177\/10668969211056013","journal-title":"Int J Surg Pathol"},{"issue":"6","key":"1811_CR56","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1111\/odi.13835","volume":"28","author":"CJ Shi","year":"2022","unstructured":"Shi CJ, Xu SM, Li CW, Tian Z, Wang LZ, Hu YH et al (2022) Epithelioid sarcoma: A clinicopathological study of 12 head and neck cases. Oral Dis 28(6):1519\u20131527. https:\/\/doi.org\/10.1111\/odi.13835","journal-title":"Oral Dis"},{"key":"1811_CR57","doi-asserted-by":"publisher","unstructured":"Frank R, Sadri N, Bhatti T, Biegel JA, Livolsi VA, Zhang PJ (2013) Proximal-type epithelioid sarcoma of the head and neck (HN): A study with immunohistochemical and molecular analysis of SMARCB1. J Clin Exp Oncol 2(2). https:\/\/doi.org\/10.4172\/2324-9110.1000106","DOI":"10.4172\/2324-9110.1000106"},{"issue":"1","key":"1811_CR58","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12105-024-01722-6","volume":"18","author":"WW MacDonald","year":"2024","unstructured":"MacDonald WW, Wakely PE, Argyris PP (2024) On vascular lesions of the thyroid gland with emphasis on intrathyroidal hemangioma: clinicopathologic characterization of two cases and review of the literature. Head Neck Pathol 18(1):108. https:\/\/doi.org\/10.1007\/s12105-024-01722-6","journal-title":"Head Neck Pathol"},{"issue":"2","key":"1811_CR59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s12022-018-9513-z","volume":"29","author":"YP Hung","year":"2018","unstructured":"Hung YP, Hornick JL (2018) Immunohistochemical biomarkers of mesenchymal neoplasms in endocrine organs: diagnostic pitfalls and recent discoveries. Endocr Pathol 29(2):189\u2013198. https:\/\/doi.org\/10.1007\/s12022-018-9513-z","journal-title":"Endocr Pathol"},{"issue":"7","key":"1811_CR60","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.humpath.2011.10.018","volume":"43","author":"A Agaimy","year":"2012","unstructured":"Agaimy A, Kirsche H, Semrau S, Iro H, Hartmann A (2012) Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. Hum Pathol 43(7):1142\u20131147. https:\/\/doi.org\/10.1016\/j.humpath.2011.10.018","journal-title":"Hum Pathol"},{"issue":"3","key":"1811_CR61","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12105-022-01412-1","volume":"16","author":"M Bal","year":"2022","unstructured":"Bal M, Shah A, Rekhi B, Mittal N, Rane SU, Rabade K et al (2022) Adamantinoma-Like ewing sarcoma of the head and neck: A Case-Series of a rare and challenging diagnosis. Head Neck Pathol 16(3):679\u2013694. https:\/\/doi.org\/10.1007\/s12105-022-01412-1","journal-title":"Head Neck Pathol"},{"issue":"1","key":"1811_CR62","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12105-020-01189-1","volume":"15","author":"IG Koutlas","year":"2021","unstructured":"Koutlas IG, Olson DR, Rawwas J (2021) FET(EWSR1)-TFCP2 rhabdomyosarcoma: an additional example of this aggressive variant with predilection for the gnathic bones. Head Neck Pathol 15(1):374\u2013380. https:\/\/doi.org\/10.1007\/s12105-020-01189-1","journal-title":"Head Neck Pathol"},{"issue":"2","key":"1811_CR63","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s12105-022-01507-9","volume":"17","author":"KPD Gallagher","year":"2023","unstructured":"Gallagher KPD, Roza A, Tager E, Mariz B, Soares CD, Rocha AC et al (2023) Rhabdomyosarcoma with TFCP2 rearrangement or typical Co-expression of AE1\/AE3 and ALK: report of three new cases in the head and neck region and literature review. Head Neck Pathol 17(2):546\u2013561. https:\/\/doi.org\/10.1007\/s12105-022-01507-9","journal-title":"Head Neck Pathol"},{"key":"1811_CR64","doi-asserted-by":"publisher","unstructured":"Dehner CA, Rudzinski ER, Davis JL, Rhabdomyosarcoma (2024) Updates on classification and the necessity of molecular testing beyond immunohistochemistry. Hum Pathol 147:72\u201381. https:\/\/doi.org\/10.1016\/j.humpath.2023.12.004","DOI":"10.1016\/j.humpath.2023.12.004"},{"issue":"6","key":"1811_CR65","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1016\/j.oooo.2023.12.792","volume":"137","author":"F Chen","year":"2024","unstructured":"Chen F, Wang J, Sun Y, Zhang J (2024) Mandibular rhabdomyosarcoma with TFCP2 rearrangement and osteogenic differentiation: a case misdiagnosed as fibrous dysplasia or low-grade central osteosarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol 