{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:01:33Z","timestamp":1789826493790,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-025-01818-7","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:04:00Z","timestamp":1750820640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rethinking Ameloblastic Fibroma and Fibro-odontoma: A Serie of 6 Cases and Reclassification Proposal"],"prefix":"10.1007","volume":"19","author":[{"given":"Jonas","family":"Ver Berne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhilde","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hauben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"1818_CR1","volume-title":"Pathology & genetics of head and neck tumours","author":"L Barnes","year":"2005","unstructured":"Barnes L, Eveson J, Reichart P, Sidransky D (2005) Pathology & genetics of head and neck tumours. International Agency for Research on Cancer, Lyon"},{"key":"1818_CR2","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/J.OOOO.2013.06.039","volume":"116","author":"A Buchner","year":"2013","unstructured":"Buchner A, Vered M (2013) Ameloblastic fibroma: a stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analysis of 162 previously reported cases plus 10 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol 116:598\u2013606. https:\/\/doi.org\/10.1016\/J.OOOO.2013.06.039","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"1818_CR3","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/J.ORALONCOLOGY.2007.05.009","volume":"43","author":"Y Chen","year":"2007","unstructured":"Chen Y, Wang JM, Li TJ (2007) Ameloblastic fibroma: a review of published studies with special reference to its nature and biological behavior. Oral Oncol 43:960\u2013969. https:\/\/doi.org\/10.1016\/J.ORALONCOLOGY.2007.05.009","journal-title":"Oral Oncol"},{"key":"1818_CR4","volume-title":"WHO classification of head and neck tumours","author":"AK El-Naggar","year":"2017","unstructured":"El-Naggar AK, Chan JKC, Grandis JR et al (2017) WHO classification of head and neck tumours, 4th edn. International Agency for Research on Cancer, Lyon","edition":"4"},{"key":"1818_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/1097-0142(196101\/02)14:1<73::AID-CNCR2820140111>3.0.CO;2-T","volume":"14","author":"RJ Gorlin","year":"1961","unstructured":"Gorlin RJ, Chaudhry AP, Pindborg JJ (1961) Odontogenic tumors. Classification, histopathology, and clinical behavior in man and domesticated animals. Cancer 14:73\u2013101","journal-title":"Cancer"},{"key":"1818_CR6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/0030-4220(71)90322-7","volume":"32","author":"LR Eversole","year":"1971","unstructured":"Eversole LR, Tomich CE, Cherrick HM (1971) Histogenesis of odontogenic tumors. Oral Surg, Oral Med, Oral Pathol 32:569\u2013581. https:\/\/doi.org\/10.1016\/0030-4220(71)90322-7","journal-title":"Oral Surg, Oral Med, Oral Pathol"},{"key":"1818_CR7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0030-4220(84)90158-0","volume":"57","author":"DG Gardner","year":"1984","unstructured":"Gardner DG (1984) The mixed odontogenic tumors. Oral Surg, Oral Med, Oral Pathol 57:395\u2013397. https:\/\/doi.org\/10.1016\/0030-4220(84)90158-0","journal-title":"Oral Surg, Oral Med, Oral Pathol"},{"key":"1818_CR8","volume-title":"Head and neck tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board (2022) Head and neck tumours, 5th edn. International Agency for Research on Cancer, Lyon","edition":"5"},{"key":"1818_CR9","doi-asserted-by":"publisher","DOI":"10.5897\/JMGG11.022","author":"KC Chinsembu","year":"2012","unstructured":"Chinsembu KC (2012) Teeth are bones: signature genes and molecules that underwrite odontogenesis. J Med Genetics Genomics. https:\/\/doi.org\/10.5897\/JMGG11.022","journal-title":"J Med Genetics Genomics"},{"key":"1818_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2023.1313927","author":"M Lee","year":"2023","unstructured":"Lee M, Lee YS, Shon WJ, Park JC (2023) Physiologic dentin regeneration: its past, present, and future perspectives. Front Physiol. https:\/\/doi.org\/10.3389\/FPHYS.2023.1313927","journal-title":"Front Physiol"},{"key":"1818_CR11","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/J.GDE.2009.09.002","volume":"19","author":"M Bei","year":"2009","unstructured":"Bei M (2009) Molecular genetics of tooth development. Curr Opin Genet Dev 19:504. https:\/\/doi.org\/10.1016\/J.GDE.2009.09.002","journal-title":"Curr Opin Genet Dev"},{"key":"1818_CR12","doi-asserted-by":"publisher","DOI":"10.1242\/DEV.184754","author":"T Yu","year":"2020","unstructured":"Yu T, Klein OD (2020) Molecular and cellular mechanisms of tooth development, homeostasis and repair. Development (Cambridge). https:\/\/doi.org\/10.1242\/DEV.184754","journal-title":"Development (Cambridge)"},{"key":"1818_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/J.1600-0714.1980.TB01385.X","volume":"9","author":"PJ Slootweg","year":"1980","unstructured":"Slootweg PJ (1980) Epithelio-mesenchymal morphology in ameloblastic fibro-odontoma: a light and electron microscopic study. J Oral Pathol Med 9:29\u201340. https:\/\/doi.org\/10.1111\/J.1600-0714.1980.TB01385.X","journal-title":"J Oral Pathol Med"},{"key":"1818_CR14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.mod.2007.02.003","volume":"124","author":"S Oka","year":"2007","unstructured":"Oka S, Oka K, Xu X et al (2007) Cell autonomous requirement for TGF-\u03b2 signaling during odontoblast differentiation and dentin matrix formation. Mech Dev 124:409\u2013415. https:\/\/doi.org\/10.1016\/j.mod.2007.02.003","journal-title":"Mech Dev"},{"key":"1818_CR15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/J.1600-0714.1983.TB00314.X","volume":"12","author":"CW van Wyk","year":"1983","unstructured":"van Wyk CW, van der Vyver PC (1983) Ameloblastic fibroma with dentinoid formation\/immature dentinoma: a microscopic and ultrastructural study of the epithelial-connective tissue interface. J Oral Pathol Med 12:37\u201346. https:\/\/doi.org\/10.1111\/J.1600-0714.1983.TB00314.X","journal-title":"J Oral Pathol Med"},{"key":"1818_CR16","volume-title":"Ten cate\u2019s oral histology","author":"A Nanci","year":"2012","unstructured":"Nanci A (2012) Ten cate\u2019s oral histology, 8th edn. Elsevier Mosby, St. Louis","edition":"8"},{"key":"1818_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/J.1600-0722.1980.TB01199.X","volume":"88","author":"K Josephsen","year":"1980","unstructured":"Josephsen K, Larsson A, Fejerskov O (1980) Ultrastructural features of the epithelial-mesenchymal interface in an ameloblastic fibro-odontoma. Scand J Dent Res 88:79\u201395. https:\/\/doi.org\/10.1111\/J.1600-0722.1980.TB01199.X","journal-title":"Scand J Dent Res"},{"key":"1818_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/JOP.13401","volume":"52","author":"IP Gomes","year":"2023","unstructured":"Gomes IP, Bastos VC, Guimar\u00e3es LM, Gomes CC (2023) The molecular basis of odontogenic cysts and tumours. J Oral Pathol Med 52:351\u2013356. https:\/\/doi.org\/10.1111\/JOP.13401","journal-title":"J Oral Pathol Med"},{"key":"1818_CR19","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1016\/J.ORALONCOLOGY.2015.07.010","volume":"51","author":"P Brunner","year":"2015","unstructured":"Brunner P, Bihl M, Jundt G et al (2015) BRAF p. V600E mutations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology. Oral Oncol 51:e77\u2013e78. https:\/\/doi.org\/10.1016\/J.ORALONCOLOGY.2015.07.010","journal-title":"Oral Oncol"},{"key":"1818_CR20","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.1158\/1078-0432.CCR-14-1069","volume":"20","author":"NA Brown","year":"2014","unstructured":"Brown NA, Rolland D, McHugh JB et al (2014) Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res 20:5517\u20135526. https:\/\/doi.org\/10.1158\/1078-0432.CCR-14-1069","journal-title":"Clin Cancer Res"},{"key":"1818_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/JOP.13108","volume":"50","author":"KY Oh","year":"2021","unstructured":"Oh KY, Cho SD, Yoon HJ et al (2021) Discrepancy between immunohistochemistry and sequencing for BRAF V600E in odontogenic tumours: comparative analysis of two VE1 antibodies. J Oral Pathol Med 50:85\u201391. https:\/\/doi.org\/10.1111\/JOP.13108","journal-title":"J Oral Pathol Med"},{"key":"1818_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/J.JORMAS.2018.03.007","volume":"119","author":"BR Chrcanovic","year":"2018","unstructured":"Chrcanovic BR, Gomez RS (2018) Ameloblastic fibrodentinosarcoma and ameloblastic fibro-odontosarcoma: a systematic review. J Stomatol Oral Maxillofac Surg 119:401\u2013406. https:\/\/doi.org\/10.1016\/J.JORMAS.2018.03.007","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"1818_CR23","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/S0300-9785(76)80063-4","volume":"5","author":"M Altini","year":"1976","unstructured":"Altini M (1976) Ameloblastic dentinosarcoma\u2014a case report. Int J Oral Surg 5:142\u2013147. https:\/\/doi.org\/10.1016\/S0300-9785(76)80063-4","journal-title":"Int J Oral Surg"},{"key":"1818_CR24","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/0278-2391(85)90336-2","volume":"43","author":"M Altini","year":"1985","unstructured":"Altini M, Thompson SH, Lownie JF, Berezowski BB (1985) Ameloblastic sarcoma of the mandible. J Oral Maxillofac Surg 43:789\u2013794. https:\/\/doi.org\/10.1016\/0278-2391(85)90336-2","journal-title":"J Oral Maxillofac Surg"},{"key":"1818_CR25","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1034\/J.1600-0714.2001.300510.X","volume":"30","author":"RC