{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:18:14Z","timestamp":1791850694186,"version":"4.3.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"DOI":"10.1007\/s12105-025-01833-8","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T06:57:45Z","timestamp":1754290665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinico-Pathological Assessment and Malignant Transformation in Patients with Oral Epithelial Dysplasia - A Follow-up Cohort Study"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-0356","authenticated-orcid":false,"given":"Dinesh","family":"Yasothkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-3506","authenticated-orcid":false,"given":"Pratibha","family":"Ramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abilasha","family":"Ramasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"1833_CR1","first-page":"100664","volume":"34","author":"R Ellonen","year":"2022","unstructured":"Ellonen R, Suominen A, Kelppe J, Willberg J, Rautava J, Laine H (2022) Histopathological findings of oral epithelial dysplasias and their relation to malignant transformation. Cancer Treat Res Commun 34:100664","journal-title":"Cancer Treat Res Commun"},{"key":"1833_CR2","doi-asserted-by":"publisher","first-page":"15611","DOI":"10.1038\/s41598-025-98096-8","volume":"15","author":"JK Gautam","year":"2025","unstructured":"Gautam JK, Mohanty SS, Babu BV (2025) Prevalence and determinants of oral potentially malignant disorders in Western Rajasthan. Sci Rep 15:15611","journal-title":"Sci Rep"},{"key":"1833_CR3","doi-asserted-by":"crossref","unstructured":"Anuhya J, Sagar K, Sunitha C, Vasudeva G, Spoorti K Malignant transformation in oral epithelial dysplasticlesions: An observational study. JHSCI, 2025 Apr. 30;15(1):50\u2013\u20096","DOI":"10.17532\/jhsci.2025.2714"},{"key":"1833_CR4","doi-asserted-by":"publisher","unstructured":"M\u00fcller S (2018) Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology [Internet]. Vol. 125, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. pp. 591\u2013602. Available from: https:\/\/doi.org\/10.1016\/j.oooo.2018.02.012","DOI":"10.1016\/j.oooo.2018.02.012"},{"key":"1833_CR5","doi-asserted-by":"crossref","unstructured":"Sengupta N, Sarode SC, Sarode GS, Anand R, Mehta V (2023) Force, alternate movements, snap, suction and vibration functions of tongue are altered in oral submucous fibrosis patients. Journal of oral biology and craniofacial research [Internet]. Sep [cited 2023 Dec 23];13(5). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/37663369\/","DOI":"10.1016\/j.jobcr.2023.08.006"},{"issue":"1","key":"1833_CR6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12105-021-01402-9","volume":"16","author":"S Muller","year":"2022","unstructured":"Muller S, Tilakaratne WM (2022) Update from the 5th edition of the world health organization classification of head and neck tumors: tumours of the oral cavity and mobile tongue. Head Neck Pathol 16(1):54\u201362","journal-title":"Head Neck Pathol"},{"issue":"2","key":"1833_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4103\/jomfp.jomfp_536_22","volume":"27","author":"SP Bansal","year":"2023","unstructured":"Bansal SP, Pereira T, Desai RS, Jena A, Mehta V (2023) Expression of transforming growth factor-\u03b2 in oral submucous fibrosis: A systematic review. J Oral Maxillofac Pathol 27(2):348\u2013358","journal-title":"J Oral Maxillofac Pathol"},{"issue":"8","key":"1833_CR8","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1111\/odi.13993","volume":"27","author":"E Odell","year":"2021","unstructured":"Odell E, Kujan O, Warnakulasuriya S, Sloan P (2021) Oral epithelial dysplasia: recognition, grading and clinical significance. Oral Dis 27(8):1947\u20131976","journal-title":"Oral Dis"},{"issue":"3","key":"1833_CR9","doi-asserted-by":"publisher","first-page":"034001","DOI":"10.1088\/2633-1357\/ac95e2","volume":"3","author":"J Ingham","year":"2022","unstructured":"Ingham J, Smith CI, Ellis BG, Whitley CA, Triantafyllou A, Gunning PJ et al (2022) Prediction of malignant transformation in oral epithelial dysplasia using machine learning. IOP SciNotes 3(3):034001","journal-title":"IOP SciNotes"},{"key":"1833_CR10","doi-asserted-by":"publisher","unstructured":"Sperandio M, Warnakulasuriya S, Soares AB, Passador-Santos F, Mariano FV, Lima CSP et al (2022) Oral epithelial dysplasia grading: Comparing the binary system to the traditional 3-tier system, an actuarial study with malignant transformation as outcome. J Oral Pathol Med [Internet]. Available from: https:\/\/doi.org\/10.1111\/jop.13365","DOI":"10.1111\/jop.13365"},{"key":"1833_CR11","doi-asserted-by":"publisher","unstructured":"Nevanp\u00e4\u00e4 TT, Ter\u00e4v\u00e4 AE, Laine HK, Rautava J (2022) Malignant transformation of oral epithelial dysplasia in Southwest Finland [Internet]. Vol. 12, Scientific Reports. Available from: https:\/\/doi.org\/10.1038\/s41598-022-12441-9","DOI":"10.1038\/s41598-022-12441-9"},{"issue":"4","key":"1833_CR12","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1007\/s12109-022-09920-2","volume":"38","author":"L Fiorillo","year":"2022","unstructured":"Fiorillo L, Cicci\u00f9 M (2022) The use of Fi-Index tool to assess Per-manuscript Self-citations. Publishing Res Q 38(4):684\u2013692","journal-title":"Publishing Res Q"},{"issue":"3","key":"1833_CR13","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s12109-022-09892-3","volume":"38","author":"L Fiorillo","year":"2022","unstructured":"Fiorillo L (2022) Fi-index: A new method to evaluate authors Hirsch-index reliability. Publ Res Q 38(3):465\u2013474","journal-title":"Publ Res Q"},{"key":"1833_CR14","doi-asserted-by":"publisher","unstructured":"Kierce J, Klieb H, Blanas N, Magalhaes M (2020) Risk Factors Associated with Malignant Transformation of Oral Epithelial Dysplasia: A Retrospective Review [Internet]. Vol. 78, Journal of Oral and Maxillofacial Surgery. pp. e88\u20139. Available from: https:\/\/doi.org\/10.1016\/j.joms.2020.07.175","DOI":"10.1016\/j.joms.2020.07.175"},{"key":"1833_CR15","doi-asserted-by":"crossref","unstructured":"Sharma J, Bhargava M, Aggarwal S, Aggarwal A, Varshney A, Chopra D (2022 Oct-Dec) Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma. Indian J Pathol Microbiol 65(4):755\u2013760","DOI":"10.4103\/ijpm.ijpm_31_21"},{"key":"1833_CR16","doi-asserted-by":"publisher","unstructured":"Tilakaratne WM, Sherriff M, Morgan PR, Odell EW (2011) Grading oral epithelial dysplasia: analysis of individual features [Internet]. Vol. 40, Journal of Oral Pathology & Medicine. pp. 533\u201340. Available from: https:\/\/doi.org\/10.1111\/j.1600-0714.2011.01033.x","DOI":"10.1111\/j.1600-0714.2011.01033.x"},{"key":"1833_CR17","doi-asserted-by":"publisher","unstructured":"Jaber MA, Elameen EM (2021) Long-term follow-up of oral epithelial dysplasia: A hospital based cross-sectional study [Internet]. Vol. 16, Journal of Dental Sciences. pp. 304\u201310. Available from: https:\/\/doi.org\/10.1016\/j.jds.2020.04.003","DOI":"10.1016\/j.jds.2020.04.003"},{"key":"1833_CR18","doi-asserted-by":"publisher","unstructured":"Mehanna HM, Rattay T, Smith J, McConkey CC (2009) Treatment and follow-up of oral dysplasia - A systematic review and meta-analysis [Internet]. Vol. 31, Head & Neck. pp. 1600\u20139. Available from: https:\/\/doi.org\/10.1002\/hed.21131","DOI":"10.1002\/hed.21131"},{"key":"1833_CR19","doi-asserted-by":"publisher","first-page":"809248","DOI":"10.1155\/2013\/809248","volume":"2013","author":"A Diajil","year":"2013","unstructured":"Diajil A, Robinson CM, Sloan P, Thomson PJ (2013) Clinical outcome following oral potentially malignant disorder treatment: a 100 patient cohort study. Int J Dent 2013:809248","journal-title":"Int J Dent"},{"issue":"1","key":"1833_CR20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10147-010-0157-3","volume":"16","author":"T Amagasa","year":"2011","unstructured":"Amagasa T, Yamashiro M, Uzawa N (2011) Oral premalignant lesions: from a clinical perspective. Int J Clin Oncol 16(1):5\u201314","journal-title":"Int J Clin Oncol"},{"issue":"3","key":"1833_CR21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/his.12746","volume":"68","author":"T Fonseca-Silva","year":"2016","unstructured":"Fonseca-Silva T, Diniz MG, de Sousa SF, Gomez RS, Gomes CC (2016) Association between histopathological features of dysplasia in oral leukoplakia and loss of heterozygosity. Histopathology 68(3):456\u2013460","journal-title":"Histopathology"},{"key":"1833_CR22","doi-asserted-by":"crossref","unstructured":"Rao UKM, Thavarajah R, Joshua E, Ranganathan K (2018 May-Aug) Loss of heterozygosity as a marker to predict progression of oral epithelial dysplasia to oral squamous cell carcinoma. J Oral Maxillofac Pathol 22(2):155\u2013160","DOI":"10.4103\/jomfp.JOMFP_151_18"},{"issue":"3","key":"1833_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.oooo.2020.06.021","volume":"130","author":"RH Ramani","year":"2020","unstructured":"Ramani RH, Ramanathan P, R A, Ramasubramanian JMSG (2020) CYP2 C9 polymorphism among patients with oral squamous cell carcinoma and its role in altering the metabolism of benzo[a]pyrene. Oral Surg Oral Med Oral Pathol Oral Radiol 130(3):306\u2013312","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"20","key":"1833_CR24","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2217\/epi-2022-0294","volume":"14","author":"VP Jayaseelan","year":"2022","unstructured":"Jayaseelan VP, Arumugam P (2022) Epigenetic