137(6):e143\u2013e9. https:\/\/doi.org\/10.1016\/j.oooo.2023.12.792","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"7","key":"1811_CR66","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/gcc.23145","volume":"62","author":"H Carrillo-Ng","year":"2023","unstructured":"Carrillo-Ng H, Liang Y, Chang S, Afkhami M, Gernon T, Bell D et al (2023) Complete mimicry: rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma-diagnostic challenge and report of two cases. Genes Chromosomes Cancer 62(7):430\u2013436. https:\/\/doi.org\/10.1002\/gcc.23145","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"1811_CR67","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/his.14323","volume":"79","author":"B Xu","year":"2021","unstructured":"Xu B, Suurmeijer AJH, Agaram NP, Zhang L, Antonescu CR (2021) Head and neck rhabdomyosarcoma with TFCP2 fusions and ALK overexpression: a clinicopathological and molecular analysis of 11 cases. Histopathology 79(3):347\u2013357. https:\/\/doi.org\/10.1111\/his.14323","journal-title":"Histopathology"},{"issue":"3","key":"1811_CR68","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/his.13649","volume":"73","author":"NK Dashti","year":"2018","unstructured":"Dashti NK, Wehrs RN, Thomas BC, Nair A, Davila J, Buckner JC et al (2018) Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype. Histopathology 73(3):514\u2013520. https:\/\/doi.org\/10.1111\/his.13649","journal-title":"Histopathology"},{"issue":"5","key":"1811_CR69","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00428-020-02870-0","volume":"477","author":"JSA Chrisinger","year":"2020","unstructured":"Chrisinger JSA, Wehrli B, Dickson BC, Fasih S, Hirbe AC, Shultz DB et al (2020) Epithelioid and spindle cell rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusion: report of two cases. Virchows Arch 477(5):725\u2013732. https:\/\/doi.org\/10.1007\/s00428-020-02870-0","journal-title":"Virchows Arch"},{"issue":"2","key":"1811_CR70","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s12105-017-0851-9","volume":"12","author":"LDR Thompson","year":"2018","unstructured":"Thompson LDR, Jo VY, Agaimy A, Llombart-Bosch A, Morales GN, Machado I et al (2018) Sinonasal tract alveolar rhabdomyosarcoma in adults: A clinicopathologic and immunophenotypic study of Fifty-Two cases with emphasis on epithelial immunoreactivity. Head Neck Pathol 12(2):181\u2013192. https:\/\/doi.org\/10.1007\/s12105-017-0851-9","journal-title":"Head Neck Pathol"},{"key":"1811_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2024.08.016","author":"GC Speakman","year":"2024","unstructured":"Speakman GC, McNamara KK, Kalmar JR, Argyris PP (2024) SATB2 expression in oral sarcomatoid (spindle cell) squamous cell carcinoma: clinicopathologic and immunophenotypic characterization of 10 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. https:\/\/doi.org\/10.1016\/j.oooo.2024.08.016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1811_CR72","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.humpath.2023.12.002","volume":"147","author":"C Wakefield","year":"2024","unstructured":"Wakefield C, Hornick JL (2024) Update on immunohistochemistry in bone and soft tissue tumors: Cost-effectively replacing molecular testing with immunohistochemistry. Hum Pathol 147:58\u201371. https:\/\/doi.org\/10.1016\/j.humpath.2023.12.002","journal-title":"Hum Pathol"},{"issue":"6","key":"1811_CR73","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1097\/PAP.0000000000000204","volume":"25","author":"IM Schaefer","year":"2018","unstructured":"Schaefer IM, Hornick JL (2018) Diagnostic immunohistochemistry for soft tissue and bone tumors: an update. Adv Anat Pathol 25(6):400\u2013412. https:\/\/doi.org\/10.1097\/PAP.0000000000000204","journal-title":"Adv Anat Pathol"},{"issue":"4","key":"1811_CR74","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/PAS.0000000000001663","volume":"45","author":"JL Hornick","year":"2021","unstructured":"Hornick JL (2021) Replacing molecular genetic testing with immunohistochemistry using antibodies that recognize the protein products of gene rearrangements: Next-generation immunohistochemistry. Am J Surg Pathol 45(4):584\u2013586. https:\/\/doi.org\/10.1097\/PAS.0000000000001663","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"1811_CR75","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.prp.2016.06.012","volume":"212","author":"I