Bregni","year":"2001","unstructured":"Bregni RC, Taylor AM, Garc\u00eda AM (2001) Ameloblastic fibrosarcoma of the mandible: report of two cases and review of the literature. J Oral Pathol Med 30:316\u2013320. https:\/\/doi.org\/10.1034\/J.1600-0714.2001.300510.X","journal-title":"J Oral Pathol Med"},{"key":"1818_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.09.077","author":"N Zabolinejad","year":"2008","unstructured":"Zabolinejad N, Hiradfar M, Anvari K, Razavi AS (2008) Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up. J Pediatr Surg. https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.09.077","journal-title":"J Pediatr Surg"},{"key":"1818_CR27","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.bjorl.2015.04.009","volume":"82","author":"LP da Silva","year":"2016","unstructured":"da Silva LP, da Rocha TJ, de Melo J\u00fanior BC et al (2016) Fibrodentinossarcoma amelobl\u00e1stico: um raro tumor odontog\u00eanico maligno. Braz J Otorhinolaryngol 82:610\u2013613. https:\/\/doi.org\/10.1016\/j.bjorl.2015.04.009","journal-title":"Braz J Otorhinolaryngol"},{"key":"1818_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0030-4220(55)90180-8","volume":"8","author":"VG Villa","year":"1955","unstructured":"Villa VG (1955) Ameloblastic sarcoma in the mandible. Report of a case. Oral Surg, Oral Med, Oral Pathol 8:123\u2013129. https:\/\/doi.org\/10.1016\/0030-4220(55)90180-8","journal-title":"Oral Surg, Oral Med, Oral Pathol"},{"key":"1818_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0266-4356(88)90149-0","volume":"26","author":"VM Phillips","year":"1988","unstructured":"Phillips VM, Grotepass FW, Hendricks R (1988) Ameloblastic odontosarcoma with epithelial atypia: a case report. Br J Oral Maxillofac Surg 26:45\u201351. https:\/\/doi.org\/10.1016\/0266-4356(88)90149-0","journal-title":"Br J Oral Maxillofac Surg"},{"key":"1818_CR30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ijom.2008.11.025","volume":"38","author":"P Mainenti","year":"2009","unstructured":"Mainenti P, Oliveira GS, Val\u00e9rio JB et al (2009) Ameloblastic fibro-odontosarcoma: a case report. Int J Oral Maxillofac Surg 38:289\u2013292. https:\/\/doi.org\/10.1016\/j.ijom.2008.11.025","journal-title":"Int J Oral Maxillofac Surg"},{"key":"1818_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.08.027","author":"V Reiser","year":"2013","unstructured":"Reiser V, Alterman M, Shuster A, Kaplan I (2013) Pediatric ameloblastic fibro-odontosarcoma of the mandible: a challenge of diagnosis and treatment. J Oral Maxillofac Surg. https:\/\/doi.org\/10.1016\/j.joms.2012.08.027","journal-title":"J Oral Maxillofac Surg"},{"key":"1818_CR32","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/PBC.25627","volume":"62","author":"SA Gatz","year":"2015","unstructured":"Gatz SA, Thway K, Mandeville H et al (2015) Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro-odontosarcoma of the maxilla. Pediatr Blood Cancer 62:2029\u20132032. https:\/\/doi.org\/10.1002\/PBC.25627","journal-title":"Pediatr Blood Cancer"},{"key":"1818_CR33","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/J.ANORL.2015.11.010","volume":"133","author":"SJ Chen","year":"2016","unstructured":"Chen SJ, Zheng XW, Lin X, Liu H (2016) Ameloblastic fibro-odontosarcoma of the mandible in a pediatric patient. Eur Ann Otorhinolaryngol Head Neck Dis 133:419\u2013421. https:\/\/doi.org\/10.1016\/J.ANORL.2015.11.010","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"1818_CR34","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.4103\/JOMFP.JOMFP_74_17","volume":"22","author":"S Atarbashi-Moghadam","year":"2018","unstructured":"Atarbashi-Moghadam S, Lotfi A, Mokhtari S (2018) A mixed odontogenic sarcoma: a challenging histopathologic case and brief review of the literature. J Oral Maxillofac Pathol 22:S29\u2013S34. https:\/\/doi.org\/10.4103\/JOMFP.JOMFP_74_17","journal-title":"J Oral Maxillofac Pathol"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01818-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01818-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01818-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:17Z","timestamp":1767588797000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01818-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1818"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01818-7","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Cases were collected under IRB approval S65708.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"For this type of study consent for publication is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"For this type of study formal consent is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}],"article-number":"77"}}