{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:54:53Z","timestamp":1767588893843,"version":"3.48.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Head and Neck Pathol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 58-year-old woman presented with an asymptomatic, soft-to-palpation, mobile, right thyroid mass. Subsequent ultrasonography revealed numerous, bilateral, mildly heterogenous, cystic and solid nodules, including a hypoechoic, 1.7\u2009\u00d7\u20091.0\u2009\u00d7\u20091.6\u00a0cm, solid, left superior pole nodule of intermediate morphologic suspicion, meeting ATA criteria for FNA biopsy. Cytopathologic diagnosis was suspicious for papillary thyroid carcinoma and ThyroSeq molecular testing revealed an underlying\n                    <jats:italic>CREB3L2::PPAR\u03b3<\/jats:italic>\n                    fusion, implying a high risk for \u201cmalignancy or non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)\u201d. A left thyroid lobectomy was performed. Gross examination revealed a 1.1\u2009\u00d7\u20090.7\u2009\u00d7\u20091.0\u00a0cm, white-tan, firm, well-circumscribed nodule lacking gross evidence of invasion, which was entirely submitted for histologic examination. Microscopically, the nodule was fully enveloped by a thin fibrous capsule and composed entirely of microfollicles. Follicular epithelial cells featured moderate amounts of pale, eosinophilic, cytoplasm, and enlarged, wrinkled or irregular nuclei with chromatin clearing, grooves, and occasional intranuclear cytoplasmic pseudoinclusions. Papillary or solid growth patterns, psammoma bodies, increased mitoses, necrosis, or invasion were absent. As anticipated, immunostaining using the BRAF V600E mutant specific antibody (VE1) was negative. However, the intranuclear pseudoinclusions were negative for ubiquitin. Here, we report the clinical, radiologic, cytologic, histologic, and molecular characteristics of an example of NIFTP harboring a rare\n                    <jats:italic>CREB3L2::PPAR\u03b3<\/jats:italic>\n                    fusion.\n                  <\/jats:p>","DOI":"10.1007\/s12105-025-01837-4","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:18:08Z","timestamp":1755782288000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features and CREB3L2::PPAR\u03b3 Fusion"],"prefix":"10.1007","volume":"19","author":[{"given":"Christopher J.","family":"Dennis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prokopios P.","family":"Argyris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-2746","authenticated-orcid":false,"given":"Nicole A.","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"1837_CR1","unstructured":"WHO Classification of Tumours Editorial Board Endocrine and neuroendocrine tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2025 [cited on 07\/27\/25]. (WHO classification of tumours series, 5th ed.; vol. 10). https:\/\/tumourclassification.iarc.who.int\/chapters\/53"},{"issue":"4","key":"1837_CR2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1089\/thy.2016.0583","volume":"27","author":"VA Paulson","year":"2017","unstructured":"Paulson VA, Shivdasani P, Angell TE, Cibas ES, Krane JF, Lindeman NI et al (2017) Noninvasive follicular thyroid neoplasm with Papillary-Like nuclear features accounts for more than half of carcinomas harboring RAS mutations. Thyroid 27(4):506\u2013511. https:\/\/doi.org\/10.1089\/thy.2016.0583","journal-title":"Thyroid"},{"issue":"5","key":"1837_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1053\/j.semdp.2020.06.001","volume":"37","author":"YH Chu","year":"2020","unstructured":"Chu YH, Sadow PM (2020) Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): diagnostic updates and molecular advances. Semin Diagn Pathol 37(5):213\u2013218. https:\/\/doi.org\/10.1053\/j.semdp.2020.06.001","journal-title":"Semin Diagn Pathol"},{"issue":"17","key":"1837_CR4","doi-asserted-by":"publisher","first-page":"7156","DOI":"10.1158\/0008-5472.CAN-08-1085","volume":"68","author":"WO Lui","year":"2008","unstructured":"Lui WO, Zeng L, Rehrmann V, Deshpande S, Tretiakova M, Kaplan EL et al (2008) CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis. Cancer Res 68(17):7156\u20137164. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1085","journal-title":"Cancer Res"},{"key":"1837_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0905-7","author":"V Cracolici","year":"2018","unstructured":"Cracolici V, Krausz T, Cipriani NA (2018) Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP. Head Neck Pathol 12(4):522\u2013528. https:\/\/doi.org\/10.1007\/s12105-018-0905-7."}],"container-title":["Head and Neck Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01837-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12105-025-01837-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12105-025-01837-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:53:12Z","timestamp":1767588792000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12105-025-01837-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1837"],"URL":"https:\/\/doi.org\/10.1007\/s12105-025-01837-4","relation":{"references":[{"id-type":"doi","id":"10.1007\/s12105-018-0905-7","asserted-by":"subject"}]},"ISSN":["1936-0568"],"issn-type":[{"type":"electronic","value":"1936-0568"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent To Participate"}}],"article-number":"105"}}