{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:54:50Z","timestamp":1767588890509,"version":"3.48.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009913","name":"Naval Medical Center San Diego","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009913","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>BCM is an uncommon cytomorphologic variant with the potential to mimic unrelated neoplastic conditions, especially in the absence of a known cutaneous primary lesion or limited access to immunohistochemical stains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 28-year-old male patient presented with recent onset parotid gland mass. The mass was excised, and the subsequent workup elicited an interpretation of metastatic balloon cell melanoma (BCM). Despite an extensive evaluation, no evidence of a primary tumor site was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis<\/jats:title>\n                    <jats:p>The diagnosis was confirmed based on positive staining for BRAF, HMB45, Melan-A, PRAME, S100, and SOX-10 in the malignant cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Familiarity with the histologic and immunophenotypic findings may help to ensure an accurate diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12105-025-01814-x","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T15:00:03Z","timestamp":1752505203000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic Intraparotid Balloon Cell Melanoma: A Diagnostic Challenge"],"prefix":"10.1007","volume":"19","author":[{"given":"Reed A.","family":"McKinney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry B.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-0861","authenticated-orcid":false,"given":"Robert D.","family":"Foss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"1814_CR1","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1002\/1097-0142(19920615)69:12<2942::AID-CNCR2820691213>3.0.CO;2-0","volume":"69","author":"GF Kao","year":"1992","unstructured":"Kao GF, Helwig EB, Graham JH (1992) Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations. Cancer 69:2942\u20132952","journal-title":"Cancer"},{"issue":"2","key":"1814_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/dermatopathology9020013","volume":"9","author":"G Cazzato","year":"2022","unstructured":"Cazzato G, Cascardi E, Colagrande A, Cimmino A, Ingravallo G, Lospalluti L, Romita P, Demarco A, Arezzo F, Loizzi V, Dellino M, Trilli I, Bellitti E, Parente P, Lettini T, Foti C, Cormio G, Maiorano E, Resta L (2022) Balloon cell melanoma: presentation of four cases with a comprehensive review of the literature. Dermatopathol (Basel) 9(2):100\u2013110","journal-title":"Dermatopathol (Basel)"},{"key":"1814_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/ijd.15448","volume":"61","author":"G Wei","year":"2022","unstructured":"Wei G et al (2022) Balloon cell melanoma: a systematic review. Int J Dermatol 61:266\u2013277","journal-title":"Int J Dermatol"},{"issue":"3","key":"1814_CR4","first-page":"315","volume":"4","author":"L Lee","year":"2011","unstructured":"Lee L et al (2011) Metastatic balloon cell malignant melanoma: a case report and literature review. Int J Clin Exp Pathol 4(3):315\u2013321","journal-title":"Int J Clin Exp Pathol"},{"issue":"5","key":"1814_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1097\/DAD.0000000000000794","volume":"39","author":"S Chavez-Alvarez","year":"2017","unstructured":"Chavez-Alvarez S et al (2017) Balloon cell melanoma and its metastasis, a rare entity. Am J Dermatopathol 39(5):404\u2013411","journal-title":"Am J Dermatopathol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01814-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01814-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01814-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:04Z","timestamp":1767588784000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01814-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1814"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01814-x","relation":{},"ISSN":["1936-0568"],"issn-type":[{"type":"electronic","value":"1936-0568"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"No funds, grants, or other support was received for this manuscript. The authors declare they have no conflict of interest. Formal consent is not required. No datasets were generated or analyzed during the current manuscript. There is no software or custom code associated with this manuscript. No statistical analysis was performed in the preparation of this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The opinions and assertions expressed herein are those of the author(s) and do not reflect the official policy or position of the Uniformed Services University of the Health Sciences, the United States Department of the Navy, or the United States Department of Defense. References to non-Federal entities or products do not constitute or imply a Department of Defense, Department of the Navy, or Uniformed Services University of the Health Sciences endorsement.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"84"}}