modulator LSD1, a theragnostic target for potentially malignant oral disorders and malignant lesions. Epigenomics 14(20):1229\u20131232","journal-title":"Epigenomics"},{"key":"1833_CR25","doi-asserted-by":"publisher","unstructured":"Nankivell P, Mehanna H (2011) Oral Dysplasia: Biomarkers, Treatment, and Follow-up [Internet]. Vol. 13, Current Oncology Reports. pp. 145\u201352. Available from: https:\/\/doi.org\/10.1007\/s11912-010-0150-z","DOI":"10.1007\/s11912-010-0150-z"},{"key":"1833_CR26","doi-asserted-by":"crossref","unstructured":"Brennan PA, Aldridge T, Dwivedi RC (2019) Premalignant conditions of the oral cavity. Springer, p 276","DOI":"10.1007\/978-981-13-2931-9"},{"issue":"10","key":"1833_CR27","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1093\/jnci\/djz238","volume":"112","author":"AK Chaturvedi","year":"2020","unstructured":"Chaturvedi AK, Udaltsova N, Engels EA, Katzel JA, Yanik EL, Katki HA et al (2020) Oral leukoplakia and risk of progression to oral cancer: A Population-Based cohort study. J Natl Cancer Inst 112(10):1047\u20131054","journal-title":"J Natl Cancer Inst"},{"key":"1833_CR28","doi-asserted-by":"crossref","unstructured":"Shah MDFACSJ, Johnson CMG (2018) FMedSci MDSc N. Oral and oropharyngeal cancer. CRC, p 553","DOI":"10.1201\/9781351138543"},{"issue":"6","key":"1833_CR29","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1600-0714.2009.00782.x","volume":"38","author":"PG Arduino","year":"2009","unstructured":"Arduino PG, Surace A, Carbone M, Elia A, Massolini G, Gandolfo S et al (2009) Outcome of oral dysplasia: a retrospective hospital-based study of 207 patients with a long follow-up. J Oral Pathol Med 38(6):540\u2013544","journal-title":"J Oral Pathol Med"},{"issue":"2","key":"1833_CR30","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4103\/jomfp.JOMFP_166_20","volume":"26","author":"N Puneeta","year":"2022","unstructured":"Puneeta N, Santosh T, Mishra I, Gaikwad P, Sahu A (2022) Evaluation of e-cadherin and vimentin expression for different grades of oral epithelial dysplasia and oral squamous cell carcinoma - An immunohistochemical study. J Oral Maxillofac Pathol 26(2):285\u2013286","journal-title":"J Oral Maxillofac Pathol"},{"key":"1833_CR31","doi-asserted-by":"publisher","unstructured":"Mariz BALA, Sales de S\u00e1 R, Ara\u00fajo ALD, Rodrigues Fernandes CI, Mariano FV, Santos-Silva AR et al (2022) FGFR1 is an important prognostic factor in oral leukoplakia and tongue squamous cell carcinoma. J Oral Pathol Med [Internet]. Available from: https:\/\/doi.org\/10.1111\/jop.13398","DOI":"10.1111\/jop.13398"},{"issue":"9","key":"1833_CR32","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/s41379-022-01067-x","volume":"35","author":"Prediction of malignant transformation","year":"2022","unstructured":"Prediction of malignant transformation (2022) And recurrence of oral epithelial dysplasia using architectural and cytological feature specific prognostic models. Mod Pathol 35(9):1151\u20131159","journal-title":"Mod Pathol"},{"issue":"1","key":"1833_CR33","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1186\/s12903-022-02646-9","volume":"22","author":"B Klongnoi","year":"2022","unstructured":"Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N et al (2022) Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in Northeastern Thailand. BMC Oral Health 22(1):613","journal-title":"BMC Oral Health"},{"issue":"12","key":"1833_CR34","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1002\/hed.27539","volume":"45","author":"C Bernard","year":"2023","unstructured":"Bernard C, Zhang JZ, Klieb H, Blanas N, Xu W, Magalhaes M (2023) Clinical outcomes of oral epithelial dysplasia managed by observation versus excision. Head Neck 45(12):3096\u20133106","journal-title":"Head Neck"},{"key":"1833_CR35","doi-asserted-by":"publisher","unstructured":"Adeoye J, Koohi-Moghadam M, Lo AWI, Tsang RKY, Chow VLY, Zheng LW et al (2021) Deep Learning Predicts the Malignant-Transformation-Free Survival of Oral Potentially Malignant Disorders. Cancers [Internet]. 13(23). Available from: https:\/\/doi.org\/10.3390\/cancers13236054","DOI":"10.3390\/cancers13236054"}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01833-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01833-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01833-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:27Z","timestamp":1767588807000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01833-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1833"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01833-8","relation":{},"ISSN":["1936-0568"],"issn-type":[{"value":"1936-0568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"96"}}