Machado","year":"2016","unstructured":"Machado I, Navarro S, Picci P, Llombart-Bosch A (2016) The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as ewing sarcomas and chondrosarcomas. Pathol Res Pract 212(9):811\u2013816. https:\/\/doi.org\/10.1016\/j.prp.2016.06.012","journal-title":"Pathol Res Pract"},{"issue":"1","key":"1811_CR76","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/his.12911","volume":"69","author":"JL Davis","year":"2016","unstructured":"Davis JL, Horvai AE (2016) Special AT-rich sequence-binding protein 2 (SATB2) expression is sensitive but May not be specific for osteosarcoma as compared with other high-grade primary bone sarcomas. Histopathology 69(1):84\u201390. https:\/\/doi.org\/10.1111\/his.12911","journal-title":"Histopathology"},{"issue":"1","key":"1811_CR77","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/his.12138","volume":"63","author":"JR Conner","year":"2013","unstructured":"Conner JR, Hornick JL (2013) SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours. Histopathology 63(1):36\u201349. https:\/\/doi.org\/10.1111\/his.12138","journal-title":"Histopathology"},{"issue":"9","key":"1811_CR78","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/modpathol.2010.124","volume":"23","author":"A Yoshida","year":"2010","unstructured":"Yoshida A, Ushiku T, Motoi T, Shibata T, Beppu Y, Fukayama M et al (2010) Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod Pathol 23(9):1279\u20131288. https:\/\/doi.org\/10.1038\/modpathol.2010.124","journal-title":"Mod Pathol"},{"issue":"4","key":"1811_CR79","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s12105-020-01139-x","volume":"14","author":"AL Limbach","year":"2020","unstructured":"Limbach AL, Lingen MW, McElherne J, Mashek H, Fitzpatrick C, Hyjek E et al (2020) The utility of MDM2 and CDK4 immunohistochemistry and MDM2 FISH in craniofacial osteosarcoma. Head Neck Pathol 14(4):889\u2013898. https:\/\/doi.org\/10.1007\/s12105-020-01139-x","journal-title":"Head Neck Pathol"},{"issue":"9","key":"1811_CR80","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1097\/PAS.0000000000001125","volume":"42","author":"X He","year":"2018","unstructured":"He X, Pang Z, Zhang X, Lan T, Chen H, Chen M et al (2018) Consistent amplification of FRS2 and MDM2 in Low-grade osteosarcoma: A genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol 42(9):1143\u20131155. https:\/\/doi.org\/10.1097\/PAS.0000000000001125","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"1811_CR81","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/modpathol.2010.229","volume":"24","author":"F Dujardin","year":"2011","unstructured":"Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret A et al (2011) MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. Mod Pathol 24(5):624\u2013637. https:\/\/doi.org\/10.1038\/modpathol.2010.229","journal-title":"Mod Pathol"},{"issue":"6","key":"1811_CR82","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00428-023-03530-9","volume":"482","author":"C Chen","year":"2023","unstructured":"Chen C, He X, Chen M, Du T, Qin W, Jing W et al (2023) Diagnostic value of MDM2 RNA in situ hybridization for low-grade osteosarcoma: consistency comparison of RNA in situ hybridization, fluorescence in situ hybridization, and immunohistochemistry. Virchows Arch 482(6):999\u20131010. https:\/\/doi.org\/10.1007\/s00428-023-03530-9","journal-title":"Virchows Arch"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01811-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01811-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01811-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:49Z","timestamp":1767588829000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01811-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":82,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1811"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01811-0","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"30 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This research was approved by The Ohio State University Biomedical Sciences Institutional Review Board (Study Number: 2022C0194).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent To Participate"}}],"article-number":"74"}}